{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:39:09Z","timestamp":1792733949135,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"vor","delay-in-days":369,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.cmet.2012.08.003","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T11:30:15Z","timestamp":1346758215000},"page":"348-362","source":"Crossref","is-referenced-by-count":322,"title":["PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors"],"prefix":"10.1016","volume":"16","author":[{"given":"Joan","family":"Sanchez-Gurmaches","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Min","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia\u00a0A.","family":"Sparks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0A.","family":"Guertin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2012.08.003_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ydbio.2006.04.449","article-title":"Beta-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse","volume":"296","author":"Atit","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cmet.2012.08.003_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s12015-011-9242-x","article-title":"Developmental origins of the adipocyte lineage: new insights from genetics and genomics studies","volume":"8","author":"Billon","year":"2012","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.cmet.2012.08.003_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1534-5807(02)00199-5","article-title":"Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance","volume":"3","author":"Bl\u00fcher","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2012.08.003_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cmet.2012.08.003_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/01913128309141834","article-title":"Ultrastructural features of cultured mature adipocyte precursors from adipose tissue in multiple symmetric lipomatosis","volume":"5","author":"Cinti","year":"1983","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.cmet.2012.08.003_bib6","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrm3198","article-title":"Forming functional fat: a growing understanding of adipocyte differentiation","volume":"12","author":"Cristancho","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2012.08.003_bib7","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2012.08.003_bib8","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.2337\/diabetes.50.8.1863","article-title":"Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance","volume":"50","author":"de Souza","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2012.08.003_bib9","first-page":"E374","article-title":"In\u00a0vitro lipid synthesis in human adipose tissue from three abdominal sites","volume":"265","author":"Edens","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cmet.2012.08.003_bib10","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMcibr0809610","article-title":"The origins of brown adipose tissue","volume":"360","author":"Enerb\u00e4ck","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2012.08.003_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.cmet.2010.03.008","article-title":"Human brown adipose tissue","volume":"11","author":"Enerb\u00e4ck","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2012.08.003_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/sj.ijo.0801867","article-title":"Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study","volume":"26","author":"Enzi","year":"2002","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.cmet.2012.08.003_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1128\/MCB.21.1.319-329.2001","article-title":"Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes","volume":"21","author":"Fasshauer","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2012.08.003_bib14","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1194\/jlr.M500081-JLR200","article-title":"Human hormone-sensitive lipase (HSL): expression in white fat corrects the white adipose phenotype of HSL-deficient mice","volume":"46","author":"Fortier","year":"2005","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2012.08.003_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/j.1550-8528.1993.tb00026.x","article-title":"Lipolysis in intraabdominal adipose tissues of obese women and men","volume":"1","author":"Fried","year":"1993","journal-title":"Obes. Res."},{"key":"10.1016\/j.cmet.2012.08.003_bib16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cmet.2010.03.004","article-title":"Distribution and development of brown adipocytes in the murine and human adipose organ","volume":"11","author":"Frontini","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2012.08.003_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.tips.2009.05.003","article-title":"BAT: a new target for human obesity?","volume":"30","author":"Fr\u00fchbeck","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cmet.2012.08.003_bib18","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1242\/dev.019331","article-title":"Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis","volume":"135","author":"Gensch","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.cmet.2012.08.003_bib19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cell.2007.10.004","article-title":"Developmental origin of fat: tracking obesity to its source","volume":"131","author":"Gesta","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2012.08.003_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1067\/mhn.2002.122004","article-title":"Madelung's lipomatosis associated with head and neck malignant neoplasia: a study of 2 cases","volume":"126","author":"Guastella","year":"2002","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.cmet.2012.08.003_bib21","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.devcel.2008.01.002","article-title":"Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis","volume":"14","author":"Haldar","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2012.08.003_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/aps.2011.153","article-title":"Rare adipose disorders (RADs) masquerading as obesity","volume":"33","author":"Herbst","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cmet.2012.08.003_bib23","doi-asserted-by":"crossref","first-page":"11755","DOI":"10.1074\/jbc.R800071200","article-title":"PTEN, stem cells, and cancer stem cells","volume":"284","author":"Hill","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2012.08.003_bib24","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1096\/fj.05-5678fje","article-title":"Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression","volume":"20","author":"Jern\u00e5s","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.cmet.2012.08.003_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ncb2015","article-title":"Muscle injury activates resident fibro\/adipogenic progenitors that facilitate myogenesis","volume":"12","author":"Joe","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2012.08.003_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cmet.2010.03.005","article-title":"Transcriptional control of brown fat development","volume":"11","author":"Kajimura","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2012.08.003_bib27","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1128\/MCB.25.6.2498-2510.2005","article-title":"Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue","volume":"25","author":"Kurlawalla-Martinez","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2012.08.003_bib28","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.cmet.2012.03.009","article-title":"In\u00a0vivo identification of bipotential adipocyte progenitors recruited by \u03b23-adrenoceptor activation and high-fat feeding","volume":"15","author":"Lee","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2012.08.003_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ydbio.2011.10.011","article-title":"Intramuscular adipose is derived from a non-Pax3 lineage and required for efficient regeneration of skeletal muscles","volume":"361","author":"Liu","year":"2012","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cmet.2012.08.003_bib30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cmet.2010.03.007","article-title":"The changed metabolic world with human brown adipose tissue: therapeutic visions","volume":"11","author":"Nedergaard","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2012.08.003_bib31","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/path.1212","article-title":"Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells","volume":"198","author":"Nisoli","year":"2002","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.cmet.2012.08.003_bib32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cmet.2012.02.001","article-title":"Pten positively regulates brown adipose function, energy expenditure, and longevity","volume":"15","author":"Ortega-Molina","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2012.08.003_bib33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/SAP.0b013e31819bd729","article-title":"Madelung disease: a not-so-rare disorder","volume":"64","author":"Ramos","year":"2010","journal-title":"Ann. Plast. Surg."},{"key":"10.1016\/j.cmet.2012.08.003_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cell.2008.09.036","article-title":"Identification of white adipocyte progenitor cells in\u00a0vivo","volume":"135","author":"Rodeheffer","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2012.08.003_bib35","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrm2066","article-title":"Adipocyte differentiation from the inside out","volume":"7","author":"Rosen","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2012.08.003_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1073\/pnas.1010929108","article-title":"Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat","volume":"108","author":"Schulz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2012.08.003_bib37","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature07182","article-title":"PRDM16 controls a brown fat\/skeletal muscle switch","volume":"454","author":"Seale","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2012.08.003_bib38","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1101\/gad.1779209","article-title":"Transcriptional control of brown adipocyte development and physiological function\u2014of mice and men","volume":"23","author":"Seale","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2012.08.003_bib39","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1242\/dev.127.23.5059","article-title":"Early\u00a0myotome specification regulates PDGFA expression and axial skeleton development","volume":"127","author":"Tallquist","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.cmet.2012.08.003_bib40","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.1156232","article-title":"White fat progenitor cells reside in the adipose vasculature","volume":"322","author":"Tang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.cmet.2012.08.003_bib41","doi-asserted-by":"crossref","first-page":"E267","DOI":"10.1152\/ajpendo.00265.2004","article-title":"Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots","volume":"288","author":"Tchkonia","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2012.08.003_bib42","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1073\/pnas.0610615104","article-title":"Myogenic gene expression signature establishes that brown and white\u00a0adipocytes originate from distinct cell lineages","volume":"104","author":"Timmons","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2012.08.003_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrendo.2010.20","article-title":"Transplantation of adipose tissue and stem cells: role in metabolism and disease","volume":"6","author":"Tran","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cmet.2012.08.003_bib44","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd3138","article-title":"Cellular bioenergetics as a target for obesity therapy","volume":"9","author":"Tseng","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cmet.2012.08.003_bib45","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-activated brown adipose tissue in healthy men","volume":"360","author":"van Marken Lichtenbelt","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2012.08.003_bib46","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1056\/NEJMoa0808949","article-title":"Functional brown adipose tissue in healthy adults","volume":"360","author":"Virtanen","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2012.08.003_bib47","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1152\/ajpendo.00249.2011","article-title":"Recruited vs. nonrecruited molecular signatures of brown, \u201cbrite,\u201d and white adipose tissues","volume":"302","author":"Wald\u00e9n","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2012.08.003_bib48","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1038\/onc.2008.242","article-title":"Post-translational regulation of PTEN","volume":"27","author":"Wang","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2012.08.003_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1194\/jlr.M600287-JLR200","article-title":"Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat","volume":"48","author":"Xue","year":"2007","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2012.08.003_bib50","first-page":"253","article-title":"Multiple symmetric lipomatosis. Ultrastructural investigation of\u00a0the tissue and preadipocytes in primary culture","volume":"63","author":"Zancanaro","year":"1990","journal-title":"Lab. Invest."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413112003257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413112003257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T23:49:02Z","timestamp":1643327342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413112003257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S1550413112003257"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2012.08.003","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717985989.793472225","asserted-by":"object"}]},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}