{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:49:10Z","timestamp":1793713750986,"version":"4.6.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key Areas of Guangdong Province","doi-asserted-by":"publisher","award":["2019B030335001"],"award-info":[{"award-number":["2019B030335001"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92149304"],"award-info":[{"award-number":["92149304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871147"],"award-info":[{"award-number":["31871147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171120"],"award-info":[{"award-number":["32171120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874076"],"award-info":[{"award-number":["81874076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073126"],"award-info":[{"award-number":["82073126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925011"],"award-info":[{"award-number":["81925011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.cmet.2024.10.006","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T10:34:24Z","timestamp":1730889264000},"page":"169-186.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":176,"title":["Microbiota-derived lysophosphatidylcholine alleviates Alzheimer\u2019s disease pathology via suppressing ferroptosis"],"prefix":"10.1016","volume":"37","author":[{"given":"Xu","family":"Zha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xicheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengping","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenyan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2024.10.006_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer\u2019s disease","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2024.10.006_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41582-018-0116-6","article-title":"A critical appraisal of amyloid-beta-targeting therapies for Alzheimer disease","volume":"15","author":"Panza","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.cmet.2024.10.006_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnins.2018.00025","article-title":"Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer\u2019s Disease","volume":"12","author":"Kametani","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cmet.2024.10.006_bib4","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3389\/fnins.2019.00446","article-title":"Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses","volume":"13","author":"Chen","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cmet.2024.10.006_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer Disease: An Update on Pathobiology and Treatment Strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib6","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1016\/j.cell.2023.08.021","article-title":"Alzheimer\u2019s disease: From immunotherapy to immunoprevention","volume":"186","author":"Jucker","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(08)61075-2","article-title":"Long-term effects of Abeta42 immunisation in Alzheimer\u2019s disease: follow-up of a randomised, placebo-controlled phase I trial","volume":"372","author":"Holmes","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2024.10.006_bib8","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/s41593-020-00737-w","article-title":"Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life","volume":"23","author":"Uhlmann","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cmet.2024.10.006_bib9","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3390\/nu13020690","article-title":"Crosstalk between Gut and Brain in Alzheimer\u2019s Disease: The Role of Gut Microbiota Modulation Strategies","volume":"13","author":"Shabbir","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.cmet.2024.10.006_bib10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/lam.12882","article-title":"Shifts in gut microbiota composition in an APP\/PSS1 transgenic mouse model of Alzheimer\u2019s disease during lifespan","volume":"66","author":"B\u00e4uerl","year":"2018","journal-title":"Lett. Appl. Microbiol."},{"key":"10.1016\/j.cmet.2024.10.006_bib11","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1212\/WNL.0000000000003391","article-title":"Gram-negative bacterial molecules associate with Alzheimer disease pathology","volume":"87","author":"Zhan","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.cmet.2024.10.006_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut microbiome alterations in Alzheimer\u2019\u2019s disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2024.10.006_bib13","article-title":"Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota","volume":"7","author":"Harach","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2024.10.006_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/srep30028","article-title":"Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer\u2019s disease","volume":"6","author":"Minter","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2024.10.006_bib15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41422-019-0216-x","article-title":"Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer\u2019s disease progression","volume":"29","author":"Wang","year":"2019","journal-title":"Cell Res."},{"key":"10.1016\/j.cmet.2024.10.006_bib16","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cmet.2024.10.006_bib17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41586-022-04396-8","article-title":"A gut-derived metabolite alters brain activity and anxiety behaviour in mice","volume":"602","author":"Needham","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.006_bib18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41551-021-00759-0","article-title":"Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer\u2019s disease alleviates amyloid-related pathologies in mice","volume":"6","author":"Duan","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.cmet.2024.10.006_bib19","doi-asserted-by":"crossref","first-page":"9100","DOI":"10.1007\/s12035-018-1015-y","article-title":"Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration","volume":"55","author":"Zhao","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.cmet.2024.10.006_bib20","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3233\/JAD-180176","article-title":"Gut Microbiota is Altered in Patients with Alzheimer\u2019s Disease","volume":"63","author":"Zhuang","year":"2018","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.cmet.2024.10.006_bib21","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1523\/JNEUROSCI.4970-06.2007","article-title":"Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway","volume":"27","author":"Shankar","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cmet.2024.10.006_bib22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neuron.2017.09.041","article-title":"Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels","volume":"96","author":"Zhao","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.cmet.2024.10.006_bib23","doi-asserted-by":"crossref","first-page":"E3699","DOI":"10.1073\/pnas.1510329112","article-title":"Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer\u2019s disease amyloid plaques","volume":"112","author":"Gowrishankar","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2024.10.006_bib24","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.cmet.2024.10.006_bib25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb8680","article-title":"Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer\u2019s disease","volume":"6","author":"Zhang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cmet.2024.10.006_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-023-06120-6","article-title":"Myelin dysfunction drives amyloid-beta deposition in models of Alzheimer\u2019s disease","volume":"618","author":"Depp","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.006_bib28","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.cell.2021.02.009","article-title":"Dissecting the contribution of host genetics and the microbiome in complex behaviors","volume":"184","author":"Buffington","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib29","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.neurobiolaging.2004.02.016","article-title":"Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients","volume":"25","author":"Walter","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cmet.2024.10.006_bib30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13241","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid","volume":"509","author":"Nguyen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.006_bib31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nm.3466","article-title":"Plasma phospholipids identify antecedent memory impairment in older adults","volume":"20","author":"Mapstone","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2024.10.006_bib32","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/ajcn\/nqz148","article-title":"Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study","volume":"110","author":"Ylilauri","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cmet.2024.10.006_bib33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00394-009-0086-y","article-title":"Association between food and nutrient intakes and cognitive capacity in a group of institutionalized elderly people","volume":"49","author":"Aparicio Vizuete","year":"2010","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.cmet.2024.10.006_bib34","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.cell.2024.01.030","article-title":"Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis","volume":"187","author":"Qiu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib35","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cmet.2024.10.006_bib37","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cmet.2024.10.006_bib38","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.cell.2023.05.003","article-title":"Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones","volume":"186","author":"Liang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib39","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.cmet.2024.10.006_bib40","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-022-05443-0","article-title":"Ferroptosis of tumour neutrophils causes immune suppression in cancer","volume":"612","author":"Kim","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.006_bib41","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.006_bib42","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/s41594-022-00816-5","article-title":"Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119","volume":"29","author":"Xu","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.cmet.2024.10.006_bib43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fnins.2020.00267","article-title":"Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases","volume":"14","author":"Song","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cmet.2024.10.006_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.freeradbiomed.2022.05.023","article-title":"Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2\/GPX4 signal axis","volume":"187","author":"Wang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cmet.2024.10.006_bib45","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-019-1405-y","article-title":"Intestinal infection triggers Parkinson\u2019s disease-like symptoms in Pink1-\/- mice","volume":"571","author":"Matheoud","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.006_bib46","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson\u2019s Disease","volume":"167","author":"Sampson","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41586-020-2288-7","article-title":"C9orf72 suppresses systemic and neural inflammation induced by gut bacteria","volume":"582","author":"Burberry","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.006_bib48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-023-00700-w","article-title":"Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner","volume":"19","author":"Bosch","year":"2024","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.cmet.2024.10.006_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/science.add1236","article-title":"ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy","volume":"379","author":"Seo","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cmet.2024.10.006_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19931-2","article-title":"Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system","volume":"11","author":"Chevalier","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2024.10.006_bib51","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo2984","article-title":"Gut microbiome composition may be an indicator of preclinical Alzheimer\u2019s disease","volume":"15","author":"Ferreiro","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2024.10.006_bib52","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00018-017-2693-8","article-title":"Mouse models for human intestinal microbiota research: a critical evaluation","volume":"75","author":"Hugenholtz","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cmet.2024.10.006_bib53","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.cell.2015.11.055","article-title":"Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis","volume":"163","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.006_bib54","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.3945\/ajcn.117.160515","article-title":"Eggs early in complementary feeding increase choline pathway biomarkers and DHA: a randomized controlled trial in Ecuador","volume":"106","author":"Iannotti","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cmet.2024.10.006_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5080843","article-title":"Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cmet.2024.10.006_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104998","article-title":"GPR119 agonists: novel therapeutic agents for type 2 diabetes mellitus","volume":"113","author":"Manaithiya","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.cmet.2024.10.006_bib57","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-981-32-9358-8_16","article-title":"Amyloid-beta and Tau at the Crossroads of Alzheimer\u2019s Disease","volume":"1184","author":"Gallardo","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.cmet.2024.10.006_bib63","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1209791","article-title":"The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine","volume":"334","author":"Vaishnava","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cmet.2024.10.006_bib58","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione peroxidase 4 senses and translates oxidative stress into 12\/15-lipoxygenase dependent- and AIF-mediated cell death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2024.10.006_bib59","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nprot.2006.205","article-title":"Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study \u2018recognition memory\u2019","volume":"1","author":"Bevins","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cmet.2024.10.006_bib60","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cmet.2024.10.006_bib61","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3389\/fncel.2019.00105","article-title":"Proteomics Study of Peripheral Blood Mononuclear Cells (PBMCs) in Autistic Children","volume":"13","author":"Shen","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.cmet.2024.10.006_bib62","doi-asserted-by":"crossref","first-page":"E2695","DOI":"10.1073\/pnas.1524589113","article-title":"\u03b1\/\u03b2-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors","volume":"113","author":"Wei","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413124004029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413124004029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T02:35:48Z","timestamp":1762396548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413124004029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1550413124004029"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2024.10.006","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbiota-derived lysophosphatidylcholine alleviates Alzheimer\u2019s disease pathology via suppressing ferroptosis","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2024.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}