{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:57:18Z","timestamp":1792220238896,"version":"4.4.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"vor","delay-in-days":369,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.cmet.2014.07.016","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T15:58:02Z","timestamp":1407254282000},"page":"201-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Insulin-Degrading Enzyme Inhibition, a Novel Therapy for Type 2 Diabetes?"],"prefix":"10.1016","volume":"20","author":[{"given":"Safia","family":"Costes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u00a0C.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2014.07.016_bib1","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.2337\/diabetes.52.9.2315","volume":"52","author":"Bennett","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2014.07.016_bib2","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1126\/science.290.5500.2302","volume":"290","author":"Bertram","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.cmet.2014.07.016_bib3","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.2337\/db13-0949","volume":"63","author":"Dimas","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2014.07.016_bib4","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0002-9440(10)63229-4","volume":"164","author":"Farris","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cmet.2014.07.016_bib5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.arr.2010.02.001","volume":"10","author":"Koga","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cmet.2014.07.016_bib6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0968-0004(01)01876-X","volume":"26","author":"Kurochkin","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cmet.2014.07.016_bib7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nature13297","volume":"511","author":"Maianti","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2014.07.016_bib8","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/nature05143","volume":"443","author":"Shen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2014.07.016_bib9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05616","volume":"445","author":"Sladek","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2014.07.016_bib10","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.2337\/db12-1045","volume":"62","author":"Steneberg","year":"2013","journal-title":"Diabetes"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413114003246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413114003246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T04:52:04Z","timestamp":1538369524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413114003246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S1550413114003246"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2014.07.016","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin-Degrading Enzyme Inhibition, a Novel Therapy for Type 2 Diabetes?","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2014.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}