{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:46:36Z","timestamp":1790041596797,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1543,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.cmet.2009.05.005","type":"journal-article","created":{"date-parts":[[2009,6,3]],"date-time":"2009-06-03T08:44:01Z","timestamp":1244018641000},"page":"512-524","source":"Crossref","is-referenced-by-count":386,"title":["Activation of a HIF1\u03b1-PPAR\u03b3 Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy"],"prefix":"10.1016","volume":"9","author":[{"given":"Jaya","family":"Krishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Suter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Windak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Felley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Montessuit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Tokarska-Schlattner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Aasum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bogdanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Perriard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Perriard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terje","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Pedrazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Krek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2009.05.005_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1440-1681.2004.03954.x","article-title":"An antidiabetic thiazolidinedione induces eccentric cardiac hypertrophy by cardiac volume overload in rats","volume":"31","author":"Arakawa","year":"2004","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cmet.2009.05.005_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.prostaglandins.2006.10.004","article-title":"Pioglitazone induces de novo ceramide synthesis in the rat heart","volume":"83","author":"Baranowski","year":"2007","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.cmet.2009.05.005_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bbrc.2007.10.062","article-title":"Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of\u00a0peroxisome proliferator-activated receptor alpha\/retinoid X receptor","volume":"364","author":"Belanger","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cmet.2009.05.005_bib4","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1161\/01.RES.0000088344.15288.E6","article-title":"Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells","volume":"93","author":"Bruemmer","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2009.05.005_bib5","doi-asserted-by":"crossref","first-page":"19695","DOI":"10.1073\/pnas.0609140103","article-title":"Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis","volume":"103","author":"Cao","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2009.05.005_bib6","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1242\/dev.125.10.1943","article-title":"Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis","volume":"125","author":"Chen","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.cmet.2009.05.005_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation","volume":"7","author":"DeBerardinis","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2009.05.005_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/bj1100027","article-title":"The control of fatty acid and triglyceride synthesis in rat epididymal adipose tissue. Roles of coenzyme A derivatives, citrate and L-glycerol 3-phosphate","volume":"110","author":"Denton","year":"1968","journal-title":"Biochem. J."},{"key":"10.1016\/j.cmet.2009.05.005_bib9","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/01.RES.0000179226.34112.6d","article-title":"Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice","volume":"97","author":"Duan","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2009.05.005_bib10","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/emboj\/18.7.1905","article-title":"Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP\/p300","volume":"18","author":"Ema","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2009.05.005_bib11","doi-asserted-by":"crossref","first-page":"G1195","DOI":"10.1152\/ajpgi.00553.2006","article-title":"Regulation of triglyceride metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action","volume":"292","author":"Gonzalez-Baro","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cmet.2009.05.005_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cmet.2005.05.001","article-title":"Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing","volume":"1","author":"Guzy","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2009.05.005_bib13","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1073\/pnas.98.4.1583","article-title":"Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor","volume":"98","author":"Haase","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2009.05.005_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0092-8674(00)80769-2","article-title":"Induction of GADD45 and JNK\/SAPK-dependent apoptosis following inducible expression of BRCA1","volume":"97","author":"Harkin","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2009.05.005_bib15","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1096\/fj.04-1510fje","article-title":"Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart","volume":"18","author":"Huang","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.cmet.2009.05.005_bib16","doi-asserted-by":"crossref","first-page":"13624","DOI":"10.1073\/pnas.0405499101","article-title":"Hyperleptinemia prevents lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice","volume":"101","author":"Lee","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2009.05.005_bib17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2006.03.062","article-title":"Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice","volume":"344","author":"Lee","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cmet.2009.05.005_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1015332726303","article-title":"Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth","volume":"7","author":"Lehman","year":"2002","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.cmet.2009.05.005_bib19","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1128\/MCB.01580-07","article-title":"Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein","volume":"28","author":"Lei","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2009.05.005_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbalip.2003.09.006","article-title":"Regulation of myocardial triacylglycerol synthesis and metabolism","volume":"1634","author":"Lewin","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cmet.2009.05.005_bib21","doi-asserted-by":"crossref","first-page":"9491","DOI":"10.1128\/MCB.25.21.9491-9502.2005","article-title":"Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy","volume":"25","author":"Luo","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2009.05.005_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.physiol.62.1.289","article-title":"Genetic dissection of cardiac growth control pathways","volume":"62","author":"MacLellan","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cmet.2009.05.005_bib23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.7326\/0003-4819-144-7-200604040-00011","article-title":"Adiposity of the heart, revisited","volume":"144","author":"McGavock","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cmet.2009.05.005_bib24","doi-asserted-by":"crossref","first-page":"10990","DOI":"10.1073\/pnas.180329197","article-title":"Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer","volume":"97","author":"Mueller","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2009.05.005_bib25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1096\/fj.02-0486fje","article-title":"Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene","volume":"17","author":"Muller","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.cmet.2009.05.005_bib26","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.4049\/jimmunol.166.12.7543","article-title":"Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia","volume":"166","author":"Narravula","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.cmet.2009.05.005_bib27","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1056\/NEJMoa072761","article-title":"Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes","volume":"356","author":"Nissen","year":"2007","journal-title":"N. Engl. J.\u00a0Med."},{"key":"10.1016\/j.cmet.2009.05.005_bib28","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1172\/JCI200420468","article-title":"PPARalpha governs glycerol metabolism","volume":"114","author":"Patsouris","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2009.05.005_bib29","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1093\/emboj\/17.11.3005","article-title":"HIF-1 alpha is required for solid tumor formation and embryonic vascularization","volume":"17","author":"Ryan","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2009.05.005_bib30","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of\u00a0Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2009.05.005_bib31","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.934301","article-title":"Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival","volume":"15","author":"Schipani","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2009.05.005_bib32","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI30335","article-title":"Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice","volume":"117","author":"Son","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2009.05.005_bib33","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/diabetes.47.4.507","article-title":"PPAR-gamma: adipogenic regulator and thiazolidinedione receptor","volume":"47","author":"Spiegelman","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2009.05.005_bib34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature01874","article-title":"Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL","volume":"425","author":"Staller","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2009.05.005_bib35","first-page":"1187","article-title":"Involvement of the Oct-1 regulatory element of the gadd45 promoter in the p53-independent response to ultraviolet irradiation","volume":"61","author":"Takahashi","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2009.05.005_bib36","first-page":"55","article-title":"An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure","volume":"42","author":"Taylor","year":"2001","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.cmet.2009.05.005_bib37","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ccr.2007.04.001","article-title":"HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity","volume":"11","author":"Zhang","year":"2007","journal-title":"Cancer Cell"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413109001399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413109001399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T04:16:15Z","timestamp":1710389775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413109001399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S1550413109001399"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2009.05.005","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}