{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:43:39Z","timestamp":1791845019994,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014881","name":"Guangzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272714"],"award-info":[{"award-number":["82272714"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372747"],"award-info":[{"award-number":["82372747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173149"],"award-info":[{"award-number":["82173149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370777"],"award-info":[{"award-number":["82370777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403492"],"award-info":[{"award-number":["82403492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024B03J0067"],"award-info":[{"award-number":["2024B03J0067"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1515020016"],"award-info":[{"award-number":["2021B1515020016"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cmet.2025.06.011","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T14:36:43Z","timestamp":1752763003000},"page":"1835-1851.e10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Xylulose 5-phosphate fosters sustained antitumor activity of progenitor-like exhausted SLC35E2+ CD8+ T effector cells"],"prefix":"10.1016","volume":"37","author":[{"given":"Tiezhu","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanzhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninghan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2025.06.011_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.immuni.2016.07.011","article-title":"Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis","volume":"45","author":"Schietinger","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2025.06.011_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41416-022-02119-4","article-title":"Tumour-infiltrating lymphocytes: from prognosis to treatment selection","volume":"128","author":"Brummel","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.cmet.2025.06.011_bib3","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.celrep.2018.01.040","article-title":"Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions","volume":"22","author":"Menk","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2025.06.011_bib4","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/s42255-023-00855-2","article-title":"Glutarate regulates T cell metabolism and anti-tumour immunity","volume":"5","author":"Minogue","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2025.06.011_bib5","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1126\/science.aax0860","article-title":"T cells with dysfunctional mitochondria induce multimorbidity and premature senescence","volume":"368","author":"Desd\u00edn-Mic\u00f3","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cmet.2025.06.011_bib6","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.immuni.2020.04.014","article-title":"Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms","volume":"52","author":"Beltra","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2025.06.011_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2025.06.011_bib8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-00478-8","article-title":"Redox regulation of immunometabolism","volume":"21","author":"Muri","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41586-020-2124-0","article-title":"Dietary modifications for enhanced cancer therapy","volume":"579","author":"Kanarek","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2025.06.011_bib10","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.trecan.2023.06.003","article-title":"Diet, nutrient supply, and tumor immune responses","volume":"9","author":"McIntyre","year":"2023","journal-title":"Trends Cancer"},{"key":"10.1016\/j.cmet.2025.06.011_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adg3868","article-title":"Cellular and molecular waypoints along the path of T cell exhaustion","volume":"8","author":"Lan","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.it.2013.10.001","article-title":"Tolerance and exhaustion: defining mechanisms of T cell dysfunction","volume":"35","author":"Schietinger","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2022.12.002","article-title":"CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor","volume":"56","author":"Prokhnevska","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2025.06.011_bib14","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41568-023-00615-0","article-title":"Stem-like exhausted and memory CD8+ T cells in cancer","volume":"23","author":"Gebhardt","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cmet.2025.06.011_bib15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-019-1836-5","article-title":"An intra-tumoral niche maintains and differentiates stem-like CD8 T cells","volume":"576","author":"Jansen","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2025.06.011_bib16","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1038\/s41590-022-01338-4","article-title":"Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics","volume":"23","author":"Giles","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib17","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aar4060","article-title":"Cancer immunotherapy using checkpoint blockade","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cmet.2025.06.011_bib18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature23270","article-title":"In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target","volume":"547","author":"Manguso","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2025.06.011_bib19","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cell.2021.02.021","article-title":"In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions","volume":"184","author":"Huang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2025.06.011_bib20","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41586-021-04109-7","article-title":"CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity","volume":"600","author":"Long","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2025.06.011_bib21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/s41590-022-01315-x","article-title":"In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer","volume":"23","author":"Dubrot","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib22","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/0002-9343(59)90231-1","article-title":"Pentose metabolism and pentosuria","volume":"26","author":"Touster","year":"1959","journal-title":"Am. J. Med."},{"key":"10.1016\/j.cmet.2025.06.011_bib23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.7326\/0003-4819-53-2-372","article-title":"Carbohydrate metabolism in pentosuria","volume":"53","author":"Hiatt","year":"1960","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cmet.2025.06.011_bib24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/184463a0","article-title":"Essential pentosuria: renal or enzymic disorder","volume":"184","author":"Bozian","year":"1959","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2025.06.011_bib25","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1074\/jbc.271.10.5321","article-title":"Transcriptional glucose signaling through the glucose response element is mediated by the pentose phosphate pathway","volume":"271","author":"Doiron","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2025.06.011_bib26","first-page":"977","article-title":"Essential pentosuria and the glucuronate-xylulose pathway","volume":"19","author":"Touster","year":"1960","journal-title":"Fed. Proc."},{"key":"10.1016\/j.cmet.2025.06.011_bib27","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1074\/jbc.M112.427997","article-title":"Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism","volume":"288","author":"Bunker","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2025.06.011_bib28","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/s42255-023-00913-9","article-title":"The glucose transporter 2 regulates CD8+ T cell function via environment sensing","volume":"5","author":"Fu","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2025.06.011_bib29","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.immuni.2016.10.017","article-title":"Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral","volume":"45","author":"Phan","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2025.06.011_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bau012","article-title":"COMPARTMENTS: unification and visualization of protein subcellular localization evidence","volume":"2014","author":"Binder","year":"2014","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.cmet.2025.06.011_bib31","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41568-020-0273-y","article-title":"Metabolism of immune cells in cancer","volume":"20","author":"Leone","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cmet.2025.06.011_bib32","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ni969","article-title":"Similarities and differences in CD4+ and CD8+ effector and memory T cell generation","volume":"4","author":"Seder","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib33","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1073\/pnas.0730817100","article-title":"Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver","volume":"100","author":"Kabashima","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2025.06.011_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41577-019-0221-9","article-title":"Defining \u2018T cell exhaustion'","volume":"19","author":"Blank","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-biochem-051710-134100","article-title":"The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis","volume":"81","author":"Shilatifard","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.cmet.2025.06.011_bib36","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/emboj.2012.357","article-title":"TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1\/COMPASS","volume":"32","author":"Deplus","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.cmet.2025.06.011_bib37","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molcel.2012.12.019","article-title":"Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells","volume":"49","author":"Vella","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2025.06.011_bib38","doi-asserted-by":"crossref","DOI":"10.1242\/dev.183129","article-title":"The roles of TET family proteins in development and stem cells","volume":"147","author":"Yang","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.cmet.2025.06.011_bib39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12964-021-00753-8","article-title":"JMJD3: a critical epigenetic regulator in stem cell fate","volume":"19","author":"Ding","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.cmet.2025.06.011_bib40","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/s41586-023-06546-y","article-title":"Reductive carboxylation epigenetically instructs T cell differentiation","volume":"621","author":"Jaccard","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2025.06.011_bib41","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1038\/s41590-023-01636-5","article-title":"The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate","volume":"24","author":"Weisshaar","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41577-023-00973-8","article-title":"Immunotherapy combination approaches: mechanisms, biomarkers and clinical observations","volume":"24","author":"Butterfield","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib43","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/s41392-023-01522-4","article-title":"Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cmet.2025.06.011_bib44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41568-022-00485-y","article-title":"Developing dietary interventions as therapy for cancer","volume":"22","author":"Taylor","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cmet.2025.06.011_bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.apsb.2019.12.006","article-title":"Solute carrier transporters: the metabolic gatekeepers of immune cells","volume":"10","author":"Song","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.cmet.2025.06.011_bib46","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.4049\/jimmunol.180.7.4476","article-title":"Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways","volume":"180","author":"Jacobs","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-med-012017-043208","article-title":"CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions","volume":"69","author":"Hashimoto","year":"2018","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.cmet.2025.06.011_bib48","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41586-022-05192-0","article-title":"PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells","volume":"610","author":"Codarri Deak","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2025.06.011_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adg0539","article-title":"PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors","volume":"8","author":"Gill","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cmet.2025.06.011_bib50","first-page":"245","article-title":"American Cancer Society guideline for diet and physical activity for cancer prevention","volume":"70","author":"Rock","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cmet.2025.06.011_bib51","first-page":"230","article-title":"American Cancer Society nutrition and physical activity guideline for cancer survivors","volume":"72","author":"Rock","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cmet.2025.06.011_bib52","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.cell.2023.03.011","article-title":"Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment","volume":"186","author":"Bender","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2025.06.011_bib53","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.ccell.2023.08.014","article-title":"Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I","volume":"41","author":"Ferrari","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cmet.2025.06.011_bib54","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nprot.2017.016","article-title":"Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening","volume":"12","author":"Joung","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cmet.2025.06.011_bib55","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41596-018-0113-7","article-title":"Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute","volume":"14","author":"Wang","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.cmet.2025.06.011_bib56","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cmet.2025.06.011_bib57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.cmet.2025.06.011_bib58","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/j.1541-0420.2008.00995.x","article-title":"Generalized maximally selected statistics","volume":"64","author":"Hothorn","year":"2008","journal-title":"Biometrics"},{"key":"10.1016\/j.cmet.2025.06.011_bib59","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cell.2023.12.004","article-title":"Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies","volume":"187","author":"Liu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2025.06.011_bib60","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2025.06.011_bib61","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cmet.2025.06.011_bib62","article-title":"A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells","volume":"140","author":"Kueberuwa","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.cmet.2025.06.011_bib63","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1182\/blood-2010-01-265041","article-title":"Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells","volume":"116","author":"Kochenderfer","year":"2010","journal-title":"Blood"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413125003249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413125003249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:36:13Z","timestamp":1778618173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413125003249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":63,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1550413125003249"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2025.06.011","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Xylulose 5-phosphate fosters sustained antitumor activity of progenitor-like exhausted SLC35E2+ CD8+ T effector cells","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2025.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}