{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:32:47Z","timestamp":1791138767875,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":905,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.cmet.2011.01.017","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T20:16:19Z","timestamp":1299528979000},"page":"274-282","source":"Crossref","is-referenced-by-count":106,"title":["Phosphate Incorporation during Glycogen Synthesis and Lafora Disease"],"prefix":"10.1016","volume":"13","author":[{"given":"Vincent\u00a0S.","family":"Tagliabracci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Heiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra","family":"Karthik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher\u00a0J.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Glushka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parastoo","family":"Azadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas\u00a0D.","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u00a0A.","family":"DePaoli-Roach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u00a0J.","family":"Roach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2011.01.017_bib1","first-page":"83","article-title":"Lafora disease, seizures and sugars","volume":"26","author":"Andrade","year":"2007","journal-title":"Acta Myol."},{"key":"10.1016\/j.cmet.2011.01.017_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0092-8674(00)80107-5","article-title":"From glycogen to amylopectin: a model for the biogenesis of the plant starch granule","volume":"86","author":"Ball","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2011.01.017_bib3","doi-asserted-by":"crossref","first-page":"17563","DOI":"10.1073\/pnas.1006340107","article-title":"Structural basis for glucose-6-phosphate activation of glycogen synthase","volume":"107","author":"Baskaran","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2011.01.017_bib4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1360-1385(02)02332-4","article-title":"Starch phosphorylation: a new front line in starch research","volume":"7","author":"Blennow","year":"2002","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.cmet.2011.01.017_bib5","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1128\/MCB.15.12.6632","article-title":"Requirement of the self-glucosylating initiator proteins Glg1p and Glg2p for glycogen accumulation in Saccharomyces cerevisiae","volume":"15","author":"Cheng","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2011.01.017_bib6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/s11910-007-0066-7","article-title":"Advances in lafora progressive myoclonus epilepsy","volume":"7","author":"Delgado-Escueta","year":"2007","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.cmet.2011.01.017_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0076-6879(03)66002-7","article-title":"Determination of mammalian glycogen synthase phosphatase activity","volume":"366","author":"DePaoli-Roach","year":"2003","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.cmet.2011.01.017_bib8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1432-1033.1994.tb18698.x","article-title":"Purification of 1,3-beta-D-glucan synthase activity from pea tissue. Two polypeptides of 55\u00a0kDa and 70\u00a0kDa copurify with enzyme activity","volume":"220","author":"Dhugga","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.cmet.2011.01.017_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0014-5793(80)81317-2","article-title":"The presence of phosphate in glycogen","volume":"109","author":"Fontana","year":"1980","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cmet.2011.01.017_bib10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1083\/jcb.200704094","article-title":"The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease","volume":"178","author":"Gentry","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cmet.2011.01.017_bib11","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tibs.2009.08.002","article-title":"Lafora disease: insights into neurodegeneration from plant metabolism","volume":"34","author":"Gentry","year":"2009","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cmet.2011.01.017_bib12","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0003-2697(75)90388-7","article-title":"Assay of inorganic and organic phosphorus in the 0.1-5 nanomole range","volume":"63","author":"Hess","year":"1975","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cmet.2011.01.017_bib13","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.bbrc.2009.11.007","article-title":"Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene","volume":"390","author":"Heyen","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cmet.2011.01.017_bib14","doi-asserted-by":"crossref","first-page":"23892","DOI":"10.1074\/jbc.M502344200","article-title":"Requirements for catalysis in mammalian glycogenin","volume":"280","author":"Hurley","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2011.01.017_bib15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1021\/ja01559a054","article-title":"Cyclic Phosphates. III. Some General Observations on the Formation and Properties of Five-, Six- and Seven-membered Cyclic Phosphate Esters","volume":"79","author":"Khorana","year":"1957","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.cmet.2011.01.017_bib16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1146\/annurev.bi.49.070180.004305","article-title":"Enzyme-catalyzed phosphoryl transfer reactions","volume":"49","author":"Knowles","year":"1980","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cmet.2011.01.017_bib17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0005-2744(77)90054-7","article-title":"Inhibition of potato starch phosphorylase by alpha-D-glucopyranose-1,2-cyclic phosphate","volume":"483","author":"Kokesh","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cmet.2011.01.017_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0008-6215(00)80876-9","article-title":"Hydrolysis of \u03b1-glucopyranose 1,2-cyclic phosphate: the effect of pH and temperature on the product distribution, and the position of opening of the phosphate diester ring in formation of D-glucose 2-phosphate","volume":"62","author":"Kokesh","year":"1978","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.cmet.2011.01.017_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev.biochem.69.1.497","article-title":"DNA replication fidelity","volume":"69","author":"Kunkel","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cmet.2011.01.017_bib20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.biochem.76.061005.092322","article-title":"Glycosyltransferases: structures, functions, and mechanisms","volume":"77","author":"Lairson","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cmet.2011.01.017_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0014-5793(93)80234-L","article-title":"Glycogen contains phosphodiester groups that can be introduced by UDPglucose: glycogen glucose 1-phosphotransferase","volume":"329","author":"Lomako","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.cmet.2011.01.017_bib22","first-page":"167","article-title":"The role of phosphate in muscle glycogen","volume":"4","author":"Lomako","year":"1994","journal-title":"Biofactors"},{"key":"10.1016\/j.cmet.2011.01.017_bib23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/2470","article-title":"Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy","volume":"20","author":"Minassian","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2011.01.017_bib24","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1021\/bi00662a030","article-title":"The metal ion catalyzed decomposition of nucleoside diphosphate sugars","volume":"15","author":"Nunez","year":"1976","journal-title":"Biochemistry"},{"key":"10.1016\/j.cmet.2011.01.017_bib25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1042\/bj0510426","article-title":"Studies on uridine-diphosphate-glucose","volume":"51","author":"Paladini","year":"1952","journal-title":"Biochem. J."},{"key":"10.1016\/j.cmet.2011.01.017_bib26","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1128\/MCB.24.16.7179-7187.2004","article-title":"Abnormal cardiac development in the absence of heart glycogen","volume":"24","author":"Pederson","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2011.01.017_bib27","doi-asserted-by":"crossref","first-page":"17260","DOI":"10.1074\/jbc.M410448200","article-title":"Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise","volume":"280","author":"Pederson","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2011.01.017_bib28","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.2337\/diabetes.54.12.3466","article-title":"Glucose metabolism in mice lacking muscle glycogen synthase","volume":"54","author":"Pederson","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2011.01.017_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1566524024605761","article-title":"Glycogen and its metabolism","volume":"2","author":"Roach","year":"2002","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.cmet.2011.01.017_bib30","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1212\/WNL.20.2.160","article-title":"Studies in myoclonus epilepsy (Lafora body form). II. Polyglucosans in the systemic deposits of myoclonus epilepsy and in corpora amylacea","volume":"20","author":"Sakai","year":"1970","journal-title":"Neurology"},{"key":"10.1016\/j.cmet.2011.01.017_bib31","first-page":"218","article-title":"Histophysical and histochemical investigations of myoclonus bodies","volume":"3","author":"Schnabel","year":"1968","journal-title":"Pathol. Eur."},{"key":"10.1016\/j.cmet.2011.01.017_bib32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/hmg\/8.2.345","article-title":"A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2)","volume":"8","author":"Serratosa","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cmet.2011.01.017_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/star.19710230803","article-title":"Studies on starch phosphate. Part 2. Isolation of glucose 3-phosphate and maltose phosphate by acid hydrolysis of potato starch","volume":"23","author":"Tabata","year":"1971","journal-title":"Starch-St\u00e4rke"},{"key":"10.1016\/j.cmet.2011.01.017_bib34","doi-asserted-by":"crossref","first-page":"19262","DOI":"10.1073\/pnas.0707952104","article-title":"Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in\u00a0vivo","volume":"104","author":"Tagliabracci","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2011.01.017_bib35","doi-asserted-by":"crossref","first-page":"33816","DOI":"10.1074\/jbc.M807428200","article-title":"Abnormal metabolism of glycogen phosphate as a cause for Lafora disease","volume":"283","author":"Tagliabracci","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2011.01.017_bib36","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0003-2697(68)90127-9","article-title":"A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose","volume":"25","author":"Thomas","year":"1968","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.cmet.2011.01.017_bib37","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0092-8674(00)81191-5","article-title":"Transcriptional fidelity and proofreading by RNA polymerase II","volume":"93","author":"Thomas","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2011.01.017_bib38","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.carres.2008.01.044","article-title":"Structural analysis of the alpha-D-glucan (EPS35-5) produced by the Lactobacillus reuteri strain 35-5 glucansucrase GTFA enzyme","volume":"343","author":"van Leeuwen","year":"2008","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.cmet.2011.01.017_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00211777","article-title":"1H, 13C and 15N chemical shift referencing in biomolecular NMR","volume":"6","author":"Wishart","year":"1995","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.cmet.2011.01.017_bib40","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cell.2009.01.036","article-title":"Fidelity at the molecular level: lessons from protein synthesis","volume":"136","author":"Zaher","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2011.01.017_bib41","first-page":"509","article-title":"Preparation and chemical and enzymic properties of cyclic phosphates of D-glucopyranose and synthesis of derivatives of N-(D-glucopyranosyl) pyridine","volume":"11","author":"Zmudzka","year":"1964","journal-title":"Acta Biochim. Pol."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413111000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413111000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T06:52:39Z","timestamp":1543906359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413111000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S1550413111000428"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2011.01.017","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}