{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:05:17Z","timestamp":1792821917650,"version":"4.5.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-1656518"],"award-info":[{"award-number":["DGE-1656518"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001642","name":"Glenn Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG036695"],"award-info":[{"award-number":["P01AG036695"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR073248"],"award-info":[{"award-number":["R01AR073248"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.cmet.2023.08.008","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:41:52Z","timestamp":1694428912000},"page":"1814-1829.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Death-seq identifies regulators of cell death and senolytic therapies"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4070-7804","authenticated-orcid":false,"given":"Alex","family":"Colville","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rodriguez-Mateo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather D.","family":"Ishak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronghao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian D.D.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Morgens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armon","family":"Goshayeshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayesh S.","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Spees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June-Wha","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Bassik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5843-8564","authenticated-orcid":false,"given":"Thomas A.","family":"Rando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2023.08.008_bib1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2007.07.003","article-title":"Cellular senescence in cancer and aging","volume":"130","author":"Collado","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2023.08.008_bib3","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a path forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2023.08.008_bib5","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in health and disease","volume":"169","author":"He","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib6","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2017.02.031","article-title":"Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging","volume":"169","author":"Baar","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1126\/science.aaw1299","article-title":"Senolytic therapies for healthy longevity","volume":"364","author":"van Deursen","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cmet.2023.08.008_bib9","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.abb5916","article-title":"Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders","volume":"371","author":"Johmura","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cmet.2023.08.008_bib10","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cmet.2016.08.017","article-title":"A genome-wide CRISPR death screen identifies genes essential for oxidative phosphorylation","volume":"24","author":"Arroyo","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2023.08.008_bib11","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.1038\/ncomms11190","article-title":"Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL","volume":"7","author":"Yosef","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2023.08.008_bib12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nm.4010","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","volume":"22","author":"Chang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib14","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3390\/cells9020406","article-title":"Future therapeutic directions for Smac-mimetics","volume":"9","author":"Morrish","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.cmet.2023.08.008_bib15","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41588-018-0070-7","article-title":"CRISPR\u2013Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity","volume":"50","author":"Kramer","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2023.08.008_bib16","doi-asserted-by":"crossref","first-page":"eaay0271","DOI":"10.1126\/scitranslmed.aay0271","article-title":"Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy","volume":"12","author":"Lek","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13024-019-0343-3","article-title":"Application of CRISPR genetic screens to investigate neurological diseases","volume":"14","author":"So","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.cmet.2023.08.008_bib18","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nbt.3567","article-title":"Systematic comparison of CRISPR\/Cas9 and RNAi screens for essential genes","volume":"34","author":"Morgens","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cmet.2023.08.008_bib19","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1038\/s41467-019-11047-6","article-title":"Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis","volume":"10","author":"Niemi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2023.08.008_bib20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41556-020-0511-2","article-title":"FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome","volume":"22","author":"Li","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2023.08.008_bib21","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1038\/s41418-020-0564-6","article-title":"BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer","volume":"27","author":"Shahbandi","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cmet.2023.08.008_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41586-020-2099-x","article-title":"CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities","volume":"580","author":"Han","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2023.08.008_bib23","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.1038\/s41467-022-35657-9","article-title":"Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression","volume":"13","author":"Kohli","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2023.08.008_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1582-4934.2010.01238.x","article-title":"Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL","volume":"15","author":"Li","year":"2011","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib25","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1182\/blood-2011-04-347849","article-title":"Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets","volume":"118","author":"Schoenwaelder","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.cmet.2023.08.008_bib26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nm.3048","article-title":"ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets","volume":"19","author":"Souers","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib27","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1038\/sj.emboj.7601249","article-title":"A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics","volume":"25","author":"Yonashiro","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2023.08.008_bib28","doi-asserted-by":"crossref","first-page":"e54954","DOI":"10.7554\/eLife.54954","article-title":"MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation","volume":"9","author":"Arai","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2023.08.008_bib29","doi-asserted-by":"crossref","first-page":"15986","DOI":"10.18632\/oncotarget.7558","article-title":"Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA","volume":"7","author":"Subramanian","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.cmet.2023.08.008_bib30","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1038\/s41418-020-0517-0","article-title":"MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex","volume":"27","author":"Djajawi","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cmet.2023.08.008_bib31","doi-asserted-by":"crossref","first-page":"eabg0269","DOI":"10.1126\/science.abg0269","article-title":"The lysosomal Rag-Ragulator complex licenses RIPK1 and caspase-8-mediated pyroptosis by Yersinia","volume":"372","author":"Zheng","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cmet.2023.08.008_bib32","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.cmet.2021.01.011","article-title":"Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition","volume":"33","author":"Crespo-Garcia","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2023.08.008_bib33","doi-asserted-by":"crossref","first-page":"e1721","DOI":"10.1038\/cddis.2015.97","article-title":"BCL-2 is dispensable for thrombopoiesis and platelet survival","volume":"6","author":"Debrincat","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2023.08.008_bib34","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease","volume":"8","author":"Schafer","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2023.08.008_bib35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1164\/rccm.202004-1274OC","article-title":"Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis","volume":"203","author":"Yao","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.semcdb.2019.12.008","article-title":"Senotherapeutics: targeting senescence in idiopathic pulmonary fibrosis","volume":"101","author":"Merkt","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2023.08.008_bib37","doi-asserted-by":"crossref","first-page":"110836","DOI":"10.1016\/j.exger.2020.110836","article-title":"Cell senescence and fibrotic lung diseases","volume":"132","author":"Liu","year":"2020","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.cmet.2023.08.008_bib38","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/j.cell.2021.03.005","article-title":"The aging lung: physiology, disease, and immunity","volume":"184","author":"Schneider","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib39","doi-asserted-by":"crossref","first-page":"17074","DOI":"10.1038\/nrdp.2017.74","article-title":"Idiopathic pulmonary fibrosis","volume":"3","author":"Martinez","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.cmet.2023.08.008_bib40","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1513\/AnnalsATS.201305-108OT","article-title":"Perspective of a daughter turned advocate","volume":"10","author":"Barnes","year":"2013","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.cmet.2023.08.008_bib41","doi-asserted-by":"crossref","first-page":"L1164","DOI":"10.1152\/ajplung.00220.2017","article-title":"IPF lung fibroblasts have a senescent phenotype","volume":"313","author":"\u00c1lvarez","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.cmet.2023.08.008_bib42","doi-asserted-by":"crossref","first-page":"eaba1983","DOI":"10.1126\/sciadv.aba1983","article-title":"Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis","volume":"6","author":"Adams","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cmet.2023.08.008_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1164\/rccm.201810-1891OC","article-title":"Resequencing study confirms that host defense and cell senescence gene variants contribute to the risk of idiopathic pulmonary fibrosis","volume":"200","author":"Moore","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib44","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJMoa066157","article-title":"Telomerase mutations in families with idiopathic pulmonary fibrosis","volume":"356","author":"Armanios","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib45","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.celrep.2015.06.028","article-title":"Mice with pulmonary fibrosis driven by telomere dysfunction","volume":"12","author":"Povedano","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2023.08.008_bib46","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130056","article-title":"Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis","volume":"4","author":"Wiley","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.cmet.2023.08.008_bib47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijrobp.2017.02.216","article-title":"Inhibition of Bcl-2\/xl with ABT-263 selectively kills senescent type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice","volume":"99","author":"Pan","year":"2017","journal-title":"Int. J. Radiat. Oncol. Biol. Phys"},{"key":"10.1016\/j.cmet.2023.08.008_bib48","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1183\/09031936.03.00011903","article-title":"Bleomycin induces cellular senescence in alveolar epithelial cells","volume":"22","author":"Aoshiba","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.cmet.2023.08.008_bib49","doi-asserted-by":"crossref","first-page":"231ra47","DOI":"10.1126\/scitranslmed.3008182","article-title":"Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance","volume":"6","author":"Hecker","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2023.08.008_bib50","doi-asserted-by":"crossref","first-page":"e12950","DOI":"10.1111\/acel.12950","article-title":"Targeting senescent cells alleviates obesity-induced metabolic dysfunction","volume":"18","author":"Palmer","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib51","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/hep.30834","article-title":"The role of senescence in the development of nonalcoholic fatty liver disease and progression to nonalcoholic steatohepatitis","volume":"71","author":"Papatheodoridi","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2023.08.008_bib52","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.cmet.2020.09.006","article-title":"Generation of a p16 reporter mouse and its use to characterize and target p16high cells in\u00a0vivo","volume":"32","author":"Omori","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2023.08.008_bib53","doi-asserted-by":"crossref","first-page":"15691","DOI":"10.1038\/ncomms15691","article-title":"Cellular senescence drives age-dependent hepatic steatosis","volume":"8","author":"Ogrodnik","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2023.08.008_bib54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-020-2403-9","article-title":"Senolytic CAR T\u00a0cells reverse senescence-associated pathologies","volume":"583","author":"Amor","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2023.08.008_bib55","doi-asserted-by":"crossref","first-page":"101015","DOI":"10.1016\/j.isci.2020.101015","article-title":"MCL-1 inhibition by selective BH3 mimetics disrupts mitochondrial dynamics causing loss of viability and functionality of human cardiomyocytes","volume":"23","author":"Rasmussen","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.cmet.2023.08.008_bib56","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1101\/gad.215855.113","article-title":"Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction","volume":"27","author":"Wang","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2023.08.008_bib57","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.chembiol.2019.09.014","article-title":"A ZDHHC5-GOLGA7 protein acyltransferase complex promotes nonapoptotic cell death","volume":"26","author":"Ko","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cmet.2023.08.008_bib58","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/cdd.2017.183","article-title":"Why do BCL-2 inhibitors work and where should we use them in the clinic?","volume":"25","author":"Montero","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cmet.2023.08.008_bib59","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1186\/s12885-016-2606-5","article-title":"IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis","volume":"16","author":"Perimenis","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.cmet.2023.08.008_bib60","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.bcp.2012.04.023","article-title":"Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells","volume":"84","author":"Chen","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cmet.2023.08.008_bib61","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tcb.2022.04.011","article-title":"The heterogeneity of cellular senescence: insights at the single-cell level","volume":"33","author":"Cohn","year":"2023","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.cmet.2023.08.008_bib62","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s43587-023-00446-6","article-title":"Spatial mapping of cellular senescence: emerging challenges and opportunities","volume":"3","author":"Gurkar","year":"2003","journal-title":"Nat Aging"},{"key":"10.1016\/j.cmet.2023.08.008_bib63","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41586-020-2496-1","article-title":"A single-cell transcriptomic atlas characterizes ageing tissues in the mouse","volume":"583","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2023.08.008_bib64","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s43587-022-00335-4","article-title":"Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain","volume":"3","author":"Buckley","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.cmet.2023.08.008_bib65","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1101\/gr.253880.119","article-title":"Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging","volume":"29","author":"Kimmel","year":"2019","journal-title":"Genome Res."},{"key":"10.1016\/j.cmet.2023.08.008_bib66","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: linking aging to chronic disease","volume":"159","author":"Kennedy","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib67","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1001\/jama.2018.12621","article-title":"From lifespan to healthspan","volume":"320","author":"Olshansky","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.cmet.2023.08.008_bib68","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s43587-021-00080-0","article-title":"The economic value of targeting aging","volume":"1","author":"Scott","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.cmet.2023.08.008_bib69","doi-asserted-by":"crossref","first-page":"e13237","DOI":"10.1111\/acel.13237","article-title":"Cellular senescence as a potential mediator of COVID-19 severity in the elderly","volume":"19","author":"Nehme","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib70","doi-asserted-by":"crossref","first-page":"eabe4832","DOI":"10.1126\/science.abe4832","article-title":"Senolytics reduce coronavirus-related mortality in old mice","volume":"373","author":"Camell","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cmet.2023.08.008_bib71","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a cancer dependency map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib72","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.cell.2020.10.032","article-title":"A blueprint for characterizing senescence","volume":"183","author":"Roy","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2023.08.008_bib78","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cmet.2023.08.008_bib79","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cmet.2023.08.008_bib75","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2023.08.008_bib76","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1471-2105-7-207","article-title":"Development and implementation of an algorithm for detection of protein complexes in large interaction networks","volume":"7","author":"Altaf-Ul-Amin","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cmet.2023.08.008_bib77","first-page":"D498","article-title":"The reactome pathway knowledgebase","volume":"48","author":"Jassal","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cmet.2023.08.008_bib73","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/s41467-020-15838-0","article-title":"Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity","volume":"11","author":"He","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2023.08.008_bib74","doi-asserted-by":"crossref","first-page":"15178","DOI":"10.1038\/ncomms15178","article-title":"Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens","volume":"8","author":"Morgens","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2023.08.008_bib80","doi-asserted-by":"crossref","first-page":"107886","DOI":"10.1016\/j.celrep.2020.107886","article-title":"Modeling secondary iron overload cardiomyopathy with human induced pluripotent stem cell-derived cardiomyocytes","volume":"32","author":"Rhee","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2023.08.008_bib81","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nbt.3834","article-title":"Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions","volume":"35","author":"Han","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cmet.2023.08.008_bib82","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","article-title":"The toxicity of poisons applied jointly","volume":"26","author":"Bliss","year":"1939","journal-title":"Ann. Appl. Biol."},{"key":"10.1016\/j.cmet.2023.08.008_bib83","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2144\/000112729","article-title":"Standardized quantification of pulmonary fibrosis in histological samples","volume":"44","author":"H\u00fcbner","year":"2008","journal-title":"BioTechniques"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413123003030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413123003030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:04:10Z","timestamp":1777619050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413123003030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":83,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1550413123003030"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2023.08.008","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.04.01.486768","asserted-by":"object"}]},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Death-seq identifies regulators of cell death and senolytic therapies","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2023.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}