{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:44:16Z","timestamp":1790055856538,"version":"4.0.1"},"reference-count":86,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","perinatology.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Perinatology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.clp.2016.11.007","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:05:39Z","timestamp":1483056339000},"page":"151-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Variation of Metabolite and Hormone Contents in Human Milk"],"prefix":"10.1016","volume":"44","author":[{"given":"Hans","family":"Demmelmair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Koletzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.clp.2016.11.007_bib1","first-page":"435","article-title":"Breastfeeding and complementary feeding","volume":"113","author":"Prell","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.clp.2016.11.007_bib2","series-title":"World review of nutrition and dietetics: nutritional care of preterm infants","author":"Koletzko","year":"2014"},{"issue":"1","key":"10.1016\/j.clp.2016.11.007_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/MPG.0b013e3181adaee0","article-title":"Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and nutrition Committee on nutrition","volume":"50","author":"Agostoni","year":"2010","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.clp.2016.11.007_bib4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/1471-2431-14-216","article-title":"A\u00a0systematic review and meta-analysis of the nutrient content of preterm and term breast milk","volume":"14","author":"Gidrewicz","year":"2014","journal-title":"BMC Pediatr"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00005176-199008000-00013","article-title":"Variation in macronutrients in human bank milk: influencing factors and implications for human milk banking","volume":"11","author":"Michaelsen","year":"1990","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0095-5108(18)30056-3","article-title":"Nutritional and biochemical properties of human milk, Part II: lipids, micronutrients, and bioactive factors","volume":"26","author":"Rodriguez-Palmero","year":"1999","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.clp.2016.11.007_bib7","series-title":"Handbook of milk composition","author":"Jensen","year":"1995"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/apa.13362","article-title":"Breast milk nutrient content and infancy growth","volume":"105","author":"Prentice","year":"2016","journal-title":"Acta Paediatr"},{"issue":"12","key":"10.1016\/j.clp.2016.11.007_bib9","doi-asserted-by":"crossref","first-page":"e115043","DOI":"10.1371\/journal.pone.0115043","article-title":"Effect of maternal body mass index on hormones in breast milk: a systematic review","volume":"9","author":"Andreas","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.clp.2016.11.007_bib10","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/sj.ijo.0803585","article-title":"The intake of physiological doses of leptin during lactation in rats prevents obesity in later life","volume":"31","author":"Pico","year":"2007","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib11","doi-asserted-by":"crossref","first-page":"R768","DOI":"10.1152\/ajpregu.00138.2006","article-title":"Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance","volume":"291","author":"Gorski","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"11","key":"10.1016\/j.clp.2016.11.007_bib12","first-page":"1709","article-title":"The human milk metabolome reveals diverse oligosaccharide profiles","volume":"143","author":"Smilowitz","year":"2013","journal-title":"J\u00a0Nutr"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib13","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/oby.21519","article-title":"A\u00a0narrative review of the associations between six bioactive components in breast milk and infant adiposity","volume":"24","author":"Fields","year":"2016","journal-title":"Obesity (Silver Spring)"},{"issue":"12","key":"10.1016\/j.clp.2016.11.007_bib14","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1002\/oby.20901","article-title":"Metabolomic profiles and childhood obesity","volume":"22","author":"Perng","year":"2014","journal-title":"Obesity (Silver Spring)"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib15","doi-asserted-by":"crossref","first-page":"1776S","DOI":"10.3945\/ajcn.110.000596","article-title":"Milk protein intake, the metabolic-endocrine response, and growth in infancy: data from a randomized clinical trial","volume":"94","author":"Socha","year":"2011","journal-title":"Am J Clin Nutr"},{"issue":"18","key":"10.1016\/j.clp.2016.11.007_bib16","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/elps.201500011","article-title":"Multiplatform characterization of dynamic changes in breast milk during lactation","volume":"36","author":"Andreas","year":"2015","journal-title":"Electrophoresis"},{"issue":"16","key":"10.1016\/j.clp.2016.11.007_bib17","doi-asserted-by":"crossref","first-page":"8245","DOI":"10.1021\/ac501853d","article-title":"Breast milk metabolome characterization in a single-phase extraction, multiplatform analytical approach","volume":"86","author":"Villasenor","year":"2014","journal-title":"Anal Chem"},{"issue":"1","key":"10.1016\/j.clp.2016.11.007_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/MPG.0000000000000806","article-title":"An opinion on \u201cstaging\u201d of infant formula: a developmental perspective on infant feeding","volume":"62","author":"Lonnerdal","year":"2016","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/MCO.0000000000000562","article-title":"Infant formula: does one size fit all?","volume":"19","author":"Koletzko","year":"2016","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.clp.2016.11.007_bib20","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s11745-999-0477-2","article-title":"Lipids in human milk","volume":"34","author":"Jensen","year":"1999","journal-title":"Lipids"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00394-012-0378-5","article-title":"Breast milk fatty acid composition differs between overweight and normal weight women: the STEPS Study","volume":"52","author":"Makela","year":"2013","journal-title":"Eur J Nutr"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/ajcn\/53.2.457","article-title":"Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 mo of lactation: the DARLING Study","volume":"53","author":"Nommsen","year":"1991","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1016\/j.clp.2016.11.007_bib23","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/ajhb.22266","article-title":"Predictors of breast milk macronutrient composition in Filipino mothers","volume":"24","author":"Quinn","year":"2012","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.clp.2016.11.007_bib24","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0378-3782(01)00204-3","article-title":"Physiological aspects of human milk lipids","volume":"65","author":"Koletzko","year":"2001","journal-title":"Early Hum Dev"},{"issue":"11","key":"10.1016\/j.clp.2016.11.007_bib25","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/j.1651-2227.2011.02343.x","article-title":"Physiological aspects of human milk lipids and implications for infant feeding: a workshop report","volume":"100","author":"Koletzko","year":"2011","journal-title":"Acta Paediatr"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib26","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/10256016.2015.1071362","article-title":"Human lactation: oxidation and maternal transfer of dietary (13)C-labelled alpha-linolenic acid into human milk","volume":"52","author":"Demmelmair","year":"2016","journal-title":"Isotopes Environ Health Stud"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib27","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3945\/ajcn.110.004515","volume":"93","author":"Lattka","year":"2011","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1016\/j.clp.2016.11.007_bib28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4162\/nrp.2015.9.4.433","article-title":"Macronutrient composition of human milk from Korean mothers of full term infants born at 37-42 gestational weeks","volume":"9","author":"Chang","year":"2015","journal-title":"Nutr Res Pract"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib29","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.3945\/ajcn.2008.27091","article-title":"Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial","volume":"89","author":"Koletzko","year":"2009","journal-title":"Am J Clin Nutr"},{"issue":"3\u20134","key":"10.1016\/j.clp.2016.11.007_bib30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000365033","article-title":"Excessive weight gain during full breast-feeding","volume":"64","author":"Grunewald","year":"2014","journal-title":"Ann Nutr Metab"},{"issue":"5","key":"10.1016\/j.clp.2016.11.007_bib31","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3945\/ajcn.113.064071","article-title":"Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial","volume":"99","author":"Weber","year":"2014","journal-title":"Am J Clin Nutr"},{"issue":"12","key":"10.1016\/j.clp.2016.11.007_bib32","doi-asserted-by":"crossref","first-page":"4800","DOI":"10.3390\/nu5124800","article-title":"Amino acid profiles in term and preterm human milk through lactation: a systematic review","volume":"5","author":"Zhang","year":"2013","journal-title":"Nutrients"},{"issue":"11\u201312","key":"10.1016\/j.clp.2016.11.007_bib33","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.nut.2016.05.013","article-title":"Higher concentrations of branched-chain amino acids in breast milk of obese mothers","volume":"32","author":"De Luca","year":"2016","journal-title":"Nutrition"},{"issue":"3\u20134","key":"10.1016\/j.clp.2016.11.007_bib34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000365040","article-title":"Metabolomic biomarkers for obesity in humans: a short review","volume":"64","author":"Rauschert","year":"2014","journal-title":"Ann Nutr Metab"},{"issue":"4","key":"10.1016\/j.clp.2016.11.007_bib35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A\u00a0branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.clp.2016.11.007_bib36","first-page":"2108909","article-title":"Tyrosine is associated with insulin resistance in longitudinal metabolomic profiling of obese children","volume":"2016","author":"Hellmuth","year":"2016","journal-title":"J\u00a0Diabetes Res"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00726-012-1371-2","article-title":"Amino acid sensing in the gastrointestinal tract","volume":"45","author":"San Gabriel","year":"2013","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.clp.2016.11.007_bib38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/10408398.2012.713047","article-title":"The nutritional value of protein-hydrolyzed formulae","volume":"56","author":"Agostoni","year":"2016","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib39","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s13105-015-0419-7","article-title":"Over-nutrient environment during both prenatal and postnatal development increases severity of islet injury, hyperglycemia, and metabolic disorders in the offspring","volume":"71","author":"Li","year":"2015","journal-title":"J\u00a0Physiol Biochem"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib40","doi-asserted-by":"crossref","first-page":"237.e1-e13","DOI":"10.1016\/j.ajog.2014.03.025","article-title":"Maternal obesity and high-fat diet program offspring metabolic syndrome","volume":"211","author":"Desai","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.clp.2016.11.007_bib41","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jnutbio.2015.02.012","article-title":"Perinatal protein restriction affects milk free amino acid and fatty acid profile in lactating rats: potential role on pup growth and metabolic status","volume":"26","author":"Martin Agnoux","year":"2015","journal-title":"J\u00a0Nutr Biochem"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib42","doi-asserted-by":"crossref","first-page":"R184","DOI":"10.1152\/ajpregu.00015.2014","article-title":"Time window-dependent effect of perinatal maternal protein restriction on insulin sensitivity and energy substrate oxidation in adult male offspring","volume":"307","author":"Agnoux","year":"2014","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib43","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2265.2009.03585.x","article-title":"Can hormones contained in mothers' milk account for the beneficial effect of breast-feeding on obesity in children?","volume":"71","author":"Savino","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib44","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.coph.2004.06.008","article-title":"Gastric leptin: a new manager of gastrointestinal function","volume":"4","author":"Guilmeau","year":"2004","journal-title":"Curr Opin Pharmacol"},{"issue":"1","key":"10.1016\/j.clp.2016.11.007_bib45","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/dvdy.1233","article-title":"Perinatal expression of leptin in rat stomach","volume":"223","author":"Oliver","year":"2002","journal-title":"Dev Dyn"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib46","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1203\/PDR.0b013e31823214ea","article-title":"Leptin in maternal serum and breast milk: association with infants' body weight gain in a longitudinal study over 6\u00a0months of lactation","volume":"70","author":"Schuster","year":"2011","journal-title":"Pediatr Res"},{"issue":"8","key":"10.1016\/j.clp.2016.11.007_bib47","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/oby.2006.155","article-title":"A\u00a0physiological role of breast milk leptin in body weight control in developing infants","volume":"14","author":"Miralles","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib48","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1515\/JPEM.2005.18.2.181","article-title":"Longitudinal investigation of the relationship between breast milk leptin levels and growth in breast-fed infants","volume":"18","author":"Dundar","year":"2005","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib49","doi-asserted-by":"crossref","first-page":"G242","DOI":"10.1152\/ajpgi.00334.2005","article-title":"Secretion of soluble leptin receptors by exocrine and endocrine cells of the gastric mucosa","volume":"290","author":"Cammisotto","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.clp.2016.11.007_bib50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mehy.2015.11.014","article-title":"Human breast milk and adipokines\u2013A potential role for the soluble leptin receptor (sOb-R) in the regulation of infant energy intake and development","volume":"86","author":"Zepf","year":"2016","journal-title":"Med Hypotheses"},{"issue":"10","key":"10.1016\/j.clp.2016.11.007_bib51","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1590\/0102-311X00159914","article-title":"Maternal obesity and offspring body composition by indirect methods: a systematic review and meta-analysis","volume":"31","author":"Castillo-Laura","year":"2015","journal-title":"Cad Saude Publica"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib52","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1097\/EDE.0b013e3181567ed4","article-title":"Adipokines in human milk and risk of overweight in early childhood: a prospective cohort study","volume":"18","author":"Weyermann","year":"2007","journal-title":"Epidemiology"},{"issue":"5","key":"10.1016\/j.clp.2016.11.007_bib53","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/08035250510027642","article-title":"Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life","volume":"94","author":"Savino","year":"2005","journal-title":"Acta Paediatr"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib54","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/ajcn\/72.2.484","article-title":"Serum leptin concentrations in infants: effects of diet, sex, and adiposity","volume":"72","author":"Lonnerdal","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.clp.2016.11.007_bib55","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1203\/PDR.0b013e3181df5421","article-title":"Body composition from birth to 4.5\u00a0months in infants born to non-obese women","volume":"68","author":"Carberry","year":"2010","journal-title":"Pediatr Res"},{"issue":"4","key":"10.1016\/j.clp.2016.11.007_bib56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4274\/jcrpe.1531","article-title":"Adipokines in breast milk: an update","volume":"6","author":"Catli","year":"2014","journal-title":"J\u00a0Clin Res Pediatr Endocrinol"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib57","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10911-010-9187-8","article-title":"Diverse and active roles for adipocytes during mammary gland growth and function","volume":"15","author":"Hovey","year":"2010","journal-title":"J\u00a0Mammary Gland Biol Neoplasia"},{"issue":"5","key":"10.1016\/j.clp.2016.11.007_bib58","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/dvdy.21947","article-title":"Diet-induced obesity disrupts ductal development in the mammary glands of nonpregnant mice","volume":"238","author":"Kamikawa","year":"2009","journal-title":"Dev Dyn"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/01.mpg.0000226377.03247.fb","article-title":"Gastrointestinal tract as a target organ for orally administered insulin","volume":"43","author":"Shehadeh","year":"2006","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"5","key":"10.1016\/j.clp.2016.11.007_bib60","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3945\/ajcn.115.126375","article-title":"Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome","volume":"103","author":"Lemas","year":"2016","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"10.1016\/j.clp.2016.11.007_bib61","doi-asserted-by":"crossref","first-page":"e010778","DOI":"10.1136\/bmjopen-2015-010778","article-title":"Impact of maternal BMI and sampling strategy on the concentration of leptin, insulin, ghrelin and resistin in breast milk across a single feed: a longitudinal cohort study","volume":"6","author":"Andreas","year":"2016","journal-title":"BMJ Open"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib62","first-page":"1355","article-title":"Diagnosis and classification of diabetes mellitus: new criteria","volume":"58","author":"Mayfield","year":"1998","journal-title":"Am Fam Physician"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib63","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/j.1536-4801.1987.tb09269.x","article-title":"Hormones in milk","volume":"6","author":"Koldovsky","year":"1987","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"4","key":"10.1016\/j.clp.2016.11.007_bib64","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3945\/ajcn.111.028431","article-title":"Associations of prenatal metabolic abnormalities with insulin and adiponectin concentrations in human milk","volume":"95","author":"Ley","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clp.2016.11.007_bib65","doi-asserted-by":"crossref","first-page":"296368","DOI":"10.1155\/2012\/296368","article-title":"Analysis of insulin in human breast milk in mothers with type 1 and type 2 diabetes mellitus","volume":"2012","author":"Whitmore","year":"2012","journal-title":"Int J Endocrinol"},{"issue":"Pt A","key":"10.1016\/j.clp.2016.11.007_bib66","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cca.2015.02.021","article-title":"Clinical impact of human breast milk metabolomics","volume":"451","author":"Cesare Marincola","year":"2015","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib67","first-page":"546","article-title":"Nutrimetabolomics and adipocitokines in the \u201cgreat obstetrical syndromes\u201d","volume":"13","author":"De Magistris","year":"2015","journal-title":"Pediatr Endocrinol Rev"},{"issue":"Suppl 5","key":"10.1016\/j.clp.2016.11.007_bib68","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/14767058.2012.715436","article-title":"A\u00a0metabolomic study of preterm human and formula milk by high resolution NMR and GC\/MS analysis: preliminary results","volume":"25","author":"Marincola","year":"2012","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib69","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/14786419.2013.843180","article-title":"Exploring human breast milk composition by NMR-based metabolomics","volume":"28","author":"Pratico","year":"2014","journal-title":"Nat Prod Res"},{"issue":"Suppl 2","key":"10.1016\/j.clp.2016.11.007_bib70","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/14767058.2014.955958","article-title":"A\u00a0metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results","volume":"27","author":"Longini","year":"2014","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"8","key":"10.1016\/j.clp.2016.11.007_bib71","first-page":"1698","article-title":"Infant maturity at birth reveals minor differences in the maternal milk metabolome in the first month of lactation","volume":"145","author":"Spevacek","year":"2015","journal-title":"J\u00a0Nutr"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib72","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.bbrc.2015.11.114","article-title":"NMR-based metabolite profiling of human milk: a pilot study of methods for investigating compositional changes during lactation","volume":"469","author":"Wu","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.clp.2016.11.007_bib73","doi-asserted-by":"crossref","DOI":"10.3390\/nu8050304","article-title":"The effect of gestational and lactational age on the human milk metabolome","volume":"8","author":"Sundekilde","year":"2016","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.clp.2016.11.007_bib74","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1006\/bbrc.1997.7736","article-title":"Leptin is present in human milk and is related to maternal plasma leptin concentration and adiposity","volume":"240","author":"Houseknecht","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib75","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1515\/JPEM.2000.13.2.149","article-title":"Breast milk leptin concentrations in initial and terminal milk samples: relationships to maternal and infant plasma leptin concentrations, adiposity, serum glucose, insulin, lipid and lipoprotein levels","volume":"13","author":"Ucar","year":"2000","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib76","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1054\/clnu.2001.0525","article-title":"Breast milk leptin: its relationship to maternal and infant adiposity","volume":"21","author":"Uysal","year":"2002","journal-title":"Clin Nutr"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib77","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1530\/eje.0.1510271","article-title":"Time-course of leptin levels in term and preterm human milk","volume":"151","author":"Bielicki","year":"2004","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"10.1016\/j.clp.2016.11.007_bib78","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1373\/clinchem.2005.063032","article-title":"Adiponectin, adipocyte fatty acid binding protein, and epidermal fatty acid binding protein: proteins newly identified in human breast milk","volume":"52","author":"Bronsky","year":"2006","journal-title":"Clin Chem"},{"issue":"4","key":"10.1016\/j.clp.2016.11.007_bib79","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/MPG.0b013e3182062fcc","article-title":"Adiponectin, AFABP, and leptin in human breast milk during 12\u00a0months of lactation","volume":"52","author":"Bronsky","year":"2011","journal-title":"J\u00a0Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib80","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.earlhumdev.2011.03.004","article-title":"Leptin determination in colostrum and early human milk from mothers of preterm and term infants","volume":"87","author":"Eilers","year":"2011","journal-title":"Early Hum Dev"},{"issue":"4","key":"10.1016\/j.clp.2016.11.007_bib81","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.2047-6310.2012.00059.x","article-title":"Relationship of insulin, glucose, leptin, IL-6 and TNF-alpha in human breast milk with infant growth and body composition","volume":"7","author":"Fields","year":"2012","journal-title":"Pediatr Obes"},{"issue":"10","key":"10.1016\/j.clp.2016.11.007_bib82","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.earlhumdev.2012.05.004","article-title":"Resistin and leptin in breast milk and infants in early life","volume":"88","author":"Savino","year":"2012","journal-title":"Early Hum Dev"},{"issue":"7","key":"10.1016\/j.clp.2016.11.007_bib83","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/oby.20345","article-title":"Presence and dynamics of leptin, GLP-1, and PYY in human breast milk at early postpartum","volume":"21","author":"Schueler","year":"2013","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"10.1016\/j.clp.2016.11.007_bib84","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.2047-6310.2014.222.x","article-title":"Breast milk leptin and adiponectin in relation to infant body composition up to 2 years","volume":"10","author":"Brunner","year":"2015","journal-title":"Pediatr Obes"},{"issue":"2","key":"10.1016\/j.clp.2016.11.007_bib85","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/0890334414553247","article-title":"Maternal characteristics associated with milk leptin content in a sample of Filipino women and associations with infant weight for age","volume":"31","author":"Quinn","year":"2015","journal-title":"J\u00a0Hum Lact"},{"issue":"6","key":"10.1016\/j.clp.2016.11.007_bib86","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/nu8060383","article-title":"Mother and infant body mass index, breast milk leptin and their serum leptin values","volume":"8","author":"Savino","year":"2016","journal-title":"Nutrients"}],"container-title":["Clinics in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510816301051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510816301051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T13:57:43Z","timestamp":1718978263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0095510816301051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0095510816301051"],"URL":"https:\/\/doi.org\/10.1016\/j.clp.2016.11.007","relation":{},"ISSN":["0095-5108"],"issn-type":[{"value":"0095-5108","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variation of Metabolite and Hormone Contents in Human Milk","name":"articletitle","label":"Article Title"},{"value":"Clinics in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clp.2016.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}