{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:03:40Z","timestamp":1790193820558,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","perinatology.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Perinatology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.clp.2016.07.001","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T06:46:03Z","timestamp":1478760363000},"page":"621-631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Physiologic Basis for Nasal Continuous Positive Airway Pressure, Heated and Humidified High-Flow Nasal Cannula, and Nasal Ventilation"],"prefix":"10.1016","volume":"43","author":[{"given":"Kevin C.","family":"Dysart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.clp.2016.07.001_bib1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.siny.2016.01.003","article-title":"Nasal intermittent positive pressure ventilation in preterm infants: equipment, evidence, and synchronization","volume":"21","author":"Owen","year":"2016","journal-title":"Semin Fetal Neonatal Med"},{"issue":"1","key":"10.1016\/j.clp.2016.07.001_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1542\/peds.2010-3875","article-title":"Targeting inflammation to prevent bronchopulmonary dysplasia: can new insights be translated into therapies?","volume":"128","author":"Wright","year":"2011","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.clp.2016.07.001_bib3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000341754","article-title":"High-flow nasal cannulae for respiratory support of preterm infants: a review of the evidence","volume":"102","author":"Manley","year":"2012","journal-title":"Neonatology"},{"issue":"24","key":"10.1016\/j.clp.2016.07.001_bib4","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJM197106172842401","article-title":"Treatment of the idiopathic respiratory-distress syndrome with continuous positive airway pressure","volume":"284","author":"Gregory","year":"1971","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.clp.2016.07.001_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000143","article-title":"Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants","author":"Davis","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"10.1016\/j.clp.2016.07.001_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003212","article-title":"Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation","author":"Davis","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clp.2016.07.001_bib7","unstructured":"Hansen JT, Koeppen BM. Netter\u2019s atlas of human physiology. 2002. Available at: http:\/\/158.69.150.236:1080\/jspui\/handle\/961944\/72970."},{"issue":"1","key":"10.1016\/j.clp.2016.07.001_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1542\/peds.74.1.58","article-title":"Apnea of prematurity: I. Lung function and regulation of breathing","volume":"74","author":"Gerhardt","year":"1984","journal-title":"Pediatrics"},{"issue":"91","key":"10.1016\/j.clp.2016.07.001_bib9","first-page":"998","article-title":"Pathophysiology of apnea of prematurity","volume":"1","author":"Miller","year":"2004","journal-title":"Fetal Neonatal Physiol"},{"key":"10.1016\/j.clp.2016.07.001_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/00016485209136866","article-title":"Humidification of the air passages","volume":"41","author":"Negus","year":"2009","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"10.1016\/j.clp.2016.07.001_bib11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0022-3476(05)82165-1","article-title":"Airway responsiveness to low inspired gas temperature in preterm neonates","volume":"118","author":"Greenspan","year":"1991","journal-title":"J\u00a0Pediatr"},{"issue":"4","key":"10.1016\/j.clp.2016.07.001_bib12","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1152\/jappl.1996.81.4.1739","article-title":"Changes in airway resistance induced by nasal inhalation of cold dry, dry, or moist air in normal individuals","volume":"81","author":"Fontanari","year":"1996","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"8","key":"10.1016\/j.clp.2016.07.001_bib13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.jp.7211543","article-title":"Comparing two methods of delivering high-flow gas therapy by nasal cannula following endotracheal extubation: a prospective, randomized, masked, crossover trial","volume":"26","author":"Woodhead","year":"2006","journal-title":"J\u00a0Perinatol"},{"issue":"1","key":"10.1016\/j.clp.2016.07.001_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0022-3476(85)80475-3","article-title":"Continuous positive airway pressure selectively reduces obstructive apnea in preterm infants","volume":"106","author":"Miller","year":"1985","journal-title":"J\u00a0Pediatr"},{"issue":"2","key":"10.1016\/j.clp.2016.07.001_bib15","first-page":"301818","article-title":"Flow-synchronized nasal intermittent positive pressure ventilation for infants <32\u00a0weeks\u2019 gestation with respiratory distress syndrome","volume":"2012","author":"Gizzi","year":"2012","journal-title":"Crit Care Res Pract"},{"issue":"1","key":"10.1016\/j.clp.2016.07.001_bib16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1442-200X.2007.02525.x","article-title":"Nasal flow-synchronized intermittent positive pressure ventilation to facilitate weaning in very low-birthweight infants: unmasked randomized controlled trial","volume":"50","author":"Moretti","year":"2008","journal-title":"Pediatr Int"},{"issue":"12","key":"10.1016\/j.clp.2016.07.001_bib17","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/ppul.23000","article-title":"High flow nasal cannula (HFNC) with Heliox decreases diaphragmatic injury in a newborn porcine lung injury model","volume":"49","author":"Jassar","year":"2014","journal-title":"Pediatr Pulmonol"},{"issue":"8","key":"10.1016\/j.clp.2016.07.001_bib18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/sj.jp.7211530","article-title":"Work of breathing using high-flow nasal cannula in preterm infants","volume":"26","author":"Saslow","year":"2006","journal-title":"J\u00a0Perinatol"},{"issue":"10","key":"10.1016\/j.clp.2016.07.001_bib19","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.rmed.2009.04.007","article-title":"Research in high flow therapy: mechanisms of action","volume":"103","author":"Dysart","year":"2009","journal-title":"Respir Med"},{"issue":"1","key":"10.1016\/j.clp.2016.07.001_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ppul.21326","article-title":"High-flow nasal cannula: impact on oxygenation and ventilation in an acute lung injury model","volume":"46","author":"Frizzola","year":"2011","journal-title":"Pediatr Pulmonol"},{"issue":"12","key":"10.1016\/j.clp.2016.07.001_bib21","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.jp.7211825","article-title":"Heated humidified high-flow nasal cannula: use and a neonatal early extubation protocol","volume":"27","author":"Holleman-Duray","year":"2007","journal-title":"J\u00a0Perinatol"},{"issue":"1","key":"10.1016\/j.clp.2016.07.001_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.burns.2005.05.003","article-title":"Use of high flow nasal cannula on a pediatric burn patient with inhalation injury and post-extubation stridor","volume":"32","author":"Byerly","year":"2006","journal-title":"Burns"},{"issue":"4","key":"10.1016\/j.clp.2016.07.001_bib23","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1378\/chest.105.4.1061","article-title":"Effect of low flow and high flow oxygen delivery on exercise tolerance and sensation of dyspnea. A study comparing the transtracheal catheter and nasal prongs","volume":"105","author":"Dewan","year":"1994","journal-title":"Chest"},{"key":"10.1016\/j.clp.2016.07.001_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1213\/00000539-193511000-00065","article-title":"The use of helium as a new therapeutic gas*","volume":"14","author":"Barach","year":"1935","journal-title":"Anesth Analg"},{"issue":"9","key":"10.1016\/j.clp.2016.07.001_bib25","first-page":"1209","article-title":"Nasal continuous positive airway pressure (CPAP) for the respiratory care of the newborn infant","volume":"54","author":"Diblasi","year":"2009","journal-title":"Respir Care"},{"issue":"6","key":"10.1016\/j.clp.2016.07.001_bib26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.7326\/0003-4819-9-6-739","article-title":"The use of helium in the treatment of asthma and obstructive lesions in the larynx and trachea","volume":"9","author":"Barach","year":"1935","journal-title":"Ann Intern Med"},{"issue":"1 Spec No","key":"10.1016\/j.clp.2016.07.001_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/adc.65.1_Spec_No.68","article-title":"Dr von Reuss on continuous positive airway pressure in 1914","volume":"65","author":"Dunn","year":"1990","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.clp.2016.07.001_bib28","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3181\/00379727-32-7724P","article-title":"Rare gases not essential to life","volume":"32","author":"Barach","year":"1934","journal-title":"Proc Soc Exp Biol Med"},{"issue":"2","key":"10.1016\/j.clp.2016.07.001_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/tropej\/fms061","article-title":"Bubble CPAP versus ventilator CPAP in preterm neonates with early onset respiratory distress\u2013a randomized controlled trial","volume":"59","author":"Tagare","year":"2013","journal-title":"J\u00a0Trop Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2016.07.001_bib30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2223\/JPED.2145","article-title":"Bubble CPAP versus CPAP with variable flow in newborns with respiratory distress: a randomized controlled trial","volume":"87","author":"Yagui","year":"2011","journal-title":"J\u00a0Pediatr (Rio J)"},{"issue":"9","key":"10.1016\/j.clp.2016.07.001_bib31","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s12098-011-0651-2","article-title":"Bubble vs conventional continuous positive airway pressure for prevention of extubation failure in preterm very low birth weight infants: a pilot study","volume":"79","author":"Yadav","year":"2012","journal-title":"Indian J Pediatr"},{"issue":"5","key":"10.1016\/j.clp.2016.07.001_bib32","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1542\/peds.112.5.1031","article-title":"A\u00a0randomized, controlled trial comparing two different continuous positive airway pressure systems for the successful extubation of extremely low birth weight infants","volume":"112","author":"Stefanescu","year":"2003","journal-title":"Pediatrics"},{"issue":"15","key":"10.1016\/j.clp.2016.07.001_bib33","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1056\/NEJMoa1300071","article-title":"High-flow nasal cannulae in very preterm infants after extubation","volume":"369","author":"Manley","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.clp.2016.07.001_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006405.pub2","article-title":"High flow nasal cannula for respiratory support in preterm infants","author":"Wilkinson","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.clp.2016.07.001_bib35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1440-1754.2011.02186.x","article-title":"High-flow nasal cannulae and nasal continuous positive airway pressure use in non-tertiary special care nurseries in Australia and New Zealand","volume":"48","author":"Manley","year":"2012","journal-title":"J\u00a0Paediatr Child Health"},{"issue":"3","key":"10.1016\/j.clp.2016.07.001_bib36","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1542\/peds.41.3.549","article-title":"The significance of grunting in hyaline membrane disease","volume":"41","author":"Harrison","year":"1968","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2016.07.001_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003212.pub2","article-title":"Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation","volume":"9","author":"Lemyre","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.clp.2016.07.001_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/MOP.0000000000000066","article-title":"Noninvasive respiratory support for neonates","volume":"26","author":"Demauro","year":"2014","journal-title":"Curr Opin Pediatr"}],"container-title":["Clinics in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510816300604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510816300604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:26:47Z","timestamp":1657672007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0095510816300604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0095510816300604"],"URL":"https:\/\/doi.org\/10.1016\/j.clp.2016.07.001","relation":{},"ISSN":["0095-5108"],"issn-type":[{"value":"0095-5108","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiologic Basis for Nasal Continuous Positive Airway Pressure, Heated and Humidified High-Flow Nasal Cannula, and Nasal Ventilation","name":"articletitle","label":"Article Title"},{"value":"Clinics in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clp.2016.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}