{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:06:36Z","timestamp":1793239596985,"version":"4.5.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","award":["3-PDF-2014-110-A-N"],"award-info":[{"award-number":["3-PDF-2014-110-A-N"]}],"id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001232","name":"Royal Australasian College of Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK099473-01"],"award-info":[{"award-number":["DK099473-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK072381"],"award-info":[{"award-number":["DK072381"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R37DK039773"],"award-info":[{"award-number":["R37DK039773"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014269","name":"Philippe Foundation","doi-asserted-by":"publisher","award":["TW-37"],"award-info":[{"award-number":["TW-37"]}],"id":[{"id":"10.13039\/100014269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014959","name":"Tizona Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.cmet.2021.04.004","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T10:42:18Z","timestamp":1620124938000},"page":"1042-1061.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":290,"title":["KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease"],"prefix":"10.1016","volume":"33","author":[{"given":"Yutaro","family":"Mori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrendra K.","family":"Ajay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Hyung","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Kishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung-Myong","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata S.","family":"Sabbisetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suetonia C.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Galichon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K.","family":"Kuchroo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaharu","family":"Ichimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph V.","family":"Bonventre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2021.04.004_bib1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cmet.2021.04.004_bib2","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1101\/gad.914401","article-title":"Cell cycle checkpoint signaling through the ATM and ATR kinases","volume":"15","author":"Abraham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2021.04.004_bib3","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/s41379-019-0218-8","article-title":"Detection of DNA damage response in nonalcoholic fatty liver disease via p53-binding protein 1 nuclear expression","volume":"32","author":"Akazawa","year":"2019","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.cmet.2021.04.004_bib4","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.ASN.0000042167.66685.EA","article-title":"Stimulation of proximal tubular cell apoptosis by albumin-bound fatty acids mediated by peroxisome proliferator activated receptor-gamma","volume":"14","author":"Arici","year":"2003","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib6","doi-asserted-by":"crossref","first-page":"39739","DOI":"10.1074\/jbc.M200562200","article-title":"Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration","volume":"277","author":"Bailly","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2021.04.004_bib7","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1172\/JCI8862","article-title":"Cubilin is an albumin binding protein important for renal tubular albumin reabsorption","volume":"105","author":"Birn","year":"2000","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.semnephrol.2012.07.008","article-title":"Can we target tubular damage to prevent renal function decline in diabetes?","volume":"32","author":"Bonventre","year":"2012","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib9","doi-asserted-by":"crossref","first-page":"e73076","DOI":"10.1371\/journal.pone.0073076","article-title":"The human urine metabolome","volume":"8","author":"Bouatra","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2021.04.004_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1478-7954-8-29","article-title":"Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence","volume":"8","author":"Boyle","year":"2010","journal-title":"Popul. Health Metr."},{"key":"10.1016\/j.cmet.2021.04.004_bib11","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1056\/NEJMoa011161","article-title":"Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy","volume":"345","author":"Brenner","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1681\/ASN.2004080648","article-title":"Mouse models of diabetic nephropathy","volume":"16","author":"Breyer","year":"2005","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib13","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.15252\/embj.201489838","article-title":"KIM-1-\/TIM-1-mediated phagocytosis links ATG5-\/ULK1-dependent clearance of apoptotic cells to antigen presentation","volume":"34","author":"Brooks","year":"2015","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2021.04.004_bib14","doi-asserted-by":"crossref","first-page":"eaav4754","DOI":"10.1126\/scitranslmed.aav4754","article-title":"Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair","volume":"11","author":"Canaud","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib15","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1172\/JCI79641","article-title":"Albumin-associated free fatty acids induce macropinocytosis in podocytes","volume":"125","author":"Chung","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib16","first-page":"943","article-title":"Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis","volume":"119","author":"Crowley","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.semnephrol.2007.01.012","article-title":"Histopathology of diabetic nephropathy","volume":"27","author":"Fioretto","year":"2007","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib18","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1681\/ASN.2007020220","article-title":"End-stage renal disease in the United States: an update from the United States Renal Data System","volume":"18","author":"Foley","year":"2007","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib19","first-page":"393","article-title":"The role of ATM and ATR in DNA damage-induced cell cycle control","volume":"5","author":"Goodarzi","year":"2003","journal-title":"Prog. Cell Cycle Res."},{"key":"10.1016\/j.cmet.2021.04.004_bib20","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ki.2012.20","article-title":"Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis","volume":"82","author":"Grgic","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.cmet.2021.04.004_bib21","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1681\/ASN.2004070530","article-title":"Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma","volume":"16","author":"Han","year":"2005","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib22","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1172\/JCI45361","article-title":"Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis","volume":"123","author":"Humphreys","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib23","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1074\/jbc.273.7.4135","article-title":"Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury","volume":"273","author":"Ichimura","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2021.04.004_bib24","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI34487","article-title":"Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells","volume":"118","author":"Ichimura","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ki.2008.128","article-title":"Proteinuria in diabetic kidney disease: a mechanistic viewpoint","volume":"74","author":"Jefferson","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.cmet.2021.04.004_bib26","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1046\/j.1523-1755.2002.00618.x","article-title":"Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage","volume":"62","author":"Kamijo","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.cmet.2021.04.004_bib27","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.kint.2019.07.025","article-title":"Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes","volume":"96","author":"Kammer","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.cmet.2021.04.004_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nm.3762","article-title":"Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development","volume":"21","author":"Kang","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib29","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.trsl.2011.08.007","article-title":"Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus","volume":"158","author":"Khan","year":"2011","journal-title":"Transl. Res."},{"key":"10.1016\/j.cmet.2021.04.004_bib30","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1172\/JCI71863","article-title":"Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis","volume":"124","author":"Khan","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1681\/ASN.2017030314","article-title":"Kidney proximal tubule lipoapoptosis is regulated by fatty acid transporter-2 (FATP2)","volume":"29","author":"Khan","year":"2018","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib32","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.ebiom.2015.07.035","article-title":"Meclizine preconditioning protects the kidney against ischemia-reperfusion injury","volume":"2","author":"Kishi","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.cmet.2021.04.004_bib33","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1172\/JCI122313","article-title":"Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses","volume":"129","author":"Kishi","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib34","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.freeradbiomed.2011.05.028","article-title":"SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells","volume":"51","author":"Koyama","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib35","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1681\/ASN.2007010089","article-title":"Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet","volume":"18","author":"Kume","year":"2007","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bcp.2014.08.013","article-title":"Free fatty acids as modulators of the NLRP3 inflammasome in obesity\/type 2 diabetes","volume":"92","author":"Legrand-Poels","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cmet.2021.04.004_bib37","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1038\/emm.2016.157","article-title":"Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes","volume":"49","author":"Ly","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib38","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/315641a0","article-title":"Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs","volume":"315","author":"March","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2021.04.004_bib39","doi-asserted-by":"crossref","first-page":"e0142291","DOI":"10.1371\/journal.pone.0142291","article-title":"Renal lipotoxicity-associated inflammation and insulin resistance affects actin cytoskeleton organization in podocytes","volume":"10","author":"Mart\u00ednez-Garc\u00eda","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2021.04.004_bib40","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.200940168","article-title":"Signaling by ROS drives inflammasome activation","volume":"40","author":"Martinon","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.cmet.2021.04.004_bib41","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI111523","article-title":"Structural-functional relationships in diabetic nephropathy","volume":"74","author":"Mauer","year":"1984","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib42","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1056\/NEJM198402093100605","article-title":"Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes","volume":"310","author":"Mogensen","year":"1984","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJM198407123110204","article-title":"Predicting diabetic nephropathy in insulin-dependent patients","volume":"311","author":"Mogensen","year":"1984","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib44","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jnutbio.2011.05.004","article-title":"Renal and glycemic effects of high-dose chromium picolinate in db\/db mice: assessment of DNA damage","volume":"23","author":"Mozaffari","year":"2012","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.cmet.2021.04.004_bib45","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/labinvest.3700240","article-title":"Evidence for megalin-mediated proximal tubular uptake of L-FABP, a carrier of potentially nephrotoxic molecules","volume":"85","author":"Oyama","year":"2005","journal-title":"Lab. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib46","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00125-003-1155-z","article-title":"Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension","volume":"46","author":"Palm","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2021.04.004_bib47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cellimm.2018.08.006","article-title":"Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release","volume":"332","author":"Pan","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.cmet.2021.04.004_bib48","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.2337\/dc14-2330","article-title":"Kidney injury molecule-1 and the loss of kidney function in diabetic nephropathy: a likely causal link in patients with type 1 diabetes","volume":"38","author":"Panduru","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cmet.2021.04.004_bib49","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1056\/NEJMoa011489","article-title":"The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes","volume":"345","author":"Parving","year":"2001","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib50","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/sj.ki.5002567","article-title":"Adaptation to hypoxia in the diabetic rat kidney","volume":"73","author":"Rosenberger","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.cmet.2021.04.004_bib52","doi-asserted-by":"crossref","first-page":"F896","DOI":"10.1152\/ajprenal.00484.2013","article-title":"Albumin-bound fatty acids but not albumin itself alter redox balance in tubular epithelial cells and induce a peroxide-mediated redox-sensitive apoptosis","volume":"306","author":"Ruggiero","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.cmet.2021.04.004_bib53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/toxsci\/kfs268","article-title":"Novel assays for detection of urinary KIM-1 in mouse models of kidney injury","volume":"131","author":"Sabbisetti","year":"2013","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.cmet.2021.04.004_bib54","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1681\/ASN.2013070758","article-title":"Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes","volume":"25","author":"Sabbisetti","year":"2014","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib55","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/S0002-9440(10)61114-5","article-title":"Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope","volume":"160","author":"Samulowitz","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.cmet.2021.04.004_bib56","doi-asserted-by":"crossref","first-page":"C374","DOI":"10.1152\/ajpcell.00096.2010","article-title":"Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes","volume":"299","author":"Satriano","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.cmet.2021.04.004_bib57","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1194\/jlr.M074427","article-title":"Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids","volume":"58","author":"Scerbo","year":"2017","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2021.04.004_bib58","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bbrc.2010.10.012","article-title":"Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell","volume":"402","author":"Soumura","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cmet.2021.04.004_bib59","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.numecd.2005.08.007","article-title":"High-fat diet in low-dose-streptozotocin-treated heminephrectomized rats induces all features of human type 2 diabetic nephropathy: a new rat model of diabetic nephropathy","volume":"16","author":"Sugano","year":"2006","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.cmet.2021.04.004_bib60","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1093\/ndt\/gfs260","article-title":"The pathogenic role of the renal proximal tubular cell in diabetic nephropathy","volume":"27","author":"Tang","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.cmet.2021.04.004_bib61","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.3168\/jds.2008-1749","article-title":"Long-chain fatty acid effects on peroxisome proliferator-activated receptor-alpha-regulated genes in Madin-Darby bovine kidney cells: optimization of culture conditions using palmitate","volume":"92","author":"Thering","year":"2009","journal-title":"J.\u00a0Dairy Sci."},{"key":"10.1016\/j.cmet.2021.04.004_bib62","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1159\/000168653","article-title":"Contribution of proteinuria to progressive renal injury: consequences of tubular uptake of fatty acid bearing albumin","volume":"13","author":"Thomas","year":"1993","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib63","doi-asserted-by":"crossref","first-page":"F640","DOI":"10.1152\/ajprenal.00001.2002","article-title":"Fatty acids exacerbate tubulointerstitial injury in protein-overload proteinuria","volume":"283","author":"Thomas","year":"2002","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.cmet.2021.04.004_bib64","doi-asserted-by":"crossref","first-page":"524","DOI":"10.5812\/numonthly.1954","article-title":"Lessons from the KK-Ay mouse, a spontaneous animal model for the treatment of human type 2 diabetic nephropathy","volume":"4","author":"Tomino","year":"2012","journal-title":"Nephrourol. Mon."},{"key":"10.1016\/j.cmet.2021.04.004_bib65","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cmet.2021.04.004_bib66","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.physiol.65.092101.142622","article-title":"The physiology of cellular liporegulation","volume":"65","author":"Unger","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cmet.2021.04.004_bib67","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/ki.2010.404","article-title":"Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-\u03b2-D-glucosaminidase","volume":"79","author":"Vaidya","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.cmet.2021.04.004_bib68","doi-asserted-by":"crossref","first-page":"R1009","DOI":"10.1152\/ajpregu.00809.2010","article-title":"The proximal tubule in the pathophysiology of the diabetic kidney","volume":"300","author":"Vallon","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.cmet.2021.04.004_bib69","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1097\/01.tp.0000295982.78039.ef","article-title":"High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients","volume":"84","author":"van Timmeren","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.cmet.2021.04.004_bib70","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/path.2175","article-title":"Tubular kidney injury molecule-1 (KIM-1) in human renal disease","volume":"212","author":"van Timmeren","year":"2007","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.cmet.2021.04.004_bib71","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1021\/jm060460o","article-title":"Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins","volume":"49","author":"Wang","year":"2006","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.cmet.2021.04.004_bib72","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cmet.2012.01.009","article-title":"Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells","volume":"15","author":"Wang","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2021.04.004_bib73","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2021.04.004_bib74","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1681\/ASN.V1191667","article-title":"Type 2 diabetic patients with nephropathy show structural-functional relationships that are similar to type 1 disease","volume":"11","author":"White","year":"2000","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib75","doi-asserted-by":"crossref","first-page":"12105","DOI":"10.1073\/pnas.1120914109","article-title":"Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice","volume":"109","author":"Xiao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2021.04.004_bib76","doi-asserted-by":"crossref","first-page":"e12690","DOI":"10.1111\/jpi.12690","article-title":"Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner","volume":"69","author":"Xu","year":"2020","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.cmet.2021.04.004_bib77","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1681\/ASN.2012111080","article-title":"Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions","volume":"24","author":"Yamahara","year":"2013","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib78","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1681\/ASN.2016070731","article-title":"High-fat diet-induced lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in the kidney","volume":"28","author":"Yamamoto","year":"2017","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib79","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2021.04.004_bib80","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1172\/JCI75417","article-title":"KIM-1-mediated phagocytosis reduces acute injury to the kidney","volume":"125","author":"Yang","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2021.04.004_bib81","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1073\/pnas.0511154103","article-title":"Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology","volume":"103","author":"Yu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2021.04.004_bib82","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1681\/ASN.V991670","article-title":"Ceramide accumulation during oxidant renal tubular injury: mechanisms and potential consequences","volume":"9","author":"Zager","year":"1998","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.cmet.2021.04.004_bib83","doi-asserted-by":"crossref","first-page":"8698","DOI":"10.1158\/0008-5472.CAN-05-3691","article-title":"Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2","volume":"66","author":"Zeitlin","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2021.04.004_bib84","doi-asserted-by":"crossref","first-page":"e2329","DOI":"10.1371\/journal.pone.0002329","article-title":"Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis","volume":"3","author":"Zeng","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmet.2021.04.004_bib85","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ki.2012.441","article-title":"Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology","volume":"83","author":"Zhan","year":"2013","journal-title":"Kidney Int."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413121001704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413121001704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:39:33Z","timestamp":1761550773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413121001704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":85,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S1550413121001704"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2021.04.004","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740063282.793589530","asserted-by":"object"}]},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2021.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}