{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:58:19Z","timestamp":1793534299662,"version":"4.5.0"},"reference-count":182,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.cmet.2026.02.010","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:36:41Z","timestamp":1773239801000},"page":"673-693.e17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates"],"prefix":"10.1016","volume":"38","author":[{"given":"Lixiao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zikai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanbang","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chencan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzhao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueda","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaowen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaobin","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansheng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Haghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepcion","family":"Rodriguez Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0557-8875","authenticated-orcid":false,"given":"Juan Carlos","family":"Izpisua Belmonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8885-5104","authenticated-orcid":false,"given":"Weiqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-8177","authenticated-orcid":false,"given":"Guang-Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2026.02.010_bib1","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0092-8674(04)00343-5","article-title":"Balancing acts: molecular control of mammalian iron metabolism","volume":"117","author":"Hentze","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrn3453","article-title":"Iron metabolism in the CNS: implications for neurodegenerative diseases","volume":"14","author":"Rouault","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cmet.2026.02.010_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2021.100866","article-title":"The critical roles of iron during the journey from fetus to adolescent: Developmental aspects of iron homeostasis","volume":"50","author":"Donker","year":"2021","journal-title":"Blood Rev."},{"key":"10.1016\/j.cmet.2026.02.010_bib5","doi-asserted-by":"crossref","first-page":"lnaf015","DOI":"10.1093\/lifemedi\/lnaf015","article-title":"Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases","volume":"4","author":"Wang","year":"2025","journal-title":"Life Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1073\/pnas.1314885111","article-title":"Fenton chemistry at aqueous interfaces","volume":"111","author":"Enami","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2026.02.010_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-2797(89)90087-2","article-title":"The role of iron in oxygen radical mediated lipid peroxidation","volume":"71","author":"Minotti","year":"1989","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.cmet.2026.02.010_bib9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the role of lipoxygenases in the initiation and execution of ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib10","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2026.02.010_bib11","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s11427-022-2297-y","article-title":"Ferrodifferentiation regulates neurodevelopment via ROS generation","volume":"66","author":"Chang","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib12","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: a theory based on free radical and radiation chemistry","volume":"11","author":"Harman","year":"1956","journal-title":"J. Gerontol."},{"key":"10.1016\/j.cmet.2026.02.010_bib13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0925-4439(97)00067-7","article-title":"Lipid peroxidation, antioxidant protection and aging","volume":"1362","author":"Rikans","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.cmet.2026.02.010_bib14","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1126\/science.1106653","article-title":"Extension of murine life span by overexpression of catalase targeted to mitochondria","volume":"308","author":"Schriner","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib15","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.mad.2004.07.009","article-title":"The role of oxidative damage and stress in aging","volume":"125","author":"Bokov","year":"2004","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cmet.2026.02.010_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.273.5271.59","article-title":"Oxidative stress, caloric restriction, and aging","volume":"273","author":"Sohal","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib17","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.devcel.2021.03.034","article-title":"Lipid metabolism and lipid signals in aging and longevity","volume":"56","author":"Mutlu","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib18","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/acel.12064","article-title":"Lipidomics of familial longevity","volume":"12","author":"Gonzalez-Covarrubias","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/lifemedi\/lnaf032","article-title":"Iron metabolism disorder promotes postovulatory oocyte aging by inducing oxidative stress damage","volume":"4","author":"Huang","year":"2025","journal-title":"Life Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib20","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s13311-018-0656-x","article-title":"Marked age-related changes in brain iron homeostasis in amyloid protein precursor knockout mice","volume":"15","author":"Belaidi","year":"2018","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.cmet.2026.02.010_bib21","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2026.02.010_bib22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/s41380-023-02399-z","article-title":"Iron imbalance in neurodegeneration","volume":"29","author":"Levi","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.cmet.2026.02.010_bib23","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/CIRCRESAHA.122.321667","article-title":"Iron metabolism in cardiovascular disease: physiology, mechanisms, and therapeutic targets","volume":"132","author":"Sawicki","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tips.2023.12.003","article-title":"Tumor iron homeostasis and immune regulation","volume":"45","author":"Zhang","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib25","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1111\/odi.15303","article-title":"Ferroptosis: a new challenge and target in oral diseases","volume":"31","author":"Jiao","year":"2025","journal-title":"Oral Dis."},{"key":"10.1016\/j.cmet.2026.02.010_bib26","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","article-title":"Regulators of iron homeostasis: new players in metabolism, cell death, and disease","volume":"41","author":"Bogdan","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/5979","article-title":"Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse","volume":"21","author":"Vulpe","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2026.02.010_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-07244-x","article-title":"Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications","volume":"15","author":"Zheng","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2026.02.010_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1182\/blood-2018-06-815894","article-title":"Liver iron sensing and body iron homeostasis","volume":"133","author":"Wang","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.cmet.2026.02.010_bib30","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1016\/j.molcel.2021.08.027","article-title":"Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity","volume":"81","author":"Yoon","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib31","doi-asserted-by":"crossref","first-page":"lnaf003","DOI":"10.1093\/lifemedi\/lnaf003","article-title":"Unraveling the metabolic heterogeneity and commonality in senescent cells using systems modeling","volume":"4","author":"Li","year":"2025","journal-title":"Life Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib33","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib35","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41586-023-06983-9","article-title":"7-Dehydrocholesterol dictates ferroptosis sensitivity","volume":"626","author":"Li","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.02.010_bib36","doi-asserted-by":"crossref","DOI":"10.1186\/s40164-023-00427-w","article-title":"Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy","volume":"12","author":"Zheng","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.cmet.2026.02.010_bib37","doi-asserted-by":"crossref","DOI":"10.1177\/15330338221078728","article-title":"STEAP3 affects ferroptosis and progression of renal cell carcinoma through the p53\/xCT pathway","volume":"21","author":"Ye","year":"2022","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.cmet.2026.02.010_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101670","article-title":"Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis","volume":"36","author":"Fuhrmann","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib39","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/ng1658","article-title":"Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells","volume":"37","author":"Ohgami","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.cmet.2026.02.010_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202100308","article-title":"A tale of two lipids: Lipid unsaturation commands ferroptosis sensitivity","volume":"23","author":"Rodencal","year":"2023","journal-title":"Proteomics"},{"key":"10.1016\/j.cmet.2026.02.010_bib41","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41421-022-00390-6","article-title":"Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis","volume":"8","author":"Yu","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.cmet.2026.02.010_bib43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","article-title":"CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4","volume":"40","author":"Liao","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellin.2023.100091","article-title":"Origins of nervous tissue susceptibility to ferroptosis","volume":"2","author":"Snyder","year":"2023","journal-title":"Cell Insight"},{"key":"10.1016\/j.cmet.2026.02.010_bib45","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41556-021-00818-3","article-title":"PKC\u03b2II phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis","volume":"24","author":"Zhang","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41421-025-00829-6","article-title":"Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma","volume":"11","author":"Shan","year":"2025","journal-title":"Cell Discov."},{"key":"10.1016\/j.cmet.2026.02.010_bib47","first-page":"1","article-title":"The dual function of mitophagy in ferroptosis","volume":"11","author":"Zeng","year":"2025","journal-title":"Biophys. Rep."},{"key":"10.1016\/j.cmet.2026.02.010_bib48","doi-asserted-by":"crossref","first-page":"416","DOI":"10.52601\/bpr.2024.240908","article-title":"Neuronal STING activation mediates inflammation-induced neurodegeneration via ferroptosis pathways in multiple sclerosis","volume":"10","author":"Wang","year":"2024","journal-title":"Biophys. Rep."},{"key":"10.1016\/j.cmet.2026.02.010_bib49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Dr\u00f6ge","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cmet.2026.02.010_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103195","article-title":"Iron accumulation in ovarian microenvironment damages the local redox balance and oocyte quality in aging mice","volume":"73","author":"Chen","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib51","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.02.010_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2019.100982","article-title":"Ageing, age-related diseases and oxidative stress: What to do next?","volume":"57","author":"Luo","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cmet.2026.02.010_bib54","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cmet.2026.02.010_bib55","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1158\/0008-5472.CAN-22-3977","article-title":"Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells","volume":"83","author":"Bi","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.exger.2016.12.005","article-title":"An overview of nonhuman primates in aging research","volume":"94","author":"Mattison","year":"2017","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.cmet.2026.02.010_bib57","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ajp.22281","article-title":"Why primate models matter","volume":"76","author":"Phillips","year":"2014","journal-title":"Am. J. Primatol."},{"key":"10.1016\/j.cmet.2026.02.010_bib58","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1126\/science.272.5259.258","article-title":"Positional cloning of the Werner\u2019s syndrome gene","volume":"272","author":"Yu","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib59","doi-asserted-by":"crossref","DOI":"10.1126\/science.1084125","article-title":"Lamin a truncation in Hutchinson-Gilford progeria","volume":"300","author":"De Sandre-Giovannoli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib60","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s13238-020-00740-8","article-title":"Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing","volume":"11","author":"Wang","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib61","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cell.2022.12.017","article-title":"Resurrection of endogenous retroviruses during aging reinforces senescence","volume":"186","author":"Liu","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib62","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41580-024-00775-3","article-title":"Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases","volume":"25","author":"Wu","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib63","article-title":"Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging","author":"Sun","year":"2025","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib64","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41586-018-0437-z","article-title":"SIRT6 deficiency results in developmental retardation in cynomolgus monkeys","volume":"560","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.02.010_bib65","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41586-023-06783-1","article-title":"CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord","volume":"624","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.02.010_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113396","article-title":"Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging","volume":"42","author":"Zhang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.cmet.2026.02.010_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2025.103633","article-title":"Protocols for the application of human embryonic stem cell-derived neurons for aging modeling and gene manipulation","volume":"6","author":"Zhang","year":"2025","journal-title":"Star Protoc."},{"key":"10.1016\/j.cmet.2026.02.010_bib68","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.aau7307","article-title":"Long-term functional maintenance of primary human hepatocytes in vitro","volume":"364","author":"Xiang","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib69","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cell.2024.10.047","article-title":"ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization","volume":"188","author":"Wang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib70","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2016.05.017","article-title":"Repression of the antioxidant NRF2 pathway in premature aging","volume":"165","author":"Kubben","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib71","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1016\/j.cell.2024.08.021","article-title":"Metformin decelerates aging clock in male monkeys","volume":"187","author":"Yang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib72","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.stem.2025.09.008","article-title":"Vitamin C conveys geroprotection on primate ovaries","volume":"32","author":"Jing","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib73","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/cr.2016.4","article-title":"SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2","volume":"26","author":"Pan","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib74","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-med-043021-032816","article-title":"Hepcidin and iron in health and disease","volume":"74","author":"Nemeth","year":"2023","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib75","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1224577","article-title":"Hepcidin and the iron-infection axis","volume":"338","author":"Drakesmith","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib76","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.1016\/j.cell.2025.05.021","article-title":"Senescence-resistant human mesenchymal progenitor cells counter aging in primates","volume":"188","author":"Lei","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib77","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s41580-025-00883-8","article-title":"Biomarkers of ageing of humans and non-human primates","volume":"26","author":"Wu","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib78","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11427-023-2305-0","article-title":"Biomarkers of aging","volume":"66","author":"Bao","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib79","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/procel\/pwae035","article-title":"CRISPR-based screening pinpoints H2AZ1 as a driver of senescence in human mesenchymal stem cells","volume":"16","author":"Li","year":"2025","journal-title":"Protein Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib80","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/procel\/pwad060","article-title":"Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling","volume":"15","author":"Liu","year":"2024","journal-title":"Protein Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib81","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s11427-023-2451-3","article-title":"CRL2APPBP2-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence","volume":"67","author":"Huang","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib82","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13619-020-00055-3","article-title":"Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters","volume":"9","author":"Li","year":"2020","journal-title":"Cell Regen."},{"key":"10.1016\/j.cmet.2026.02.010_bib83","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1016\/j.cell.2025.06.001","article-title":"Systematic profiling reveals betaine as an exercise mimetic for geroprotection","volume":"188","author":"Geng","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13238-019-0623-2","article-title":"Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR\/Cas9-mediated gene correction","volume":"11","author":"Wang","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib85","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1007\/s11427-024-2844-8","article-title":"RIG-I-driven CDKN1A stabilization reinforces cellular senescence","volume":"68","author":"Wang","year":"2025","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib86","doi-asserted-by":"crossref","DOI":"10.1093\/lifemedi\/lnad022","article-title":"SenoIndex: S100A8\/S100A9 as a novel aging biomarker","volume":"2","author":"Zhang","year":"2023","journal-title":"Life Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib87","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd2655","article-title":"A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence","volume":"13","author":"Wang","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib88","article-title":"A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement","volume":"3","author":"Jiang","year":"2024","journal-title":"Life Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib89","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11427-017-9207-x","article-title":"Inorganic nitrate alleviates the senescence-related decline in liver function","volume":"61","author":"Wang","year":"2018","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib90","article-title":"A framework of biomarkers for brain aging: a consensus statement by the Aging Biomarker Consortium","volume":"2","author":"Jia","year":"2023","journal-title":"Life Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib91","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tree.2008.10.008","article-title":"Generalized linear mixed models: a practical guide for ecology and evolution","volume":"24","author":"Bolker","year":"2009","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.cmet.2026.02.010_bib92","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.neurobiolaging.2005.05.023","article-title":"Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region","volume":"26","author":"Allen","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cmet.2026.02.010_bib93","doi-asserted-by":"crossref","first-page":"8488","DOI":"10.1523\/JNEUROSCI.0391-14.2014","article-title":"Differential longitudinal changes in cortical thickness, surface area and volume across the adult life span: regions of accelerating and decelerating change","volume":"34","author":"Storsve","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.cmet.2026.02.010_bib94","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrn2753","article-title":"A new perspective on the role of the orbitofrontal cortex in adaptive behaviour","volume":"10","author":"Schoenbaum","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cmet.2026.02.010_bib95","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/brain\/awn350","article-title":"Role of right posterior parietal cortex in maintaining attention to spatial locations over time","volume":"132","author":"Malhotra","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.cmet.2026.02.010_bib96","doi-asserted-by":"crossref","first-page":"R691","DOI":"10.1016\/j.cub.2017.06.007","article-title":"Posterior parietal cortex","volume":"27","author":"Whitlock","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib97","doi-asserted-by":"crossref","DOI":"10.1093\/lifemedi\/lnaf028","article-title":"Fat talks first: how adipose tissue sets the pace of aging?","volume":"4","author":"Liu","year":"2025","journal-title":"Life Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib98","article-title":"A framework of biomarkers for adipose tissue aging: a consensus statement by the Aging Biomarker Consortium","volume":"4","author":"Yu","year":"2025","journal-title":"Life Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib99","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1089\/ars.2013.5228","article-title":"The free radical theory of aging is dead. Long live the damage theory!","volume":"20","author":"Gladyshev","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.cmet.2026.02.010_bib100","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1355616","article-title":"Protein oxidation and aging","volume":"257","author":"Stadtman","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib101","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.freeradbiomed.2011.07.020","article-title":"Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage","volume":"51","author":"Cabreiro","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib102","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.freeradbiomed.2010.09.029","article-title":"Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster","volume":"49","author":"Mockett","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib103","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1474-9726.2008.00449.x","article-title":"The overexpression of major antioxidant enzymes does not extend the lifespan of mice","volume":"8","author":"P\u00e9rez","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib104","doi-asserted-by":"crossref","first-page":"526","DOI":"10.7326\/0003-4819-107-4-526","article-title":"Oxygen radicals and human disease","volume":"107","author":"Cross","year":"1987","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cmet.2026.02.010_bib105","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib106","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","article-title":"Physiological roles of mitochondrial reactive oxygen species","volume":"48","author":"Sena","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib107","article-title":"Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases","volume":"10","author":"Huang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cmet.2026.02.010_bib108","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hep.32148","article-title":"Therapeutic targeting of hepatic ACSL4 ameliorates NASH in mice","volume":"75","author":"Duan","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.cmet.2026.02.010_bib109","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbi.2023.02.012","article-title":"ACSL4 promotes microglia-mediated neuroinflammation by regulating lipid metabolism and VGLL4 expression","volume":"109","author":"Zhou","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cmet.2026.02.010_bib110","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbi.2021.01.003","article-title":"ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation","volume":"93","author":"Cui","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.cmet.2026.02.010_bib111","article-title":"FTO deficiency in older livers exacerbates ferroptosis during ischaemia\/reperfusion injury by upregulating ACSL4 and TFRC","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.02.010_bib112","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mad.2017.11.012","article-title":"Ferrosenescence: The iron age of neurodegeneration?","volume":"174","author":"Sfera","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cmet.2026.02.010_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117081","article-title":"Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis","volume":"177","author":"Hong","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.cmet.2026.02.010_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellin.2025.100254","article-title":"Gene therapy strategies for aging intervention","volume":"4","author":"Jing","year":"2025","journal-title":"Cell Insight"},{"key":"10.1016\/j.cmet.2026.02.010_bib115","doi-asserted-by":"crossref","first-page":"1203S","DOI":"10.1093\/ajcn\/54.6.1203s","article-title":"Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis","volume":"54","author":"Nishikimi","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cmet.2026.02.010_bib116","doi-asserted-by":"crossref","first-page":"13685","DOI":"10.1016\/S0021-9258(17)36884-9","article-title":"Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man","volume":"269","author":"Nishikimi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2026.02.010_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3164\/jcbn.20-181","article-title":"Ascorbate is a multifunctional micronutrient whose synthesis is lacking in primates","volume":"69","author":"Fujii","year":"2021","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.cmet.2026.02.010_bib118","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/dom.13571","article-title":"Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial","volume":"21","author":"Mason","year":"2019","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cmet.2026.02.010_bib119","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.aaa1356","article-title":"Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging","volume":"348","author":"Zhang","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib120","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41592-023-01943-7","article-title":"Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender","volume":"20","author":"Fleming","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cmet.2026.02.010_bib121","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.cmet.2026.02.010_bib122","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib123","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib124","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cmet.2026.02.010_bib125","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib126","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.02.010_bib127","series-title":"Ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2009"},{"key":"10.1016\/j.cmet.2026.02.010_bib128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.cmet.2026.02.010_bib129","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41587-020-0605-1","article-title":"Cell type prioritization in single-cell data","volume":"39","author":"Skinnider","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.cmet.2026.02.010_bib130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cmet.2026.02.010_bib131","doi-asserted-by":"crossref","first-page":"5","DOI":"10.6026\/97320630002005","article-title":"Mfuzz: a software package for soft clustering of microarray data","volume":"2","author":"Kumar","year":"2007","journal-title":"Bioinformation"},{"key":"10.1016\/j.cmet.2026.02.010_bib132","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.cmet.2026.02.010_bib133","article-title":"SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions","volume":"46","author":"Zhou","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib134","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.cmet.2026.02.010_bib135","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib136","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.cmet.2026.02.010_bib137","doi-asserted-by":"crossref","DOI":"10.54294\/uvnhin","article-title":"Advanced normalization tools, V1.0","author":"Avants","year":"2009","journal-title":"Insight Journal"},{"key":"10.1016\/j.cmet.2026.02.010_bib138","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput. Biomed. Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib139","article-title":"BrainNet Viewer: a network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cmet.2026.02.010_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116137","article-title":"MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation","volume":"202","author":"Tournier","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.cmet.2026.02.010_bib141","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.cmet.2026.02.010_bib142","unstructured":"Delano, W.L. (2002) PyMOL: an Open-Source Molecular Graphics Tool."},{"key":"10.1016\/j.cmet.2026.02.010_bib143","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jcc.20291","article-title":"GROMACS: fast, flexible, and free","volume":"26","author":"Van Der Spoel","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.cmet.2026.02.010_bib144","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s13238-018-0517-8","article-title":"Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome","volume":"9","author":"Wu","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib145","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10068","article-title":"PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype","volume":"6","author":"Duan","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.02.010_bib146","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-017-0003-0","article-title":"ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells","volume":"4","author":"Wang","year":"2018","journal-title":"Cell Discov."},{"key":"10.1016\/j.cmet.2026.02.010_bib147","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/cr.2017.86","article-title":"Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib148","article-title":"A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis","volume":"14","author":"Huang","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib149","article-title":"A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body","volume":"4","author":"Sun","year":"2023","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.cmet.2026.02.010_bib150","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.18632\/aging.202460","article-title":"Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest","volume":"13","author":"Chen","year":"2021","journal-title":"Aging (Milano)"},{"key":"10.1016\/j.cmet.2026.02.010_bib151","doi-asserted-by":"crossref","DOI":"10.1177\/1179069518820323","article-title":"Assessment of improvement in oxidative stress indices with resocialization in memory retrieval in Y-maze in male rats","volume":"12","author":"Famitafreshi","year":"2018","journal-title":"J. Exp. Neurosci."},{"key":"10.1016\/j.cmet.2026.02.010_bib152","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nchembio.935","article-title":"Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells","volume":"8","author":"Liu","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib153","first-page":"37","article-title":"A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicron in vivo","volume":"14","author":"Zuo","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib154","article-title":"Raddeanin A enhances mitochondrial DNA-cGAS\/STING axis-mediated antitumor immunity by targeting transactive responsive DNA-binding protein 43","volume":"10","author":"Yin","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.cmet.2026.02.010_bib155","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk5382","article-title":"Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction","volume":"384","author":"Liu","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib156","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2024.09.009","article-title":"Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation","volume":"37","author":"Lam","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2026.02.010_bib157","article-title":"Lipidome atlas of the developing heart uncovers dynamic membrane lipid attributes underlying cardiac structural and metabolic maturation","volume":"2022","author":"Miao","year":"2022","journal-title":"Research (Wash D. C)"},{"key":"10.1016\/j.cmet.2026.02.010_bib158","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/s42255-021-00425-4","article-title":"A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19","volume":"3","author":"Lam","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2026.02.010_bib159","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.scib.2020.07.023","article-title":"A robust, integrated platform for comprehensive analyses of acyl-coenzyme As and acyl-carnitines revealed chain length-dependent disparity in fatty acyl metabolic fates across Drosophila development","volume":"65","author":"Lam","year":"2020","journal-title":"Sci. Bull."},{"key":"10.1016\/j.cmet.2026.02.010_bib160","doi-asserted-by":"crossref","DOI":"10.1093\/lifemeta\/loae004","article-title":"Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production","volume":"3","author":"Li","year":"2024","journal-title":"Life Metab."},{"key":"10.1016\/j.cmet.2026.02.010_bib161","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1021\/ac1027353","article-title":"Stable isotope labeling by essential nutrients in cell culture for preparation of labeled coenzyme A and its thioesters","volume":"83","author":"Basu","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cmet.2026.02.010_bib162","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28355-z","article-title":"A mammalian methylation array for profiling methylation levels at conserved sequences","volume":"13","author":"Arneson","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.02.010_bib163","doi-asserted-by":"crossref","DOI":"10.1126\/science.abq5693","article-title":"DNA methylation networks underlying mammalian traits","volume":"381","author":"Haghani","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.02.010_bib164","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/procel\/pwad039","article-title":"A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes","volume":"15","author":"Yang","year":"2024","journal-title":"Protein Cell"},{"key":"10.1016\/j.cmet.2026.02.010_bib165","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwaa127","article-title":"A single-cell transcriptomic atlas of primate pancreatic islet aging","volume":"8","author":"Li","year":"2021","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.cmet.2026.02.010_bib166","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.02.010_bib167","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1021\/acs.jcim.3c01053","article-title":"SwissParam 2023: a modern web-based tool for efficient small molecule parametrization","volume":"63","author":"Bugnon","year":"2023","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.cmet.2026.02.010_bib168","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.cmet.2026.02.010_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117997","article-title":"A comprehensive macaque fMRI pipeline and hierarchical atlas","volume":"235","author":"Jung","year":"2021","journal-title":"Neuroimage"},{"key":"10.1016\/j.cmet.2026.02.010_bib170","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.neuroimage.2007.02.016","article-title":"Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution","volume":"35","author":"Tournier","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.cmet.2026.02.010_bib171","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging","volume":"6","author":"Behrens","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cmet.2026.02.010_bib172","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1098\/rstb.2005.1639","article-title":"Probabilistic anatomical connectivity derived from the microscopic persistent angular structure of cerebral tissue","volume":"360","author":"Parker","year":"2005","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.cmet.2026.02.010_bib173","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.neuroimage.2012.06.005","article-title":"Anatomically-constrained tractography: improved diffusion MRI streamlines tractography through effective use of anatomical information","volume":"62","author":"Smith","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.cmet.2026.02.010_bib174","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neuroimage.2015.06.092","article-title":"SIFT2: Enabling dense quantitative assessment of brain white matter connectivity using streamlines tractography","volume":"119","author":"Smith","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.cmet.2026.02.010_bib175","doi-asserted-by":"crossref","unstructured":"Smith, R.E., Raffelt, D., Tournier, J.-D., and Connelly, A. (2020). Quantitative streamlines tractography: methods and inter-subject normalisation. https:\/\/doi.org\/10.31219\/osf.io\/c67kn.","DOI":"10.31219\/osf.io\/c67kn"},{"key":"10.1016\/j.cmet.2026.02.010_bib176","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060159","article-title":"Mapping the structural core of human cerebral cortex","volume":"6","author":"Hagmann","year":"2008","journal-title":"PLOS Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib177","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.neuroimage.2014.09.034","article-title":"Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance","volume":"104","author":"Malone","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.cmet.2026.02.010_bib178","doi-asserted-by":"crossref","first-page":"D571","DOI":"10.1093\/nar\/gkac935","article-title":"FerrDb V2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations","volume":"51","author":"Zhou","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cmet.2026.02.010_bib179","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-020-01990-9","article-title":"A multidimensional systems biology analysis of cellular senescence in aging and disease","volume":"21","author":"Avelar","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.cmet.2026.02.010_bib180","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.02.010_bib181","doi-asserted-by":"crossref","first-page":"5975","DOI":"10.1038\/onc.2008.213","article-title":"Critical pathways in cellular senescence and immortalization revealed by gene expression profiling","volume":"27","author":"Fridman","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.cmet.2026.02.010_bib182","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/procel\/pwae011","article-title":"DNA methylation clocks for estimating biological age in Chinese cohorts","volume":"15","author":"Zheng","year":"2024","journal-title":"Protein Cell"}],"updated-by":[{"DOI":"10.1016\/j.cmet.2026.08.011","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000}},{"DOI":"10.1016\/j.cmet.2026.08.011","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000}}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413126000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413126000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:31:30Z","timestamp":1792215090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413126000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":182,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1550413126000537"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2026.02.010","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2026.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}