{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:36:45Z","timestamp":1792773405179,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Metabolism"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.cmet.2026.09.020","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:05:04Z","timestamp":1792767904000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic force sensing by bone delays aging and extends lifespan"],"prefix":"10.1016","author":[{"given":"Zhimin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shencai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuju","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junnan","family":"Huangfu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bocheng","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenquan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-4781","authenticated-orcid":false,"given":"Xiaochun","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmet.2026.09.020_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41586-018-0457-8","article-title":"Facing up to the global challenges of ageing","volume":"561","author":"Partridge","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.09.020_bib2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0140-6736(25)00184-9","article-title":"Neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing","volume":"405","author":"Tari","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.cmet.2026.09.020_bib3","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1001\/jama.2022.21680","article-title":"Effects of mindfulness training and exercise on cognitive function in older adults: a randomized clinical trial","volume":"328","author":"Lenze","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.cmet.2026.09.020_bib4","article-title":"Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study","volume":"14","author":"Feng","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.09.020_bib5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.tem.2025.04.001","article-title":"Dietary and pharmacological energy restriction and exercise for healthspan extension","volume":"36","author":"Cagigas","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.cmet.2026.09.020_bib6","doi-asserted-by":"crossref","first-page":"e306","DOI":"10.1016\/S2468-2667(24)00054-9","article-title":"The association between disability and mortality: a mixed-methods study","volume":"9","author":"Kuper","year":"2024","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.cmet.2026.09.020_bib7","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1007\/s11357-024-01329-3","article-title":"Active longevity and aging: dissecting the impacts of physical and sedentary behaviors on longevity and age acceleration","volume":"47","author":"Lu","year":"2024","journal-title":"GeroScience"},{"key":"10.1016\/j.cmet.2026.09.020_bib8","article-title":"Mimicking the health benefits of exercise","volume":"24","author":"Crunkhorn","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.cmet.2026.09.020_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.cmet.2017.02.009","article-title":"Enhanced protein translation underlies improved metabolic and physical adaptations to different exercise training modes in young and old humans","volume":"25","author":"Robinson","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2026.09.020_bib10","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1016\/j.cell.2025.06.001","article-title":"Systematic profiling reveals betaine as an exercise mimetic for geroprotection","volume":"188","author":"Geng","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.09.020_bib11","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s41580-025-00883-8","article-title":"Biomarkers of ageing of humans and non-human primates","volume":"26","author":"Wu","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.09.020_bib12","doi-asserted-by":"crossref","first-page":"14522","DOI":"10.18632\/aging.203051","article-title":"Effects of exercise on cellular and tissue aging","volume":"13","author":"Carapeto","year":"2021","journal-title":"Aging US"},{"key":"10.1016\/j.cmet.2026.09.020_bib13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41580-023-00606-x","article-title":"Exercise metabolism and adaptation in skeletal muscle","volume":"24","author":"Smith","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.09.020_bib14","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/acel.12126","article-title":"The influence of skeletal muscle on systemic aging and lifespan","volume":"12","author":"Demontis","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.09.020_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112685","article-title":"Exercise and exerkines: mechanisms and roles in anti-aging and disease prevention","volume":"200","author":"Lu","year":"2025","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.cmet.2026.09.020_bib16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-023-06877-w","article-title":"Temporal dynamics of the multi-omic response to endurance exercise training","volume":"629","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.09.020_bib17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41574-019-0170-1","article-title":"Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity","volume":"15","author":"Pagnotti","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cmet.2026.09.020_bib18","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.09.020_bib19","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1593","article-title":"Skeletal remodeling in health and disease","volume":"13","author":"Zaidi","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2026.09.020_bib20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature10763","article-title":"The contribution of bone to whole-organism physiology","volume":"481","author":"Karsenty","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.09.020_bib21","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41580-024-00770-8","article-title":"The role of the haematopoietic stem cell niche in development and ageing","volume":"26","author":"Cain","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.09.020_bib22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1210\/er.2012-1026","article-title":"The osteocyte: an endocrine cell \u2026 and more","volume":"34","author":"Dallas","year":"2013","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.cmet.2026.09.020_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41413-018-0019-6","article-title":"Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts","volume":"6","author":"Han","year":"2018","journal-title":"Bone Res."},{"key":"10.1016\/j.cmet.2026.09.020_bib24","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41574-025-01162-4","article-title":"The role of bone in whole-body energy metabolism","volume":"21","author":"Lecka-Czernik","year":"2025","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.cmet.2026.09.020_bib25","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10522-016-9641-0","article-title":"Physical activity in older age: perspectives for healthy ageing and frailty","volume":"17","author":"Mcphee","year":"2016","journal-title":"Biogerontology"},{"key":"10.1016\/j.cmet.2026.09.020_bib26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature25743","article-title":"Structure and mechanogating mechanism of the piezo1 channel","volume":"554","author":"Zhao","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.09.020_bib27","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41580-024-00773-5","article-title":"Mechanisms of mechanotransduction and physiological roles of PIEZO channels","volume":"25","author":"Xiao","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.cmet.2026.09.020_bib28","article-title":"Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.09.020_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13846","article-title":"Piezo1 opposes age-associated cortical bone loss","volume":"22","author":"Li","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.cmet.2026.09.020_bib30","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023999118","article-title":"Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-\u03b2 signaling","volume":"118","author":"Schurman","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cmet.2026.09.020_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101608","article-title":"Osteocytes in bone aging: advances, challenges, and future perspectives","volume":"77","author":"Cui","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.cmet.2026.09.020_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.cmet.2026.09.020_bib33","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1016\/j.cell.2024.08.021","article-title":"Metformin decelerates aging clock in male monkeys","volume":"187","author":"Yang","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.09.020_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbm.2025.100115","article-title":"Toward a clear relationship between mechanical signals and bone adaptation","volume":"3","author":"Wang","year":"2025","journal-title":"Mechanobiol. Med."},{"key":"10.1016\/j.cmet.2026.09.020_bib35","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jbiomech.2013.10.052","article-title":"Experimental and finite element analysis of strains induced by axial tibial compression in young-adult and old female c57bl\/6 mice","volume":"47","author":"Patel","year":"2014","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmet.2026.09.020_bib36","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-021-04183-x","article-title":"Exercise plasma boosts memory and dampens brain inflammation via clusterin","volume":"600","author":"De Miguel","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.cmet.2026.09.020_bib37","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/s41591-018-0131-6","article-title":"The exerkine apelin reverses age-associated sarcopenia","volume":"24","author":"Vinel","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.cmet.2026.09.020_bib38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.aaw2622","article-title":"Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain","volume":"369","author":"Horowitz","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.cmet.2026.09.020_bib39","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s43587-024-00612-4","article-title":"Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism","volume":"4","author":"Chen","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.cmet.2026.09.020_bib40","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.stem.2022.04.017","article-title":"Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues","volume":"29","author":"Ma","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cmet.2026.09.020_bib41","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/s42255-022-00609-6","article-title":"Systemic induction of senescence in young mice after single heterochronic blood exchange","volume":"4","author":"Jeon","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2026.09.020_bib42","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2016.02.043","article-title":"Bone and muscle endocrine functions: unexpected paradigms of inter-organ communication","volume":"164","author":"Karsenty","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.09.020_bib43","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nrn1176","article-title":"PEDF: a multifaceted neurotrophic factor","volume":"4","author":"Tombran-Tink","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cmet.2026.09.020_bib44","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn1209-1481","article-title":"Pigment epithelium-derived growth factor: modulating adult neural stem cell self-renewal","volume":"12","author":"Chojnacki","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.cmet.2026.09.020_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.111891","article-title":"Pigment epithelium-derived factor regulation of neuronal and stem cell fate","volume":"389","author":"Brook","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.cmet.2026.09.020_bib46","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/aps.2016.9","article-title":"Metrnl: a secreted protein with new emerging functions","volume":"37","author":"Zheng","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cmet.2026.09.020_bib47","article-title":"A novel piezo1 agonist promoting mesenchymal stem cell proliferation and osteogenesis to attenuate disuse osteoporosis","volume":"4","author":"Hao","year":"2024","journal-title":"Small Sci."},{"key":"10.1016\/j.cmet.2026.09.020_bib48","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-023-00515-3","article-title":"S100a6: molecular function and biomarker role","volume":"11","author":"Wang","year":"2023","journal-title":"Biomark. Res."},{"key":"10.1016\/j.cmet.2026.09.020_bib49","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.cell.2020.02.008","article-title":"Caloric restriction reprograms the single-cell transcriptional landscape of rattus norvegicus aging","volume":"180","author":"Ma","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cmet.2026.09.020_bib50","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-023-02840-8","article-title":"Astrocyte-derived SerpinA3n promotes neuroinflammation and epileptic seizures by activating the NF-\u03bab signaling pathway in mice with temporal lobe epilepsy","volume":"20","author":"Liu","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.cmet.2026.09.020_bib51","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s42255-024-00989-x","article-title":"Osteocyte-derived sclerostin impairs cognitive function during ageing and alzheimer\u2019s disease progression","volume":"6","author":"Shi","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cmet.2026.09.020_bib52","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.cmet.2024.03.006","article-title":"An integrated multi-omics analysis reveals osteokines involved in global regulation","volume":"36","author":"Liang","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.cmet.2026.09.020_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.domaniend.2018.04.004","article-title":"Lactation-related changes in tissue expression of PEDF in dairy cows","volume":"64","author":"Sadri","year":"2018","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.cmet.2026.09.020_bib54","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/ijo.2010.212","article-title":"Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells","volume":"35","author":"Famulla","year":"2011","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.cmet.2026.09.020_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111478","article-title":"The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease","volume":"196","author":"Abooshahab","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.cmet.2026.09.020_bib56","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1111\/bph.16436","article-title":"Insulin-degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver","volume":"181","author":"Andres","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.cmet.2026.09.020_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154735","article-title":"Loss of postprandial insulin clearance control by insulin-degrading enzyme drives dysmetabolism traits","volume":"118","author":"Borges","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.cmet.2026.09.020_bib58","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41401-025-01491-0","article-title":"Kruppel-like factor 9 alleviates Alzheimer's disease via IDE-mediated abeta degradation","volume":"46","author":"Feng","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.cmet.2026.09.020_bib59","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05401","article-title":"Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF","volume":"3","author":"Cheng","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.cmet.2026.09.020_bib60","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1074\/jbc.272.5.2668","article-title":"Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase\/ERK kinase kinase 3 (MEKK) derivative","volume":"272","author":"Ellinger-Ziegelbauer","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.cmet.2026.09.020_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13071780","article-title":"PEDF and its role in metabolic disease, angiogenesis, cardiovascular disease, and diabetes","volume":"13","author":"Dass","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.cmet.2026.09.020_bib62","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-025-08055-4","article-title":"Insulin-degrading enzyme confers neuroprotection in parkinson\u2019s disease by inhibiting the hippo signaling pathway","volume":"16","author":"Zheng","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.cmet.2026.09.020_bib63","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.stem.2024.09.001","article-title":"A human organoid drug screen identifies \u03b12-adrenergic receptor signaling as a therapeutic target for cartilage regeneration","volume":"31","author":"Wei","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cmet.2026.09.020_bib64","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1182\/blood.2020007731","article-title":"Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment","volume":"137","author":"Xiao","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.cmet.2026.09.020_bib65","article-title":"Osteocytes\/osteoblasts produce SAA3 to regulate hepatic metabolism of cholesterol","volume":"11","author":"Huang","year":"2024","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.cmet.2026.09.020_bib66","article-title":"Prostaglandin e2 mediates sensory nerve regulation of bone homeostasis","volume":"10","author":"Chen","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cmet.2026.09.020_bib67","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.clinbiomech.2008.12.007","article-title":"Internal loads in the human tibia during gait","volume":"24","author":"Wehner","year":"2009","journal-title":"Clin. Biomech. (Bristol)"},{"key":"10.1016\/j.cmet.2026.09.020_bib68","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1016\/j.jbiomech.2007.05.024","article-title":"Bone contact forces on the distal tibia during the stance phase of running","volume":"40","author":"Sasimontonkul","year":"2007","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmet.2026.09.020_bib69","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.5385","article-title":"Western blotting and immunoprecipitation of native human PIEZO1 channels","volume":"15","author":"Li","year":"2025","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.cmet.2026.09.020_bib70","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s13311-018-0628-1","article-title":"Pigment epithelium-derived factor plays a role in alzheimer's disease by negatively regulating a\u03b242","volume":"15","author":"Huang","year":"2018","journal-title":"Neurotherapeutics"}],"container-title":["Cell Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155041312600433X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S155041312600433X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:05:11Z","timestamp":1792767911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S155041312600433X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":70,"alternative-id":["S155041312600433X"],"URL":"https:\/\/doi.org\/10.1016\/j.cmet.2026.09.020","relation":{},"ISSN":["1550-4131"],"issn-type":[{"value":"1550-4131","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic force sensing by bone delays aging and extends lifespan","name":"articletitle","label":"Article Title"},{"value":"Cell Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmet.2026.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}