{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:41:22Z","timestamp":1791726082096,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":368,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.cmet.2014.08.011","type":"journal-article","created":{"date-parts":[[2014,10,4]],"date-time":"2014-10-04T00:47:11Z","timestamp":1412383631000},"page":"827-839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":202,"title":["Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans"],"prefix":"10.1016","volume":"20","author":[{"given":"Roxane","family":"Paulin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dromparis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopinath","family":"Sutendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Gurtu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Zervopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsay","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"Haromy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steeve","family":"Provencher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos\u00a0D.","family":"Michelakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2014.08.011_bib1","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1073\/pnas.0803790105","article-title":"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis","volume":"105","author":"Ahn","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2014.08.011_bib2","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.4161\/cc.6.21.4866","article-title":"SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways","volume":"6","author":"Allison","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.cmet.2014.08.011_bib3","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial dynamics\u2014mitochondrial fission and fusion in human diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2014.08.011_bib4","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1172\/JCI333","article-title":"Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes","volume":"101","author":"Archer","year":"1998","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2014.08.011_bib5","doi-asserted-by":"crossref","first-page":"H570","DOI":"10.1152\/ajpheart.01324.2007","article-title":"Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer","volume":"294","author":"Archer","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cmet.2014.08.011_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ygeno.2006.09.004","article-title":"Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13","volume":"89","author":"Bellizzi","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/j.cmet.2014.08.011_bib7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI36703","article-title":"Disruption of the Ang II type 1 receptor promotes longevity in mice","volume":"119","author":"Benigni","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2014.08.011_bib8","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1161\/CIRCULATIONAHA.105.609008","article-title":"An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension","volume":"113","author":"Bonnet","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.cmet.2014.08.011_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ccr.2006.10.020","article-title":"A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth","volume":"11","author":"Bonnet","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cmet.2014.08.011_bib10","doi-asserted-by":"crossref","first-page":"11418","DOI":"10.1073\/pnas.0610467104","article-title":"The nuclear factor of activated T\u00a0cells in pulmonary arterial hypertension can be therapeutically targeted","volume":"104","author":"Bonnet","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2014.08.011_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.cb.04.110188.001103","article-title":"Mitochondrial membrane potential in living cells","volume":"4","author":"Chen","year":"1988","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.cmet.2014.08.011_bib12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1465-9921-12-128","article-title":"Kr\u00fcppel-like factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension","volume":"12","author":"Courboulin","year":"2011","journal-title":"Respir. Res."},{"key":"10.1016\/j.cmet.2014.08.011_bib13","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1093\/carcin\/bgi335","article-title":"Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress","volume":"27","author":"Derd\u00e1k","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.cmet.2014.08.011_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCRESAHA.112.300699","article-title":"Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension","volume":"113","author":"Dromparis","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2014.08.011_bib15","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ccr.2011.02.014","article-title":"SIRT3 opposes reprogramming of cancer cell metabolism through HIF1\u03b1 destabilization","volume":"19","author":"Finley","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cmet.2014.08.011_bib16","doi-asserted-by":"crossref","first-page":"e23295","DOI":"10.1371\/journal.pone.0023295","article-title":"Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity","volume":"6","author":"Finley","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2014.08.011_bib17","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1093\/jn\/134.12.3264","article-title":"Metabolic adaptations of three inbred strains of mice (C57BL\/6, DBA\/2, and 129T2) in response to a high-fat diet","volume":"134","author":"Funkat","year":"2004","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.cmet.2014.08.011_bib18","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ng.2581","article-title":"Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension","volume":"45","author":"Germain","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2014.08.011_bib19","doi-asserted-by":"crossref","first-page":"16958","DOI":"10.1074\/jbc.M110.202390","article-title":"Peroxisome proliferator-activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype","volume":"286","author":"Giralt","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2014.08.011_bib20","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1161\/CIRCULATIONAHA.106.663120","article-title":"Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation","volume":"115","author":"Hansmann","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.cmet.2014.08.011_bib21","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1093\/ndt\/gfg299","article-title":"Strain differences in the development of hypertension and glomerular lesions induced by deoxycorticosterone acetate salt in mice","volume":"18","author":"Hartner","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cmet.2014.08.011_bib22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tem.2012.07.004","article-title":"Mitochondrial sirtuins: regulators of protein acylation and metabolism","volume":"23","author":"He","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2014.08.011_bib23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molcel.2011.07.019","article-title":"SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome","volume":"44","author":"Hirschey","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2014.08.011_bib24","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.2337\/db12-1650","article-title":"Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation","volume":"62","author":"Jing","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2014.08.011_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ccr.2009.11.023","article-title":"SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress","volume":"17","author":"Kim","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cmet.2014.08.011_bib26","first-page":"25","article-title":"Different mechanisms for changes in glucose uptake of the right and left ventricular myocardium in pulmonary hypertension","volume":"46","author":"Kluge","year":"2005","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.cmet.2014.08.011_bib27","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1210\/en.2007-0285","article-title":"Differential regulation of hypoxia-inducible factor-1 through receptor tyrosine kinase transactivation in vascular smooth muscle cells","volume":"148","author":"Lauzier","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2014.08.011_bib28","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1128\/MCB.01636-07","article-title":"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation","volume":"27","author":"Lombard","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2014.08.011_bib29","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/sj.onc.1204386","article-title":"Partners in transcription: NFAT and AP-1","volume":"20","author":"Maci\u00e1n","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2014.08.011_bib30","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1128\/MCB.01927-06","article-title":"Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells","volume":"27","author":"MacKenzie","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2014.08.011_bib31","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCRESAHA.111.263848","article-title":"Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension","volume":"110","author":"Marsboom","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2014.08.011_bib32","doi-asserted-by":"crossref","first-page":"236572","DOI":"10.1155\/2012\/236572","article-title":"PGC-1\u03b1 induction in pulmonary arterial hypertension","volume":"2012","author":"Mata","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cmet.2014.08.011_bib33","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1172\/JCI23203","article-title":"Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension","volume":"115","author":"McMurtry","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2014.08.011_bib34","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1161\/01.RES.0000024689.07590.C2","article-title":"Diversity in mitochondrial function explains differences in vascular oxygen sensing","volume":"90","author":"Michelakis","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2014.08.011_bib35","doi-asserted-by":"crossref","first-page":"31ra34","DOI":"10.1126\/scitranslmed.3000677","article-title":"Metabolic modulation of glioblastoma with dichloroacetate","volume":"2","author":"Michelakis","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2014.08.011_bib36","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1091\/mbc.e05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins","volume":"16","author":"Michishita","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cmet.2014.08.011_bib37","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1172\/JCI118228","article-title":"Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension","volume":"96","author":"Morrell","year":"1995","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2014.08.011_bib38","doi-asserted-by":"crossref","first-page":"10545","DOI":"10.1158\/0008-5472.CAN-05-1925","article-title":"Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity","volume":"65","author":"Pastorino","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2014.08.011_bib39","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1161\/CIRCULATIONAHA.110.963314","article-title":"Signal transducers and activators of transcription-3\/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension","volume":"123","author":"Paulin","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.cmet.2014.08.011_bib40","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMoa031314","article-title":"Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes","volume":"350","author":"Petersen","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2014.08.011_bib41","first-page":"904","article-title":"Unrecognized glucose intolerance is common in pulmonary arterial hypertension","volume":"30","author":"Pugh","year":"2011","journal-title":"J.\u00a0Heart Lung Transplant."},{"key":"10.1016\/j.cmet.2014.08.011_bib42","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.1142984","article-title":"Complex I binding by a virally encoded RNA regulates mitochondria-induced cell death","volume":"316","author":"Reeves","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.cmet.2014.08.011_bib43","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1164\/rccm.201209-1687OC","article-title":"PGC1\u03b1-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension","volume":"187","author":"Ryan","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cmet.2014.08.011_bib44","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1128\/MCB.01483-13","article-title":"SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress","volume":"34","author":"Samant","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2014.08.011_bib45","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jmb.2008.07.048","article-title":"Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5","volume":"382","author":"Schlicker","year":"2008","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cmet.2014.08.011_bib46","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/oby.2006.74","article-title":"Uncoupling protein 2 promoter polymorphism -866G\/A, central adiposity, and metabolic syndrome in Asians","volume":"14","author":"Shen","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.cmet.2014.08.011_bib47","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1242\/jcs.103093","article-title":"GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis","volume":"125","author":"Shulga","year":"2012","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cmet.2014.08.011_bib48","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1152\/jappl.1997.83.1.166","article-title":"Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM","volume":"83","author":"Simoneau","year":"1997","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.cmet.2014.08.011_bib49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fonc.2013.00038","article-title":"Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology","volume":"3","author":"Sutendra","year":"2013","journal-title":"Front Oncol"},{"key":"10.1016\/j.cmet.2014.08.011_bib50","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cmet.2014.01.004","article-title":"The metabolic basis of pulmonary arterial hypertension","volume":"19","author":"Sutendra","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2014.08.011_bib51","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/onc.2012.198","article-title":"Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer","volume":"32","author":"Sutendra","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2014.08.011_bib52","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1097\/01.ASN.0000017902.77985.84","article-title":"Blood pressure, cardiac, and renal responses to salt and deoxycorticosterone acetate in mice: role of Renin genes","volume":"13","author":"Wang","year":"2002","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2014.08.011_bib53","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1165\/rcmb.2013-0191OC","article-title":"Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension","volume":"49","author":"Waypa","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cmet.2014.08.011_bib54","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1183\/09031936.00030312","article-title":"A potential role for insulin resistance in experimental pulmonary hypertension","volume":"41","author":"West","year":"2013","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cmet.2014.08.011_bib55","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1073\/pnas.0605080104","article-title":"Alterations of cellular bioenergetics in pulmonary artery endothelial cells","volume":"104","author":"Xu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2014.08.011_bib56","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(05)78495-6","article-title":"Attenuated K+ channel gene transcription in primary pulmonary hypertension","volume":"351","author":"Yuan","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2014.08.011_bib57","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1183\/09031936.00000508","article-title":"Insulin resistance in pulmonary arterial hypertension","volume":"33","author":"Zamanian","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cmet.2014.08.011_bib58","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1126\/science.1179689","article-title":"Regulation of cellular metabolism by protein lysine acetylation","volume":"327","author":"Zhao","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.cmet.2014.08.011_bib59","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1161\/CIRCULATIONAHA.113.004136","article-title":"Heterogeneity in lung (18)FDG uptake in pulmonary arterial hypertension: potential of dynamic (18)FDG positron emission tomography with kinetic analysis as a bridging biomarker for pulmonary vascular remodeling targeted treatments","volume":"128","author":"Zhao","year":"2013","journal-title":"Circulation"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413114003775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413114003775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T21:04:41Z","timestamp":1565903081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413114003775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S1550413114003775"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2014.08.011","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2014.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}