{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:11:34Z","timestamp":1791994294068,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.cmet.2015.10.013","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T13:49:32Z","timestamp":1447940972000},"page":"128-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":358,"title":["Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges"],"prefix":"10.1016","volume":"23","author":[{"given":"Aiwu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmoyee","family":"Maharana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqian","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Marosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Misiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilhelm\u00a0A.","family":"Bohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00a0P.","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2015.10.013_bib1","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1073\/pnas.0803790105","article-title":"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis","volume":"105","author":"Ahn","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2015.10.013_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/exnr.2000.7525","article-title":"Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP","volume":"167","author":"Andreassen","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.cmet.2015.10.013_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/1531-8249(199901)45:1<8::AID-ART4>3.0.CO;2-V","article-title":"Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults","volume":"45","author":"Bruce-Keller","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cmet.2015.10.013_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrendo.2011.225","article-title":"Sirtuins mediate mammalian metabolic responses to nutrient availability","volume":"8","author":"Chalkiadaki","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cmet.2015.10.013_bib5","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/ncomms2238","article-title":"Involvement of PGC-1\u03b1 in the formation and maintenance of neuronal dendritic spines","volume":"3","author":"Cheng","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2015.10.013_bib6","doi-asserted-by":"crossref","first-page":"e731","DOI":"10.1038\/cddis.2013.254","article-title":"Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress","volume":"4","author":"Cheng","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2015.10.013_bib7","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nrm3841","article-title":"The growing landscape of lysine acetylation links metabolism and cell signalling","volume":"15","author":"Choudhary","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2015.10.013_bib8","doi-asserted-by":"crossref","first-page":"24460","DOI":"10.1074\/jbc.M112.382226","article-title":"trans-(-)-\u03b5-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease","volume":"287","author":"Fu","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2015.10.013_bib9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrn2665","article-title":"Mitochondrial membrane permeabilization in neuronal injury","volume":"10","author":"Galluzzi","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cmet.2015.10.013_bib10","first-page":"914","article-title":"Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy","volume":"2","author":"Hafner","year":"2010","journal-title":"Aging (Albany, N.Y.)"},{"key":"10.1016\/j.cmet.2015.10.013_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tem.2012.07.004","article-title":"Mitochondrial sirtuins: regulators of protein acylation and metabolism","volume":"23","author":"He","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2015.10.013_bib12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.molcel.2012.10.024","article-title":"Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome","volume":"49","author":"Hebert","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2015.10.013_bib13","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1152\/japplphysiol.00335.2009","article-title":"Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles","volume":"109","author":"Hokari","year":"2010","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.cmet.2015.10.013_bib14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1523\/JNEUROSCI.18-02-00687.1998","article-title":"Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction","volume":"18","author":"Keller","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cmet.2015.10.013_bib15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fnagi.2013.00048","article-title":"Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration","volume":"5","author":"Kincaid","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.cmet.2015.10.013_bib16","doi-asserted-by":"crossref","first-page":"e11707","DOI":"10.1371\/journal.pone.0011707","article-title":"Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis","volume":"5","author":"Kong","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2015.10.013_bib17","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0006-8993(98)01082-8","article-title":"Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons","volume":"814","author":"Li","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.cmet.2015.10.013_bib18","doi-asserted-by":"crossref","first-page":"e85636","DOI":"10.1371\/journal.pone.0085636","article-title":"Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2015.10.013_bib19","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1128\/MCB.01636-07","article-title":"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation","volume":"27","author":"Lombard","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2015.10.013_bib20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35040009","article-title":"Apoptosis in neurodegenerative disorders","volume":"1","author":"Mattson","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2015.10.013_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1385\/NMM:3:2:65","article-title":"Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders","volume":"3","author":"Mattson","year":"2003","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.cmet.2015.10.013_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2007.08.007","article-title":"Hormesis defined","volume":"7","author":"Mattson","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cmet.2015.10.013_bib23","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.cmet.2012.08.012","article-title":"Energy intake and exercise as determinants of brain health and vulnerability to injury and disease","volume":"16","author":"Mattson","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2015.10.013_bib24","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.neuron.2008.10.010","article-title":"Mitochondria in neuroplasticity and neurological disorders","volume":"60","author":"Mattson","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.cmet.2015.10.013_bib25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbr.2013.02.009","article-title":"Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice","volume":"245","author":"Nishijima","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.cmet.2015.10.013_bib26","first-page":"771","article-title":"Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle","volume":"1","author":"Palacios","year":"2009","journal-title":"Aging (Albany, N.Y.)"},{"key":"10.1016\/j.cmet.2015.10.013_bib27","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.mad.2007.10.013","article-title":"Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging","volume":"128","author":"Paul","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cmet.2015.10.013_bib28","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.cmet.2010.11.015","article-title":"Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation","volume":"12","author":"Qiu","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2015.10.013_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1083\/jcb.201404118","article-title":"Drosophila Sirt2\/mammalian SIRT3 deacetylates ATP synthase \u03b2 and regulates complex V activity","volume":"206","author":"Rahman","year":"2014","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cmet.2015.10.013_bib30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.200205057","article-title":"The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase","volume":"158","author":"Schwer","year":"2002","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cmet.2015.10.013_bib31","doi-asserted-by":"crossref","first-page":"e50545","DOI":"10.1371\/journal.pone.0050545","article-title":"Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3","volume":"7","author":"Sol","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2015.10.013_bib32","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.cell.2010.10.002","article-title":"Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction","volume":"143","author":"Someya","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2015.10.013_bib33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.nbd.2012.07.004","article-title":"Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1\u03b1","volume":"51","author":"Song","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cmet.2015.10.013_bib34","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.molcel.2010.12.013","article-title":"Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress","volume":"40","author":"Tao","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2015.10.013_bib35","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1089\/ars.2013.5482","article-title":"Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis","volume":"20","author":"Tao","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cmet.2015.10.013_bib36","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1123\/pes.2014-0112","article-title":"Aerobic training increases expression levels of SIRT3 and PGC-1\u03b1 in skeletal muscle of overweight adolescents without change in caloric intake","volume":"27","author":"Vargas-Ortiz","year":"2015","journal-title":"Pediatr. Exerc. Sci."},{"key":"10.1016\/j.cmet.2015.10.013_bib37","doi-asserted-by":"crossref","first-page":"14078","DOI":"10.1074\/jbc.M112.355206","article-title":"SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status","volume":"287","author":"Yu","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"issue":"Suppl 1","key":"10.1016\/j.cmet.2015.10.013_bib38","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/S1353-8020(13)70030-0","article-title":"Exercise: is it a neuroprotective and if so, how does it work?","volume":"20","author":"Zigmond","year":"2014","journal-title":"Parkinsonism Relat. Disord."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155041311500529X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155041311500529X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T20:34:03Z","timestamp":1786221243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S155041311500529X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S155041311500529X"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2015.10.013","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2015.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}