{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:48:07Z","timestamp":1792450087254,"version":"4.5.0"},"reference-count":255,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK-40936"],"award-info":[{"award-number":["DK-40936"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK-45735"],"award-info":[{"award-number":["DK-45735"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK-R01 DK 11398401"],"award-info":[{"award-number":["DK-R01 DK 11398401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.cmet.2017.08.002","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T14:46:15Z","timestamp":1504190775000},"page":"22-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":712,"title":["Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases"],"prefix":"10.1016","volume":"27","author":[{"given":"Varman T.","family":"Samuel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald I.","family":"Shulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2017.08.002_bib1","doi-asserted-by":"crossref","first-page":"12578","DOI":"10.1074\/jbc.M111.309559","article-title":"Acetyl-CoA carboxylase 2-\/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions","volume":"287","author":"Abu-Elheiga","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib2","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1096\/fj.201700001R","article-title":"A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice","volume":"31","author":"Abulizi","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.cmet.2017.08.002_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1021\/acsmedchemlett.5b00323","article-title":"Discovery of a potent and orally efficacious TGR5 receptor agonist","volume":"7","author":"Agarwal","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.cmet.2017.08.002_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-9822(06)00122-9","article-title":"Characterization of a 3-phosphoinositide-dependent\u00a0protein kinase which phosphorylates and activates protein kinase Balpha","volume":"7","author":"Alessi","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cmet.2017.08.002_bib5","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s11695-017-2576-y","article-title":"Omentectomy in addition to bariatric surgery\u2014a 5-year follow-up","volume":"27","author":"Andersson","year":"2017","journal-title":"Obes. Surg."},{"key":"10.1016\/j.cmet.2017.08.002_bib6","doi-asserted-by":"crossref","first-page":"e003995","DOI":"10.1136\/bmjopen-2013-003995","article-title":"Liraglutide efficacy and action in non-alcoholic steatohepatitis (LEAN): study protocol for a phase II multicentre, double-blinded, randomised, controlled trial","volume":"3","author":"Armstrong","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.cmet.2017.08.002_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2015.08.038","article-title":"Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis","volume":"64","author":"Armstrong","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.cmet.2007.05.002","article-title":"Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states","volume":"5","author":"Badman","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib9","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/dom.12918","article-title":"Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: Results of a randomized controlled trial using 2 dietary approaches","volume":"19","author":"Baldry","year":"2017","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1194\/jlr.M011205","article-title":"Pnpla3\/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome","volume":"52","author":"Basantani","year":"2011","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2017.08.002_bib11","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa060326","article-title":"A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis","volume":"355","author":"Belfort","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib12","first-page":"359","article-title":"New concepts in extracellular signaling for insulin action: the single gateway hypothesis","volume":"52","author":"Bergman","year":"1997","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.cmet.2017.08.002_bib13","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1074\/jbc.M808818200","article-title":"Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis","volume":"284","author":"Bhatnagar","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib14","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s11695-015-2006-y","article-title":"Combined non-alcoholic fatty liver disease and type 2 diabetes mellitus: sleeve gastrectomy or gastric bypass?\u2014a controlled matched pair study of 34 patients","volume":"26","author":"Billeter","year":"2016","journal-title":"Obes. Surg."},{"key":"10.1016\/j.cmet.2017.08.002_bib15","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1194\/jlr.M049130","article-title":"Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity","volume":"56","author":"Bindesb\u00f8ll","year":"2015","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2017.08.002_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/MOL.0b013e32835cc949","article-title":"Peroxisome proliferator-activated receptor \u03b4: a multifaceted metabolic player","volume":"24","author":"Bojic","year":"2013","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.cmet.2017.08.002_bib17","doi-asserted-by":"crossref","first-page":"10132","DOI":"10.1021\/jm401601s","article-title":"Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase","volume":"56","author":"Bourbeau","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib18","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/hep.28356","article-title":"The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota","volume":"63","author":"Boursier","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib19","doi-asserted-by":"crossref","first-page":"950","DOI":"10.2337\/dc13-2085","article-title":"Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar","volume":"37","author":"Bray","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cmet.2017.08.002_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1126\/science.1218099","article-title":"A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans","volume":"337","author":"Bricker","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cmet.2017.08.002_bib21","doi-asserted-by":"crossref","first-page":"e0136873","DOI":"10.1371\/journal.pone.0136873","article-title":"Novel small molecule agonist of TGR5 possesses anti-diabetic effects but causes gallbladder filling in mice","volume":"10","author":"Briere","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2017.08.002_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cmet.2007.12.009","article-title":"Selective versus total insulin resistance: a pathogenic paradox","volume":"7","author":"Brown","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/MOL.0b013e32833854ac","article-title":"Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery","volume":"21","author":"Brown","year":"2010","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.cmet.2017.08.002_bib24","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib25","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1038\/ng.3417","article-title":"A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis","volume":"47","author":"Buch","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2017.08.002_bib26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/BJ20130609","article-title":"Diacylglycerol kinase \u03b8 couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes","volume":"454","author":"Cai","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.cmet.2017.08.002_bib27","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1210\/en.2013-1191","article-title":"Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice","volume":"154","author":"Camporez","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2017.08.002_bib28","doi-asserted-by":"crossref","first-page":"41838","DOI":"10.1074\/jbc.M111.245456","article-title":"Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases","volume":"286","author":"Cao","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib29","doi-asserted-by":"crossref","first-page":"42801","DOI":"10.1038\/srep42801","article-title":"BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis","volume":"7","author":"Carino","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2017.08.002_bib30","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.2337\/dc12-2012","article-title":"Dual peroxisome proliferator-activated receptor \u03b1\/\u03b4 agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects","volume":"36","author":"Cariou","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cmet.2017.08.002_bib31","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/hep.23812","article-title":"Patatin-like phospholipase domain-containing 3\/adiponutrin deficiency in mice is not associated with fatty liver disease","volume":"52","author":"Chen","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib32","doi-asserted-by":"crossref","first-page":"23537","DOI":"10.1074\/jbc.M112.363960","article-title":"Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor \u03b3-sparing thiazolidinedione","volume":"287","author":"Chen","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib33","doi-asserted-by":"crossref","first-page":"22678","DOI":"10.1074\/jbc.M704213200","article-title":"Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance","volume":"282","author":"Choi","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib34","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.molmet.2014.02.004","article-title":"Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation","volume":"3","author":"Chow","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1056\/NEJM199907223410404","article-title":"Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes","volume":"341","author":"Cline","year":"1999","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib36","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1161\/01.ATV.19.10.2448","article-title":"Gender difference in postprandial lipemia : importance of visceral adipose tissue accumulation","volume":"19","author":"Couillard","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cmet.2017.08.002_bib37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.7326\/M15-1774","article-title":"Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial","volume":"165","author":"Cusi","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib38","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/ijo.2017.4","article-title":"What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications?","volume":"41","author":"Cuthbertson","year":"2017","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.cmet.2017.08.002_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrd.2015.9","article-title":"Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23","volume":"15","author":"Degirolamo","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cmet.2017.08.002_bib40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1161\/01.ATV.10.4.497","article-title":"Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease","volume":"10","author":"Despr\u00e9s","year":"1990","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.cmet.2017.08.002_bib41","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1073\/pnas.1303360110","article-title":"Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier","volume":"110","author":"Divakaruni","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib42","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1172\/JCI5001","article-title":"Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity","volume":"103","author":"Dresner","year":"1999","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib44","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2015.05.044","article-title":"Association of adipose tissue inflammation with histologic severity of nonalcoholic fatty liver disease","volume":"149","author":"du Plessis","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molmet.2014.09.008","article-title":"Fructose ingestion acutely stimulates circulating FGF21 levels in humans","volume":"4","author":"Dushay","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib46","doi-asserted-by":"crossref","first-page":"e91863","DOI":"10.1172\/jci.insight.91863","article-title":"Insulin\u2019s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion","volume":"2","author":"Edgerton","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.cmet.2017.08.002_bib47","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/en.2012-1725","article-title":"The role of the carbohydrate response element-binding protein in male fructose-fed rats","volume":"154","author":"Erion","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2017.08.002_bib48","doi-asserted-by":"crossref","first-page":"15430","DOI":"10.1073\/pnas.0904944106","article-title":"Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity","volume":"106","author":"Fabbrini","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib49","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1210\/jc.2009-2622","article-title":"Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease","volume":"95","author":"Fabbrini","year":"2010","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib50","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/j.gastro.2010.04.056","article-title":"Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults","volume":"139","author":"Fabbrini","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib51","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/j.gastro.2016.01.005","article-title":"Hepatic transmembrane 6 superfamily member 2 regulates cholesterol metabolism in mice","volume":"150","author":"Fan","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib52","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.dld.2007.10.002","article-title":"A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease","volume":"40","author":"Fern\u00e1ndez-Miranda","year":"2008","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.cmet.2017.08.002_bib53","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.cell.2016.09.014","article-title":"Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease","volume":"167","author":"Finan","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2017.08.002_bib54","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.2337\/db12-0206","article-title":"Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly","volume":"61","author":"Flannery","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib55","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1007\/s00125-014-3244-6","article-title":"\u2018Exercise snacks\u2019 before meals: a novel strategy\u00a0to improve glycaemic control in individuals with insulin resistance","volume":"57","author":"Francois","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2017.08.002_bib56","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.soard.2015.04.004","article-title":"Effect of Roux-en-Y gastric bypass and sleeve gastrectomy on nonalcoholic fatty liver disease: a comparative study","volume":"12","author":"Froylich","year":"2016","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.1016\/j.cmet.2017.08.002_bib57","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10620-016-4152-z","article-title":"Editors\u2019 introduction to the NAFLD and NASH special issue","volume":"61","author":"Fuchs","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.cmet.2017.08.002_bib58","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1021\/acs.jmedchem.5b01006","article-title":"Discovery and optimization of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2)","volume":"58","author":"Futatsugi","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib59","doi-asserted-by":"crossref","first-page":"30235","DOI":"10.1074\/jbc.M806194200","article-title":"Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils","volume":"283","author":"Gij\u00f3n","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib60","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1001\/jamasurg.2015.2202","article-title":"Long-term metabolic effects of laparoscopic sleeve gastrectomy","volume":"150","author":"Golomb","year":"2015","journal-title":"JAMA Surg."},{"key":"10.1016\/j.cmet.2017.08.002_bib61","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cmet.2015.07.027","article-title":"Hepatic mitochondrial pyruvate carrier 1 is required for efficient regulation of gluconeogenesis and whole-body glucose homeostasis","volume":"22","author":"Gray","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","article-title":"Defining the role of mTOR in cancer","volume":"12","author":"Guertin","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cmet.2017.08.002_bib63","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1172\/JCI26991","article-title":"Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance","volume":"116","author":"Guti\u00e9rrez-Ju\u00e1rez","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib64","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cmet.2012.05.002","article-title":"Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression","volume":"15","author":"Haas","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib65","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1194\/jlr.P025536","article-title":"Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver","volume":"53","author":"Hall","year":"2012","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2017.08.002_bib66","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.2337\/db13-1502","article-title":"Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice","volume":"63","author":"Hall","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib67","doi-asserted-by":"crossref","first-page":"E1796","DOI":"10.1073\/pnas.1520686113","article-title":"Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats","volume":"113","author":"Harriman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib68","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/hep.22575","article-title":"Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial","volume":"49","author":"Harrison","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib69","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1016\/S0168-8278(17)30448-8","article-title":"LBO-07 - NGM282, a novel variant of FGF19, significantly reduces hepatic steatosis and key biomarkers of NASH: results of a Phase 2, multicenter, randomized, double-blinded, placebo controlled trial in biopsy-confirmed NASH patients","volume":"66","author":"Harrison","year":"2017","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib70","doi-asserted-by":"crossref","first-page":"37099","DOI":"10.1074\/jbc.M304481200","article-title":"Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals","volume":"278","author":"Harwood","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib71","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/dom.12735","article-title":"Robust anti-obesity and metabolic effects of a dual GLP-1\/glucagon receptor peptide agonist in rodents and non-human primates","volume":"18","author":"Henderson","year":"2016","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib72","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.tem.2016.06.005","article-title":"The sweet path to metabolic demise: fructose and lipid synthesis","volume":"27","author":"Herman","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib73","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1218530","article-title":"Identification and functional expression of the mitochondrial pyruvate carrier","volume":"337","author":"Herzig","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cmet.2017.08.002_bib74","doi-asserted-by":"crossref","first-page":"15801","DOI":"10.1074\/jbc.O112.356915","article-title":"Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice","volume":"287","author":"Hoehn","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib75","doi-asserted-by":"crossref","first-page":"7164","DOI":"10.1021\/acs.jmedchem.5b01008","article-title":"Discovery of selective small molecule inhibitors of monoacylglycerol acyltransferase 3","volume":"58","author":"Huard","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib76","doi-asserted-by":"crossref","first-page":"11196","DOI":"10.1038\/ncomms11196","article-title":"The dynamic organization of fungal acetyl-CoA carboxylase","volume":"7","author":"Hunkeler","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2017.08.002_bib77","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/ijo.2015.75","article-title":"Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype","volume":"39","author":"Hwang","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.cmet.2017.08.002_bib78","doi-asserted-by":"crossref","first-page":"10531","DOI":"10.1038\/ncomms10531","article-title":"Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes","volume":"7","author":"Imamura","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2017.08.002_bib79","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1021\/acs.jmedchem.5b01345","article-title":"Discovery and pharmacology of a novel class of diacylglycerol acyltransferase 2 inhibitors","volume":"58","author":"Imbriglio","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib80","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib81","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.cmet.2007.05.003","article-title":"Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21","volume":"5","author":"Inagaki","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib82","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1056\/NEJM199803263381303","article-title":"Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus","volume":"338","author":"Inzucchi","year":"1998","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib83","doi-asserted-by":"crossref","first-page":"10455","DOI":"10.1074\/jbc.M117.786525","article-title":"Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice","volume":"292","author":"Irimia","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib84","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.2337\/diabetes.51.7.2005","article-title":"Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha","volume":"51","author":"Itani","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib85","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.molmet.2017.02.002","article-title":"Monomeric GLP-1\/GIP\/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice","volume":"6","author":"Jall","year":"2017","journal-title":"Mol. Metab."},{"issue":"11, Suppl 1","key":"10.1016\/j.cmet.2017.08.002_bib86","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1210\/jc.2008-1585","article-title":"Role of body fat distribution and the metabolic complications of obesity","volume":"93","author":"Jensen","year":"2008","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib87","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1172\/JCI200523962","article-title":"Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1","volume":"115","author":"Jiang","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib88","doi-asserted-by":"crossref","first-page":"10166","DOI":"10.1038\/ncomms10166","article-title":"Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction","volume":"6","author":"Jiang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2017.08.002_bib89","doi-asserted-by":"crossref","first-page":"E620","DOI":"10.1152\/ajpendo.00069.2016","article-title":"Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives","volume":"311","author":"Jin","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib90","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1073\/pnas.1103451108","article-title":"Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2","volume":"108","author":"Jornayvaz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib91","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/sj.ijo.0803248","article-title":"Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study","volume":"30","author":"Kadowaki","year":"2006","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.cmet.2017.08.002_bib92","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jhep.2015.02.022","article-title":"Effect of aerobic exercise training dose on liver fat and visceral adiposity","volume":"63","author":"Keating","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib93","doi-asserted-by":"crossref","first-page":"E906","DOI":"10.1152\/ajpendo.00117.2003","article-title":"Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance","volume":"285","author":"Kelley","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib94","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.soard.2017.01.031","article-title":"Trends in utilization of bariatric surgery, 2010-2014: sleeve gastrectomy dominates","volume":"13","author":"Khorgami","year":"2017","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.1016\/j.cmet.2017.08.002_bib95","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cgh.2016.08.028","article-title":"Nonobese fatty liver disease","volume":"15","author":"Kim","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib96","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1074\/jbc.275.12.8456","article-title":"Mechanism of insulin resistance in A-ZIP\/F-1 fatless mice","volume":"275","author":"Kim","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib97","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1073\/pnas.121164498","article-title":"Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance","volume":"98","author":"Kim","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib98","doi-asserted-by":"crossref","first-page":"9626","DOI":"10.1073\/pnas.1001292107","article-title":"Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis","volume":"107","author":"Kim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib99","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1126\/science.1198363","article-title":"FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis","volume":"331","author":"Kir","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cmet.2017.08.002_bib100","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1053\/j.gastro.2006.01.042","article-title":"Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease","volume":"130","author":"Klein","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib101","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000371670","article-title":"Bile acids as hormones: the FXR-FGF15\/19 pathway","volume":"33","author":"Kliewer","year":"2015","journal-title":"Dig. Dis."},{"key":"10.1016\/j.cmet.2017.08.002_bib102","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s001250051123","article-title":"Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study","volume":"42","author":"Krssak","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2017.08.002_bib103","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.cmet.2012.04.008","article-title":"Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase","volume":"15","author":"Kumari","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib104","doi-asserted-by":"crossref","first-page":"16381","DOI":"10.1073\/pnas.1113359108","article-title":"Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease","volume":"108","author":"Kumashiro","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib105","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1002\/hep.26170","article-title":"Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats","volume":"57","author":"Kumashiro","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib106","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1056\/NEJMoa0905633","article-title":"Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia","volume":"362","author":"Ladenson","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib107","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.beem.2016.06.006","article-title":"Non-alcoholic fatty liver disease and risk of type 2 diabetes","volume":"30","author":"Lallukka","year":"2016","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib108","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.2337\/dc10-0856","article-title":"Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes","volume":"33","author":"Lazo","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cmet.2017.08.002_bib109","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2337\/diab.5.3.209","article-title":"The relation of insulin to liver metabolism","volume":"5","author":"Levine","year":"1956","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib110","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2337\/diab.45.4.454","article-title":"Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans","volume":"45","author":"Lewis","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib111","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1381\/096089206777346682","article-title":"Change in liver size and fat content after treatment with Optifast very low calorie diet","volume":"16","author":"Lewis","year":"2006","journal-title":"Obes. Surg."},{"key":"10.1016\/j.cmet.2017.08.002_bib112","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1073\/pnas.0914798107","article-title":"Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib113","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1172\/JCI65179","article-title":"Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis","volume":"122","author":"Li","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib114","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1007\/s00125-011-2204-7","article-title":"Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol","volume":"54","author":"Lim","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2017.08.002_bib115","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1113\/JP272235","article-title":"Aerobic exercise training in the treatment of non-alcoholic fatty liver disease related fibrosis","volume":"594","author":"Linden","year":"2016","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.cmet.2017.08.002_bib116","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1194\/jlr.M074849","article-title":"Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats","volume":"58","author":"Lindquist","year":"2017","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2017.08.002_bib117","doi-asserted-by":"crossref","first-page":"e00193","DOI":"10.1002\/prp2.193","article-title":"Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor","volume":"3","author":"Liu","year":"2015","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.cmet.2017.08.002_bib118","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.2337\/db11-1556","article-title":"Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling","volume":"61","author":"Lockie","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib119","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng.3714","article-title":"Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance","volume":"49","author":"Lotta","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2017.08.002_bib120","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jhep.2016.07.045","article-title":"The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans","volume":"65","author":"Luukkonen","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib121","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.jhep.2016.01.002","article-title":"Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease","volume":"64","author":"Luukkonen","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib122","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jhep.2017.02.014","article-title":"Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD","volume":"67","author":"Luukkonen","year":"2017","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib123","doi-asserted-by":"crossref","first-page":"G958","DOI":"10.1152\/ajpgi.00384.2012","article-title":"Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans","volume":"304","author":"Maciejewski","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cmet.2017.08.002_bib124","doi-asserted-by":"crossref","first-page":"176","DOI":"10.7326\/0003-4819-128-3-199802010-00002","article-title":"Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial","volume":"128","author":"Maggs","year":"1998","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib125","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/oby.2010.90","article-title":"Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction","volume":"18","author":"Magkos","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.cmet.2017.08.002_bib126","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.03.003","article-title":"Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects","volume":"142","author":"Magkos","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib127","doi-asserted-by":"crossref","first-page":"8913","DOI":"10.1073\/pnas.1323785111","article-title":"TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content","volume":"111","author":"Mahdessian","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib128","doi-asserted-by":"crossref","first-page":"E821","DOI":"10.1210\/jc.2014-4464","article-title":"Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant","volume":"100","author":"Mancina","year":"2015","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib129","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2016.01.032","article-title":"The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent","volume":"150","author":"Mancina","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib130","doi-asserted-by":"crossref","first-page":"8552","DOI":"10.1073\/pnas.0603115103","article-title":"Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis","volume":"103","author":"Mao","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib131","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.2337\/db14-0595","article-title":"Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding","volume":"63","author":"Markan","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib132","doi-asserted-by":"crossref","first-page":"e0122987","DOI":"10.1371\/journal.pone.0122987","article-title":"The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob\/ob mice","volume":"10","author":"Martag\u00f3n","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2017.08.002_bib133","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/01.sla.0000179652.07502.3f","article-title":"Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome","volume":"242","author":"Mattar","year":"2005","journal-title":"Ann. Surg."},{"key":"10.1016\/j.cmet.2017.08.002_bib134","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2337\/diabetes.51.3.797","article-title":"The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes","volume":"51","author":"Mayerson","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib135","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.cmet.2015.07.028","article-title":"Loss of mitochondrial pyruvate carrier 2 in the liver leads to defects in gluconeogenesis and compensation via pyruvate-alanine cycling","volume":"22","author":"McCommis","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib136","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/hep.29025","article-title":"Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis","volume":"65","author":"McCommis","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib137","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12944-015-0006-5","article-title":"Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome","volume":"14","author":"Meyers","year":"2015","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.cmet.2017.08.002_bib138","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrgastro.2013.183","article-title":"NAFLD, NASH and liver cancer","volume":"10","author":"Michelotti","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib139","doi-asserted-by":"crossref","first-page":"675","DOI":"10.2337\/diabetes.52.3.675","article-title":"Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy","volume":"52","author":"Miles","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib140","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1210\/jcem.87.6.8567","article-title":"Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients","volume":"87","author":"Miyazaki","year":"2002","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib141","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cmet.2007.10.014","article-title":"Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis","volume":"6","author":"Miyazaki","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib142","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2337\/diacare.22.6.908","article-title":"Effect of troglitazone on body fat distribution in type 2 diabetic patients","volume":"22","author":"Mori","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cmet.2017.08.002_bib143","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2013.05.042","article-title":"Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease","volume":"145","author":"Mudaliar","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib144","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.cmet.2009.01.011","article-title":"The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance","volume":"9","author":"Nagai","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib145","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1172\/JCI200523219","article-title":"Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus","volume":"115","author":"Nagashima","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib146","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.2337\/db16-0662","article-title":"Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice","volume":"66","author":"Nagata","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib147","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1172\/JCI200112876","article-title":"The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression","volume":"108","author":"Nakae","year":"2001","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib148","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3945\/ajcn.112.035758","volume":"96","author":"Nazare","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cmet.2017.08.002_bib149","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2017.08.002_bib150","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1016\/S0002-9440(10)61177-7","article-title":"A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice","volume":"160","author":"Nicholes","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cmet.2017.08.002_bib151","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1172\/JCI21047","article-title":"Splanchnic lipolysis in human obesity","volume":"113","author":"Nielsen","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib152","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.132384699","article-title":"Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity","volume":"99","author":"Ntambi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib153","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejphar.2015.03.072","article-title":"JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity","volume":"758","author":"Okuma","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.cmet.2017.08.002_bib154","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jphs.2015.06.007","article-title":"JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis","volume":"128","author":"Okuma","year":"2015","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.cmet.2017.08.002_bib155","doi-asserted-by":"crossref","first-page":"7598","DOI":"10.1073\/pnas.0913492107","article-title":"Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake","volume":"107","author":"Olson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib156","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cmet.2014.07.012","article-title":"FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss","volume":"20","author":"Owen","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib157","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.exger.2016.02.013","article-title":"Aging and adipose tissue: potential interventions for diabetes and regenerative medicine","volume":"86","author":"Palmer","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.cmet.2017.08.002_bib158","doi-asserted-by":"crossref","first-page":"27938","DOI":"10.1038\/srep27938","article-title":"CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis","volume":"6","author":"Park","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2017.08.002_bib159","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib160","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.cmet.2013.10.004","article-title":"Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler","volume":"18","author":"Perry","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib161","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.3579","article-title":"Leptin reverses diabetes by\u00a0suppression of the hypothalamic-pituitary-adrenal axis","volume":"20","author":"Perry","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib162","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2015.01.012","article-title":"Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes","volume":"160","author":"Perry","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2017.08.002_bib163","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1126\/science.aaa0672","article-title":"Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats","volume":"347","author":"Perry","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cmet.2017.08.002_bib164","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1056\/NEJM199610313351804","article-title":"Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects","volume":"335","author":"Perseghin","year":"1996","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib165","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.2337\/diabetes.48.8.1600","article-title":"Intramyocellular triglyceride content is a determinant of in\u00a0vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents","volume":"48","author":"Perseghin","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib166","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/ijo.2011.154","article-title":"Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content","volume":"36","author":"Peter","year":"2012","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.cmet.2017.08.002_bib167","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2337\/diabetes.47.3.381","article-title":"13C\/31P NMR studies on the mechanism of insulin resistance in obesity","volume":"47","author":"Petersen","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib168","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1172\/JCI579","article-title":"Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans","volume":"101","author":"Petersen","year":"1998","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib169","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2337\/diabetes.49.5.827","article-title":"Mechanism of troglitazone action in type 2 diabetes","volume":"49","author":"Petersen","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib170","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI0215001","article-title":"Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy","volume":"109","author":"Petersen","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib171","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2337\/diabetes.54.3.603","article-title":"Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes","volume":"54","author":"Petersen","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib172","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1073\/pnas.0705408104","article-title":"The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome","volume":"104","author":"Petersen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib173","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1056\/NEJMoa0907295","article-title":"Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease","volume":"362","author":"Petersen","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib174","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1172\/JCI86013","article-title":"Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance","volume":"126","author":"Petersen","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib175","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cell.2011.06.034","article-title":"mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway","volume":"146","author":"Peterson","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2017.08.002_bib176","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbalip.2013.12.006","article-title":"Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function","volume":"1841","author":"Pingitore","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cmet.2017.08.002_bib177","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.2337\/db09-0278","article-title":"Glucagon-like peptide 1\/glucagon receptor dual agonism reverses obesity in mice","volume":"58","author":"Pocai","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib178","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.cmet.2011.03.019","article-title":"FGF15\/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1\u03b1 pathway","volume":"13","author":"Potthoff","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib179","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1101\/gad.184788.111","article-title":"Endocrine fibroblast growth factors 15\/19 and 21: from feast to famine","volume":"26","author":"Potthoff","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2017.08.002_bib180","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2337\/diab.36.5.607","article-title":"Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects","volume":"36","author":"Prager","year":"1987","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib181","first-page":"E154","article-title":"A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in\u00a0vivo","volume":"277","author":"Previs","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cmet.2017.08.002_bib182","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1677\/joe.0.1620207","article-title":"Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding","volume":"162","author":"Qu","year":"1999","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.cmet.2017.08.002_bib183","doi-asserted-by":"crossref","first-page":"13705","DOI":"10.1073\/pnas.1110105108","article-title":"Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals","volume":"108","author":"Rab\u00f8l","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib184","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00125-011-2073-0","article-title":"Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice","volume":"54","author":"Raddatz","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2017.08.002_bib185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.14218\/JCTH.2015.00001","article-title":"Diabetes mellitus predicts occurrence of cirrhosis and hepatocellular cancer in alcoholic liver and non-alcoholic fatty liver diseases","volume":"3","author":"Raff","year":"2015","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.cmet.2017.08.002_bib186","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2016.01.038","article-title":"Elafibranor, an agonist of the peroxisome proliferator-activated receptor-\u03b1 and -\u03b4, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening","volume":"150","author":"Ratziu","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib187","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1172\/JCI118846","article-title":"Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs","volume":"98","author":"Rebrin","year":"1996","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib188","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0026-0495(90)90160-E","article-title":"Metabolism of adipose tissue in intraabdominal depots in severely obese men and women","volume":"39","author":"Rebuff\u00e9-Scrive","year":"1990","journal-title":"Metabolism"},{"key":"10.1016\/j.cmet.2017.08.002_bib189","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1172\/JCI118742","article-title":"Mechanism of free fatty acid-induced insulin resistance in humans","volume":"97","author":"Roden","year":"1996","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib190","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/ng.257","article-title":"Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease","volume":"40","author":"Romeo","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2017.08.002_bib191","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cell.2017.06.011","article-title":"Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms","volume":"170","author":"Rusu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2017.08.002_bib192","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.cgh.2014.04.038","article-title":"The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease","volume":"12","author":"Safadi","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib193","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jhep.2013.02.007","article-title":"The liver diseases of lipodystrophy: the long-term effect of leptin treatment","volume":"59","author":"Safar Zadeh","year":"2013","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib194","doi-asserted-by":"crossref","first-page":"19961","DOI":"10.1074\/jbc.M109.014225","article-title":"Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity","volume":"284","author":"Sampath","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib195","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cell.2012.02.017","article-title":"Mechanisms for insulin resistance: common threads and missing links","volume":"148","author":"Samuel","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2017.08.002_bib196","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI77812","article-title":"The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux","volume":"126","author":"Samuel","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib197","doi-asserted-by":"crossref","first-page":"32345","DOI":"10.1074\/jbc.M313478200","article-title":"Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease","volume":"279","author":"Samuel","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib198","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1172\/JCI30400","article-title":"Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease","volume":"117","author":"Samuel","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib199","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/hep.24806","article-title":"Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents","volume":"55","author":"Santoro","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib200","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1056\/NEJMoa0907929","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"362","author":"Sanyal","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib201","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1016\/S0168-8278(17)30443-9","article-title":"BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: a phase 2 study","volume":"66","author":"Sanyal","year":"2017","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib202","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1172\/JCI27300","article-title":"Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2","volume":"116","author":"Savage","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib203","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1056\/NEJMoa1600869","article-title":"Bariatric surgery versus intensive medical therapy for diabetes\u20145-year outcomes","volume":"376","author":"Schauer","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib204","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.molcel.2014.09.026","article-title":"A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth","volume":"56","author":"Schell","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2017.08.002_bib205","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1194\/jlr.M035154","article-title":"Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats","volume":"54","author":"Schober","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2017.08.002_bib206","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00125-012-2738-3","article-title":"Direct effect of GLP-1 infusion on endogenous glucose production in humans","volume":"56","author":"Seghieri","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2017.08.002_bib207","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1210\/jc.2006-1268","article-title":"Review: Peroxisome proliferator-activated receptor gamma and adipose tissue--understanding obesity-related changes in regulation of lipid and glucose metabolism","volume":"92","author":"Sharma","year":"2007","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib208","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1152\/ajpendo.90949.2008","article-title":"Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism","volume":"297","author":"Shi","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib209","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1172\/JCI10583","article-title":"Cellular mechanisms of insulin resistance","volume":"106","author":"Shulman","year":"2000","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib211","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ajg.2013.476","article-title":"The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis","volume":"109","author":"Singal","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.cmet.2017.08.002_bib212","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.2337\/diabetes.51.4.1022","article-title":"Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity","volume":"51","author":"Sinha","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib213","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1172\/JCI72434","article-title":"Neuronal GLP1R mediates liraglutide\u2019s anorectic but not glucose-lowering effect","volume":"124","author":"Sisley","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib214","doi-asserted-by":"crossref","first-page":"10659","DOI":"10.1074\/jbc.M116.719955","article-title":"Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins","volume":"291","author":"Smagris","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib215","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1172\/JCI81507","article-title":"Abdominal obesity: a marker of ectopic fat accumulation","volume":"125","author":"Smith","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2017.08.002_bib216","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.2337\/db16-0564","article-title":"Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK-\u03b21","volume":"65","author":"Smith","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib217","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.3748\/wjg.v20.i23.7339","article-title":"Mediterranean diet and non-alcoholic fatty liver disease: new therapeutic option around the corner?","volume":"20","author":"Sofi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.cmet.2017.08.002_bib218","doi-asserted-by":"crossref","first-page":"30177","DOI":"10.1074\/jbc.M114.595850","article-title":"Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice","volume":"289","author":"Soufi","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib219","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/hep.26461","article-title":"Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha\/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"58","author":"Staels","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib220","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1126\/science.279.5351.710","article-title":"Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B","volume":"279","author":"Stephens","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.cmet.2017.08.002_bib221","doi-asserted-by":"crossref","first-page":"9597","DOI":"10.1073\/pnas.1409229111","article-title":"Role of diacylglycerol activation of PKC\u03b8 in lipid-induced muscle insulin resistance in humans","volume":"111","author":"Szendroedi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib222","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nm.3699","article-title":"Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice","volume":"20","author":"Tao","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib223","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1056\/NEJMra0912063","article-title":"Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease","volume":"363","author":"Targher","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2017.08.002_bib224","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.celrep.2017.05.035","article-title":"Hepatic diacylglycerol-associated protein kinase C\u03b5 translocation links hepatic steatosis to hepatic insulin resistance in humans","volume":"19","author":"Ter Horst","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2017.08.002_bib225","doi-asserted-by":"crossref","first-page":"12757","DOI":"10.1038\/ncomms12757","article-title":"MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C","volume":"7","author":"Thabet","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2017.08.002_bib226","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jphs.2015.08.005","article-title":"JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice","volume":"129","author":"Tomimoto","year":"2015","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.cmet.2017.08.002_bib227","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2337\/diabetes.53.6.1621","article-title":"Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes","volume":"53","author":"Tonelli","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib228","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1002\/jcb.21077","article-title":"Acetyl-coenzyme A carboxylases: versatile targets for drug discovery","volume":"99","author":"Tong","year":"2006","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.cmet.2017.08.002_bib229","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cmet.2006.06.008","article-title":"Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis","volume":"4","author":"Uyeda","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib230","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/hep.28962","article-title":"A novel glucagon-like peptide 1\/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice","volume":"65","author":"Valdecantos","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2017.08.002_bib231","doi-asserted-by":"crossref","first-page":"E89","DOI":"10.1152\/ajpendo.00573.2012","article-title":"Thyroid hormone receptor-\u03b2 agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways","volume":"305","author":"Vatner","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib232","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1073\/pnas.1423952112","article-title":"Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids","volume":"112","author":"Vatner","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib233","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2015.04.005","article-title":"Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis","volume":"149","author":"Vilar-Gomez","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib234","first-page":"914","article-title":"Pioglitazone and risk for bone fracture: safety data from a randomized clinical trial","volume":"102","author":"Viscoli","year":"2017","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib235","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cmet.2013.06.001","article-title":"A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition","volume":"18","author":"Wan","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2017.08.002_bib236","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature04330","article-title":"Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation","volume":"439","author":"Watanabe","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2017.08.002_bib237","doi-asserted-by":"crossref","first-page":"e3887","DOI":"10.1097\/MD.0000000000003887","article-title":"Nonalcoholic fatty liver disease is associated with excessive calorie intake rather than a distinctive dietary pattern","volume":"95","author":"Wehmeyer","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cmet.2017.08.002_bib238","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1073\/pnas.1200797109","article-title":"Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor \u03b3","volume":"109","author":"Wei","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2017.08.002_bib239","doi-asserted-by":"crossref","first-page":"17958","DOI":"10.1038\/srep17958","article-title":"Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference","volume":"6","author":"Wen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2017.08.002_bib240","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12828","article-title":"Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico","volume":"506","author":"Williams","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2017.08.002_bib241","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/j.gastro.2014.11.039","article-title":"Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States","volume":"148","author":"Wong","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib242","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1210\/me.2013-1427","article-title":"Minireview: Challenges and opportunities in development of PPAR agonists","volume":"28","author":"Wright","year":"2014","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cmet.2017.08.002_bib243","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2337\/db15-0941","article-title":"Mesenteric fat lipolysis mediates obesity-associated hepatic steatosis and insulin resistance","volume":"65","author":"Wueest","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib244","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.2337\/diabetes.54.8.2390","article-title":"Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial","volume":"54","author":"Wynne","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib245","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2337\/db08-0392","article-title":"Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice","volume":"58","author":"Xu","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib246","first-page":"1","article-title":"Mortality in the United States, 2015","volume":"267","author":"Xu","year":"2016","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.cmet.2017.08.002_bib247","doi-asserted-by":"crossref","first-page":"e6712","DOI":"10.1097\/MD.0000000000006712","article-title":"Nonoverweight nonalcoholic fatty liver disease and incident cardiovascular disease: A post hoc analysis of a cohort study","volume":"96","author":"Yoshitaka","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cmet.2017.08.002_bib248","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1053\/j.gastro.2016.03.005","article-title":"Contribution of alcoholic and nonalcoholic fatty liver disease to the burden of liver-related morbidity and mortality","volume":"150","author":"Younossi","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.cmet.2017.08.002_bib249","doi-asserted-by":"crossref","first-page":"50230","DOI":"10.1074\/jbc.M200958200","article-title":"Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle","volume":"277","author":"Yu","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2017.08.002_bib250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/DMSO.S50209","article-title":"TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity","volume":"7","author":"Zambad","year":"2013","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.cmet.2017.08.002_bib251","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db07-1476","article-title":"Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2017.08.002_bib252","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jhep.2009.03.025","article-title":"Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis","volume":"51","author":"Zhang","year":"2009","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.cmet.2017.08.002_bib253","doi-asserted-by":"crossref","first-page":"e00065","DOI":"10.7554\/eLife.00065","article-title":"The starvation hormone, fibroblast growth factor-21, extends lifespan in mice","volume":"1","author":"Zhang","year":"2012","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2017.08.002_bib254","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1007\/s10620-016-4120-7","article-title":"APOC3 rs2070666 is associated with the hepatic steatosis independently of PNPLA3 rs738409 in Chinese Han patients with nonalcoholic fatty liver diseases","volume":"61","author":"Zhang","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.cmet.2017.08.002_bib255","doi-asserted-by":"crossref","first-page":"37758","DOI":"10.18632\/oncotarget.5386","article-title":"Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in\u00a0vitro","volume":"6","author":"Zhong","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.cmet.2017.08.002_bib256","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1158\/0008-5472.CAN-14-0208","article-title":"Separating tumorigenicity from bile acid regulatory activity for endocrine hormone FGF19","volume":"74","author":"Zhou","year":"2014","journal-title":"Cancer Res."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413117304874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413117304874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:31:38Z","timestamp":1761550298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413117304874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":255,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1550413117304874"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2017.08.002","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2017.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}