{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:44:00Z","timestamp":1770745440606,"version":"3.49.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Perinatology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.clp.2020.05.014","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T11:27:36Z","timestamp":1589974056000},"page":"653-670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hemodynamic Complications in Pregnancy"],"prefix":"10.1016","volume":"47","author":[{"given":"Anne","family":"Doherty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Kingdom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9741","key":"10.1016\/j.clp.2020.05.014_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib3","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/AOG.0000000000000472","article-title":"Maternal morbidity associated with early-onset and late-onset preeclampsia","volume":"124","author":"Lisonkova","year":"2014","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2020.05.014_bib4","doi-asserted-by":"crossref","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"366","author":"Burton","year":"2019","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"issue":"7","key":"10.1016\/j.clp.2020.05.014_bib6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.placenta.2009.04.011","article-title":"Utero-placental haemodynamics in the pathogenesis of pre-eclampsia","volume":"30","author":"Hutchinson","year":"2009","journal-title":"Placenta"},{"issue":"Suppl 1","key":"10.1016\/j.clp.2020.05.014_bib7","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/S0301-2115(03)00169-6","article-title":"Structure adaptation and blood flow control in the uterine arterial system after hemochorial placentation","volume":"110","author":"Moll","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1471-0528.1994.tb13011.x","article-title":"The effects of maternal vascular pressure on the dimensions of the placental capillaries","volume":"101","author":"Karimu","year":"1994","journal-title":"Br J Obstet Gynaecol"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ajog.2004.06.066","article-title":"Shunting the intervillous space: new concepts in human uteroplacental vascularization","volume":"192","author":"Schaaps","year":"2005","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.clp.2020.05.014_bib10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3109\/14767058.2013.766705","article-title":"Physiological implications of arteriovenous anastomoses and venous hemodynamic dysfunction in early gestational uterine circulation: a review","volume":"26","author":"Gyselaers","year":"2013","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"6 Pt 1","key":"10.1016\/j.clp.2020.05.014_bib11","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/0002-9378(89)90900-9","article-title":"Central hemodynamic assessment of normal term pregnancy","volume":"161","author":"Clark","year":"1989","journal-title":"Am J Obstet Gynecol"},{"issue":"6 Pt 1","key":"10.1016\/j.clp.2020.05.014_bib12","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/0002-9378(89)90902-2","article-title":"Cardiovascular changes in early phase of pregnancy","volume":"161","author":"Capeless","year":"1989","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/clc.4960020503","article-title":"Cardiocirculatory adjustments during pregnancy -- an echocardiographic study","volume":"2","author":"Laird-Meeter","year":"1979","journal-title":"Clin Cardiol"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib14","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/HYPERTENSIONAHA.115.06667","article-title":"Maternal cardiovascular function in normal pregnancy: evidence of maladaptation to chronic volume overload","volume":"67","author":"Melchiorre","year":"2016","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.clp.2020.05.014_bib15","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1471-0528.1976.tb00921.x","article-title":"Measurement of intervillous and myometrial blood flow by an intravenous 133Xe method","volume":"83","author":"Rekonen","year":"1976","journal-title":"Br J Obstet Gynaecol"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/uog.17431","article-title":"Physiological adaptation of endothelial function to pregnancy: systematic review and meta-analysis","volume":"50","author":"Lopes van Balen","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1095\/biolreprod.116.140681","article-title":"Quantification of gestational changes in the uteroplacental vascular tree reveals vessel specific hemodynamic roles during pregnancy in mice","volume":"95","author":"Rennie","year":"2016","journal-title":"Biol Reprod"},{"key":"10.1016\/j.clp.2020.05.014_bib18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.placenta.2018.05.001","article-title":"Understanding abnormal uterine artery Doppler waveforms: a novel computational model to explore potential causes within the utero-placental vasculature","volume":"66","author":"Clark","year":"2018","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib19","doi-asserted-by":"crossref","first-page":"544.e1-12","DOI":"10.1016\/j.ajog.2013.08.019","article-title":"Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease","volume":"209","author":"Lisonkova","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"7491","key":"10.1016\/j.clp.2020.05.014_bib20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/bmj.38380.674340.E0","article-title":"Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies","volume":"330","author":"Duckitt","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.clp.2020.05.014_bib21","doi-asserted-by":"crossref","first-page":"i1753","DOI":"10.1136\/bmj.i1753","article-title":"Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies","volume":"353","author":"Bartsch","year":"2016","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.clp.2020.05.014_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \"Great Obstetrical Syndromes\" are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1515\/JPM.2006.089","article-title":"Normal and abnormal transformation of the spiral arteries during pregnancy","volume":"34","author":"Espinoza","year":"2006","journal-title":"J\u00a0Perinat Med"},{"issue":"10","key":"10.1016\/j.clp.2020.05.014_bib24","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1471-0528.1986.tb07830.x","article-title":"Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants","volume":"93","author":"Khong","year":"1986","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.clp.2020.05.014_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000422961","article-title":"Structure, molecular assembly and tissue distribution of FACIT collagen molecules","volume":"107","author":"Lethias","year":"1994","journal-title":"Contrib Nephrol"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib26","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0002-9378(92)91700-K","article-title":"Venous drainage of the human uterus: respiratory gas studies in normal and fetal growth-retarded pregnancies","volume":"166","author":"Pardi","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2020.05.014_bib27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jri.2016.08.008","article-title":"Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia","volume":"119","author":"Tannetta","year":"2017","journal-title":"J\u00a0Reprod Immunol"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib28","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1038\/s41598-017-06178-z","article-title":"Endothelial dysfunction in severe preeclampsia is mediated by soluble factors, rather than extracellular vesicles","volume":"7","author":"O'Brien","year":"2017","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib29","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/HYPERTENSIONAHA.117.09256","article-title":"Angiogenic markers and cardiovascular indices in the prediction of hypertensive disorders of pregnancy","volume":"69","author":"Verlohren","year":"2017","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.clp.2020.05.014_bib30","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S1701-2163(15)30511-9","article-title":"Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1\/PlGF ratio before the onset of early severe preeclampsia","volume":"36","author":"Doherty","year":"2014","journal-title":"J\u00a0Obstet Gynaecol Can"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib31","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/GCO.0b013e32834cb7a4","article-title":"Maternal cardiac function in preeclampsia","volume":"23","author":"Melchiorre","year":"2011","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib32","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/HYPERTENSIONAHA.108.117358","article-title":"Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease","volume":"52","author":"Valensise","year":"2008","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/1471-0528.12068","article-title":"Mid-gestational maternal cardiovascular profile in preterm and term pre-eclampsia: a prospective study","volume":"120","author":"Melchiorre","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.clp.2020.05.014_bib34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ejogrb.2017.07.018","article-title":"Non-invasive cardiac output monitoring (NICOM((R))) can predict the evolution of uteroplacental disease-Results of the prospective HANDLE study","volume":"216","author":"Monteith","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1161\/HYPERTENSIONAHA.110.162321","article-title":"Maternal cardiac dysfunction and remodeling in women with preeclampsia at term","volume":"57","author":"Melchiorre","year":"2011","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib36","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/uog.17340","article-title":"Longitudinal maternal hemodynamics in pregnancies affected by fetal growth restriction","volume":"49","author":"Stott","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib37","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/uog.3901","article-title":"Maternal cardiac function in fetal growth-restricted and non-growth-restricted small-for-gestational age pregnancies","volume":"29","author":"Bamfo","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.112.194159","article-title":"Maternal cardiovascular impairment in pregnancies complicated by severe fetal growth restriction","volume":"60","author":"Melchiorre","year":"2012","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.clp.2020.05.014_bib39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/aogs.12823","article-title":"Maternal demographics and hemodynamics for the prediction of fetal growth restriction at booking, in pregnancies at high risk for placental insufficiency","volume":"95","author":"Stott","year":"2016","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib40","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/uog.17379","article-title":"Screening for pre-eclampsia in the first trimester: role of maternal hemodynamics and bioimpedance in non-obese patients","volume":"50","author":"Gagliardi","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib41","doi-asserted-by":"crossref","first-page":"519.e1-9","DOI":"10.1016\/j.ajog.2007.11.014","article-title":"Serial hemodynamic measurement in normal pregnancy, preeclampsia, and intrauterine growth restriction","volume":"198","author":"Rang","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib42","first-page":"610","article-title":"Microvascular vasodilator response to acetylcholine is increased in women with pre-eclampsia","volume":"108","author":"Davis","year":"2001","journal-title":"BJOG"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib43","first-page":"371","article-title":"Mechanisms and clinical significance of endothelial dysfunction in high-risk pregnancies","volume":"34","author":"McLaughlin","year":"2018","journal-title":"Can J Cardiol"},{"issue":"3","key":"10.1016\/j.clp.2020.05.014_bib44","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.placenta.2014.01.008","article-title":"Placental perfusion in normal pregnancy and early and late preeclampsia: a magnetic resonance imaging study","volume":"35","author":"Sohlberg","year":"2014","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib45","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/HYPERTENSIONAHA.111.182170","article-title":"Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia","volume":"59","author":"Rajakumar","year":"2012","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.clp.2020.05.014_bib46","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/cvr\/cvq346","article-title":"Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling","volume":"89","author":"Cindrova-Davies","year":"2011","journal-title":"Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.clp.2020.05.014_bib47","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"7203","key":"10.1016\/j.clp.2020.05.014_bib48","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.clp.2020.05.014_bib49","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1471-0528.2002.01045.x","article-title":"Does endothelial cell activation occur with intrauterine growth restriction?","volume":"109","author":"Johnson","year":"2002","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib50","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.placenta.2004.11.007","article-title":"Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction","volume":"27","author":"Goswami","year":"2006","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/14767050701832833","article-title":"The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulation","volume":"21","author":"Chaiworapongsa","year":"2008","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"7","key":"10.1016\/j.clp.2020.05.014_bib52","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCULATIONAHA.111.054361","article-title":"Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia","volume":"125","author":"Rana","year":"2012","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.clp.2020.05.014_bib53","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1471-0528.1981.tb02222.x","article-title":"Morphological changes of the spiral arteries in the placental bed in relation to pre-eclampsia and fetal growth retardation","volume":"88","author":"Gerretsen","year":"1981","journal-title":"Br J Obstet Gynaecol"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib54","first-page":"1122","article-title":"Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task force on hypertension in pregnancy","volume":"122","year":"2013","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.clp.2020.05.014_bib55","doi-asserted-by":"crossref","first-page":"c2207","DOI":"10.1136\/bmj.c2207","article-title":"Management of hypertensive disorders during pregnancy: summary of NICE guidance","volume":"341","author":"Visintin","year":"2010","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib56","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/uog.19039","article-title":"Comparison of diagnostic accuracy of early screening for pre-eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE","volume":"51","author":"Tan","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib57","doi-asserted-by":"crossref","first-page":"103.e1","DOI":"10.1016\/j.ajog.2015.08.034","article-title":"Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13\u00a0weeks gestation","volume":"214","author":"O'Gorman","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib58","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/uog.17399","article-title":"Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13\u00a0weeks' gestation","volume":"49","author":"O'Gorman","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajog.2018.11.1087","article-title":"Predictive performance of the competing risk model in screening for preeclampsia","volume":"220","author":"Wright","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"10183","key":"10.1016\/j.clp.2020.05.014_bib60","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(18)33212-4","article-title":"Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial","volume":"393","author":"Duhig","year":"2019","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib61","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ejogrb.2010.04.009","article-title":"The preeclampsia biomarkers soluble fms-like tyrosine kinase-1 and placental growth factor: current knowledge, clinical implications and future application","volume":"151","author":"Lapaire","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"17","key":"10.1016\/j.clp.2020.05.014_bib62","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s40265-017-0823-0","article-title":"Aspirin for prevention of preeclampsia","volume":"77","author":"Atallah","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.clp.2020.05.014_bib63","doi-asserted-by":"crossref","first-page":"l5119","DOI":"10.1136\/bmj.l5119","article-title":"Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance","volume":"366","author":"Webster","year":"2019","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib64","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.placenta.2015.01.004","article-title":"Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1","volume":"36","author":"Li","year":"2015","journal-title":"Placenta"},{"issue":"9","key":"10.1016\/j.clp.2020.05.014_bib65","article-title":"Effect of low-dose aspirin on soluble FMS-like tyrosine kinase 1\/placental growth factor (sFlt-1\/PlGF ratio) in pregnancies at high risk for the development of preeclampsia","volume":"8","author":"Mayer-Pickel","year":"2019","journal-title":"J\u00a0Clin Med"},{"issue":"7","key":"10.1016\/j.clp.2020.05.014_bib66","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia","volume":"377","author":"Rolnik","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib67","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1161\/HYPERTENSIONAHA.116.08298","article-title":"Low molecular weight heparin improves endothelial function in pregnant women at high risk of preeclampsia","volume":"69","author":"McLaughlin","year":"2017","journal-title":"Hypertension"},{"issue":"15","key":"10.1016\/j.clp.2020.05.014_bib68","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1161\/CIRCULATIONAHA.105.590083","article-title":"Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase","volume":"113","author":"Baldus","year":"2006","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib69","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1161\/01.HYP.0000149950.05182.a3","article-title":"Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women","volume":"45","author":"Mello","year":"2005","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib70","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/AOG.0000000000001673","article-title":"Enoxaparin and aspirin compared with aspirin alone to prevent placenta-mediated pregnancy complications: a randomized controlled trial","volume":"128","author":"Haddad","year":"2016","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib71","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12929-017-0340-1","article-title":"Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair","volume":"24","author":"Tsai","year":"2017","journal-title":"J\u00a0Biomed Sci"},{"issue":"3","key":"10.1016\/j.clp.2020.05.014_bib72","doi-asserted-by":"crossref","first-page":"356.e1-15","DOI":"10.1016\/j.ajog.2015.12.019","article-title":"Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction","volume":"214","author":"Brownfoot","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib73","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/HYPERTENSIONAHA.117.10318","article-title":"Assessment of the fullPIERS risk prediction model in women with early-onset preeclampsia","volume":"71","author":"Ukah","year":"2018","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib74","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1056\/NEJMoa1404595","article-title":"Less-tight versus tight control of hypertension in pregnancy","volume":"372","author":"Magee","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1016\/j.clp.2020.05.014_bib75","article-title":"Drugs for treatment of very high blood pressure during pregnancy","author":"Duley","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib76","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/HYPERTENSIONAHA.117.09972","article-title":"Labetalol versus nifedipine as antihypertensive treatment for chronic hypertension in pregnancy: a randomized controlled trial","volume":"70","author":"Webster","year":"2017","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib77","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/uog.17368","article-title":"Change in maternal cardiac output from preconception to mid-pregnancy is associated with birth weight in healthy pregnancies","volume":"49","author":"Mahendru","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.clp.2020.05.014_bib78","first-page":"427","article-title":"Treatment of hypertension in pregnancy: effect of atenolol on maternal disease, preterm delivery, and fetal growth","volume":"98","author":"Easterling","year":"2001","journal-title":"Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.clp.2020.05.014_bib79","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/1471-0528.13569","article-title":"Do labetalol and methyldopa have different effects on pregnancy outcome? Analysis of data from the Control of Hypertension In Pregnancy Study (CHIPS) trial","volume":"123","author":"Magee","year":"2016","journal-title":"BJOG"},{"issue":"3","key":"10.1016\/j.clp.2020.05.014_bib80","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0731","article-title":"Late pregnancy beta blocker exposure and risks of neonatal hypoglycemia and bradycardia","volume":"138","author":"Bateman","year":"2016","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib81","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0002-9378(99)70315-7","article-title":"A\u00a0randomized, double-blind, hemodynamic evaluation of nifedipine and labetalol in preeclamptic hypertensive emergencies","volume":"181","author":"Scardo","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib82","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/HYPERTENSIONAHA.117.10606","article-title":"Should maternal hemodynamics guide antihypertensive therapy in preeclampsia?","volume":"71","author":"McLaughlin","year":"2018","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib83","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/bja\/aex045","article-title":"Comparison of bioreactance and echocardiographic non-invasive cardiac output monitoring and myocardial function assessment in primagravida women","volume":"118","author":"Doherty","year":"2017","journal-title":"Br J Anaesth"},{"issue":"9694","key":"10.1016\/j.clp.2020.05.014_bib84","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0140-6736(09)60736-4","article-title":"Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36\u00a0weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial","volume":"374","author":"Koopmans","year":"2009","journal-title":"Lancet"},{"issue":"10204","key":"10.1016\/j.clp.2020.05.014_bib85","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0140-6736(19)31963-4","article-title":"Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial","volume":"394","author":"Chappell","year":"2019","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.clp.2020.05.014_bib86","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1001\/jamapediatrics.2016.1936","article-title":"Association of neurodevelopmental outcomes and neonatal Morbidities of Extremely premature infants with differential exposure to antenatal steroids","volume":"170","author":"Chawla","year":"2016","journal-title":"JAMA Pediatr"},{"issue":"3","key":"10.1016\/j.clp.2020.05.014_bib87","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","author":"Roberts","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib88","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/GCO.0000000000000047","article-title":"Antenatal steroids: can we optimize the dose?","volume":"26","author":"Romejko-Wolniewicz","year":"2014","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.clp.2020.05.014_bib89","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bpobgyn.2016.10.006","article-title":"An integrated approach to fetal growth restriction","volume":"38","author":"Figueras","year":"2017","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib90","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/uog.13190","article-title":"Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)","volume":"42","author":"Lees","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.clp.2020.05.014_bib91","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ejogrb.2019.08.007","article-title":"A\u00a0prediction model for short-term neonatal outcomes in severe early-onset fetal growth restriction","volume":"241","author":"Sharp","year":"2019","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"10.1016\/j.clp.2020.05.014_bib92","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1080\/14656566.2019.1570134","article-title":"Current and emerging pharmacotherapy for emergency management of preeclampsia","volume":"20","author":"Cox","year":"2019","journal-title":"Expert Opin Pharmacother"},{"issue":"11","key":"10.1016\/j.clp.2020.05.014_bib93","article-title":"Magnesium sulphate and other anticonvulsants for women with pre-eclampsia","author":"Duley","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"10.1016\/j.clp.2020.05.014_bib94","doi-asserted-by":"crossref","first-page":"e1002398","DOI":"10.1371\/journal.pmed.1002398","article-title":"Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: an individual participant data meta-analysis","volume":"14","author":"Crowther","year":"2017","journal-title":"PLoS Med"},{"issue":"5","key":"10.1016\/j.clp.2020.05.014_bib95","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ajog.2004.02.037","article-title":"Delayed postpartum preeclampsia: an experience of 151 cases","volume":"190","author":"Matthys","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib96","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/ALN.0b013e3182410b22","article-title":"Peripartum subarachnoid hemorrhage: nationwide data and institutional experience","volume":"116","author":"Bateman","year":"2012","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib97","first-page":"181","article-title":"Diagnosis and management of gestational hypertension and preeclampsia","volume":"102","author":"Sibai","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib98","doi-asserted-by":"crossref","first-page":"233.e1-7","DOI":"10.1016\/j.ajog.2007.08.041","article-title":"Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium--a register-based case-control study","volume":"198","author":"Jacobsen","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"18","key":"10.1016\/j.clp.2020.05.014_bib99","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1161\/CIRCULATIONAHA.115.015721","article-title":"Epidemiology and mechanisms of de Novo and persistent hypertension in the postpartum period","volume":"132","author":"Goel","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.clp.2020.05.014_bib100","doi-asserted-by":"crossref","first-page":"j3078","DOI":"10.1136\/bmj.j3078","article-title":"Risk of post-pregnancy hypertension in women with a history of hypertensive disorders of pregnancy: nationwide cohort study","volume":"358","author":"Behrens","year":"2017","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.clp.2020.05.014_bib101","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/uog.17356","volume":"49","author":"Boardman","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.clp.2020.05.014_bib102","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/AOG.0000000000001534","article-title":"All-cause and cause-specific mortality after hypertensive disease of pregnancy","volume":"128","author":"Theilen","year":"2016","journal-title":"Obstet Gynecol"},{"issue":"13","key":"10.1016\/j.clp.2020.05.014_bib103","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/1471-0528.15394","article-title":"Recurrence of pre-eclampsia and the risk of future hypertension and cardiovascular disease: a systematic review and meta-analysis","volume":"125","author":"Brouwers","year":"2018","journal-title":"BJOG"},{"key":"10.1016\/j.clp.2020.05.014_bib104","doi-asserted-by":"crossref","first-page":"k4109","DOI":"10.1136\/bmj.k4109","article-title":"Pre-eclampsia and risk of dementia later in life: nationwide cohort study","volume":"363","author":"Basit","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.clp.2020.05.014_bib105","doi-asserted-by":"crossref","first-page":"l1516","DOI":"10.1136\/bmj.l1516","article-title":"Pre-eclampsia and risk of later kidney disease: nationwide cohort study","volume":"365","author":"Kristensen","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.clp.2020.05.014_bib106","doi-asserted-by":"crossref","first-page":"953150","DOI":"10.1155\/2013\/953150","article-title":"Preeclampsia is a biomarker for vascular disease in both mother and child: the need for a medical alert system","volume":"2013","author":"Hakim","year":"2013","journal-title":"Int J Pediatr"},{"issue":"4","key":"10.1016\/j.clp.2020.05.014_bib107","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/HYPERTENSIONAHA.116.08414","article-title":"Hypertension in pregnancy and offspring cardiovascular risk in young adulthood: prospective and sibling studies in the HUNT study (Nord-Trondelag Health Study) in Norway","volume":"69","author":"Alsnes","year":"2017","journal-title":"Hypertension"}],"container-title":["Clinics in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009551082030066X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009551082030066X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:58:07Z","timestamp":1758815887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009551082030066X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":107,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S009551082030066X"],"URL":"https:\/\/doi.org\/10.1016\/j.clp.2020.05.014","relation":{},"ISSN":["0095-5108"],"issn-type":[{"value":"0095-5108","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemodynamic Complications in Pregnancy","name":"articletitle","label":"Article Title"},{"value":"Clinics in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clp.2020.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}