{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:29:05Z","timestamp":1786483745510,"version":"build-2736575974"},"reference-count":7,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK140330"],"award-info":[{"award-number":["R01 DK140330"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2152221"],"award-info":[{"award-number":["2152221"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["1R01 NS134932"],"award-info":[{"award-number":["1R01 NS134932"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.cmet.2026.06.016","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:35:07Z","timestamp":1783438507000},"page":"1267-1268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycerol activates tissue-nonspecific alkaline phosphatase for temperature and bone homeostasis"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-2228","authenticated-orcid":false,"given":"Sarah R.","family":"Coffey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-7400","authenticated-orcid":false,"given":"Jonathan R.","family":"Brestoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2026.06.016_bib1","series-title":"Phosphatase Modulators","first-page":"27","article-title":"Multisystemic Functions of Alkaline Phosphatases","author":"Buchet","year":"2013"},{"key":"10.1016\/j.cmet.2026.06.016_bib2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11302-005-5435-6","article-title":"Alkaline Phosphatases","volume":"2","author":"Mill\u00e1n","year":"2006","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.cmet.2026.06.016_bib3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/s41586-021-03533-z","article-title":"Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine","volume":"593","author":"Sun","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.06.016_bib4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2012.09.010","article-title":"Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria","volume":"151","author":"Fedorenko","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.06.016_bib5","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1038\/s41467-025-58294-4","article-title":"The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT","volume":"16","author":"Bunk","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.06.016_bib6","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/s41586-026-10396-9","article-title":"Glycerol-driven TNAP activation in thermogenesis and mineralization","volume":"654","author":"Hussain","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.06.016_bib7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00223-015-0079-1","article-title":"Alkaline Phosphatase and Hypophosphatasia","volume":"98","author":"Mill\u00e1n","year":"2016","journal-title":"Calcif. Tissue Int."}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413126002421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1550413126002421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:45:10Z","timestamp":1786481110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1550413126002421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1550413126002421"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2026.06.016","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycerol activates tissue-nonspecific alkaline phosphatase for temperature and bone homeostasis","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2026.06.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}