{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:19:24Z","timestamp":1787905164865,"version":"build-2784847793"},"reference-count":74,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/X004643\/1"],"award-info":[{"award-number":["MR\/X004643\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/S025618\/1"],"award-info":[{"award-number":["MR\/S025618\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012205","name":"Saint Mary&apos;s Foundation","doi-asserted-by":"publisher","award":["23\/0006627"],"award-info":[{"award-number":["23\/0006627"]}],"id":[{"id":"10.13039\/100012205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK142423"],"award-info":[{"award-number":["DK142423"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK046492"],"award-info":[{"award-number":["DK046492"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK125353"],"award-info":[{"award-number":["DK125353"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK141090"],"award-info":[{"award-number":["DK141090"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100027211","name":"Diabetes Research Wellness Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100027211","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000273","name":"Diabetes Research and Wellness Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["KL 2399\/8-1"],"award-info":[{"award-number":["KL 2399\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["101042046"],"award-info":[{"award-number":["101042046"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-153156"],"award-info":[{"award-number":["PJT-153156"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["EP\/X026833\/1"],"award-info":[{"award-number":["EP\/X026833\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["22\/0006389"],"award-info":[{"award-number":["22\/0006389"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cmet.2025.06.009","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T19:27:13Z","timestamp":1752607633000},"page":"1698-1714.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication"],"prefix":"10.1016","volume":"37","author":[{"given":"Jason C.L.","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Frazer-Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali H.","family":"Shilleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Viloria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"de Bray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adithya Muraleedaran","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.V.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Spiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Kobiita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladapo E.","family":"Olaniru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanta J.","family":"Persaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hauffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Kleinridders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bruce Verchere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canqi","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Cyranka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Epanchintsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"\u00c4mm\u00e4l\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Broichhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-8568","authenticated-orcid":false,"given":"David J.","family":"Hodson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2025.06.009_bib1","doi-asserted-by":"crossref","DOI":"10.1080\/19382014.2015.1024405","article-title":"Structural similarities and differences between the human and the mouse pancreas","volume":"7","author":"Dolen\u0161ek","year":"2015","journal-title":"Islets"},{"key":"10.1016\/j.cmet.2025.06.009_bib2","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.2337\/db16-0365","article-title":"Islet Pericytes Are Required for \u03b2-Cell Maturity","volume":"65","author":"Sasson","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2025.06.009_bib3","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1016\/j.celrep.2018.08.035","article-title":"Local Integrin Activation in Pancreatic \u03b2 Cells Targets Insulin Secretion to the Vasculature","volume":"24","author":"Gan","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2025.06.009_bib4","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61308","article-title":"Reduced synchroneity of intra-islet Ca(2+) oscillations in vivo in Robo-deficient beta cells","volume":"10","author":"Adams","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2025.06.009_bib5","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76262","article-title":"Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ signalling to control glucose-dependent insulin secretion","volume":"11","author":"Jevon","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2025.06.009_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcdb.2012.09.007","article-title":"Paracrine and autocrine interactions in the human islet: more than meets the eye","volume":"24","author":"Caicedo","year":"2013","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2025.06.009_bib7","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1007\/s00125-020-05213-5","article-title":"Paracrine regulation of insulin secretion","volume":"63","author":"Huising","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2025.06.009_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20141384","article-title":"Pancreatic beta-cell identity, glucose sensing and the control of insulin secretion","volume":"466","author":"Rutter","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/j.cmet.2025.06.009_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1152\/physrev.00008.2017","article-title":"Pancreatic beta-Cell Electrical Activity and Insulin Secretion: Of Mice and Men","volume":"98","author":"Rorsman","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cmet.2025.06.009_bib10","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.cmet.2020.10.007","article-title":"Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway","volume":"32","author":"Lewandowski","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib11","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.cmet.2022.06.003","article-title":"Metabolic cycles and signals for insulin secretion","volume":"34","author":"Merrins","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib12","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1113\/jphysiol.2013.269910","article-title":"Neurotransmitters act as paracrine signals to regulate insulin secretion from the human pancreatic islet","volume":"592","author":"Rodriguez-Diaz","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.cmet.2025.06.009_bib13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cmet.2018.01.015","article-title":"Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point","volume":"27","author":"Rodriguez-Diaz","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.934775","article-title":"Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion","volume":"13","author":"Holter","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.cmet.2025.06.009_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s42255-023-00944-2","article-title":"Paracrine signalling by pancreatic \u03b4 cells determines the glycaemic set point in mice","volume":"6","author":"Huang","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0140-6736(65)90761-0","article-title":"Promotion of Insulin Secretion by Glucagon","volume":"2","author":"Samols","year":"1965","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2025.06.009_bib17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2337\/diab.47.1.66","article-title":"Dual Glucagon Recognition by Pancreatic \u03b2-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors","volume":"47","author":"Moens","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2025.06.009_bib18","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nm.2371","article-title":"Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans","volume":"17","author":"Rodriguez-Diaz","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2025.06.009_bib19","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.2337\/db13-1371","article-title":"Control Of Insulin Secretion By Cholinergic Signaling In The Human Pancreatic Islet","volume":"63","author":"Molina","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2025.06.009_bib20","article-title":"Intraislet glucagon signaling is critical for maintaining glucose homeostasis","volume":"5","author":"Zhu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.cmet.2025.06.009_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126742","article-title":"beta Cell tone is defined by proglucagon peptides through cAMP signaling","volume":"4","author":"Capozzi","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.cmet.2025.06.009_bib22","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1074\/jbc.RA118.005682","article-title":"Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP","volume":"294","author":"Chepurny","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2025.06.009_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13611","article-title":"Glucose-induced cAMP elevation in beta-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling","volume":"231","author":"Shuai","year":"2021","journal-title":"Acta Physiol. (Oxf.)"},{"key":"10.1016\/j.cmet.2025.06.009_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101484","article-title":"Intra-islet glucagon confers \u03b2-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon","volume":"298","author":"Cabrera","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2025.06.009_bib25","article-title":"Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics","volume":"11","author":"Ast","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2025.06.009_bib26","doi-asserted-by":"crossref","first-page":"11529","DOI":"10.1074\/jbc.RA120.014368","article-title":"Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells","volume":"295","author":"Gray","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2025.06.009_bib27","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.celrep.2018.10.018","article-title":"Insulin Secretion Depends on Intra-islet Glucagon Signaling","volume":"25","author":"Svendsen","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2025.06.009_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092495","article-title":"Glucagon Potentiates Insulin Secretion Via \u03b2-Cell GCGR at Physiological Concentrations of Glucose","volume":"10","author":"Zhang","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cmet.2025.06.009_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101947","article-title":"Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis","volume":"85","author":"Suba","year":"2024","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib30","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/0026-0495(87)90131-4","article-title":"Effect of low concentrations of glucagon on insulin release and cyclic AMP content in isolated rat islets","volume":"36","author":"Siegel","year":"1987","journal-title":"Metabolism"},{"key":"10.1016\/j.cmet.2025.06.009_bib31","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1073\/pnas.84.10.3434","article-title":"Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line","volume":"84","author":"Drucker","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2025.06.009_bib32","doi-asserted-by":"crossref","first-page":"17749","DOI":"10.1074\/jbc.270.30.17749","article-title":"Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1","volume":"270","author":"Holz","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2025.06.009_bib33","first-page":"62","article-title":"Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate","volume":"10","author":"Widmann","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.cmet.2025.06.009_bib34","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.mce.2013.11.010","article-title":"Real-time trafficking and signaling of the glucagon-like peptide-1 receptor","volume":"382","author":"Roed","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.cmet.2025.06.009_bib35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/bj3100203","article-title":"Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas","volume":"310","author":"Widmann","year":"1995","journal-title":"Biochem. J."},{"key":"10.1016\/j.cmet.2025.06.009_bib36","doi-asserted-by":"crossref","first-page":"E161","DOI":"10.1152\/ajpendo.00551.2012","article-title":"Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic beta-cells","volume":"305","author":"Kuna","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35716-1","article-title":"Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling","volume":"14","author":"Ast","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2025.06.009_bib38","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1073\/pnas.0510790103","article-title":"The unique cytoarchitecture of human pancreatic islets has implications for islet cell function","volume":"103","author":"Cabrera","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2025.06.009_bib39","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.2337\/db09-1177","article-title":"Unique arrangement of alpha- and beta-cells in human islets of Langerhans","volume":"59","author":"Bosco","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2025.06.009_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103739","article-title":"Reagents and models for detecting endogenous GLP1R and GIPR","volume":"74","author":"Ast","year":"2021","journal-title":"EBiomedicine"},{"key":"10.1016\/j.cmet.2025.06.009_bib41","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1530\/JOE-20-0608","article-title":"Decreased expression of the GLP-1 receptor after segmental artery injury in mice","volume":"248","author":"Bj\u00f8rnholm","year":"2021","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.cmet.2025.06.009_bib42","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1210\/en.2013-1934","article-title":"GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody","volume":"155","author":"Pyke","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2025.06.009_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-76722-1","article-title":"Cystic fibrosis-related diabetes is associated with reduced islet protein expression of GLP-1 receptor and perturbation of cell-specific transcriptional programs","volume":"14","author":"Gharib","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cmet.2025.06.009_bib44","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1172\/JCI68459","article-title":"Lipotoxicity disrupts incretin-regulated human beta cell connectivity","volume":"123","author":"Hodson","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.cmet.2025.06.009_bib45","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1039\/D1OB02216D","article-title":"Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins","volume":"20","author":"Birke","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.cmet.2025.06.009_bib46","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/jacsau.2c00130","article-title":"Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo","volume":"2","author":"Ast","year":"2022","journal-title":"JACS Au"},{"key":"10.1016\/j.cmet.2025.06.009_bib47","doi-asserted-by":"crossref","first-page":"E807","DOI":"10.1152\/ajpendo.00715.2009","article-title":"Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo","volume":"298","author":"Nyman","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib48","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2337\/db15-1168","article-title":"Metabolism Regulates Exposure of Pancreatic Islets to Circulating Molecules In Vivo","volume":"65","author":"Michau","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2025.06.009_bib49","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2337\/db19-1034","article-title":"Integrated Pancreatic Blood Flow: Bidirectional Microcirculation Between Endocrine and Exocrine Pancreas","volume":"69","author":"Dybala","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2025.06.009_bib50","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa246","article-title":"Using a Reporter Mouse to Map Known and Novel Sites of GLP-1 Receptor Expression in Peripheral Tissues of Male Mice","volume":"162","author":"Andersen","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.cmet.2025.06.009_bib51","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.chembiol.2017.03.001","article-title":"A Ratiometric Sensor for Imaging Insulin Secretion in Single beta Cells","volume":"24","author":"Schifferer","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.cmet.2025.06.009_bib52","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s42255-023-00962-0","article-title":"Readily releasable \u03b2 cells with tight Ca2+\u2013exocytosis coupling dictate biphasic glucose-stimulated insulin secretion","volume":"6","author":"Peng","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib53","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41587-022-01219-z","article-title":"Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells","volume":"40","author":"Balboa","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cmet.2025.06.009_bib54","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cmet.2016.06.020","article-title":"Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose","volume":"24","author":"Johnston","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib55","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2016.08.020","article-title":"Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes","volume":"24","author":"Segerstolpe","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib56","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.cmet.2020.04.005","article-title":"Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes","volume":"31","author":"Camunas-Soler","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001761","article-title":"Functional architecture of pancreatic islets identifies a population of first responder cells that drive the first-phase calcium response","volume":"20","author":"Kravets","year":"2022","journal-title":"PLoS Biol."},{"key":"10.1016\/j.cmet.2025.06.009_bib58","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.molmet.2016.04.007","article-title":"Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets","volume":"5","author":"DiGruccio","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib59","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1007\/s00125-016-4033-1","article-title":"Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets","volume":"59","author":"Adriaenssens","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2025.06.009_bib60","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72919","article-title":"Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes","volume":"10","author":"Kim","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2025.06.009_bib61","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.152852","article-title":"\u03b1-cell Gq signaling is critical for maintaining euglycemia","volume":"6","author":"Liu","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.cmet.2025.06.009_bib62","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-2952(02)01482-X","article-title":"Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity","volume":"65","author":"Miguel","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cmet.2025.06.009_bib63","article-title":"Pancreatic islet \u03b1 cells regulate microtubule stability in neighboring \u03b2 cells to tune insulin secretion and induce functional heterogeneity in individual mouse and human islets","author":"Ho","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.cmet.2025.06.009_bib64","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59912","article-title":"Microtubules regulate pancreatic \u03b2-cell heterogeneity via spatiotemporal control of insulin secretion hot spots","volume":"10","author":"Trogden","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2025.06.009_bib65","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s42255-019-0075-2","article-title":"Leader \u03b2 cells coordinate Ca2+ dynamics across pancreatic islets in vivo","volume":"6","author":"Salem","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2025.06.009_bib66","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s00125-024-06173-w","article-title":"Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca2+ dynamics in prediabetic beta cells","volume":"67","author":"Visa","year":"2024","journal-title":"Diabetologia"},{"key":"10.1016\/j.cmet.2025.06.009_bib67","article-title":"Role of GLP1-receptor-mediated \u03b1-\u03b2-cell communication in functional \u03b2-cell heterogeneity","author":"Balasenthilkumaran","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.cmet.2025.06.009_bib68","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.2337\/dbi23-0023","article-title":"An Intraislet Paracrine Signaling Pathway That Enables Glucagon to Stimulate Pancreatic \u03b2-Cells","volume":"72","author":"Caicedo","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2025.06.009_bib69","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.2337\/db23-0292","article-title":"Conflicting Views About Interactions Between Pancreatic \u03b1-Cells and \u03b2-Cells","volume":"72","author":"Weir","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.cmet.2025.06.009_bib70","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nbt.3033","article-title":"Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells","volume":"32","author":"Rezania","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cmet.2025.06.009_bib71","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.devcel.2010.02.013","article-title":"Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis","volume":"18","author":"Gavet","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2025.06.009_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107761","article-title":"Vitamin-D-Binding Protein Contributes to the Maintenance of \u03b1 Cell Function and Glucagon Secretion","volume":"31","author":"Viloria","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2025.06.009_bib73","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.devcel.2018.11.001","article-title":"Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas","volume":"48","author":"Farack","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2025.06.009_bib74","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.molmet.2017.01.003","article-title":"High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting","volume":"6","author":"Ackermann","year":"2017","journal-title":"Mol. Metab."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413125003043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413125003043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:36:09Z","timestamp":1778618169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413125003043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":74,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1550413125003043"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2025.06.009","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2025.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}