{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:26:26Z","timestamp":1791239186093,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3088,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.cmet.2004.12.009","type":"journal-article","created":{"date-parts":[[2005,2,16]],"date-time":"2005-02-16T15:06:19Z","timestamp":1108566379000},"page":"93-106","source":"Crossref","is-referenced-by-count":193,"title":["Krox20 stimulates adipogenesis via C\/EBP\u03b2-dependent and -independent mechanisms"],"prefix":"10.1016","volume":"1","author":[{"given":"Zhu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier I.","family":"Torrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashim","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"Spiegelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2004.12.009_bib1","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1128\/MCB.22.22.8015-8025.2002","article-title":"Early B-cell factor (O\/E-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation","volume":"22","author":"Akerblad","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2004.12.009_bib2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1101\/gad.10.8.974","article-title":"Differential activation of adipogenesis by multiple PPAR isoforms","volume":"10","author":"Brun","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2004.12.009_bib3","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1101\/gad.5.9.1538","article-title":"Regulated expression of three C\/EBP isoforms during adipose conversion of 3T3-L1 cells","volume":"5","author":"Cao","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2004.12.009_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/j.1460-2075.1988.tb02780.x","article-title":"A gene encoding a protein with zinc fingers is activated during G0\/G1 transition in cultured cells","volume":"7","author":"Chavrier","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2004.12.009_bib5","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/j.1460-2075.1990.tb08228.x","article-title":"The segment-specific gene Krox-20 encodes a transcription factor with binding sites in the promoter region of the Hox-1.4 gene","volume":"9","author":"Chavrier","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2004.12.009_bib6","doi-asserted-by":"crossref","first-page":"16070","DOI":"10.1074\/jbc.M100681200","article-title":"Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2004.12.009_bib7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1006\/bbrc.1997.7160","article-title":"Developmental profile of homeobox gene expression during 3T3-L1 adipogenesis","volume":"237","author":"Cowherd","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cmet.2004.12.009_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1534-5807(02)00190-9","article-title":"E2Fs regulate adipocyte differentiation","volume":"3","author":"Fajas","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2004.12.009_bib9","doi-asserted-by":"crossref","first-page":"29729","DOI":"10.1074\/jbc.272.47.29729","article-title":"Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis","volume":"272","author":"Garces","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2004.12.009_bib10","doi-asserted-by":"crossref","first-page":"18464","DOI":"10.1074\/jbc.M100797200","article-title":"A role for C\/EBPbeta in regulating peroxisome proliferator-activated receptor gamma activity during adipogenesis in 3T3-L1 preadipocytes","volume":"276","author":"Hamm","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2004.12.009_bib11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1101\/gad.10.9.1096","article-title":"ADD1\/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism","volume":"10","author":"Kim","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2004.12.009_bib12","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1073\/pnas.95.8.4333","article-title":"ADD1\/SREBP1 activates PPARgamma through the production of endogenous ligand","volume":"95","author":"Kim","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2004.12.009_bib13","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1073\/pnas.0138064100","article-title":"The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity","volume":"100","author":"Landsberg","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2004.12.009_bib14","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.273.5279.1219","article-title":"Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)","volume":"273","author":"Lee","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cmet.2004.12.009_bib15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1172\/JCI15924","article-title":"Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1)","volume":"111","author":"Lee","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2004.12.009_bib16","doi-asserted-by":"crossref","first-page":"8757","DOI":"10.1073\/pnas.91.19.8757","article-title":"CCAAT\/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program","volume":"91","author":"Lin","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2004.12.009_bib17","doi-asserted-by":"crossref","first-page":"35503","DOI":"10.1074\/jbc.M402937200","article-title":"Wnt10b inhibits development of white and brown adipose tissues","volume":"279","author":"Longo","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2004.12.009_bib18","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1128\/MCB.22.15.5585-5592.2002","article-title":"Mice lacking paternally expressed Pref-1\/Dlk1 display growth retardation and accelerated adiposity","volume":"22","author":"Moon","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2004.12.009_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1534-5807(02)00401-X","article-title":"The forkhead transcription factor Foxo1 regulates adipocyte differentiation","volume":"4","author":"Nakae","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2004.12.009_bib20","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1073\/pnas.90.18.8392","article-title":"Production of high-titer helper-free retroviruses by transient transfection","volume":"90","author":"Pear","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2004.12.009_bib21","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","article-title":"PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro","volume":"4","author":"Rosen","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2004.12.009_bib22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1101\/gad.948702","article-title":"C\/EBPalpha induces adipogenesis through PPARgamma: a unified pathway","volume":"16","author":"Rosen","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2004.12.009_bib23","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/0092-8674(93)90329-O","article-title":"Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain","volume":"75","author":"Schneider-Maunoury","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2004.12.009_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0092-8674(93)90659-E","article-title":"The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation","volume":"72","author":"Sham","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2004.12.009_bib25","doi-asserted-by":"crossref","first-page":"34167","DOI":"10.1074\/jbc.M104421200","article-title":"Distinct transcriptional profiles of adipogenesis in vivo and in vitro","volume":"276","author":"Soukas","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2004.12.009_bib26","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1101\/gad.7.11.2071","article-title":"Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20","volume":"7","author":"Swiatek","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2004.12.009_bib27","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1128\/MCB.15.4.2275","article-title":"DNA-binding specificity of NGFI-A and related zinc finger transcription factors","volume":"15","author":"Swirnoff","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2004.12.009_bib28","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1093\/emboj\/16.24.7432","article-title":"Defective adipocyte differentiation in mice lacking the C\/EBPbeta and\/or C\/EBPdelta gene","volume":"16","author":"Tanaka","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2004.12.009_bib29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbrc.2004.04.176","article-title":"Sequential gene promoter interactions of C\/EBPbeta, C\/EBPalpha, and PPARgamma during adipogenesis","volume":"319","author":"Tang","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cmet.2004.12.009_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1126\/science.290.5489.134","article-title":"Function of GATA transcription factors in preadipocyte-adipocyte transition","volume":"290","author":"Tong","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cmet.2004.12.009_bib31","first-page":"1271","article-title":"Stimulation of adipogenesis in fibroblasts by PPARg2, a lipid-activated transcription factor","volume":"43","author":"Tontonoz","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2004.12.009_bib32","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/371796a0","article-title":"Krox-20 controls myelination in the peripheral nervous system","volume":"371","author":"Topilko","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2004.12.009_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/1757","article-title":"Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3","volume":"20","author":"Tourtellotte","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2004.12.009_bib34","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1126\/science.1987644","article-title":"CCAAT-enhancer binding protein: a component of a differentiation switch","volume":"251","author":"Umek","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.cmet.2004.12.009_bib35","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1242\/dev.128.24.4967","article-title":"Hindbrain patterning: Krox20 couples segmentation and specification of regional identity","volume":"128","author":"Voiculescu","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.cmet.2004.12.009_bib36","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ng0498-382","article-title":"Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies","volume":"18","author":"Warner","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2004.12.009_bib37","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/337461a0","article-title":"Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse","volume":"337","author":"Wilkinson","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2004.12.009_bib38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1172\/JCI18698","article-title":"Role of Foxa-2 in adipocyte metabolism and differentiation","volume":"112","author":"Wolfrum","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2004.12.009_bib39","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1101\/gad.9.19.2350","article-title":"Conditional ectopic expression of C\/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis","volume":"9","author":"Wu","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2004.12.009_bib40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1101\/gad.9.2.168","article-title":"Cascade regulation of terminal adipocyte differentiation by three members of the C\/EBP family of leucine zipper proteins","volume":"9","author":"Yeh","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2004.12.009_bib41","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1194\/jlr.M200126-JLR200","article-title":"Identification of Egr1 as the oncostatin M-induced transcription activator that binds to sterol-independent regulatory element of human LDL receptor promoter","volume":"43","author":"Zhang","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cmet.2004.12.009_bib42","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1074\/jbc.M311327200","article-title":"Role of CREB in transcriptional regulation of CCAAT\/enhancer-binding protein beta gene during adipogenesis","volume":"279","author":"Zhang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2004.12.009_bib43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/mcne.1996.0052","article-title":"The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation","volume":"8","author":"Zorick","year":"1996","journal-title":"Mol. Cell. Neurosci."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413105000276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413105000276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T03:30:15Z","timestamp":1625455815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413105000276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S1550413105000276"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2004.12.009","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}