{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:16:20Z","timestamp":1792048580598,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":376,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.cmet.2016.01.019","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T11:58:27Z","timestamp":1456401507000},"page":"635-648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":283,"title":["Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism"],"prefix":"10.1016","volume":"23","author":[{"given":"Joni","family":"Nikkanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Forsstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliya","family":"Euro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Paetau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca\u00a0A.","family":"Kohnz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri","family":"Chilov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Viinam\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Roivainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Marjam\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Liljenb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Ahola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Buzkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcgen","family":"Terzioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid\u00a0A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sini","family":"Pirnes-Karhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Paetau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuula","family":"L\u00f6nnqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Sajantila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo","family":"Isohanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henna","family":"Tyynismaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel\u00a0K.","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan\u00a0J.","family":"Battersby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Velagapudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher\u00a0J.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Suomalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2016.01.019_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cmet.2016.01.019_bib2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2165\/00007256-199418040-00005","article-title":"Creatine in humans with special reference to creatine supplementation","volume":"18","author":"Balsom","year":"1994","journal-title":"Sports Med."},{"key":"10.1016\/j.cmet.2016.01.019_bib3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High levels of\u00a0mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib4","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ng2040","article-title":"Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion","volume":"39","author":"Bourdon","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/bies.20420","article-title":"Mitochondrial one-carbon metabolism is adapted to the specific needs of yeast, plants and mammals","volume":"28","author":"Christensen","year":"2006","journal-title":"BioEssays"},{"key":"10.1016\/j.cmet.2016.01.019_bib6","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1073\/pnas.89.16.7370","article-title":"A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues","volume":"89","author":"Cortopassi","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2016.01.019_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.molcel.2005.11.027","article-title":"DNA-induced switch from independent to sequential dTTP hydrolysis in the bacteriophage T7 DNA helicase","volume":"21","author":"Crampton","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2016.01.019_bib8","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/ng.3421","article-title":"NRF2 regulates serine biosynthesis in non-small cell lung cancer","volume":"47","author":"DeNicola","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib9","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbagen.2004.06.014","article-title":"The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth","volume":"1674","author":"Di Pietro","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cmet.2016.01.019_bib10","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1074\/jbc.M510624200","article-title":"Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma","volume":"281","author":"Field","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2016.01.019_bib11","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1093\/brain\/awu068","article-title":"Deoxynucleoside stress exacerbates the phenotype of a mouse model of mitochondrial neurogastrointestinal encephalopathy","volume":"137","author":"Garcia-Diaz","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.cmet.2016.01.019_bib12","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1021\/bi00068a027","article-title":"Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine","volume":"32","author":"Garc\u00eda-Mart\u00ednez","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.cmet.2016.01.019_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/hmg\/ddn359","article-title":"Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in\u00a0vivo mtDNA replication stalling","volume":"18","author":"Goffart","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1086\/444548","article-title":"Mitochondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin","volume":"77","author":"Hakonen","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib15","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1093\/hmg\/ddn280","article-title":"Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion","volume":"17","author":"Hakonen","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib16","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1021\/bi9521497","article-title":"Cooperative interactions of nucleotide ligands are linked to oligomerization and DNA binding in bacteriophage T7 gene 4 helicases","volume":"35","author":"Hingorani","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.cmet.2016.01.019_bib17","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.1218595","article-title":"Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation","volume":"336","author":"Jain","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cmet.2016.01.019_bib18","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/emmm.201403943","article-title":"Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3","volume":"6","author":"Khan","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cmet.2016.01.019_bib19","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1038\/sj.emboj.7600257","article-title":"Reconstitution of a minimal mtDNA replisome in\u00a0vitro","volume":"23","author":"Korhonen","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2016.01.019_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2014.05.034","article-title":"Expansion of biological pathways based on evolutionary inference","volume":"158","author":"Li","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2016.01.019_bib21","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jmb.2005.04.051","article-title":"Mechanochemistry of t7 DNA helicase","volume":"350","author":"Liao","year":"2005","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.cmet.2016.01.019_bib22","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/ng.890","article-title":"Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis","volume":"43","author":"Locasale","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-510X(98)00249-4","article-title":"Infantile onset spinocerebellar ataxia with sensory neuropathy (IOSCA): neuropathological features","volume":"161","author":"L\u00f6nnqvist","year":"1998","journal-title":"J.\u00a0Neurol. Sci."},{"key":"10.1016\/j.cmet.2016.01.019_bib24","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(04)16983-3","article-title":"Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study","volume":"364","author":"Luoma","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2016.01.019_bib25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ng746","article-title":"The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA","volume":"29","author":"Mandel","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-61779-504-6_9","article-title":"Measurement of mitochondrial dNTP pools","volume":"837","author":"Mart\u00ed","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cmet.2016.01.019_bib27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.celrep.2014.10.026","article-title":"Characterization of the usage of the serine metabolic network in human cancer","volume":"9","author":"Mehrmohamadi","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2016.01.019_bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/ajcn\/85.1.19","article-title":"Methyl balance and transmethylation fluxes in humans","volume":"85","author":"Mudd","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cmet.2016.01.019_bib29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/1531-8249(199901)45:1<54::AID-ART10>3.0.CO;2-B","article-title":"Mitochondrial DNA polymerase gamma deficiency and mtDNA depletion in a child with Alpers\u2019 syndrome","volume":"45","author":"Naviaux","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cmet.2016.01.019_bib30","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1093\/hmg\/ddi328","article-title":"Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and Twinky","volume":"14","author":"Nikali","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib31","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1038\/ncomms4128","article-title":"Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer","volume":"5","author":"Nilsson","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2016.01.019_bib32","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2016.01.019_bib33","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1101\/gad.229724.113","article-title":"Hallmarks of a new era in mitochondrial biochemistry","volume":"27","author":"Pagliarini","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2016.01.019_bib34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cell.2008.06.016","article-title":"A mitochondrial protein compendium elucidates complex I disease biology","volume":"134","author":"Pagliarini","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2016.01.019_bib35","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1074\/jbc.M109.079855","article-title":"Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos","volume":"285","author":"Pike","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2016.01.019_bib36","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/emboj.2011.470","article-title":"dNTP pools determine fork progression and origin usage under replication stress","volume":"31","author":"Poli","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2016.01.019_bib37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0092-8674(00)81648-7","article-title":"Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7","volume":"99","author":"Sawaya","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2016.01.019_bib38","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0003-9861(89)90120-3","article-title":"Interaction of folylpolyglutamates with enzymes in one-carbon metabolism","volume":"269","author":"Schirch","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cmet.2016.01.019_bib39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0140-6736(81)90650-4","article-title":"The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia","volume":"2","author":"Scott","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2016.01.019_bib40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4331\/wjbc.v5.i1.68","article-title":"Thioredoxin and glutaredoxin-mediated\u00a0redox regulation of ribonucleotide reductase","volume":"5","author":"Sengupta","year":"2014","journal-title":"World J. Biol. Chem."},{"key":"10.1016\/j.cmet.2016.01.019_bib41","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0092-8674(00)80871-5","article-title":"Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides","volume":"101","author":"Singleton","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2016.01.019_bib42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/90058","article-title":"Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a\u00a0phage T7 gene 4-like protein localized in mitochondria","volume":"28","author":"Spelbrink","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib43","first-page":"914","article-title":"Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man","volume":"58","author":"St\u00f6ckler","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib44","doi-asserted-by":"crossref","first-page":"12149","DOI":"10.1016\/S0021-9258(19)38324-3","article-title":"Purification and properties of serine hydroxymethyltransferase and C1-tetrahydrofolate synthase from L1210 cells","volume":"265","author":"Strong","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2016.01.019_bib45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev.nutr.21.1.255","article-title":"New perspectives on folate catabolism","volume":"21","author":"Suh","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.cmet.2016.01.019_bib46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1172\/JCI115856","article-title":"Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia","volume":"90","author":"Suomalainen","year":"1992","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2016.01.019_bib47","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1212\/WNL.48.5.1244","article-title":"Autosomal dominant progressive external ophthalmoplegia with multiple deletions of mtDNA: clinical, biochemical, and molecular genetic features of the 10q-linked disease","volume":"48","author":"Suomalainen","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.cmet.2016.01.019_bib48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.nutr.012809.104810","article-title":"Compartmentalization of Mammalian folate-mediated one-carbon metabolism","volume":"30","author":"Tibbetts","year":"2010","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.cmet.2016.01.019_bib49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/ncb2901","article-title":"Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson\u2019s disease","volume":"16","author":"Tufi","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2016.01.019_bib50","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1093\/hmg\/ddh342","article-title":"Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number","volume":"13","author":"Tyynismaa","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib51","doi-asserted-by":"crossref","first-page":"17687","DOI":"10.1073\/pnas.0505551102","article-title":"Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice","volume":"102","author":"Tyynismaa","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2016.01.019_bib52","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/hmg\/ddq310","article-title":"Mitochondrial myopathy induces a starvation-like response","volume":"19","author":"Tyynismaa","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.cmet.2016.01.019_bib53","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1212\/01.WNL.0000140494.58732.83","article-title":"POLG mutations in neurodegenerative disorders with ataxia but no muscle involvement","volume":"63","author":"Van Goethem","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.cmet.2016.01.019_bib54","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/339309a0","article-title":"An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region","volume":"339","author":"Zeviani","year":"1989","journal-title":"Nature"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413116300122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413116300122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T01:24:10Z","timestamp":1654392250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413116300122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1550413116300122"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2016.01.019","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2016.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}