{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:59:41Z","timestamp":1791107981891,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1117,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.cmet.2010.06.008","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T05:19:47Z","timestamp":1280899187000},"page":"142-153","source":"Crossref","is-referenced-by-count":213,"title":["Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions"],"prefix":"10.1016","volume":"12","author":[{"given":"Pieter","family":"Goossens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion J.J.","family":"Gijbels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Zernecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Eijgelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique N.","family":"Vergouwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"van\u00a0der\u00a0Made","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Vanderlocht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Beckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim A.","family":"Buurman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat J.A.P.","family":"Daemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Kalinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Lutgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno P.J.","family":"de Winther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2010.06.008_bib1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nm1567","article-title":"MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment","volume":"13","author":"Bernhagen","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2010.06.008_bib2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.antiviral.2006.03.006","article-title":"Anti-inflammatory properties of Type I interferons","volume":"71","author":"Billiau","year":"2006","journal-title":"Antiviral Res."},{"key":"10.1016\/j.cmet.2010.06.008_bib3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1679\/aohc.58.307","article-title":"Ultrastructural recognition of cells with dendritic cell morphology in human aortic intima. Contacting interactions of Vascular Dendritic Cells in athero-resistant and athero-prone areas of the normal aorta","volume":"58","author":"Bobryshev","year":"1995","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.cmet.2010.06.008_bib4","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nrd2422","article-title":"Interferons at age 50: past, current and future impact on biomedicine","volume":"6","author":"Borden","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cmet.2010.06.008_bib5","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/29788","article-title":"Decreased lesion formation in CCR2-\/- mice reveals a role for chemokines in the initiation of atherosclerosis","volume":"394","author":"Boring","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2010.06.008_bib6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/01.ATV.0000253886.44609.ae","article-title":"Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice","volume":"27","author":"Braunersreuther","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cmet.2010.06.008_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0014-5793(01)03276-8","article-title":"A non-classical ISRE\/ISGF3 pathway mediates induction of RANTES gene transcription by type I IFNs","volume":"511","author":"Cremer","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cmet.2010.06.008_bib8","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2010.06.008_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0092-8674(00)81289-1","article-title":"Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease","volume":"84","author":"Durbin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2010.06.008_bib10","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nri1882","article-title":"The immune response in atherosclerosis: a double-edged sword","volume":"6","author":"Hansson","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cmet.2010.06.008_bib11","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1084\/jem.20090213","article-title":"Type I interferon drives tumor necrosis factor-induced lethal shock","volume":"206","author":"Huys","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cmet.2010.06.008_bib12","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1172\/JCI200318580","article-title":"Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice","volume":"112","author":"Kanters","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2010.06.008_bib13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nri888","article-title":"Viruses and interferon: a fight for supremacy","volume":"2","author":"Katze","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cmet.2010.06.008_bib14","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1002\/art.23035","article-title":"Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus","volume":"56","author":"Lee","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cmet.2010.06.008_bib15","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1084\/jem.166.4.1180","article-title":"Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression","volume":"166","author":"Leeuwenberg","year":"1987","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cmet.2010.06.008_bib16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ejim.2003.08.010","article-title":"Low-dose interferon-alpha accelerates atherosclerosis in an LDL receptor-deficient mouse model","volume":"14","author":"Levy","year":"2003","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.cmet.2010.06.008_bib17","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm1102-1235","article-title":"The macrophage foam cell as a target for therapeutic intervention","volume":"8","author":"Li","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2010.06.008_bib18","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1582-4934.2007.00194.x","article-title":"Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction","volume":"12","author":"Liehn","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cmet.2010.06.008_bib19","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/01.RES.85.8.e17","article-title":"Protective role of interleukin-10 in atherosclerosis","volume":"85","author":"Mallat","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2010.06.008_bib20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.coi.2007.11.001","article-title":"Atherosclerosis and systemic lupus erythematosus: mechanistic basis of the association","volume":"19","author":"McMahon","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.cmet.2010.06.008_bib21","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1189\/jlb.1102577","article-title":"Expression and function of chemokines during viral infections: from molecular mechanisms to in\u00a0vivo function","volume":"74","author":"Melchjorsen","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cmet.2010.06.008_bib22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1365-2443.2001.00448.x","article-title":"Cross talk of the interferon-alpha\/beta signalling complex with gp130 for effective interleukin-6 signalling","volume":"6","author":"Mitani","year":"2001","journal-title":"Genes Cells"},{"key":"10.1016\/j.cmet.2010.06.008_bib23","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1161\/CIRCULATIONAHA.106.642801","article-title":"Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha","volume":"114","author":"Niessner","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cmet.2010.06.008_bib24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to Listeria monocytogenes infection","volume":"200","author":"O'Connell","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cmet.2010.06.008_bib25","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1212\/WNL.43.4.662","article-title":"Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial","volume":"43","author":"Paty","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.cmet.2010.06.008_bib26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.immuni.2008.03.011","article-title":"Distinct and nonredundant in\u00a0vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system","volume":"28","author":"Prinz","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2010.06.008_bib27","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.4049\/jimmunol.181.3.2092","article-title":"Type I IFNs enhance susceptibility to Chlamydia muridarum lung infection by enhancing apoptosis of local macrophages","volume":"181","author":"Qiu","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cmet.2010.06.008_bib28","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/art.21571","article-title":"The type I interferon system in systemic lupus erythematosus","volume":"54","author":"R\u00f6nnblom","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.cmet.2010.06.008_bib29","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1212\/WNL.50.5.1294","article-title":"In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis","volume":"50","author":"Rudick","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.cmet.2010.06.008_bib30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2377-6-18","article-title":"Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNbeta-responsive genes in peripheral blood lymphocytes in\u00a0vitro: an implication for IFNbeta-related adverse effects in multiple sclerosis","volume":"6","author":"Satoh","year":"2006","journal-title":"BMC Neurol."},{"key":"10.1016\/j.cmet.2010.06.008_bib31","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1161\/01.RES.0000149518.86865.3e","article-title":"Crucial role of the CCL2\/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets","volume":"95","author":"Schober","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2010.06.008_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/ni.1836","article-title":"CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer","volume":"11","author":"Stewart","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2010.06.008_bib33","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1161\/01.ATV.0000184783.04864.9f","article-title":"Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency","volume":"25","author":"Tabas","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cmet.2010.06.008_bib34","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1462-5822.2006.00716.x","article-title":"Interferon signalling network in innate defence","volume":"8","author":"Takaoka","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.cmet.2010.06.008_bib35","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1126\/science.288.5475.2357","article-title":"Cross talk between interferon-gamma and -alpha\/beta signaling components in caveolar membrane domains","volume":"288","author":"Takaoka","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cmet.2010.06.008_bib36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/35073080","article-title":"A weak signal for strong responses: interferon-alpha\/beta revisited","volume":"2","author":"Taniguchi","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2010.06.008_bib37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/physrev.00024.2005","article-title":"Cytokines in atherosclerosis: pathogenic and regulatory pathways","volume":"86","author":"Tedgui","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cmet.2010.06.008_bib38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/ATVBAHA.107.154807","article-title":"Accumulation of\u00a0myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR-\/-\u00a0mice","volume":"28","author":"van Leeuwen","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cmet.2010.06.008_bib39","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1189\/jlb.70.5.745","article-title":"Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death","volume":"70","author":"Van Weyenbergh","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.cmet.2010.06.008_bib40","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/01.RES.0000109793.17591.4E","article-title":"Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice","volume":"94","author":"Veillard","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2010.06.008_bib41","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1161\/01.ATV.20.5.1262","article-title":"Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions","volume":"20","author":"Virmani","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cmet.2010.06.008_bib42","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.CIR.103.8.1164","article-title":"Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice","volume":"103","author":"von der Th\u00fcsen","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.cmet.2010.06.008_bib43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/ana.1096","article-title":"Complex immunomodulatory effects of interferon-beta in multiple sclerosis include the upregulation of T helper 1-associated marker genes","volume":"50","author":"Wandinger","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cmet.2010.06.008_bib44","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nri2415","article-title":"The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models","volume":"8","author":"Weber","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cmet.2010.06.008_bib45","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10495-006-5146-7","article-title":"Serum deprivation induced apoptosis in macrophage is mediated by autocrine secretion of type I IFNs","volume":"11","author":"Wei","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.cmet.2010.06.008_bib46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/ni1576","article-title":"TNF\u00a0activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes","volume":"9","author":"Yarilina","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2010.06.008_bib47","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2004.04.027","article-title":"Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques","volume":"176","author":"Yilmaz","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.cmet.2010.06.008_bib48","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1182\/blood-2005-09-3922","article-title":"Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10","volume":"107","author":"Zernecke","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.cmet.2010.06.008_bib49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/CIRCRESAHA.107.160697","article-title":"Protective role of CXC receptor 4\/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis","volume":"102","author":"Zernecke","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2010.06.008_bib50","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.atherosclerosis.2007.03.019","article-title":"Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice","volume":"197","author":"Zhang","year":"2008","journal-title":"Atherosclerosis"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413110002329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413110002329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T11:49:51Z","timestamp":1685706591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413110002329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1550413110002329"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2010.06.008","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}