{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:01:52Z","timestamp":1792807312720,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Perinatology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.clp.2022.11.007","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T18:02:04Z","timestamp":1677693724000},"page":"31-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Hypoxic-Ischemic Encephalopathy"],"prefix":"10.1016","volume":"50","author":[{"given":"Athina","family":"Pappas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Milano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina F.","family":"Chalak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9462","key":"10.1016\/j.clp.2022.11.007_bib1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(05)71048-5","article-title":"4 million neonatal deaths: when? Where? Why?","volume":"365","author":"Lawn","year":"2005","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib2","first-page":"409","article-title":"No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths","volume":"83","author":"Lawn","year":"2005","journal-title":"Bull World Health Organ"},{"issue":"10 Suppl","key":"10.1016\/j.clp.2022.11.007_bib3","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.earlhumdev.2009.08.015","article-title":"Hypothermia for hypoxic ischemic encephalopathy in infants\u00a0> or\u00a0=36\u00a0weeks","volume":"85","author":"Higgins","year":"2009","journal-title":"Early Hum Dev"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.pcl.2009.03.007","article-title":"Use of therapeutic hypothermia for term infants with hypoxic-ischemic encephalopathy","volume":"56","author":"Laptook","year":"2009","journal-title":"Pediatr Clin North America"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.clp.2009.06.007","article-title":"Fetal hypoxia insults and patterns of brain injury: insights from animal models","volume":"36","author":"Gunn","year":"2009","journal-title":"Clin perinatology"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12884-020-02876-1","article-title":"Is perinatal asphyxia predictable?","volume":"20","author":"Locatelli","year":"2020","journal-title":"BMC pregnancy and childbirth"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib7","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/01.AOG.0000445580.65983.d2","article-title":"Executive summary: neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists' Task Force on neonatal encephalopathy","volume":"123","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"14","key":"10.1016\/j.clp.2022.11.007_bib8","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy","volume":"361","author":"Azzopardi","year":"2009","journal-title":"New Engl J Med"},{"issue":"15","key":"10.1016\/j.clp.2022.11.007_bib9","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy","volume":"353","author":"Shankaran","year":"2005","journal-title":"New Engl J Med"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib10","doi-asserted-by":"crossref","first-page":"e771","DOI":"10.1542\/peds.2009-2441","article-title":"Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT","volume":"126","author":"Simbruner","year":"2010","journal-title":"Pediatrics"},{"issue":"9460","key":"10.1016\/j.clp.2022.11.007_bib11","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0140-6736(05)17946-X","article-title":"Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial","volume":"365","author":"Gluckman","year":"2005","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib12","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jpeds.2010.03.030","article-title":"Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China","volume":"157","author":"Zhou","year":"2010","journal-title":"J\u00a0Pediatr"},{"issue":"7","key":"10.1016\/j.clp.2022.11.007_bib13","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1471-0528.2012.03335.x","article-title":"The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51,519 consecutive validated samples","volume":"119","author":"Yeh","year":"2012","journal-title":"BJOG : Int J Obstet Gynaecol"},{"issue":"10","key":"10.1016\/j.clp.2022.11.007_bib14","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch Neurol"},{"key":"10.1016\/j.clp.2022.11.007_bib15","series-title":"Topics in neonatal Neurology","first-page":"61","author":"Voorhies","year":"1984"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib16","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1542\/peds.2007-1839","article-title":"Accuracy of bedside electroencephalographic monitoring in comparison with simultaneous continuous conventional electroencephalography for seizure detection in term infants","volume":"121","author":"Shah","year":"2008","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib17","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1542\/peds.2007-0514","article-title":"Sensitivity of amplitude-integrated electroencephalography for neonatal seizure detection","volume":"120","author":"Shellhaas","year":"2007","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.clp.2021.11.016","article-title":"New Horizons in mild hypoxic-ischemic encephalopathy: a Standardized algorithm to Move past conundrum of care","volume":"49","author":"Chalak","year":"2022","journal-title":"Clin Perinatol"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/jp.2017.164","article-title":"Prospective research on infants with mild encephalopathy: the PRIME study","volume":"38","author":"Prempunpong","year":"2018","journal-title":"J\u00a0Perinatol"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib20","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s41390-018-0174-x","article-title":"Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22\u00a0months","volume":"84","author":"Chalak","year":"2018","journal-title":"Pediatr Res"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/archdischild-2020-320902","article-title":"Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study","volume":"106","author":"Shipley","year":"2021","journal-title":"Arch Dis Child Fetal neonatal edition"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib22","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jpeds.2011.12.052","article-title":"Which neuroprotective Agents are Ready for Bench to bedside Translation in the newborn infant?","volume":"160","author":"Robertson","year":"2012","journal-title":"J\u00a0Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib23","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/archpediatrics.2011.1772","article-title":"Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis","volume":"166","author":"Tagin","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/pch\/pxy028","article-title":"Hypothermia for newborns with hypoxic-ischemic encephalopathy","volume":"23","author":"Lemyre","year":"2018","journal-title":"Paediatr Child Health"},{"key":"10.1016\/j.clp.2022.11.007_bib25","first-page":"8","article-title":"A\u00a0report: the definition and classification of cerebral palsy April 2006","volume":"109","author":"Rosenbaum","year":"2007","journal-title":"Developmental Med child Neurol Suppl"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00008480-199912000-00002","article-title":"Causes of cerebral palsy","volume":"11","author":"Nelson","year":"1999","journal-title":"Curr Opin Pediatr"},{"issue":"22","key":"10.1016\/j.clp.2022.11.007_bib27","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa1112066","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy","volume":"366","author":"Shankaran","year":"2012","journal-title":"New Engl J Med"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib28","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jpeds.2011.09.018","article-title":"Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy","volume":"160","author":"Shankaran","year":"2012","journal-title":"J\u00a0Pediatr"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib29","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1542\/peds.2007-3758","article-title":"Candidate genes and cerebral palsy: a population-based study","volume":"122","author":"Gibson","year":"2008","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib30","doi-asserted-by":"crossref","first-page":"F398","DOI":"10.1136\/archdischild-2011-301524","article-title":"Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy","volume":"97","author":"Shankaran","year":"2012","journal-title":"Arch Dis Child"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000505519","article-title":"Predictors of outcomes in hypoxic-ischemic encephalopathy following hypothermia: a meta-analysis","volume":"117","author":"Ouwehand","year":"2020","journal-title":"Neonatology"},{"issue":"2","key":"10.1016\/j.clp.2022.11.007_bib32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/jpc.15191","article-title":"Early detection of cerebral palsy in high-risk infants: Translation of evidence into practice in an Australian hospital","volume":"57","author":"King","year":"2021","journal-title":"J\u00a0paediatrics child Health"},{"key":"10.1016\/j.clp.2022.11.007_bib33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pediatrneurol.2021.02.003","article-title":"Early identification of cerebral palsy using neonatal MRI and General movements assessment in a cohort of high-risk term neonates","volume":"118","author":"Glass","year":"2021","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.clp.2022.11.007_bib34","doi-asserted-by":"crossref","first-page":"105449","DOI":"10.1016\/j.earlhumdev.2021.105449","article-title":"Predictive validity of a qualitative and quantitative Prechtl's General Movements Assessment at term age: comparison between preterm infants and term infants with HIE","volume":"161","author":"Robinson","year":"2021","journal-title":"Early Hum Dev"},{"issue":"9","key":"10.1016\/j.clp.2022.11.007_bib35","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jamapediatrics.2017.1689","article-title":"Early, Accurate diagnosis and early intervention in cerebral palsy: Advances in diagnosis and treatment","volume":"171","author":"Novak","year":"2017","journal-title":"JAMA Pediatr"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib36","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/dmcn.13406","article-title":"Functional outcomes in children and young people with dyskinetic cerebral palsy","volume":"59","author":"Monbaliu","year":"2017","journal-title":"Developmental Med child Neurol"},{"issue":"11","key":"10.1016\/j.clp.2022.11.007_bib37","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.ridd.2014.07.005","article-title":"Functional classifications for cerebral palsy: correlations between the gross motor function classification system (GMFCS), the manual ability classification system (MACS) and the communication function classification system (CFCS)","volume":"35","author":"Compagnone","year":"2014","journal-title":"Res Dev disabilities"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib38","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1302\/1863-2548.14.190099","article-title":"Cerebral palsy with dislocated hip and scoliosis: what to deal with first?","volume":"14","author":"Helenius","year":"2020","journal-title":"J\u00a0Child Orthop"},{"issue":"11","key":"10.1016\/j.clp.2022.11.007_bib39","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1111\/dmcn.12512","article-title":"Functional status at 18\u00a0months of age as a predictor of childhood disability after neonatal hypoxic-ischemic encephalopathy","volume":"56","author":"Natarajan","year":"2014","journal-title":"Developmental Med child Neurol"},{"issue":"20","key":"10.1016\/j.clp.2022.11.007_bib40","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1080\/09638280500076178","article-title":"Responsiveness of evaluative measures for children with cerebral palsy: the gross motor function measure and the pediatric evaluation of disability Inventory","volume":"27","author":"Vos-Vromans","year":"2005","journal-title":"Disabil Rehabil"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1300\/J006v24n03_05","article-title":"Reliability of the pediatric evaluation of disability Inventory (PEDI)","volume":"24","author":"Berg","year":"2004","journal-title":"Phys Occup Ther Pediatr"},{"key":"10.1016\/j.clp.2022.11.007_bib42","series-title":"Pediatric evaluation of disability Inventory (PEDI)","author":"Haley","year":"1998"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib43","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3109\/01942638.2012.747584","article-title":"Reliable classification of functional profiles and movement disorders of children with cerebral palsy","volume":"33","author":"Randall","year":"2013","journal-title":"Phys Occup Ther Pediatr"},{"issue":"8","key":"10.1016\/j.clp.2022.11.007_bib44","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1469-8749.2012.04312.x","article-title":"Inter-relationships of functional status in cerebral palsy: analyzing gross motor function, manual ability, and communication function classification systems in children","volume":"54","author":"Hidecker","year":"2012","journal-title":"Developmental Med child Neurol"},{"issue":"12","key":"10.1016\/j.clp.2022.11.007_bib45","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/j.1469-8749.2000.tb00695.x","article-title":"Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers. Surveillance of Cerebral Palsy in Europe (SCPE)","volume":"42","year":"2000","journal-title":"Developmental Med child Neurol"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib46","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jpeds.2008.04.013","article-title":"An algorithm for identifying and classifying cerebral palsy in young children","volume":"153","author":"Kuban","year":"2008","journal-title":"J\u00a0Pediatr"},{"issue":"2","key":"10.1016\/j.clp.2022.11.007_bib47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/pr.2011.30","article-title":"Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy","volume":"71","author":"Guillet","year":"2012","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.clp.2022.11.007_bib48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11910-020-1022-z","article-title":"State of the evidence Traffic Lights 2019: systematic review of interventions for Preventing and treating children with cerebral palsy","volume":"20","author":"Novak","year":"2020","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib49","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/archdischild-2018-316509","article-title":"School-age outcomes of children without cerebral palsy cooled for neonatal hypoxic-ischaemic encephalopathy in 2008-2010","volume":"105","author":"Lee-Kelland","year":"2020","journal-title":"Arch Dis Child Fetal neonatal edition"},{"issue":"2","key":"10.1016\/j.clp.2022.11.007_bib50","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jpeds.2013.02.003","article-title":"Long-term neurodevelopmental outcome with hypoxic-ischemic encephalopathy","volume":"163","author":"Perez","year":"2013","journal-title":"J\u00a0Pediatr"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib51","doi-asserted-by":"crossref","first-page":"F380","DOI":"10.1136\/adc.2004.067520","article-title":"Neuropsychological and educational problems at school age associated with neonatal encephalopathy","volume":"90","author":"Marlow","year":"2005","journal-title":"Arch Dis Child Fetal neonatal edition"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib52","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/87565641.2011.581320","article-title":"Specific memory impairment following neonatal encephalopathy in term-born children","volume":"37","author":"van Handel","year":"2012","journal-title":"Dev Neuropsychol"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib53","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-3476(89)80132-5","article-title":"School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term","volume":"114","author":"Robertson","year":"1989","journal-title":"J\u00a0Pediatr"},{"issue":"7","key":"10.1016\/j.clp.2022.11.007_bib54","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00431-007-0437-8","article-title":"Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review","volume":"166","author":"van Handel","year":"2007","journal-title":"Eur J Pediatr"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib55","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1542\/peds.2008-1203","article-title":"Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 years","volume":"123","author":"Steinman","year":"2009","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib56","first-page":"278","article-title":"Follow-up of the term infant after hypoxic-ischemic encephalopathy","volume":"11","author":"Robertson","year":"2006","journal-title":"Paediatr Child Health"},{"issue":"12","key":"10.1016\/j.clp.2022.11.007_bib57","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/dmcn.14187","article-title":"Early intervention programmes for infants at high risk of atypical neurodevelopmental outcome","volume":"61","author":"Hutchon","year":"2019","journal-title":"Developmental Med child Neurol"},{"issue":"2","key":"10.1016\/j.clp.2022.11.007_bib58","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/10400435.2016.1265023","article-title":"Assistive technology needs, functional difficulties, and services utilization and coordination of children with developmental disabilities in the United States","volume":"30","author":"Lin","year":"2018","journal-title":"Assist Technol"},{"issue":"2","key":"10.1016\/j.clp.2022.11.007_bib59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1056\/NEJMoa1315788","article-title":"Effects of hypothermia for perinatal asphyxia on childhood outcomes","volume":"371","author":"Azzopardi","year":"2014","journal-title":"New Engl J Med"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa041367","article-title":"Neurologic and developmental disability at six years of age after extremely preterm birth","volume":"352","author":"Marlow","year":"2005","journal-title":"New Engl J Med"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib61","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/jp.2014.190","article-title":"Short-term outcomes after perinatal hypoxic ischemic encephalopathy: a report from the Children's Hospitals Neonatal Consortium HIE focus group","volume":"35","author":"Massaro","year":"2015","journal-title":"J\u00a0Perinatol"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib62","doi-asserted-by":"crossref","first-page":"e20160659","DOI":"10.1542\/peds.2016-0659","article-title":"Early EEG grade and outcome at 5 Years after mild neonatal hypoxic ischemic encephalopathy","volume":"138","author":"Murray","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.clp.2022.11.007_bib63","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.earlhumdev.2018.02.007","article-title":"Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - a systematic review","volume":"120","author":"Conway","year":"2018","journal-title":"Early Hum Dev"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2015.09.072","article-title":"Placental pathology is associated with severity of neonatal encephalopathy and adverse developmental outcomes following hypothermia","volume":"213","author":"Mir","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib65","doi-asserted-by":"crossref","first-page":"849 e841","DOI":"10.1016\/j.ajog.2015.09.072","article-title":"Placental pathology is associated with severity of neonatal encephalopathy and adverse developmental outcomes following hypothermia","volume":"213","author":"Mir","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.clp.2022.11.007_bib66","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.earlhumdev.2018.02.008","article-title":"A\u00a0review of the conundrum of mild hypoxic-ischemic encephalopathy: current challenges and moving forward","volume":"120","author":"Chalak","year":"2018","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.clp.2022.11.007_bib67","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.earlhumdev.2018.02.005","article-title":"Best practice guidelines on management of mild neonatal encephalopathy: is it really mild?","volume":"120","author":"Chalak","year":"2018","journal-title":"Early Hum Dev"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib68","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41390-019-0547-9","article-title":"A 20 years conundrum of neonatal encephalopathy and hypoxic ischemic encephalopathy: are we closer to a consensus guideline?","volume":"86","author":"Chalak","year":"2019","journal-title":"Pediatr Res"},{"key":"10.1016\/j.clp.2022.11.007_bib69","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.earlhumdev.2018.02.007","article-title":"Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - a systematic review","volume":"120","author":"Conway","year":"2018","journal-title":"Early Hum Dev"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib70","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1469-8749.1985.tb04571.x","article-title":"Term infants with hypoxic-ischemic encephalopathy: outcome at 3.5 years","volume":"27","author":"Robertson","year":"1985","journal-title":"Dev Med Child Neurol"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib71","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/jpepsy\/jsp049","article-title":"Behavioral outcome in children with a history of neonatal encephalopathy following perinatal asphyxia","volume":"35","author":"van Handel","year":"2010","journal-title":"J\u00a0Pediatr Psychol"},{"issue":"8","key":"10.1016\/j.clp.2022.11.007_bib72","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial","volume":"165","author":"Jacobs","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib73","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jpeds.2010.03.030","article-title":"Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China","volume":"157","author":"Zhou","year":"2010","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib74","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1542\/peds.107.3.480","article-title":"Neurodevelopmental outcome of infants treated with head cooling and mild hypothermia after perinatal asphyxia","volume":"107","author":"Battin","year":"2001","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib75","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1542\/peds.2006-2839","article-title":"Determinants of outcomes after head cooling for neonatal encephalopathy","volume":"119","author":"Wyatt","year":"2007","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib76","doi-asserted-by":"crossref","first-page":"e905","DOI":"10.1542\/peds.2012-3915","article-title":"Cerebral palsy and growth failure at 6 to 7 years","volume":"132","author":"Vohr","year":"2013","journal-title":"Pediatrics"},{"issue":"7","key":"10.1016\/j.clp.2022.11.007_bib77","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13039","article-title":"Pharyngeal stimulus-induced reflexes are impaired in infants with perinatal asphyxia: Does maturation modify?","volume":"29","author":"Jensen","year":"2017","journal-title":"Neurogastroenterol Motil"},{"issue":"8","key":"10.1016\/j.clp.2022.11.007_bib78","first-page":"e28564","article-title":"Filling the Gaps for feeding difficulties in neonates with hypoxic-ischemic encephalopathy","volume":"14","author":"Arora","year":"2022","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib79","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1053\/slas.2002.126994","article-title":"Laparoscopic Nissen procedure in children","volume":"9","author":"Rothenberg","year":"2002","journal-title":"Semin Laparosc Surg"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib80","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1080\/13854046.2020.1871516","article-title":"Intervention experiences among children with congenital and neonatal conditions impacting brain development: patterns of service utilization, barriers and future directions","volume":"35","author":"Vyas","year":"2021","journal-title":"Clin Neuropsychol"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib81","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12887-021-02796-9","article-title":"Predictive value of early amplitude integrated electroencephalogram (aEEG) in sleep related problems in children with perinatal hypoxic-ischemia (HIE)","volume":"21","author":"Tian","year":"2021","journal-title":"BMC Pediatr"},{"issue":"2","key":"10.1016\/j.clp.2022.11.007_bib82","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.siny.2015.01.001","article-title":"Seizures and hypothermia: importance of electroencephalographic monitoring and considerations for treatment","volume":"20","author":"Boylan","year":"2015","journal-title":"Semin Fetal neonatal Med"},{"issue":"12","key":"10.1016\/j.clp.2022.11.007_bib83","doi-asserted-by":"crossref","first-page":"e2139604","DOI":"10.1001\/jamanetworkopen.2021.39604","article-title":"Effect of treatment of clinical seizures vs electrographic seizures in full-term and near-term neonates: a randomized clinical trial","volume":"4","author":"Hunt","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"12","key":"10.1016\/j.clp.2022.11.007_bib84","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/dmcn.13215","article-title":"Seizure burden and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy","volume":"58","author":"Kharoshankaya","year":"2016","journal-title":"Developmental Med child Neurol"},{"issue":"12","key":"10.1016\/j.clp.2022.11.007_bib85","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/dmcn.13195","article-title":"Hypothermia reduces seizure burden and improves neurological outcome in severe hypoxic-ischemic encephalopathy: an observational study","volume":"58","author":"Guidotti","year":"2016","journal-title":"Developmental Med child Neurol"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib86","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","article-title":"Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009","volume":"51","author":"Berg","year":"2010","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib87","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/dmcn.14331","article-title":"Impact of therapeutic hypothermia on infantile spasms: an observational cohort study","volume":"62","author":"Abu Dhais","year":"2020","journal-title":"Developmental Med child Neurol"},{"key":"10.1016\/j.clp.2022.11.007_bib88","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.seizure.2020.07.002","article-title":"Neonatal neuroimaging and neurophysiology predict infantile onset epilepsy after perinatal hypoxic ischemic encephalopathy","volume":"80","author":"Nevalainen","year":"2020","journal-title":"Seizure : J Br Epilepsy Assoc"},{"issue":"Suppl 3","key":"10.1016\/j.clp.2022.11.007_bib89","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/dmcn.12724","article-title":"Neonatal seizures in hypoxic-ischaemic encephalopathy--risks and benefits of anticonvulsant therapy","volume":"57","author":"Shetty","year":"2015","journal-title":"Developmental Med child Neurol"},{"issue":"6","key":"10.1016\/j.clp.2022.11.007_bib90","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s40272-017-0250-4","article-title":"Pharmacotherapy for seizures in neonates with hypoxic ischemic encephalopathy","volume":"19","author":"Yozawitz","year":"2017","journal-title":"Paediatr Drugs"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib91","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00004703-198810000-00009","article-title":"Educational readiness of survivors of neonatal encephalopathy associated with birth asphyxia at term","volume":"9","author":"Robertson","year":"1988","journal-title":"J\u00a0Dev Behav Pediatr"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib92","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1080\/13854046.2020.1833987","article-title":"Towards a biopsychosocial understanding of neurodevelopmental outcomes in children with hypoxic-ischemic encephalopathy: a mixed-methods study","volume":"35","author":"Danguecan","year":"2021","journal-title":"Clin Neuropsychol"},{"key":"10.1016\/j.clp.2022.11.007_bib93","article-title":"Stakeholder engagement in neonatal clinical trials: an opportunity for mild neonatal encephalopathy research","author":"Chalak","year":"2022","journal-title":"Pediatr Res"},{"issue":"5","key":"10.1016\/j.clp.2022.11.007_bib94","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41390-019-0460-2","article-title":"Family reflections: hope for HIE","volume":"86","author":"Pilon","year":"2019","journal-title":"Pediatr Res"},{"issue":"4 Pt 1","key":"10.1016\/j.clp.2022.11.007_bib95","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: a safety study","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.clp.2022.11.007_bib96","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.pediatrneurol.2006.05.003","article-title":"Teenage outcome after being born at term with moderate neonatal encephalopathy","volume":"35","author":"Lindstrom","year":"2006","journal-title":"Pediatr Neurol"},{"issue":"2","key":"10.1016\/j.clp.2022.11.007_bib97","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jpeds.2010.02.016","article-title":"Serial MRI and neurodevelopmental outcome in 9- to 10-year-old children with neonatal encephalopathy","volume":"157","author":"van Kooij","year":"2010","journal-title":"J\u00a0Pediatr"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib98","doi-asserted-by":"crossref","first-page":"e624","DOI":"10.1542\/peds.2014-1566","article-title":"Cognitive outcomes after neonatal encephalopathy","volume":"135","author":"Pappas","year":"2015","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.clp.2022.11.007_bib99","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ejpn.2015.01.005","article-title":"Long-term motor and behavioral outcome after perinatal hypoxic-ischemic encephalopathy","volume":"19","author":"van Schie","year":"2015","journal-title":"Eur J paediatric Neurol"},{"issue":"1","key":"10.1016\/j.clp.2022.11.007_bib100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00431-017-3028-3","article-title":"Neurodevelopmental outcome in survivors of hypoxic ischemic encephalopathy without cerebral palsy","volume":"177","author":"Hayes","year":"2018","journal-title":"Eur J Pediatr"}],"container-title":["Clinics in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009551082200121X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009551082200121X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:02:10Z","timestamp":1758816130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009551082200121X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":100,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S009551082200121X"],"URL":"https:\/\/doi.org\/10.1016\/j.clp.2022.11.007","relation":{},"ISSN":["0095-5108"],"issn-type":[{"value":"0095-5108","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxic-Ischemic Encephalopathy","name":"articletitle","label":"Article Title"},{"value":"Clinics in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clp.2022.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}