{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:45:36Z","timestamp":1792215936786,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.cmet.2026.01.014","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T15:40:23Z","timestamp":1771429223000},"page":"694-711.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lipid droplet-induced T cell death sustains autoimmune tissue inflammation"],"prefix":"10.1016","volume":"38","author":[{"given":"Jitendra","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel N.","family":"Goronzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Rubino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Trousdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald J.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg J.","family":"Goronzy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-9802","authenticated-orcid":false,"given":"Cornelia M.","family":"Weyand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2026.01.014_bib1","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/S0140-6736(23)00457-9","article-title":"Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK","volume":"401","author":"Conrad","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2026.01.014_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1101\/gad.346312.120","article-title":"Chronic tissue inflammation and metabolic disease","volume":"35","author":"Lee","year":"2021","journal-title":"Genes Dev."},{"key":"10.1016\/j.cmet.2026.01.014_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cmet.2019.06.016","article-title":"The DNA repair nuclease MRE11A functions as a mitochondrial protector and prevents T cell pyroptosis and tissue inflammation","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2026.01.014_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib5","article-title":"Metabolic control of autoimmunity and tissue inflammation in rheumatoid arthritis","volume":"12","author":"Qiu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib6","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/art.43105","article-title":"Immune aging in rheumatoid arthritis","volume":"77","author":"Weyand","year":"2025","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.cmet.2026.01.014_bib7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fimmu.2019.00353","article-title":"Effector functions of CD4+ T cells at the site of local autoimmune inflammation-lessons from rheumatoid arthritis","volume":"10","author":"Chemin","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1084\/jem.20040341","article-title":"Rapid turnover of effector-memory CD4(+) T cells in healthy humans","volume":"200","author":"Macallan","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cmet.2026.01.014_bib9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s42255-022-00585-x","article-title":"The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages","volume":"4","author":"Hu","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2026.01.014_bib10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/BOR.0000000000000683","article-title":"The metabolic signature of T cells in rheumatoid arthritis","volume":"32","author":"Weyand","year":"2020","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.cmet.2026.01.014_bib11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.exger.2017.10.027","article-title":"DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system","volume":"105","author":"Li","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.cmet.2026.01.014_bib12","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/ni.3808","article-title":"Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells","volume":"18","author":"Shen","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib13","article-title":"Metabolic checkpoints in rheumatoid arthritis","volume":"70S","author":"Weyand","year":"2025","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.cmet.2026.01.014_bib14","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/s41590-021-01065-2","article-title":"Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation","volume":"22","author":"Wu","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib15","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.cmet.2020.10.025","article-title":"Succinyl-CoA ligase deficiency in pro-inflammatory and tissue-invasive T cells","volume":"32","author":"Wu","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2026.01.014_bib16","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cmet.2024.02.009","article-title":"Acetyl-CoA carboxylase obstructs CD8+ T cell lipid utilization in the tumor microenvironment","volume":"36","author":"Hunt","year":"2024","journal-title":"Cell Metab"},{"key":"10.1016\/j.cmet.2026.01.014_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib18","first-page":"435","article-title":"Lipid droplets and the management of cellular stress","volume":"92","author":"Jarc","year":"2019","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.cmet.2026.01.014_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41556-024-01364-4","article-title":"Lipid droplets and cellular lipid flux","volume":"26","author":"Mathiowetz","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib20","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.devcel.2023.07.001","article-title":"Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation","volume":"58","author":"Roberts","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2026.01.014_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-57405-5","article-title":"Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites","volume":"16","author":"Bezawork-Geleta","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.01.014_bib22","article-title":"Catching lipid droplet contacts by proteomics","volume":"2","author":"Krahmer","year":"2019","journal-title":"Contact (Thousand Oaks)"},{"key":"10.1016\/j.cmet.2026.01.014_bib23","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.it.2021.07.005","article-title":"Lipid regulation of NLRP3 inflammasome activity through organelle stress","volume":"42","author":"Liang","year":"2021","journal-title":"Trends Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay8085","article-title":"Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense","volume":"370","author":"Bosch","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.01.014_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcdb.2020.02.010","article-title":"Lipid droplets, bioenergetic fluxes, and metabolic flexibility","volume":"108","author":"Bosch","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib26","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202104005","article-title":"Lipid droplets and the host-pathogen dynamic: FATal attraction?","volume":"220","author":"Bosch","year":"2021","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109902","article-title":"Arthritis flares mediated by tissue-resident memory T cells in the joint","volume":"37","author":"Chang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2026.01.014_bib28","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.01.014_bib29","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1007\/s10753-023-01816-3","article-title":"Increased n-6 polyunsaturated fatty acids indicate pro- and anti-inflammatory lipid modifications in synovial membranes with rheumatoid arthritis","volume":"46","author":"Mustonen","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.cmet.2026.01.014_bib30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13075-019-1914-y","article-title":"Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis","volume":"21","author":"Mustonen","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.cmet.2026.01.014_bib31","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ncb3166","article-title":"Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis","volume":"17","author":"Kaushik","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14111","article-title":"Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age-dependent fashion and induces cell senescence via GDF15","volume":"23","author":"Chiariello","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.01.014_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41392-024-01801-8","article-title":"The gasdermin family: emerging therapeutic targets in diseases","volume":"9","author":"Zhu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.cmet.2026.01.014_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aav1447","article-title":"Gasdermin D activity in inflammation and host defense","volume":"4","author":"Lieberman","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib35","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s41586-023-06199-x","article-title":"CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours","volume":"618","author":"Kruse","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.01.014_bib36","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.immuni.2024.03.012","article-title":"The NLR family of innate immune and cell death sensors","volume":"57","author":"Sundaram","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2026.01.014_bib37","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41556-024-01397-9","article-title":"A palmitoylation\u2013depalmitoylation relay spatiotemporally controls GSDMD activation in pyroptosis","volume":"26","author":"Zhang","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adn1452","article-title":"The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis","volume":"9","author":"Balasubramanian","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bbalip.2006.03.010","article-title":"Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins","volume":"1761","author":"Ohno","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cmet.2026.01.014_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2025.100793","article-title":"Mechanisms and functional implications of ZDHHC5 in cellular physiology and disease","volume":"66","author":"Liu","year":"2025","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.cmet.2026.01.014_bib60","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210026","article-title":"Substrate recruitment by zDHHC protein acyltransferases","volume":"11","author":"Malgapo","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib41","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cbpa.2021.07.002","article-title":"Inhibitors of DHHC family proteins","volume":"65","author":"Lan","year":"2021","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib42","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00171-24","article-title":"2-Bromopalmitate depletes lipid droplets to inhibit viral replication","volume":"98","author":"Liu","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.cmet.2026.01.014_bib43","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cmet.2026.01.014_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/bs.ircmb.2017.12.007","article-title":"Lipid droplets as organelles","volume":"337","author":"Cohen","year":"2018","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41420-024-01807-9","article-title":"Fatty acid metabolism of immune cells: a new target of tumour immunotherapy","volume":"10","author":"Zhang","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.cmet.2026.01.014_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aad7151","article-title":"Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis","volume":"8","author":"Yang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2026.01.014_bib47","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1084\/jem.20130252","article-title":"Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells","volume":"210","author":"Yang","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.cmet.2026.01.014_bib48","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.cmet.2018.11.018","article-title":"Starvation and pseudo-starvation as drivers of cancer metastasis through translation reprogramming","volume":"29","author":"Garc\u00eda-Jim\u00e9nez","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2026.01.014_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.809539","article-title":"Lysosomes in T cell immunity and aging","volume":"2","author":"Jin","year":"2021","journal-title":"Front. Aging"},{"key":"10.1016\/j.cmet.2026.01.014_bib50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41590-018-0296-7","article-title":"N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation","volume":"20","author":"Wen","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.cmet.2026.01.014_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.746749","article-title":"Lipid droplets, the central hub integrating cell metabolism and the immune system","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.cmet.2026.01.014_bib52","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41589-022-01017-3","article-title":"Lipid metabolism in T cell signaling and function","volume":"18","author":"Lim","year":"2022","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.867341","article-title":"The ER-mitochondria interface as a dynamic hub for T cell efficacy in solid tumors","volume":"10","author":"Hunt","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cmet.2026.01.014_bib54","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.molcel.2014.09.025","article-title":"Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport","volume":"56","author":"Yang","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2026.01.014_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.hsr.2023.100108","article-title":"Association of cardiovascular risks in rheumatoid arthritis patients: Management, treatment and future perspectives","volume":"8","author":"Johri","year":"2023","journal-title":"Health Sciences Review"},{"key":"10.1016\/j.cmet.2026.01.014_bib56","doi-asserted-by":"crossref","first-page":"349S","DOI":"10.1093\/ajcn\/71.1.349S","article-title":"n-3 fatty acid supplements in rheumatoid arthritis","volume":"71","author":"Kremer","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cmet.2026.01.014_bib57","article-title":"Causal association of monounsaturated fatty acids with rheumatoid arthritis but not osteoarthritis: A two-sample Mendelian randomization study","volume":"91\u201392","author":"Sun","year":"2021","journal-title":"Nutrition"},{"key":"10.1016\/j.cmet.2026.01.014_bib58","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jchromb.2006.11.023","article-title":"Targeted quantitative analysis of fatty acids in atherosclerotic plaques by high sensitivity liquid chromatography\/tandem mass spectrometry","volume":"850","author":"Pettinella","year":"2007","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.cmet.2026.01.014_bib59","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0140-6736(03)12468-3","article-title":"Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial","volume":"361","author":"Thies","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2026.01.014_bib61","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2022-002387","article-title":"\u2018Difficult to treat\u2019 rheumatoid arthritis: current position and considerations for next steps","volume":"8","author":"Tan","year":"2022","journal-title":"RMD Open"},{"key":"10.1016\/j.cmet.2026.01.014_bib62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41584-020-00541-7","article-title":"Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis","volume":"17","author":"Buch","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.cmet.2026.01.014_bib63","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.cmet.2026.01.014_bib64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jbspin.2018.04.004","article-title":"IMSYC immunologic synovitis score: A new score for synovial membrane characterization in inflammatory and non-inflammatory arthritis","volume":"86","author":"Najm","year":"2019","journal-title":"Jt. Bone Spine"},{"key":"10.1016\/j.cmet.2026.01.014_bib65","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.immuni.2016.09.013","article-title":"Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis","volume":"45","author":"Li","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.cmet.2026.01.014_bib66","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s44161-022-00096-8","article-title":"Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease","volume":"1","author":"Zhao","year":"2022","journal-title":"Nat CardioVasc Res"},{"key":"10.1016\/j.cmet.2026.01.014_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-21242-z","article-title":"Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation","volume":"12","author":"Ye","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.01.014_bib68","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1158\/0008-5472.CAN-19-1629","article-title":"Computational staining of pathology images to study the tumor microenvironment in lung cancer","volume":"80","author":"Wang","year":"2020","journal-title":"Cancer Res."}],"updated-by":[{"DOI":"10.1016\/j.cmet.2026.10.003","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000}}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155041312600015X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155041312600015X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:32:03Z","timestamp":1792215123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S155041312600015X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S155041312600015X"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2026.01.014","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid droplet-induced T cell death sustains autoimmune tissue inflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2026.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}