{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:28:11Z","timestamp":1790857691268,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3088,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.cmet.2004.12.008","type":"journal-article","created":{"date-parts":[[2005,2,16]],"date-time":"2005-02-16T15:06:19Z","timestamp":1108566379000},"page":"107-119","source":"Crossref","is-referenced-by-count":423,"title":["Adipocyte\/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes"],"prefix":"10.1016","volume":"1","author":[{"given":"Kazuhisa","family":"Maeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem Z.","family":"Gorgun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Furuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir T.","family":"Uysal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genichi","family":"Atsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Malone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Minokoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara B.","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex A.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan S.","family":"Hotamisligil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2004.12.008_bib1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/35055575","article-title":"Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver","volume":"409","author":"Abel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2004.12.008_bib2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1999.0255","article-title":"Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity","volume":"257","author":"Arita","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cmet.2004.12.008_bib3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/scdb.1998.0271","article-title":"Fatty acid trafficking in the adipocyte","volume":"10","author":"Bernlohr","year":"1999","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2004.12.008_bib4","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1161\/01.ATV.0000033090.81345.E6","article-title":"Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia","volume":"22","author":"Boord","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cmet.2004.12.008_bib5","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/01.CIR.0000141735.13202.B6","article-title":"Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice","volume":"110","author":"Boord","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.cmet.2004.12.008_bib6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1097-2765(00)80155-0","article-title":"A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance","volume":"2","author":"Bruning","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2004.12.008_bib7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.abb.2003.08.020","article-title":"Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes","volume":"419","author":"Chavez","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cmet.2004.12.008_bib8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/science.1071527","article-title":"Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss","volume":"297","author":"Cohen","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.cmet.2004.12.008_bib9","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/S0021-9258(19)76920-8","article-title":"Microdetermination of long-chain fatty acids in plasma and tissues","volume":"235","author":"Dole","year":"1960","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2004.12.008_bib10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/sj.ijo.0800541","article-title":"Overweight and obesity in the United States: prevalence and trends, 1960\u20131994","volume":"22","author":"Flegal","year":"1998","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.cmet.2004.12.008_bib11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2004.12.008_bib12","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1073\/pnas.98.4.2005","article-title":"Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice","volume":"98","author":"Fruebis","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2004.12.008_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0003-2697(83)90429-3","article-title":"A radiochemical procedure for the assay of fatty acid binding by proteins","volume":"132","author":"Glatz","year":"1983","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cmet.2004.12.008_bib14","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1021\/bi012177r","article-title":"Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA","volume":"41","author":"Gomez","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.cmet.2004.12.008_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2004.12.008_bib16","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1126\/science.274.5291.1377","article-title":"Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein","volume":"274","author":"Hotamisligil","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cmet.2004.12.008_bib17","doi-asserted-by":"crossref","first-page":"E335","DOI":"10.1152\/ajpendo.2001.281.2.E335","article-title":"Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR","volume":"281","author":"Kaushik","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2004.12.008_bib18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2337\/diabetes.52.2.300","article-title":"Role of the fatty acid binding protein mal1 in obesity and insulin resistance","volume":"52","author":"Maeda","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2004.12.008_bib19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/89076","article-title":"Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis","volume":"7","author":"Makowski","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2004.12.008_bib20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.1999.tb07793.x","article-title":"Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances","volume":"892","author":"Matsuzawa","year":"1999","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.cmet.2004.12.008_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/415339a","article-title":"Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase","volume":"415","author":"Minokoshi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2004.12.008_bib22","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.2337\/diab.46.8.1360","article-title":"Leptin directly alters lipid partitioning in skeletal muscle","volume":"46","author":"Muoio","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2004.12.008_bib23","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.cmet.2004.12.008_bib24","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1074\/jbc.M110970200","article-title":"Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities","volume":"277","author":"Razani","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2004.12.008_bib25","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0092-8674(01)00239-2","article-title":"New perspectives into the molecular pathogenesis and treatment of type 2 diabetes","volume":"104","author":"Saltiel","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2004.12.008_bib26","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.2337\/diabetes.48.10.1987","article-title":"Altered insulin secretion associated with reduced lipolytic efficiency in aP2\u2212\/\u2212 mice","volume":"48","author":"Scheja","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2004.12.008_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/scdb.1998.0273","article-title":"The role of TNF alpha in adipocyte metabolism","volume":"10","author":"Sethi","year":"1999","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2004.12.008_bib28","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1172\/JCI119746","article-title":"Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene","volume":"100","author":"Shimano","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2004.12.008_bib29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1172\/JCI10583","article-title":"Cellular mechanisms of insulin resistance","volume":"106","author":"Shulman","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2004.12.008_bib30","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1093\/jn\/131.11.2963","article-title":"Body fat content can be predicted in vivo in mice using a modified dual-energy X-ray absorptiometry technique","volume":"131","author":"Sjogren","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.cmet.2004.12.008_bib31","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1002\/dmrr.289","article-title":"Diabetes trends in the USA","author":"Skyler","year":"2002","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.cmet.2004.12.008_bib32","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1101\/gad.14.8.963","article-title":"Leptin-specific patterns of gene expression in white adipose tissue","volume":"14","author":"Soukas","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2004.12.008_bib33","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(01)00240-9","article-title":"Obesity and the regulation of energy balance","volume":"104","author":"Spiegelman","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2004.12.008_bib34","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1056\/NEJM200011163432007","article-title":"Cytokines in alcoholic and nonalcoholic steatohepatitis","volume":"343","author":"Tilg","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cmet.2004.12.008_bib35","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1172\/JCI200112348","article-title":"Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles","volume":"108","author":"Tong","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2004.12.008_bib36","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/39335","article-title":"Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function","volume":"389","author":"Uysal","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2004.12.008_bib37","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1210\/endo.141.9.7637","article-title":"Improved glucose and lipid metabolism in genetically obese mice lacking aP2","volume":"141","author":"Uysal","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2004.12.008_bib38","first-page":"E1","article-title":"AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes","volume":"277","author":"Winder","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cmet.2004.12.008_bib39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2004.12.008_bib40","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1061620","article-title":"Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta","volume":"293","author":"Yuan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.cmet.2004.12.008_bib41","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/414782a","article-title":"Global and societal implications of the diabetes epidemic","volume":"414","author":"Zimmet","year":"2001","journal-title":"Nature"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413105000264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413105000264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T05:24:58Z","timestamp":1683005098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413105000264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S1550413105000264"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2004.12.008","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}