{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:03:57Z","timestamp":1793678637751,"version":"4.5.1"},"reference-count":301,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.cmet.2022.09.023","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T11:26:42Z","timestamp":1666092402000},"page":"1675-1699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":586,"title":["The role of lipids in cancer progression and metastasis"],"prefix":"10.1016","volume":"34","author":[{"given":"Miguel","family":"Martin-Perez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uxue","family":"Urdiroz-Urricelqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-5049","authenticated-orcid":false,"given":"Salvador Aznar","family":"Benitah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2022.09.023_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.gendis.2020.01.015","article-title":"ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis","volume":"8","author":"Adorno-Cruz","year":"2021","journal-title":"Genes Dis."},{"key":"10.1016\/j.cmet.2022.09.023_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1158\/1535-7163.MCT-12-1136","article-title":"The fatty acid synthase inhibitor orlistat reduces the growth and metastasis of orthotopic tongue oral squamous cell carcinomas","volume":"13","author":"Agostini","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.cmet.2022.09.023_bib3","doi-asserted-by":"crossref","first-page":"e8313","DOI":"10.15252\/emmm.201708313","article-title":"Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer","volume":"10","author":"Ali","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib4","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1158\/2159-8290.CD-20-0329","article-title":"Changes in aged fibroblast lipid metabolism induce age-dependent melanoma cell resistance to targeted therapy via the fatty acid transporter FATP2","volume":"10","author":"Alicea","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cmet.2022.09.023_bib5","doi-asserted-by":"crossref","first-page":"e1344804","DOI":"10.1080\/2162402X.2017.1344804","article-title":"Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells","volume":"6","author":"Al-Khami","year":"2017","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.cmet.2022.09.023_bib6","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1158\/1078-0432.CCR-19-0253","article-title":"A fatty acid oxidation-dependent metabolic shift regulates the adaptation of BRAF-mutated melanoma to MAPK inhibitors","volume":"25","author":"Aloia","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib7","doi-asserted-by":"crossref","first-page":"16028","DOI":"10.1038\/npjbcancer.2016.28","article-title":"Palmitoylation: a protein S-acylation with implications for breast cancer","volume":"2","author":"Anderson","year":"2016","journal-title":"npj Breast Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1158\/2159-8290.CD-18-1212","article-title":"A stromal lysolipid\u2013autotaxin signaling axis promotes pancreatic tumor progression","volume":"9","author":"Auciello","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cmet.2022.09.023_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fonc.2013.00224","article-title":"Current evidence linking polyunsaturated fatty acids with cancer risk and progression","volume":"3","author":"Azrad","year":"2013","journal-title":"Front Oncol"},{"key":"10.1016\/j.cmet.2022.09.023_bib10","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/s41467-017-00910-z","article-title":"The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells","volume":"8","author":"Baek","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib11","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2015.09.020","article-title":"Antioxidant role for lipid droplets in a stem cell niche of Drosophila","volume":"163","author":"Bailey","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40170-016-0163-7","article-title":"Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration","volume":"5","author":"Balaban","year":"2017","journal-title":"Cancer Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib13","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.3892\/ol.2016.4988","article-title":"SREBP-1 is an independent prognostic marker and promotes invasion and migration in breast cancer","volume":"12","author":"Bao","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.cmet.2022.09.023_bib14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11745-014-3892-9","article-title":"Effects of a diet rich in n-3 polyunsaturated fatty acids on hepatic lipogenesis and beta-oxidation in mice","volume":"49","author":"Bargut","year":"2014","journal-title":"Lipids"},{"key":"10.1016\/j.cmet.2022.09.023_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-018-1066-z","article-title":"Statin drugs to reduce breast cancer recurrence and mortality 11","volume":"20","author":"Beckwitt","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cmet.2019.06.014","article-title":"Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling","volume":"30","author":"Bi","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbrc.2017.01.051","article-title":"Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4\/ROS\/NF-\u03baB\/MMP-9 signaling pathway","volume":"484","author":"Binker-Cosen","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib19","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1038\/s41467-020-16126-7","article-title":"2,4-Dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer","volume":"11","author":"Blomme","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib20","doi-asserted-by":"crossref","first-page":"34992","DOI":"10.18632\/oncotarget.5252","article-title":"Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation","volume":"6","author":"Bollu","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.cmet.2022.09.023_bib21","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1007\/s11033-020-05352-3","article-title":"Dysregulated lipid metabolism in hepatocellular carcinoma cancer stem cells","volume":"47","author":"Bort","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13058-018-1029-4","article-title":"Obesity promotes the expansion of metastasis-initiating cells in breast cancer","volume":"20","author":"Bousquenaud","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib23","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.devcel.2021.04.013","article-title":"Lipid metabolism in cancer: new perspectives and emerging mechanisms","volume":"56","author":"Broadfield","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib24","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1158\/0008-5472.CAN-20-1954","article-title":"Fat induces glucose metabolism in nontransformed liver cells and promotes liver tumorigenesis","volume":"81","author":"Broadfield","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib25","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1038\/s41467-019-13028-1","article-title":"Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells","volume":"10","author":"Bueno","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib26","doi-asserted-by":"crossref","first-page":"659861","DOI":"10.3389\/fmolb.2021.659861","article-title":"Palmitoylation as a key regulator of Ras localization and function","volume":"8","author":"Busquets-Hern\u00e1ndez","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.cmet.2022.09.023_bib27","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/s41586-020-2502-7","article-title":"Fasting-mimicking diet and hormone therapy induce breast cancer regression","volume":"583","author":"Caffa","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nm.4055","article-title":"Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer","volume":"22","author":"Camarda","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/1724600818776838","article-title":"Plasma cholesterol and lipoprotein levels in relation to tumor aggressiveness and survival in HCC patients","volume":"33","author":"Carr","year":"2018","journal-title":"Int. J. Biol. Markers"},{"key":"10.1016\/j.cmet.2022.09.023_bib30","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1172\/JCI62129","article-title":"A metabolic prosurvival role for PML in breast cancer","volume":"122","author":"Carracedo","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.cmet.2022.09.023_bib31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fnut.2018.00044","article-title":"Colorectal cancer cells increase the production of short chain fatty acids by Propionibacterium freudenreichii impacting on cancer cells survival","volume":"5","author":"Casanova","year":"2018","journal-title":"Front. Nutr."},{"key":"10.1016\/j.cmet.2022.09.023_bib32","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/s41416-019-0711-3","article-title":"MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer","volume":"122","author":"Casciano","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib33","first-page":"430","article-title":"Mediterranean dietary pattern is associated with low risk of aggressive prostate cancer: MCC-Spain study","volume":"199","author":"Castell\u00f3","year":"2018","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.cmet.2022.09.023_bib34","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nchembio.2036","article-title":"Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway","volume":"12","author":"Chan","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib35","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1158\/0008-5472.CAN-21-0052","article-title":"PPAR\u03b1 agonist fenofibrate enhances cancer vaccine efficacy","volume":"81","author":"Chekaoui","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib36","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nchembio.2119","article-title":"ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity","volume":"12","author":"Chen","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature23887","article-title":"Palmitoylation-dependent activation of MC1R prevents melanomagenesis","volume":"549","author":"Chen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib38","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.chembiol.2018.05.003","article-title":"Protein lipidation in cell signaling and diseases: function, regulation, and therapeutic opportunities","volume":"25","author":"Chen","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib39","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41588-017-0027-2","article-title":"An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer","volume":"50","author":"Chen","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2022.09.023_bib40","doi-asserted-by":"crossref","first-page":"737776","DOI":"10.3389\/fonc.2021.737776","article-title":"PPAR-\u03b3 modulators as current and potential cancer treatments","volume":"11","author":"Chi","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib41","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3389\/fendo.2018.00807","article-title":"Cholesterol and its metabolites in tumor growth: therapeutic potential of statins in cancer treatment","volume":"10","author":"Chimento","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cmet.2022.09.023_bib42","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fimmu.2018.00038","article-title":"Bioactive lipids and chronic inflammation: managing the fire within","volume":"9","author":"Chiurchi\u00f9","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib43","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/jnci\/djj494","article-title":"Dietary fat reduction and breast cancer outcome: interim efficacy results from the women\u2019s intervention nutrition study","volume":"98","author":"Chlebowski","year":"2006","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.cmet.2022.09.023_bib44","doi-asserted-by":"crossref","first-page":"e181212","DOI":"10.1001\/jamaoncol.2018.1212","article-title":"Association of low-fat dietary pattern with breast cancer overall survival: a secondary analysis of the Women\u2019s Health Initiative randomized clinical trial","volume":"4","author":"Chlebowski","year":"2018","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib45","doi-asserted-by":"crossref","first-page":"20403","DOI":"10.1038\/s41598-019-56532-6","article-title":"Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis","volume":"9","author":"Chou","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib46","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/JLB.4HI0517-210R","article-title":"Frontline science: high fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells","volume":"103","author":"Clements","year":"2018","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib47","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.3389\/fimmu.2020.01989","article-title":"Metabolism of natural killer cells and other innate lymphoid cells","volume":"11","author":"Cong","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib48","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41467-019-14262-3","article-title":"TGF\u03b22-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells","volume":"11","author":"Corbet","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib49","doi-asserted-by":"crossref","first-page":"101055","DOI":"10.1016\/j.plipres.2020.101055","article-title":"Lipids in the tumor microenvironment: from cancer progression to treatment","volume":"80","author":"Corn","year":"2020","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib50","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41467-017-02732-5","article-title":"Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance","volume":"9","author":"Cotte","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib51","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/s41467-020-16079-x","article-title":"Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer","volume":"11","author":"Coutzac","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib52","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.cell.2015.05.025","article-title":"ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis article ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis","volume":"161","author":"Cubillos-Ruiz","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib53","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1182\/blood-2009-03-213876","article-title":"Palmitoylation of oncogenic NRAS is essential for leukemogenesis","volume":"115","author":"Cuiffo","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.cmet.2022.09.023_bib54","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1038\/ncomms2835","article-title":"Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties","volume":"4","author":"de Medina","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib55","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-pathol-012615-044359","article-title":"Obesity, inflammation, and cancer","volume":"11","author":"Deng","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.cmet.2022.09.023_bib56","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3389\/fchem.2020.00516","article-title":"The innovative potential of statins in cancer: new targets for new therapies","volume":"8","author":"di Bello","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.cmet.2022.09.023_bib57","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.cmet.2021.05.016","article-title":"Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects","volume":"33","author":"Dierge","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib58","first-page":"219","article-title":"The role of cholesterol metabolism in cancer","volume":"9","author":"Ding","year":"2019","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib59","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib60","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41586-022-04649-6","article-title":"\u03b2-Hydroxybutyrate suppresses colorectal cancer","volume":"605","author":"Dmitrieva-Posocco","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/09687681003616854","article-title":"DHHC20: a human palmitoyl acyltransferase that causes cellular transformation","volume":"27","author":"Draper","year":"2010","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib62","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3389\/fonc.2020.01185","article-title":"Inhibition of fatty acid synthase upregulates expression of CD36 to sustain proliferation of colorectal cancer cells","volume":"10","author":"Drury","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib63","doi-asserted-by":"crossref","first-page":"9230","DOI":"10.1038\/sj.onc.1208171","article-title":"Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase","volume":"23","author":"Ducker","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2022.09.023_bib64","doi-asserted-by":"crossref","first-page":"e20210042","DOI":"10.1084\/jem.20210042","article-title":"Suppressive effects of the obese tumor microenvironment on CD8 T\u00a0cell infiltration and effector function","volume":"219","author":"Dyck","year":"2022","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib65","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1200\/JCO.2010.29.7614","article-title":"Effect of obesity on prognosis after early-stage breast cancer","volume":"29","author":"Ewertz","year":"2011","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib66","doi-asserted-by":"crossref","first-page":"100797","DOI":"10.1016\/j.eclinm.2021.100797","article-title":"First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors","volume":"34","author":"Falchook","year":"2021","journal-title":"EClinicalmedicine"},{"key":"10.1016\/j.cmet.2022.09.023_bib67","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1158\/2159-8290.CD-16-0441","article-title":"Chemotherapy-resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism","volume":"7","author":"Farge","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cmet.2022.09.023_bib68","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41419-019-1958-6","article-title":"High-fat diet feeding and palmitic acid increase CRC growth in \u03b22AR-dependent manner","volume":"10","author":"Fatima","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2022.09.023_bib69","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1158\/0008-5472.CAN-13-3415","article-title":"Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer","volume":"74","author":"Feigin","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib70","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/j.celrep.2019.11.008","article-title":"CD36-mediated metabolic rewiring of breast cancer cells promotes resistance to HER2-targeted therapies","volume":"29","author":"Feng","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-020-1528-x","article-title":"Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1\u03b1\/PPAR-\u03b3\/PKM2-mediated glycolysis","volume":"39","author":"Feng","year":"2020","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib302","doi-asserted-by":"crossref","first-page":"14887","DOI":"10.1021\/acsami.1c23274","article-title":"Dual-targeting of tumor cells and tumor-associated macrophages by palmitic acid modified albumin nanoparticles for antitumor and antimetastasis therapy","volume":"14","author":"Feng","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.cmet.2022.09.023_bib72","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s43018-021-00183-y","article-title":"Fatty acid synthesis is required for breast cancer brain metastasis","volume":"2","author":"Ferraro","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib73","first-page":"3935","article-title":"Fatty acid synthase: an emerging target in cancer","volume":"25","author":"Fhu","year":"2020","journal-title":"J.\u00a0Cancer Mol."},{"key":"10.1016\/j.cmet.2022.09.023_bib74","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1093\/jn\/120.12.1601","article-title":"Effect of dietary \u03b1-linolenic acid on growth, metastasis, fatty acid profile and prostaglandin production of two murine mammary adenocarcinomas","volume":"120","author":"Fritsche","year":"1990","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.cmet.2022.09.023_bib75","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1038\/s41388-021-01707-7","article-title":"PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer","volume":"40","author":"Galbraith","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2022.09.023_bib76","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41591-020-01195-4","article-title":"Targeting metastatic cancer","volume":"27","author":"Ganesh","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib77","doi-asserted-by":"crossref","first-page":"9613","DOI":"10.1038\/srep09613","article-title":"Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer","volume":"5","author":"Gao","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib78","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1186\/s12885-019-5904-x","article-title":"SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-\u03baB pathway activation","volume":"19","author":"Gao","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib79","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1038\/s41416-020-0827-5","article-title":"Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo\/YAP pathway","volume":"122","author":"Gao","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib80","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41586-019-0945-5","article-title":"Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death","volume":"567","author":"Garcia-Bermudez","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib81","doi-asserted-by":"crossref","first-page":"590794","DOI":"10.3389\/fimmu.2020.590794","article-title":"Obesity-associated myeloid-derived suppressor cells promote apoptosis of tumor-infiltrating CD8 T\u00a0cells and immunotherapy resistance in breast cancer","volume":"11","author":"Gibson","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib82","doi-asserted-by":"crossref","first-page":"629182","DOI":"10.3389\/fcell.2021.629182","article-title":"Anti-tumor effect of oleic acid in hepatocellular carcinoma cell lines via autophagy reduction","volume":"9","author":"Giulitti","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib83","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41419-020-2434-z","article-title":"Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells","volume":"11","author":"Gong","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2022.09.023_bib84","first-page":"293","article-title":"Metabolism of odd-numbered fatty acids and even-numbered fatty acids in mouse","volume":"57","author":"Gotoh","year":"2008","journal-title":"J.\u00a0Oleo Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib85","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1158\/1055-9965.EPI-15-1336","article-title":"Association between body mass index and cancer survival in a pooled analysis of 22 clinical trials","volume":"26","author":"Greenlee","year":"2017","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.cmet.2022.09.023_bib86","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/15548627.2019.1606635","article-title":"The negative effect of lipid challenge on autophagy inhibits T\u00a0cell responses","volume":"16","author":"Guerrero-Ros","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.cmet.2022.09.023_bib87","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.2174\/13816128113199990486","article-title":"Targeting SREBP-1-driven lipid metabolism to treat cancer","volume":"20","author":"Guo","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.cmet.2022.09.023_bib88","first-page":"4280","article-title":"CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression","volume":"12","author":"Guo","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.cmet.2022.09.023_bib89","doi-asserted-by":"crossref","first-page":"e0118784","DOI":"10.1371\/journal.pone.0118784","article-title":"Obesity triggers enhanced MDSC accumulation in murine renal tumors via elevated local production of CCL2","volume":"10","author":"Hale","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.cmet.2022.09.023_bib90","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11428-017-0241-7","article-title":"Aktuelles zur Adipositas (mit und ohne Diabetes)","volume":"13","author":"Hamann","year":"2017","journal-title":"Der Diabetologe"},{"key":"10.1016\/j.cmet.2022.09.023_bib91","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/s41388-020-01574-8","article-title":"MSC-induced lncRNA AGAP2-AS1 promotes stemness and trastuzumab resistance through regulating CPT1 expression and fatty acid oxidation in breast cancer","volume":"40","author":"Han","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2022.09.023_bib92","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.hbpd.2020.05.010","article-title":"ATP-citrate lyase regulates stemness and metastasis in hepatocellular carcinoma via the Wnt\/\u03b2-catenin signaling pathway","volume":"20","author":"Han","year":"2021","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.cmet.2022.09.023_bib93","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.cmet.2018.07.006","article-title":"Circulating adipose fatty acid binding protein is a new link underlying obesity-associated breast\/mammary tumor development","volume":"28","author":"Hao","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib94","first-page":"6353","article-title":"Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects","volume":"60","author":"Hardy","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib95","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ccr.2005.09.008","article-title":"ATP citrate lyase inhibition can suppress tumor cell growth","volume":"8","author":"Hatzivassiliou","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib96","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1038\/s41388-019-0747-0","article-title":"MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer","volume":"38","author":"He","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2022.09.023_bib97","doi-asserted-by":"crossref","first-page":"25661","DOI":"10.18632\/oncotarget.25432","article-title":"Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins","volume":"9","author":"Heilos","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.cmet.2022.09.023_bib98","doi-asserted-by":"crossref","first-page":"36818","DOI":"10.1074\/jbc.M110.170431","article-title":"Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis","volume":"285","author":"Henique","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2022.09.023_bib99","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1002\/ijc.33113","article-title":"UBC12-mediated SREBP-1 neddylation worsens metastatic tumor prognosis","volume":"147","author":"Heo","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.chembiol.2016.12.007","article-title":"APT2 inhibition restores scribble localization and S-palmitoylation in snail-transformed cells","volume":"24","author":"Hernandez","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib101","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.18632\/oncotarget.1482","article-title":"Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms","volume":"4","author":"Herroon","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/j.cmet.2022.09.023_bib102","doi-asserted-by":"crossref","DOI":"10.1177\/1557988320918788","article-title":"Impact of pretreatment total cholesterol level is associated with metastasis of prostate cancer","volume":"14","author":"Hirano","year":"2020","journal-title":"Am. J. Mens Health"},{"key":"10.1016\/j.cmet.2022.09.023_bib103","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pharmthera.2018.07.006","article-title":"Bioactive lysolipids in cancer and angiogenesis","volume":"193","author":"Hisano","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.cmet.2022.09.023_bib104","doi-asserted-by":"crossref","first-page":"107809","DOI":"10.1016\/j.celrep.2020.107809","article-title":"Small molecule dysregulation of TEAD lipidation induces a dominant-negative inhibition of hippo pathway signaling","volume":"31","author":"Holden","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib105","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1158\/2326-6066.CIR-15-0036","article-title":"Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies","volume":"3","author":"Hossain","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib106","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.bbalip.2009.08.008","article-title":"N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXR\u03b1","volume":"1791","author":"Howell","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cmet.2022.09.023_bib107","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.3389\/fimmu.2017.01949","article-title":"The role of lipid metabolism in T lymphocyte differentiation and survival","volume":"8","author":"Howie","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib108","doi-asserted-by":"crossref","first-page":"924","DOI":"10.3390\/ijms16010924","article-title":"Lipid metabolism, apoptosis and cancer therapy","volume":"16","author":"Huang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib301","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12951-022-01257-4","article-title":"Engineering of small-molecule lipidic prodrugs as novel nanomedicines for enhanced drug delivery","volume":"20","author":"Huang","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.cmet.2022.09.023_bib109","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3390\/ijms21010287","article-title":"Neutrophil metabolic shift during their lifecycle: impact on their survival and activation","volume":"21","author":"Injarabian","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib110","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.4049\/jimmunol.1100587","article-title":"Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth","volume":"189","author":"James","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib111","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1074\/jbc.M114.627026","article-title":"CD36 binds oxidized low density lipoprotein (LDL) in a mechanism dependent upon fatty acid binding","volume":"290","author":"Jay","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2022.09.023_bib112","doi-asserted-by":"crossref","first-page":"10706","DOI":"10.1039\/D0CC02174A","article-title":"Fatty acid-like Pt(IV) prodrugs overcome cisplatin resistance in ovarian cancer by harnessing CD36","volume":"56","author":"Jayawardhana","year":"2020","journal-title":"Chem. Commun. (Camb)"},{"key":"10.1016\/j.cmet.2022.09.023_bib113","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.3390\/molecules20022425","article-title":"A review of odd-chain fatty acid metabolism and the role of pentadecanoic acid (c15:0) and heptadecanoic acid (c17:0) in health and disease","volume":"20","author":"Jenkins","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.cmet.2022.09.023_bib114","doi-asserted-by":"crossref","first-page":"578","DOI":"10.7150\/jca.21046","article-title":"Down-expression of CD36 in pancreatic adenocarcinoma and its correlation with clinicopathological features and prognosis","volume":"9","author":"Jia","year":"2018","journal-title":"J.\u00a0Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib115","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib116","doi-asserted-by":"crossref","first-page":"e32436","DOI":"10.7554\/eLife.32436","article-title":"SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a","volume":"6","author":"Jing","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2022.09.023_bib117","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.colsurfb.2016.06.058","article-title":"Oleic acid-embedded nanoliposome as a selective tumoricidal agent","volume":"146","author":"Jung","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.cmet.2022.09.023_bib118","doi-asserted-by":"crossref","first-page":"12284","DOI":"10.1038\/s41598-019-48678-0","article-title":"Linkage of CD8+ T\u00a0cell exhaustion with high-fat diet-induced tumourigenesis","volume":"9","author":"Kado","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib119","doi-asserted-by":"crossref","first-page":"102026","DOI":"10.1016\/j.redox.2021.102026","article-title":"Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling","volume":"45","author":"Kakimoto","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib120","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature14259","article-title":"Notum deacylates Wnt proteins to suppress signalling activity","volume":"519","author":"Kakugawa","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib121","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1099\/00221287-90-1-100","article-title":"The hydrogenation of unsaturated fatty acids by five bacterial isolates from the sheep rumen, including a new species","volume":"90","author":"Kemp","year":"1975","journal-title":"J.\u00a0Gen. Microbiol."},{"key":"10.1016\/j.cmet.2022.09.023_bib122","doi-asserted-by":"crossref","first-page":"R78","DOI":"10.1186\/bcr2927","article-title":"Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB\/c mice","volume":"13","author":"Kim","year":"2011","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib123","doi-asserted-by":"crossref","first-page":"992","DOI":"10.4149\/neo_2020_191017N1050","article-title":"Energy transfer from adipocytes to cancer cells in breast cancer","volume":"67","author":"Kim","year":"2020","journal-title":"Neoplasma"},{"key":"10.1016\/j.cmet.2022.09.023_bib124","doi-asserted-by":"crossref","first-page":"e46666","DOI":"10.15252\/embr.201846666","article-title":"Protein palmitoylation and cancer","volume":"19","author":"Ko","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib125","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1158\/0008-5472.CAN-07-5616","article-title":"Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model","volume":"68","author":"Kobayashi","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib126","doi-asserted-by":"crossref","first-page":"717503","DOI":"10.3389\/fcell.2021.717503","article-title":"Lysine fatty acylation: regulatory enzymes, research tools, and biological function","volume":"9","author":"Komaniecki","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib127","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fimmu.2017.00270","article-title":"Impact of metabolism on T-cell differentiation and function and cross talk with tumor microenvironment","volume":"8","author":"Kouidhi","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib128","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","article-title":"Reprogramming of fatty acid metabolism in cancer","volume":"122","author":"Koundouros","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib129","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1007\/s00018-020-03752-z","article-title":"The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis","volume":"78","author":"Kulkarni","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib130","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1158\/0008-5472.CAN-15-2613","article-title":"The role of cholesterol in cancer","volume":"76","author":"Kuzu","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib131","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1038\/s41467-019-12298-z","article-title":"High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program","volume":"10","author":"Labb\u00e9","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib132","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1038\/s41388-017-0093-z","article-title":"Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis","volume":"37","author":"Ladanyi","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2022.09.023_bib133","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/mc.22074","article-title":"Dietary fat without body weight gain increases in\u00a0vivo MCF-7 human breast cancer cell growth and decreases natural killer cell cytotoxicity","volume":"54","author":"Lamas","year":"2015","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.cmet.2022.09.023_bib134","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3324\/haematol.2017.169946","article-title":"CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting","volume":"103","author":"Landberg","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.cmet.2022.09.023_bib135","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1056\/NEJMsr1606602","article-title":"Body fatness and cancer\u2014viewpoint of the IARC working group","volume":"375","author":"Lauby-Secretan","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib136","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.aav0173","article-title":"Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation","volume":"363","author":"Lee","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cmet.2022.09.023_bib137","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s11745-010-3444-x","article-title":"The complex and important cellular and metabolic functions of saturated fatty acids","volume":"45","author":"Legrand","year":"2010","journal-title":"Lipids"},{"key":"10.1016\/j.cmet.2022.09.023_bib138","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.tcb.2020.01.009","article-title":"Lipid rafts: controversies resolved, mysteries remain","volume":"30","author":"Levental","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib139","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.3390\/ijms15057124","article-title":"SREBP-1 has a prognostic role and contributes to invasion and metastasis in human hepatocellular carcinoma","volume":"15","author":"Li","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib140","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cmet.2014.03.012","article-title":"Obesity, rather than diet, drives epigenomic alterations in colonic epithelium resembling cancer progression","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib141","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.stem.2016.11.004","article-title":"Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells","volume":"20","author":"Li","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib142","doi-asserted-by":"crossref","first-page":"101596","DOI":"10.1016\/j.redox.2020.101596","article-title":"Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis","volume":"36","author":"Li","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib143","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41586-021-04049-2","article-title":"Low glycaemic diets alter lipid metabolism to influence tumour growth","volume":"599","author":"Lien","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib144","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41586-021-03235-6","article-title":"Lipid signalling enforces functional specialization of T reg cells in tumours","volume":"591","author":"Lim","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib145","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/hep.29033","article-title":"Functional lipidomics: palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism","volume":"66","author":"Lin","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2022.09.023_bib146","doi-asserted-by":"crossref","first-page":"7367","DOI":"10.1002\/jcp.26572","article-title":"Oleic acid promotes prostate cancer malignant phenotype via the G protein-coupled receptor FFA1\/GPR40","volume":"233","author":"Liotti","year":"2018","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.cmet.2022.09.023_bib147","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.3390\/ijms22136965","article-title":"Effects of detary n-3 and n-6 polyunsaturated fatty acids in inflammation and cancerogenesis","volume":"22","author":"Liput","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib148","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2022.09.023_bib149","first-page":"1","article-title":"Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib150","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41467-021-27734-2","article-title":"C\/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib151","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41588-022-01045-8","article-title":"HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer","volume":"54","author":"Lu","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2022.09.023_bib152","doi-asserted-by":"crossref","first-page":"102006","DOI":"10.1016\/j.redox.2021.102006","article-title":"Tumor resistance to ferroptosis driven by stearoyl-CoA desaturase-1 (SCD1) in cancer cells and fatty acid biding protein-4 (FABP4) in tumor microenvironment promote tumor recurrence","volume":"43","author":"Luis","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib153","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0150-x","article-title":"The implications of signaling lipids in cancer metastasis","volume":"50","author":"Luo","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib154","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8+ T\u00a0cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib155","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1158\/0008-5472.CAN-18-2849","article-title":"Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling","volume":"79","author":"Madak-Erdogan","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib156","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1158\/0008-5472.CAN-17-3797","article-title":"The autotaxin-lysophosphatidic acid axis promotes lung carcinogenesis","volume":"78","author":"Magkrioti","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib157","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/cdd.2016.25","article-title":"Emerging roles for lipids in non-apoptotic cell death","volume":"23","author":"Magtanong","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cmet.2022.09.023_bib158","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib159","doi-asserted-by":"crossref","first-page":"109212","DOI":"10.1016\/j.celrep.2021.109212","article-title":"High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity","volume":"35","author":"Mana","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib160","doi-asserted-by":"crossref","first-page":"e20191920","DOI":"10.1084\/jem.20191920","article-title":"Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T\u00a0cells","volume":"217","author":"Manzo","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib161","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41523-020-00191-8","article-title":"Upregulation of lipid metabolism genes in the breast prior to cancer diagnosis","volume":"6","author":"Marino","year":"2020","journal-title":"npj Breast Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib162","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1158\/0008-5472.CAN-10-1436","article-title":"A randomized trial of dietary intervention for breast cancer prevention","volume":"71","author":"Martin","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib163","doi-asserted-by":"crossref","first-page":"100401","DOI":"10.1016\/j.coisb.2021.100401","article-title":"Lipid metabolism in metastasis and therapy","volume":"28","author":"Martin-Perez","year":"2021","journal-title":"Curr. Opin. Syst. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib164","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/sj.bjc.6605881","article-title":"Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice","volume":"103","author":"Matsuoka","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib165","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000335672","article-title":"Short-chain fatty acids induce apoptosis in colon cancer cells associated with changes to intracellular redox state and glucose metabolism","volume":"58","author":"Matthews","year":"2012","journal-title":"Chemotherapy"},{"key":"10.1016\/j.cmet.2022.09.023_bib166","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2991\/jegh.k.191008.001","article-title":"Current cancer epidemiology","volume":"9","author":"Mattiuzzi","year":"2019","journal-title":"J.\u00a0Epidemiol. Glob. Health"},{"key":"10.1016\/j.cmet.2022.09.023_bib167","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s43018-021-00194-9","article-title":"Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration","volume":"2","author":"McDowell","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib168","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1470-2045(18)30078-0","article-title":"Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis","volume":"19","author":"McQuade","year":"2018","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib169","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.trecan.2019.10.007","article-title":"Metabolic regulation of macrophage polarization in cancer","volume":"5","author":"Mehla","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib170","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/annonc\/mdi090","article-title":"Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2\/neu (erb B-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2\/neu oncogene amplification","volume":"16","author":"Menendez","year":"2005","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib171","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/s41590-018-0251-7","article-title":"Metabolic reprogramming of natural killer cells in obesity limits antitumor responses","volume":"19","author":"Michelet","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib172","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/ncb2884","article-title":"A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway","volume":"16","author":"Mohseni","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib173","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/jbmr.3951","article-title":"Myeloma cells down-regulate adiponectin in bone marrow adipocytes via TNF-alpha","volume":"35","author":"Morris","year":"2020","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib174","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1158\/0008-5472.CAN-19-1999","article-title":"Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance","volume":"80","author":"Mukherjee","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib175","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12934-020-01477-z","article-title":"Anti-cancer and anti-inflammatory effects elicited by short chain fatty acids produced by Escherichia coli isolated from healthy human gut microbiota","volume":"20","author":"Nakkarach","year":"2021","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.cmet.2022.09.023_bib176","doi-asserted-by":"crossref","first-page":"jcs213579","DOI":"10.1242\/jcs.213579","article-title":"PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts","volume":"131","author":"Nardi","year":"2018","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib177","doi-asserted-by":"crossref","first-page":"18669","DOI":"10.1038\/srep18669","article-title":"Genetic alterations in fatty acid transport and metabolism genes are associated with metastatic progression and poor prognosis of human cancers","volume":"6","author":"Nath","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib178","doi-asserted-by":"crossref","first-page":"14752","DOI":"10.1038\/srep14752","article-title":"Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma","volume":"5","author":"Nath","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib179","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1126\/science.1241908","article-title":"27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology","volume":"342","author":"Nelson","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.cmet.2022.09.023_bib180","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1186\/s12885-019-6045-y","article-title":"Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period","volume":"19","author":"Niavarani","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib181","doi-asserted-by":"crossref","first-page":"e0176793","DOI":"10.1371\/journal.pone.0176793","article-title":"Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1\u03b2","volume":"12","author":"Nicholas","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cmet.2022.09.023_bib182","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13046-017-0641-y","article-title":"Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4","volume":"36","author":"Nie","year":"2017","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib183","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1056\/NEJMoa1201735","article-title":"Statin use and reduced cancer-related mortality","volume":"367","author":"Nielsen","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib184","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm.2492","article-title":"Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth","volume":"17","author":"Nieman","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib185","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/metabo10020067","article-title":"Lipidomic analysis of cells and extracellular vesicles from high- and low-metastatic triple-negative breast cancer","volume":"10","author":"Nishida-Aoki","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.cmet.2022.09.023_bib186","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.str.2015.11.005","article-title":"Palmitoylation of TEAD transcription factors is required for their stability and function in hippo pathway signaling","volume":"24","author":"Noland","year":"2016","journal-title":"Structure"},{"key":"10.1016\/j.cmet.2022.09.023_bib187","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3390\/ijms19040962","article-title":"Differential tissue fatty acids profiling between colorectal cancer patients with and without synchronous metastasis","volume":"19","author":"Notarnicola","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib188","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrc.2017.96","article-title":"Sphingolipid metabolism in cancer signalling and therapy","volume":"18","author":"Ogretmen","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib189","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.celrep.2016.07.009","article-title":"Fatty acid oxidation mediated by acyl-CoA synthetase long chain 3 is required for mutant KRAS lung tumorigenesis","volume":"16","author":"Padanad","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib190","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tem.2017.11.009","article-title":"Palmitic and oleic acid: the yin and yang of fatty acids in type 2 diabetes mellitus","volume":"29","author":"Palomer","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib191","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13046-019-1049-7","article-title":"CD36 mediates palmitate acid-induced metastasis of gastric cancer via AKT\/GSK-3\u03b2\/\u03b2-catenin pathway","volume":"38","author":"Pan","year":"2019","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib192","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/ijc.31392","article-title":"The effect of FASN inhibition on the growth and metabolism of a cisplatin-resistant ovarian carcinoma model","volume":"143","author":"Papaevangelou","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib193","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/mc.20856","article-title":"A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB\/c mice","volume":"51","author":"Park","year":"2012","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.cmet.2022.09.023_bib194","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/nrc3379","article-title":"Phospholipase signalling networks in cancer","volume":"12","author":"Park","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib195","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature20791","article-title":"Targeting metastasis-initiating cells through the fatty acid receptor CD36","volume":"541","author":"Pascual","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib196","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41586-021-04075-0","article-title":"Dietary palmitic acid promotes a prometastatic memory via Schwann cells","volume":"599","author":"Pascual","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib197","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1210\/en.2010-1369","article-title":"Oleate blocks palmitate-induced abnormal lipid distribution, endoplasmic reticulum expansion and stress, and insulin resistance in skeletal muscle","volume":"152","author":"Peng","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2022.09.023_bib198","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41419-021-04217-2","article-title":"Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells","volume":"12","author":"Peng","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2022.09.023_bib199","doi-asserted-by":"crossref","first-page":"e213520","DOI":"10.1001\/jamanetworkopen.2021.3520","article-title":"Association of obesity with survival outcomes in patients with cancer: a systematic review and meta-analysis","volume":"4","author":"Petrelli","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.cmet.2022.09.023_bib200","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.stemcr.2019.02.012","article-title":"Stearoyl CoA desaturase is essential for regulation of endoplasmic reticulum homeostasis and tumor growth in glioblastoma cancer stem cells","volume":"12","author":"Pinkham","year":"2019","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.cmet.2022.09.023_bib201","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.cmet.2021.03.023","article-title":"Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment","volume":"33","author":"Poznanski","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib202","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-019-1689-y","article-title":"Pan-cancer whole-genome analyses of metastatic solid tumours","volume":"575","author":"Priestley","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib203","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1101\/gad.335166.119","article-title":"REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors","volume":"34","author":"Qiao","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2022.09.023_bib204","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41419-021-03833-2","article-title":"IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R","volume":"12","author":"Qiao","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2022.09.023_bib205","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/ncb3578","article-title":"Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF","volume":"19","author":"Quail","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib206","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.4049\/jimmunol.1302801","article-title":"Oxidized lipids block antigen cross-presentation by dendritic cells in cancer","volume":"192","author":"Ramakrishnan","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib207","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.cell.2018.06.025","article-title":"Toward minimal residual disease-directed therapy in melanoma","volume":"174","author":"Rambow","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-018-0711-9","article-title":"Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN","volume":"37","author":"Ran","year":"2018","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib209","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1126\/science.aat7171","article-title":"Minimal functional driver gene heterogeneity among untreated metastases","volume":"361","author":"Reiter","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cmet.2022.09.023_bib210","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s41589-021-00785-8","article-title":"ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth","volume":"17","author":"Remsberg","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib211","article-title":"Fat content and composition of animal products","year":"1976","journal-title":"Proceedings of a Symposium"},{"key":"10.1016\/j.cmet.2022.09.023_bib212","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1440-1746.2008.05733.x","article-title":"Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes","volume":"24","author":"Ricchi","year":"2009","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.cmet.2022.09.023_bib213","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.cell.2020.11.009","article-title":"Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity","volume":"183","author":"Ringel","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib214","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.cmet.2017.09.018","article-title":"Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence","volume":"26","author":"Rios Garcia","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib215","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1017\/S1751731107000122","article-title":"In rat hepatocytes, myristic acid occurs through lipogenesis, palmitic acid shortening and lauric acid elongation","volume":"1","author":"Rioux","year":"2007","journal-title":"Animal"},{"key":"10.1016\/j.cmet.2022.09.023_bib216","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1194\/jlr.M088559","article-title":"Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells","volume":"60","author":"Roy","year":"2019","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib217","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1158\/0008-5472.CAN-20-1255","article-title":"KRAS controls pancreatic cancer cell lipid metabolism and invasive potential through the lipase HSL","volume":"80","author":"Rozeveld","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib218","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s43018-020-00168-3","article-title":"LXR\u03b1 activation and Raf inhibition trigger lethal lipotoxicity in liver cancer","volume":"2","author":"Rudalska","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib219","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.molcel.2016.04.003","article-title":"Inhibition of DHHC20-mediated EGFR palmitoylation creates a dependence on EGFR signaling","volume":"62","author":"Runkle","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib220","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.stem.2019.06.004","article-title":"GPD1 specifically marks dormant glioma stem cells with a distinct metabolic profile","volume":"25","author":"Rusu","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib221","doi-asserted-by":"crossref","first-page":"8117","DOI":"10.1158\/0008-5472.CAN-09-3871","article-title":"De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation","volume":"70","author":"Rysman","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib222","first-page":"1575","article-title":"Identity noise and adipogenic traits characterize dermal fibroblast","volume":"175","author":"Salzer","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib223","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1158\/1541-7786.MCR-19-1057","article-title":"Targeting fatty acid oxidation to promote anoikis and inhibit ovarian cancer progression","volume":"18","author":"Sawyer","year":"2020","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib224","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/bjc.2012.355","article-title":"The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas","volume":"107","author":"Seguin","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib225","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.plefa.2005.05.002","article-title":"Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution","volume":"73","author":"Serhan","year":"2005","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.cmet.2022.09.023_bib226","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/bjc.2012.130","article-title":"PPARgamma inhibits hepatocellular carcinoma metastases in\u00a0vitro and in mice","volume":"106","author":"Shen","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib227","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/21655979.2019.1676485","article-title":"Targeting SREBP1 chemosensitizes colorectal cancer cells to gemcitabine by caspase-7 upregulation","volume":"10","author":"Shen","year":"2019","journal-title":"Bioengineered"},{"key":"10.1016\/j.cmet.2022.09.023_bib228","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.7150\/thno.44744","article-title":"Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis","volume":"10","author":"Shen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.cmet.2022.09.023_bib229","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology \u2014 divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cmet.2022.09.023_bib230","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cmet.2022.09.023_bib232","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.annonc.2020.01.001","article-title":"A systematic review and meta-analysis of the 2007 WCRF\/AICR score in relation to cancer-related health outcomes","volume":"31","author":"Solans","year":"2020","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib233","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s10585-010-9340-1","article-title":"Oleic acid promotes MMP-9 secretion and invasion in breast cancer cells","volume":"27","author":"Soto-Guzman","year":"2010","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.cmet.2022.09.023_bib234","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1038\/s41467-017-02221-9","article-title":"Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a","volume":"8","author":"Spinelli","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib235","doi-asserted-by":"crossref","first-page":"6586","DOI":"10.1038\/s41598-018-24633-3","article-title":"Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression","volume":"8","author":"Su","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib236","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1158\/0008-5472.CAN-19-2994","article-title":"Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages","volume":"80","author":"Su","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib237","doi-asserted-by":"crossref","first-page":"110274","DOI":"10.1016\/j.biopha.2020.110274","article-title":"Activation of SREBP-1c alters lipogenesis and promotes tumor growth and metastasis in gastric cancer","volume":"128","author":"Sun","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cmet.2022.09.023_bib238","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.nutres.2018.07.014","article-title":"Time-restricted feeding mitigates high-fat diet-enhanced mammary tumorigenesis in MMTV-PyMT mice","volume":"59","author":"Sundaram","year":"2018","journal-title":"Nutr. Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib239","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1158\/0008-5472.CAN-12-1993","article-title":"Preventing postoperative metastatic disease by inhibiting surgery-induced dysfunction in natural killer cells","volume":"73","author":"Tai","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib240","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/s41388-021-01949-5","article-title":"Cancer cells escape p53\u2019s tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation","volume":"40","author":"Tang","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2022.09.023_bib241","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12944-022-01624-y","article-title":"Dietary intake of monounsaturated and polyunsaturated fatty acids is related to the reduced risk of esophageal squamous cell carcinoma","volume":"21","author":"Tang","year":"2022","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.cmet.2022.09.023_bib243","doi-asserted-by":"crossref","first-page":"5355","DOI":"10.1158\/0008-5472.CAN-19-0369","article-title":"Stearoyl-CoA desaturase 1 protects ovarian cancer cells from ferroptotic cell death","volume":"79","author":"Tesfay","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib244","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.3390\/nu12061663","article-title":"Pentadecanoic acid, an odd-chain fatty acid, suppresses the stemness of MCF-7\/SC human breast cancer stem-like cells through JAK2\/STAT3 signaling","volume":"12","author":"To","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.cmet.2022.09.023_bib245","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1001\/jamainternmed.2015.4838","article-title":"Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED trial: a randomized clinical trial","volume":"175","author":"Toledo","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib246","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.3390\/ijms20082050","article-title":"Elevated AA\/EPA ratio represents an inflammatory biomarker in tumor tissue of metastatic colorectal cancer patients","volume":"20","author":"Tutino","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cmet.2022.09.023_bib247","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41586-020-2623-z","article-title":"Lymph protects metastasizing melanoma cells from ferroptosis","volume":"585","author":"Ubellacker","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib248","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/13685538.2018.1450854","article-title":"Adherence to Mediterranean diet and risk of prostate cancer","volume":"22","author":"Urquiza-Salvat","year":"2019","journal-title":"Aging Male"},{"key":"10.1016\/j.cmet.2022.09.023_bib249","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature20792","article-title":"Genome-wide in\u00a0vivo screen identifies novel host regulators of metastatic colonization","volume":"541","author":"van der Weyden","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib250","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00394-015-1096-6","article-title":"Increased dietary levels of \u03b1-linoleic acid inhibit mammary tumor growth and metastasis","volume":"56","author":"Vara-Messler","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.cmet.2022.09.023_bib251","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1038\/s41467-017-02186-9","article-title":"Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer","volume":"8","author":"Veglia","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2022.09.023_bib252","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-019-1118-2","article-title":"Fatty acid transport protein 2 reprograms neutrophils in cancer","volume":"569","author":"Veglia","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib253","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1038\/s41598-020-64960-y","article-title":"Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential?","volume":"10","author":"Venn-Watson","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2022.09.023_bib254","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib255","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.molcel.2019.10.014","article-title":"Lineage-restricted regulation of SCD and fatty acid saturation by MITF controls melanoma phenotypic plasticity","volume":"77","author":"Vivas-Garc\u00eda","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib256","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41586-019-0904-1","article-title":"Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity","volume":"566","author":"Vriens","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2022.09.023_bib257","doi-asserted-by":"crossref","first-page":"15707","DOI":"10.1074\/jbc.M115.639609","article-title":"Protein depalmitoylation is induced by Wnt5a and promotes polarized cell behavior","volume":"290","author":"Wang","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2022.09.023_bib258","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cmet.2017.11.001","article-title":"JAK\/STAT3-regulated fatty acid \u03b2-oxidation is critical for breast cancer stem cell self-renewal and chemoresistance","volume":"27","author":"Wang","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib259","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41591-018-0221-5","article-title":"Paradoxical effects of obesity on T\u00a0cell function during tumor progression and PD-1 checkpoint blockade","volume":"25","author":"Wang","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib260","first-page":"4480","article-title":"PPAR\u03b4 mediates the effect of dietary fat in promoting colorectal cancer metastasis","volume":"79","author":"Wang","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib261","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41590-019-0589-5","article-title":"CD36-mediated metabolic adaptation supports regulatory T\u00a0cell survival and function in tumors","volume":"21","author":"Wang","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib262","doi-asserted-by":"crossref","first-page":"108664","DOI":"10.1016\/j.abb.2020.108664","article-title":"Inhibition of carnitine palmitoyl transferase 1A-induced fatty acid oxidation suppresses cell progression in gastric cancer","volume":"696","author":"Wang","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cmet.2022.09.023_bib263","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.18632\/aging.103985","article-title":"CD36 upregulates DEK transcription and promotes cell migration and invasion via GSK-3\u03b2\/\u03b2-catenin-mediated epithelial-to-mesenchymal transition in gastric cancer","volume":"13","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.cmet.2022.09.023_bib264","doi-asserted-by":"crossref","first-page":"eaau5758","DOI":"10.1126\/scitranslmed.aau5758","article-title":"Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer","volume":"11","author":"Watt","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib265","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s13046-019-1391-9","article-title":"ACLY facilitates colon cancer cell metastasis by CTNNB1","volume":"38","author":"Wen","year":"2019","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib266","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000012776","article-title":"Does dietary \u03b1-linolenic acid promote liver metastases in pancreatic carcinoma initiated by BOP in Syrian hamster?","volume":"43","author":"Wenger","year":"1999","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.cmet.2022.09.023_bib267","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1054\/plef.2000.0162","article-title":"Does \u03b1-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters?","volume":"62","author":"Wenger","year":"2000","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.cmet.2022.09.023_bib268","doi-asserted-by":"crossref","first-page":"eabc3175","DOI":"10.1126\/sciadv.abc3175","article-title":"Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis","volume":"6","author":"Wishart","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cmet.2022.09.023_bib269","doi-asserted-by":"crossref","first-page":"e10698","DOI":"10.15252\/emmm.201910698","article-title":"Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages","volume":"11","author":"Wu","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cmet.2022.09.023_bib270","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41392-020-00327-z","article-title":"Dietary fats suppress the peritoneal seeding of colorectal cancer cells through the TLR4\/CXCL10 axis in adipose tissue macrophages","volume":"5","author":"Xiang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cmet.2022.09.023_bib271","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/abbs\/gms112","article-title":"SREBP: a novel therapeutic target","volume":"45","author":"Xiao","year":"2013","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.cmet.2022.09.023_bib272","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-019-03644-2","article-title":"SIRT3 promotes the invasion and metastasis of cervical cancer cells by regulating fatty acid synthase","volume":"464","author":"Xu","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.cmet.2022.09.023_bib273","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41420-021-00744-1","article-title":"Lipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer","volume":"7","author":"Xu","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cmet.2022.09.023_bib274","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.immuni.2021.05.003","article-title":"Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T\u00a0cells in tumors","volume":"54","author":"Xu","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2022.09.023_bib275","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000111132","article-title":"Gain of 5p15.33 is associated with progression of bladder cancer","volume":"72","author":"Yamamoto","year":"2007","journal-title":"Oncology"},{"key":"10.1016\/j.cmet.2022.09.023_bib276","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1186\/s12885-017-3554-4","article-title":"Differences in elongation of very long chain fatty acids and fatty acid metabolism between triple-negative and hormone receptor-positive breast cancer","volume":"17","author":"Yamashita","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cmet.2022.09.023_bib277","doi-asserted-by":"crossref","first-page":"e110869","DOI":"10.1371\/journal.pone.0110869","article-title":"Effects of a high-fat diet on spontaneous metastasis of Lewis lung carcinoma in plasminogen activator inhibitor-1 deficient and wild-type mice","volume":"9","author":"Yan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cmet.2022.09.023_bib278","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2014.03.010","article-title":"Prostaglandin E3 metabolism and cancer","volume":"348","author":"Yang","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cmet.2022.09.023_bib279","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41422-018-0124-5","article-title":"Palmitoylation stabilizes PD-L1 to promote breast tumor growth","volume":"29","author":"Yang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib280","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.canlet.2018.09.006","article-title":"Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src\/ERK pathway","volume":"438","author":"Yang","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cmet.2022.09.023_bib281","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41551-019-0375-6","article-title":"Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours","volume":"3","author":"Yao","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.cmet.2022.09.023_bib282","doi-asserted-by":"crossref","first-page":"590685","DOI":"10.3389\/fimmu.2020.590685","article-title":"Short-chain fatty acids: a soldier fighting against inflammation and protecting from tumorigenesis in people with diabetes","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib283","doi-asserted-by":"crossref","first-page":"8816070","DOI":"10.1155\/2020\/8816070","article-title":"Progressive and prognostic performance of an extracellular matrix-receptor interaction signature in gastric cancer","volume":"2020","author":"Yang","year":"2020","journal-title":"Dis. Markers"},{"key":"10.1016\/j.cmet.2022.09.023_bib284","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.stem.2016.06.001","article-title":"Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche","volume":"19","author":"Ye","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib285","doi-asserted-by":"crossref","first-page":"600350","DOI":"10.3389\/fcell.2020.600350","article-title":"Obesity-related fatty acid and cholesterol metabolism in cancer-associated host cells","volume":"8","author":"Ye","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2022.09.023_bib286","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1158\/2159-8290.CD-20-0318","article-title":"The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG","volume":"11","author":"Ye","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cmet.2022.09.023_bib287","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.canlet.2018.04.001","article-title":"Simvastatin inhibits sonic hedgehog signaling and stemness features of pancreatic cancer","volume":"426","author":"Yin","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cmet.2022.09.023_bib288","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41419-019-1884-7","article-title":"SREBP-1 inhibitor betulin enhances the antitumor effect of sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity","volume":"10","author":"Yin","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2022.09.023_bib289","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1245\/s10434-020-08752-8","article-title":"ASO author reflections: CD36 expression is associated with cancer aggressiveness and energy source in esophageal squamous cell carcinoma","volume":"27","author":"Yoshida","year":"2020","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib290","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00262-019-02445-2","article-title":"IL-17A promotes fatty acid uptake through the IL-17A\/IL-17RA\/p-STAT3\/FABP4 axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment","volume":"69","author":"Yu","year":"2020","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.cmet.2022.09.023_bib291","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.apsb.2020.03.008","article-title":"ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression","volume":"10","author":"Yuan","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cmet.2022.09.023_bib292","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3390\/cancers11122012","article-title":"Breast-associated adipocytes secretome induce fatty acid uptake and invasiveness in breast cancer cells via CD36 independently of body mass index, menopausal status and mammary density","volume":"11","author":"Zaoui","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cmet.2022.09.023_bib293","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.abb.2006.09.030","article-title":"Increase in fluidity in the membrane of MT3 breast cancer cells correlates with enhanced cell adhesion in\u00a0vitro and increased lung metastasis in NOD\/SCID mice","volume":"459","author":"Zeisig","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.cmet.2022.09.023_bib294","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cell.2015.08.015","article-title":"Cyclooxygenase-dependent tumor growth through evasion of immunity","volume":"162","author":"Zelenay","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2022.09.023_bib295","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1158\/2159-8290.CD-17-1371","article-title":"Adipocyte-derived lipids mediate melanoma progression via FATP proteins","volume":"8","author":"Zhang","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cmet.2022.09.023_bib296","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.molimm.2017.12.011","article-title":"Fatty acid oxidation contributes to IL-1\u03b2 secretion in M2 macrophages and promotes macrophage-mediated tumor cell migration","volume":"94","author":"Zhang","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.cmet.2022.09.023_bib297","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.3389\/fonc.2020.01025","article-title":"KDM5C represses FASN-mediated lipid metabolism to exert tumor suppressor activity in intrahepatic cholangiocarcinoma","volume":"10","author":"Zhang","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.cmet.2022.09.023_bib298","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1158\/0008-5472.CAN-15-1970","article-title":"Candidate antimetastasis drugs suppress the metastatic capacity of breast cancer cells by reducing membrane fluidity","volume":"76","author":"Zhao","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2022.09.023_bib299","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.7150\/thno.44025","article-title":"STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.cmet.2022.09.023_bib303","first-page":"12668","article-title":"Prognostic role of PPAR-\u03b3 and PTEN in the renal cell carcinoma","volume":"8","author":"Zhu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.cmet.2022.09.023_bib300","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1158\/2159-8290.CD-19-0270","article-title":"Polyunsaturated fatty acids from astrocytes activate PPAR\u03b3 signaling in cancer cells to promote brain metastasis","volume":"9","author":"Zou","year":"2019","journal-title":"Cancer Discov."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413122004478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413122004478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:45:29Z","timestamp":1761551129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413122004478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":301,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S1550413122004478"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2022.09.023","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of lipids in cancer progression and metastasis","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2022.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}