{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:13:28Z","timestamp":1787660008901,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2695,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.cmet.2006.02.001","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T07:31:19Z","timestamp":1141803079000},"page":"223-229","source":"Crossref","is-referenced-by-count":111,"title":["Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: Neuronal involvement in food-intake regulation"],"prefix":"10.1016","volume":"3","author":[{"given":"Tetsuya","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Ishigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehide","family":"Ogihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junta","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Uno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisamitsu","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Niijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Aburatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoichiro","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitomo","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2006.02.001_bib1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature03527","article-title":"Vascular respiratory uncoupling increases blood pressure and atherosclerosis","volume":"435","author":"Bernal-Mizrachi","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2006.02.001_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(00)80062-3","article-title":"Identification of SOCS-3 as a potential mediator of central leptin resistance","volume":"1","author":"Bjorbaek","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2006.02.001_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3109\/07853899209164140","article-title":"Abdominal fat distribution and disease: an overview of epidemiological data","volume":"24","author":"Bjorntorp","year":"1992","journal-title":"Ann. Med."},{"key":"10.1016\/j.cmet.2006.02.001_bib4","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2006.02.001_bib5","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0092-8674(01)00474-3","article-title":"FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance","volume":"106","author":"Cederberg","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2006.02.001_bib6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cmet.2006.02.001_bib7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0092-8674(03)01081-X","article-title":"Obesity wars: molecular progress confronts an expanding epidemic","volume":"116","author":"Flier","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2006.02.001_bib8","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.1079856","article-title":"A war on obesity, not the obese","volume":"299","author":"Friedman","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cmet.2006.02.001_bib9","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2006.02.001_bib10","doi-asserted-by":"crossref","first-page":"513S","DOI":"10.1093\/ajcn\/67.3.513S","article-title":"Fuel partitioning and food intake","volume":"67","author":"Friedman","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cmet.2006.02.001_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha","volume":"425","author":"Fu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2006.02.001_bib12","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1001\/jama.282.16.1568","article-title":"Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial","volume":"282","author":"Heymsfield","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.cmet.2006.02.001_bib13","first-page":"233","article-title":"Global gene expression analysis of gastric cancer by oligonucleotide microarrays","volume":"62","author":"Hippo","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2006.02.001_bib14","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1210\/endo.138.10.5428","article-title":"Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse","volume":"138","author":"Igel","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2006.02.001_bib15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2337\/diabetes.54.2.322","article-title":"Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity","volume":"54","author":"Ishigaki","year":"2005","journal-title":"Diabetes"},{"issue":"Suppl. 1","key":"10.1016\/j.cmet.2006.02.001_bib16","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.33549\/physiolres.930000.53.S199","article-title":"Mitochondrial uncoupling proteins\u2014facts and fantasies","volume":"53","author":"Jezek","year":"2004","journal-title":"Physiol. Res."},{"key":"10.1016\/j.cmet.2006.02.001_bib17","doi-asserted-by":"crossref","first-page":"16987","DOI":"10.1074\/jbc.271.29.16987","article-title":"Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes","volume":"271","author":"Katagiri","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2006.02.001_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0005-2736(98)00232-6","article-title":"Structure and function of the uncoupling protein from brown adipose tissue","volume":"1415","author":"Klingenberg","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cmet.2006.02.001_bib19","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1172\/JCI118363","article-title":"Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity","volume":"96","author":"Kopecky","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2006.02.001_bib20","doi-asserted-by":"crossref","first-page":"8437","DOI":"10.1073\/pnas.0401013101","article-title":"Nuclear receptor corepressor RIP140 regulates fat accumulation","volume":"101","author":"Leonardsson","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2006.02.001_bib21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1749-6632.1994.tb17336.x","article-title":"Pathophysiology and pathogenesis of visceral fat obesity","volume":"748","author":"Matsuzawa","year":"1995","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.cmet.2006.02.001_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-1838(98)00109-X","article-title":"Afferent signals from leptin sensors in the white adipose tissue of the epididymis, and their reflex effect in the rat","volume":"73","author":"Niijima","year":"1998","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.cmet.2006.02.001_bib23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1113\/jphysiol.2005.086181","article-title":"Sensory transduction of pulmonary reactive oxygen species by capsaicin-sensitive vagal lung afferent fibres in rats","volume":"565","author":"Ruan","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.cmet.2006.02.001_bib24","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0899-9007(99)00125-2","article-title":"Control of food intake by fatty acid oxidation and ketogenesis","volume":"15","author":"Scharrer","year":"1999","journal-title":"Nutrition"},{"key":"10.1016\/j.cmet.2006.02.001_bib25","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1126\/science.7268408","article-title":"Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat","volume":"213","author":"Smith","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.cmet.2006.02.001_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(00)01490-7","article-title":"Leptin injection into white adipose tissue elevates renal sympathetic nerve activity dose-dependently through the afferent nerves pathway in rats","volume":"293","author":"Tanida","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.cmet.2006.02.001_bib27","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nm1001-1128","article-title":"Adipose tissue reduction in mice lacking the translational inhibitor 4E\u2013BP1","volume":"7","author":"Tsukiyama-Kohara","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2006.02.001_bib28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nature02866","article-title":"Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity","volume":"431","author":"Um","year":"2004","journal-title":"Nature"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413106000611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413106000611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T14:05:47Z","timestamp":1683381947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413106000611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S1550413106000611"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2006.02.001","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.12417.469907","asserted-by":"object"}]},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}