{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:11:19Z","timestamp":1793139079051,"version":"4.5.0"},"reference-count":87,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003197","name":"Italian Medicines Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003500","name":"University of Padua","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004923","name":"AFM-T\u00e9l\u00e9thon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.cmet.2024.10.021","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T11:28:22Z","timestamp":1732620502000},"page":"477-495.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance"],"prefix":"10.1016","volume":"37","author":[{"given":"Gaia","family":"Gherardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Weiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavien","family":"Bermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Migliavacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Brinon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume E.","family":"Jacot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Hermant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Sturlese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Nogara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Vascon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"De Mario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mattarei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Garratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lillycrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Godfrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cendron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Barron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Blaauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Rizzuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4751-264X","authenticated-orcid":false,"given":"Jerome N.","family":"Feige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mammucari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"De Marchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2024.10.021_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2024.10.021_bib2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","article-title":"The Mitochondrial Basis of Aging","volume":"61","author":"Sun","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2024.10.021_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2020.04.001","article-title":"Benefits of Metformin in Attenuating the Hallmarks of Aging","volume":"32","author":"Kulkarni","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2024.10.021_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2024.10.021_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add5163","article-title":"Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a\u00a0twin study","volume":"9","author":"Lapatto","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cmet.2024.10.021_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03421-7","article-title":"Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults","volume":"9","author":"Martens","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2024.10.021_bib7","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.abe9985","article-title":"Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women","volume":"372","author":"Yoshino","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cmet.2024.10.021_bib8","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.4132","article-title":"Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents","volume":"22","author":"Ryu","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2024.10.021_bib9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s42255-019-0073-4","article-title":"The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans","volume":"1","author":"Andreux","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2024.10.021_bib10","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nm.4222","article-title":"Cardioprotection and lifespan extension by the natural polyamine spermidine","volume":"22","author":"Eisenberg","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2024.10.021_bib11","doi-asserted-by":"crossref","first-page":"15363","DOI":"10.1073\/pnas.2002250117","article-title":"Mitochondrial protein interaction landscape of SS-31","volume":"117","author":"Chavez","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2024.10.021_bib12","doi-asserted-by":"crossref","first-page":"e1212","DOI":"10.1212\/WNL.0000000000005255","article-title":"Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy","volume":"90","author":"Karaa","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.cmet.2024.10.021_bib13","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s42255-020-0251-4","article-title":"Skeletal muscle energy metabolism during exercise","volume":"2","author":"Hargreaves","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2024.10.021_bib14","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/gerona\/61.6.534","article-title":"Effects of exercise on mitochondrial content and function in aging human skeletal muscle","volume":"61","author":"Menshikova","year":"2006","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.cmet.2024.10.021_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13694-1","article-title":"Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities","volume":"10","author":"Migliavacca","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2024.10.021_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-physiol-020518-114310","article-title":"Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging","volume":"81","author":"Hood","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.cmet.2024.10.021_bib17","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1073\/pnas.0501559102","article-title":"Decline in skeletal muscle mitochondrial function with aging in humans","volume":"102","author":"Short","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2024.10.021_bib18","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1126\/science.1082889","article-title":"Mitochondrial dysfunction in the elderly: possible role in insulin resistance","volume":"300","author":"Petersen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cmet.2024.10.021_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/acel.12568","article-title":"Muscle strength mediates the relationship between mitochondrial energetics and walking performance","volume":"16","author":"Zane","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2024.10.021_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-26944-x","article-title":"Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly","volume":"8","author":"Andreux","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2024.10.021_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.maturitas.2019.11.007","article-title":"Nutritional strategies for maintaining muscle mass and strength from middle age to later life: A narrative review","volume":"132","author":"Cruz-Jentoft","year":"2020","journal-title":"Maturitas"},{"key":"10.1016\/j.cmet.2024.10.021_bib22","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.clnu.2017.08.016","article-title":"Does nutrition play a role in the prevention and management of sarcopenia?","volume":"37","author":"Robinson","year":"2018","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.cmet.2024.10.021_bib23","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.cmet.2016.05.007","article-title":"Exercise Promotes Healthy Aging of Skeletal Muscle","volume":"23","author":"Cartee","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2024.10.021_bib24","article-title":"Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project)","volume":"377","author":"Bernabei","year":"2022","journal-title":"BMJ"},{"key":"10.1016\/j.cmet.2024.10.021_bib25","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1001\/jama.2014.5616","article-title":"Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial","volume":"311","author":"Pahor","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.cmet.2024.10.021_bib26","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.clnu.2014.04.007","article-title":"Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group","volume":"33","author":"Deutz","year":"2014","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.cmet.2024.10.021_bib27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jamda.2010.04.014","article-title":"Nutritional recommendations for the management of sarcopenia","volume":"11","author":"Morley","year":"2010","journal-title":"J.\u00a0Am. Med. Dir. Assoc."},{"key":"10.1016\/j.cmet.2024.10.021_bib28","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa025039","article-title":"Adherence to a Mediterranean diet and survival in a Greek population","volume":"348","author":"Trichopoulou","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.cmet.2024.10.021_bib29","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1136\/bmj.311.7018.1457","article-title":"Diet and overall survival in elderly people","volume":"311","author":"Trichopoulou","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.cmet.2024.10.021_bib30","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as sensors and regulators of calcium signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2024.10.021_bib31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41418-018-0191-7","article-title":"Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference","volume":"26","author":"Gherardi","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.cmet.2024.10.021_bib32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature10234","article-title":"Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter","volume":"476","author":"Baughman","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.021_bib33","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10230","article-title":"A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter","volume":"476","author":"De Stefani","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.021_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.554904","article-title":"The Mitochondrial Ca2+ Uptake and the Fine-Tuning of Aerobic Metabolism","volume":"11","author":"Gherardi","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cmet.2024.10.021_bib35","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-27422-1","article-title":"Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity","volume":"12","author":"Zanou","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2024.10.021_bib36","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.celrep.2015.01.056","article-title":"The mitochondrial calcium uniporter controls skeletal muscle trophism in\u00a0vivo","volume":"10","author":"Mammucari","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2024.10.021_bib37","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.celrep.2019.09.063","article-title":"Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1","volume":"29","author":"Debattisti","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2024.10.021_bib38","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1152\/physrev.00041.2020","article-title":"Mitochondrial calcium exchange in physiology and disease","volume":"102","author":"Garbincius","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cmet.2024.10.021_bib39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ng.2851","article-title":"Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling","volume":"46","author":"Logan","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2024.10.021_bib40","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000059","article-title":"Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood","volume":"2","author":"Lewis-Smith","year":"2016","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.cmet.2024.10.021_bib41","doi-asserted-by":"crossref","first-page":"E1872","DOI":"10.1073\/pnas.1602264113","article-title":"Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition","volume":"113","author":"Chaudhuri","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2024.10.021_bib42","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ncb2622","article-title":"MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism","volume":"14","author":"Mallilankaraman","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2024.10.021_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cmet.2014.12.004","article-title":"CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter","volume":"21","author":"Paupe","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2024.10.021_bib44","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.celrep.2016.04.050","article-title":"MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics","volume":"15","author":"Tomar","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2024.10.021_bib45","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cmet.2015.09.015","article-title":"MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter","volume":"22","author":"Vais","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2024.10.021_bib46","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1083\/jcb.200604166","article-title":"Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release","volume":"174","author":"Weisleder","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.cmet.2024.10.021_bib47","doi-asserted-by":"crossref","first-page":"526","DOI":"10.15252\/emmm.201404433","article-title":"A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis","volume":"7","author":"Palamiuc","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.cmet.2024.10.021_bib48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/BJ20040990","article-title":"Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids","volume":"384","author":"Montero","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.cmet.2024.10.021_bib49","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/1091581815619764","article-title":"A Comprehensive Toxicological Safety Assessment of an Extract of Olea Europaea L. Leaves (Bonolive\u2122)","volume":"35","author":"Clewell","year":"2016","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.cmet.2024.10.021_bib50","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.celrep.2020.01.081","article-title":"A High-Throughput Screening Identifies MICU1 Targeting Compounds","volume":"30","author":"Di Marco","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2024.10.021_bib51","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.chembiol.2023.05.002","article-title":"MICU1 controls the sensitivity of the mitochondrial Ca2+ uniporter to activators and inhibitors","volume":"30","author":"Rodr\u00edguez-Prados","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cmet.2024.10.021_bib52","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.yrtph.2018.04.013","article-title":"Safety assessment of ethanolic extract of Olea europaea L. leaves after acute and subacute administration to Wistar rats","volume":"95","author":"Guex","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.cmet.2024.10.021_bib53","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10955","article-title":"MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration","volume":"7","author":"Antony","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2024.10.021_bib54","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00394-013-0604-9","article-title":"Bioavailability of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: comparison between pre- and postmenopausal women","volume":"53","author":"Garc\u00eda-Villalba","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.cmet.2024.10.021_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123457","article-title":"A novel combined analytical UV and MS approach for the quantification of oleuropein metabolites in human biological samples when authentic standards are not available","volume":"1210","author":"Polia","year":"2022","journal-title":"J.\u00a0Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.cmet.2024.10.021_bib56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12967-014-0219-9","article-title":"Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases","volume":"12","author":"Bulotta","year":"2014","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.cmet.2024.10.021_bib57","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1128\/MCB.01036-12","article-title":"Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia","volume":"33","author":"Ibebunjo","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.cmet.2024.10.021_bib58","doi-asserted-by":"crossref","first-page":"712","DOI":"10.18632\/aging.100926","article-title":"A robust neuromuscular system protects rat and human skeletal muscle from sarcopenia","volume":"8","author":"Pann\u00e9rec","year":"2016","journal-title":"Aging (Albany, NY)"},{"key":"10.1016\/j.cmet.2024.10.021_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.697621","article-title":"Functional Aging in Male C57BL\/6J Mice Across the Life-Span: A Systematic Behavioral Analysis of Motor, Emotional, and Memory Function to Define an Aging Phenotype","volume":"13","author":"Yanai","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.cmet.2024.10.021_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103244","article-title":"Pharmacological advances in mitochondrial therapy","volume":"65","author":"Singh","year":"2021","journal-title":"EBiomedicine"},{"key":"10.1016\/j.cmet.2024.10.021_bib61","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.44279","article-title":"Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial","volume":"5","author":"Liu","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.cmet.2024.10.021_bib62","article-title":"Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults","volume":"3","author":"Singh","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.cmet.2024.10.021_bib63","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cmet.2020.04.008","article-title":"Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy","volume":"31","author":"Pirinen","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2024.10.021_bib64","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3797\/scipharm.0912-18","article-title":"Oleuropein in olive and its pharmacological effects","volume":"78","author":"Omar","year":"2010","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.cmet.2024.10.021_bib65","doi-asserted-by":"crossref","first-page":"18508","DOI":"10.3390\/ijms151018508","article-title":"Effects of the olive-derived polyphenol oleuropein on human health","volume":"15","author":"Barbaro","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cmet.2024.10.021_bib66","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X211070205","article-title":"An oleuropein-based dietary supplement may improve joint functional capacity in older people with high knee joint pain: findings from a multicentre-RCT and post hoc analysis","volume":"14","author":"Horcajada","year":"2022","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"10.1016\/j.cmet.2024.10.021_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117833","article-title":"Effect of oleuropein on oxidative stress, inflammation and apoptosis induced by ischemia-reperfusion injury in rat kidney","volume":"255","author":"Nasrallah","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.cmet.2024.10.021_bib68","doi-asserted-by":"crossref","first-page":"35358","DOI":"10.18632\/oncotarget.6139","article-title":"Age-dependent uncoupling of mitochondria from Ca2+ release units in skeletal muscle","volume":"6","author":"Pietrangelo","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.cmet.2024.10.021_bib69","doi-asserted-by":"crossref","first-page":"4","DOI":"10.14814\/phy2.13005","article-title":"Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics","volume":"4","author":"Zampieri","year":"2016","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.cmet.2024.10.021_bib70","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/s41419-021-04400-5","article-title":"MICU3 regulates mitochondrial Ca2+-dependent antioxidant response in skeletal muscle aging","volume":"12","author":"Yang","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2024.10.021_bib71","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14129","article-title":"The cellular bases of mobility from the Study of Muscle, Mobility and Aging (SOMMA)","volume":"23","author":"Cummings","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2024.10.021_bib72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cmet.2024.10.021_bib73","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv412","article-title":"Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses","volume":"43","author":"Liu","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cmet.2024.10.021_bib74","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/jcsm.12876","article-title":"Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS)","volume":"13","author":"Antoun","year":"2022","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.cmet.2024.10.021_bib75","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0091-679X(06)80015-4","article-title":"Biosensors for the detection of calcium and pH","volume":"80","author":"Pinton","year":"2007","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.cmet.2024.10.021_bib76","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/358325a0","article-title":"Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin","volume":"358","author":"Rizzuto","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2024.10.021_bib77","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.270.17.9896","article-title":"Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation","volume":"270","author":"Brini","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.cmet.2024.10.021_bib78","series-title":"Dictionary of Food Compounds with CD-ROM","author":"Yannai","year":"2012"},{"key":"10.1016\/j.cmet.2024.10.021_bib79","doi-asserted-by":"crossref","first-page":"7","DOI":"10.21769\/BioProtoc.2155","article-title":"Ca2+ Measurements in Mammalian Cells with Aequorin-based Probes","volume":"7","author":"Tosatto","year":"2017","journal-title":"Bio Protoc."},{"key":"10.1016\/j.cmet.2024.10.021_bib80","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/embj.201386523","article-title":"Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake","volume":"33","author":"Wang","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2024.10.021_bib81","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1096\/fj.09-131870","article-title":"Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation","volume":"23","author":"Blaauw","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.cmet.2024.10.021_bib82","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cmet.2024.10.021_bib83","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.cmet.2024.10.021_bib84","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/ci800298z","article-title":"Empirical scoring functions for advanced protein-ligand docking with PLANTS","volume":"49","author":"Korb","year":"2009","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.cmet.2024.10.021_bib85","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.cmet.2024.10.021_bib86","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1021\/ct9000685","article-title":"ACEMD: Accelerating Biomolecular Dynamics in the Microsecond Time Scale","volume":"5","author":"Harvey","year":"2009","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.cmet.2024.10.021_bib87","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1038\/nprot.2013.127","article-title":"Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes","volume":"8","author":"Bonora","year":"2013","journal-title":"Nat. Protoc."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413124004170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413124004170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T11:50:58Z","timestamp":1738669858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413124004170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1550413124004170"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2024.10.021","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.02.24.529830","asserted-by":"object"}]},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2024.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}