{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:12:50Z","timestamp":1789945970386,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Perinatology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.clp.2019.02.006","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T03:37:28Z","timestamp":1553571448000},"page":"311-325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Pharmacologic Prevention and Treatment of Neonatal Brain Injury"],"prefix":"10.1016","volume":"46","author":[{"given":"Melanie A.","family":"McNally","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet S.","family":"Soul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clp.2019.02.006_bib1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.clp.2019.02.006_bib2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/heapol\/czs053","article-title":"Newborn survival: a multi-country analysis of a decade of change","volume":"27","author":"Lawn","year":"2012","journal-title":"Health Policy Plan"},{"key":"10.1016\/j.clp.2019.02.006_bib3","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0140-6736(10)60549-1","article-title":"Global, regional, and national causes of child mortality in 2008: a systematic analysis","volume":"375","author":"Black","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.clp.2019.02.006_bib4","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.clp.2019.02.006_bib5","first-page":"1","article-title":"Cooling in a low-resource environment: lost in translation","volume":"20","author":"Montaldo","year":"2014","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.clp.2019.02.006_bib6","doi-asserted-by":"crossref","first-page":"F519","DOI":"10.1136\/archdischild-2015-308398","article-title":"Management of therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in a tertiary centre in South Africa","volume":"100","author":"Kali","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.clp.2019.02.006_bib7","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1474-4422(11)70016-3","article-title":"Treatment advances in neonatal neuroprotection and neurointensive care","volume":"10","author":"Johnston","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clp.2019.02.006_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0045-9380(99)80055-3","article-title":"Erythropoietin in the neonate","volume":"29","author":"Juul","year":"1999","journal-title":"Curr Probl Pediatr"},{"key":"10.1016\/j.clp.2019.02.006_bib9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1242\/dev.129.2.505","article-title":"Erythropoietin receptor signalling is required for normal brain development","volume":"129","author":"Yu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.clp.2019.02.006_bib10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3171\/2010.5.PEDS1032","article-title":"Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury","volume":"6","author":"Mazur","year":"2010","journal-title":"J\u00a0Neurosurg Pediatr"},{"key":"10.1016\/j.clp.2019.02.006_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.pediatrneurol.2014.06.008","article-title":"Erythropoietin: emerging role of erythropoietin in neonatal neuroprotection","volume":"51","author":"Rangarajan","year":"2014","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.clp.2019.02.006_bib12","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.clp.2015.04.004","article-title":"Erythropoietin and neonatal neuroprotection","volume":"42","author":"Juul","year":"2015","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.clp.2019.02.006_bib13","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1542\/peds.2013-0143","article-title":"A\u00a0randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants","volume":"132","author":"Ohls","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib14","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1542\/peds.2008-3553","article-title":"Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy","volume":"124","author":"Zhu","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib15","doi-asserted-by":"crossref","first-page":"e1135","DOI":"10.1542\/peds.2009-2268","article-title":"Human recombinant erythropoietin in asphyxia neonatorum: pilot trial","volume":"125","author":"Elmahdy","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib16","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/jp.2017.17","article-title":"Erythropoietin monotherapy in perinatal asphyxia with moderate to severe encephalopathy: a randomized placebo-controlled trial","volume":"37","author":"Malla","year":"2017","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.clp.2019.02.006_bib17","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1542\/peds.2012-0498","article-title":"Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics","volume":"130","author":"Wu","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib18","doi-asserted-by":"crossref","first-page":"e20160191","DOI":"10.1542\/peds.2016-0191","article-title":"High-dose erythropoietin and hypothermia for hypoxic-ischemic encephalopathy: a phase II trial","volume":"137","author":"Wu","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib19","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/pr.2017.15","article-title":"High-dose erythropoietin population pharmacokinetics in neonates with hypoxic-ischemic encephalopathy receiving hypothermia","volume":"81","author":"Frymoyer","year":"2017","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clp.2019.02.006_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1159\/000486820","article-title":"High-dose erythropoietin for asphyxia and encephalopathy (HEAL): a randomized controlled trial \u2013 background, aims, and study protocol","volume":"113","author":"Juul","year":"2018","journal-title":"Neonatology"},{"key":"10.1016\/j.clp.2019.02.006_bib21","doi-asserted-by":"crossref","first-page":"e681","DOI":"10.1542\/peds.2008-2701","article-title":"Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants","volume":"124","author":"Brown","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1203\/pdr.0b013e3180332cec","article-title":"A\u00a0comparison of high-dose recombinant erythropoietin treatment regimens in brain-injured neonatal rats","volume":"61","author":"Kellert","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clp.2019.02.006_bib23","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1542\/peds.2007-2711","article-title":"A\u00a0phase I\/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety","volume":"122","author":"Juul","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jpeds.2015.02.052","article-title":"Safety of early high-dose recombinant erythropoietin for neuroprotection in very preterm infants","volume":"167","author":"Fauch\u00e8re","year":"2015","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2019.02.006_bib25","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/jama.2014.9645","article-title":"Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age","volume":"312","author":"Leuchter","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.clp.2019.02.006_bib26","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1001\/jama.2016.5504","article-title":"Effect of early prophylactic high-dose recombinant human erythropoietin in very preterm infants on neurodevelopmental outcome at 2 years","volume":"315","author":"Natalucci","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.clp.2019.02.006_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/ana.24677","article-title":"Recombinant human erythropoietin improves neurological outcomes in very preterm infants","volume":"80","author":"Song","year":"2016","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clp.2019.02.006_bib28","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1542\/peds.2013-4307","article-title":"Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo","volume":"133","author":"Ohls","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib29","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jpeds.2017.01.020","article-title":"Impact of erythropoiesis-stimulating agents on behavioral measures in children born preterm","volume":"184","author":"Lowe","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2019.02.006_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020265","article-title":"Role of antioxidants in neonatal hypoxic\u2013ischemic brain injury: new therapeutic approaches","volume":"18","author":"Arteaga","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clp.2019.02.006_bib31","first-page":"405","article-title":"Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats","volume":"33","author":"Palmer","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clp.2019.02.006_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1542\/peds.101.2.185","article-title":"Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity","volume":"101","author":"Van Bel","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib33","doi-asserted-by":"crossref","first-page":"F163","DOI":"10.1136\/adc.2005.086652","article-title":"Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia","volume":"91","author":"Benders","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.clp.2019.02.006_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pediatrneurol.2006.08.005","article-title":"Effect of allopurinol supplementation on nitric oxide levels in asphyxiated newborns","volume":"36","author":"Gunes","year":"2007","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.clp.2019.02.006_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/archdischild-2011-300356","article-title":"Long-term neuroprotective effects of allopurinol after moderate perinatal asphyxia: follow-up of two randomised controlled trials","volume":"97","author":"Kaandorp","year":"2012","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.clp.2019.02.006_bib36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/01.ogx.0000361378.74763.4b","article-title":"Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B","volume":"64","author":"Torrance","year":"2009","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.clp.2019.02.006_bib37","doi-asserted-by":"crossref","first-page":"F216","DOI":"10.1136\/archdischild-2014-306769","article-title":"Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial","volume":"100","author":"Kaandorp","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.clp.2019.02.006_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000484891","article-title":"Magnesium as a neuroprotective agent: a review of its use in the fetus, term infant with neonatal encephalopathy, and the adult stroke patient","volume":"40","author":"Lingam","year":"2018","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.clp.2019.02.006_bib39","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/2249-4847.159863","article-title":"Multicenter randomized controlled trial of therapeutic hypothermia plus magnesium sulfate versus therapeutic hypothermia plus placebo in the management of term and near-term infants with hypoxic ischemic encephalopathy (The Mag Cool study): a pilot study","volume":"4","author":"Rahman","year":"2015","journal-title":"J\u00a0Clin Neonatol"},{"key":"10.1016\/j.clp.2019.02.006_bib40","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/jp.2013.65","article-title":"Magnesium for newborns with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis","volume":"33","author":"Tagin","year":"2013","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.clp.2019.02.006_bib41","first-page":"1","article-title":"Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus","volume":"1968","author":"Doyle","year":"2009","journal-title":"Cochrane Libr"},{"key":"10.1016\/j.clp.2019.02.006_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pmed.1002398","article-title":"Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: an individual participant data meta-analysis","volume":"14","author":"Crowther","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.clp.2019.02.006_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000174.pub2","article-title":"Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants","author":"Fowlie","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clp.2019.02.006_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000485172","article-title":"Effect of prophylactic indomethacin in extremely low birth weight infants based on the predicted risk of severe intraventricular hemorrhage","volume":"113","author":"Foglia","year":"2018","journal-title":"Neonatology"},{"key":"10.1016\/j.clp.2019.02.006_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD012409.pub2","article-title":"Neonatal interventions for preventing cerebral palsy\u202f: an overview of Cochrane Systematic Reviews","author":"Shepherd","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.clp.2019.02.006_bib46","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1053\/j.semperi.2018.05.005","article-title":"Association between prophylactic indomethacin and death or bronchopulmonary dysplasia: a systematic review and meta-analysis of observational studies","volume":"42","author":"Jensen","year":"2018","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.clp.2019.02.006_bib47","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/jpi.12156","article-title":"Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia","volume":"57","author":"Carloni","year":"2014","journal-title":"J\u00a0Pineal Res"},{"key":"10.1016\/j.clp.2019.02.006_bib48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-079X.2007.00503.x","article-title":"Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats","volume":"44","author":"Carloni","year":"2008","journal-title":"J\u00a0Pineal Res"},{"key":"10.1016\/j.clp.2019.02.006_bib49","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/brain\/aws285","article-title":"Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model","volume":"136","author":"Robertson","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.clp.2019.02.006_bib50","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/jp.2014.186","article-title":"Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study","volume":"35","author":"Aly","year":"2015","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.clp.2019.02.006_bib51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1528-1157.2000.tb02163.x","article-title":"An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action","volume":"41","author":"Shank","year":"2000","journal-title":"Epilepsia"},{"key":"10.1016\/j.clp.2019.02.006_bib52","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1161\/01.STR.0000128029.50221.fa","article-title":"Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats","volume":"35","author":"Liu","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.clp.2019.02.006_bib53","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.expneurol.2006.04.038","article-title":"Neuroprotective effect of topiramate on hypoxic ischemic brain injury in neonatal rats","volume":"201","author":"Noh","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.clp.2019.02.006_bib54","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1080\/14767058.2017.1304536","article-title":"Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI): a feasibility study","volume":"31","author":"Filippi","year":"2018","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.clp.2019.02.006_bib55","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jpeds.2010.04.019","article-title":"Oral topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia: a safety study","volume":"157","author":"Filippi","year":"2010","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.clp.2019.02.006_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.pediatrneurol.2018.02.009","article-title":"Xenon combined with hypothermia in perinatal hypoxic-ischemic encephalopathy: a noble gas, a noble mission","author":"Amer","year":"2018","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.clp.2019.02.006_bib57","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/ana.22016","article-title":"Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs","volume":"68","author":"Chakkarapani","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clp.2019.02.006_bib58","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/jcbfm.2008.163","article-title":"Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia","volume":"29","author":"Thoresen","year":"2009","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.clp.2019.02.006_bib59","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1542\/peds.2013-0787","article-title":"Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study","volume":"133","author":"Dingley","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2019.02.006_bib60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(15)00347-6","article-title":"Moderate hypothermia within 6\u00a0h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial","volume":"15","author":"Azzopardi","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clp.2019.02.006_bib61","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1213\/ANE.0000000000000693","article-title":"The feasibility of using a portable xenon delivery device to permit earlier xenon ventilation with therapeutic cooling of neonates during ambulance retrieval","volume":"120","author":"Dingley","year":"2015","journal-title":"Anesth Analg"}],"container-title":["Clinics in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510819300132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0095510819300132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:57:04Z","timestamp":1758815824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0095510819300132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0095510819300132"],"URL":"https:\/\/doi.org\/10.1016\/j.clp.2019.02.006","relation":{},"ISSN":["0095-5108"],"issn-type":[{"value":"0095-5108","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacologic Prevention and Treatment of Neonatal Brain Injury","name":"articletitle","label":"Article Title"},{"value":"Clinics in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clp.2019.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}