{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:50:05Z","timestamp":1790988605655,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FI14\/00230"],"award-info":[{"award-number":["FI14\/00230"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.cmi.2015.04.012","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T02:30:43Z","timestamp":1431052243000},"page":"786.e9-786.e17","source":"Crossref","is-referenced-by-count":88,"title":["KLIC-score for predicting early failure in prosthetic joint infections treated with debridement, implant retention and antibiotics"],"prefix":"10.1016","volume":"21","author":[{"given":"E.","family":"Tornero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Morata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Mart\u00ednez-Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Climent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Garc\u00eda-Velez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Garc\u00eda-Ramiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mensa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2015.04.012_bib1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America","volume":"56","author":"Osmon","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.04.012_bib2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1086\/499234","article-title":"Outcome of prosthetic joint infections treated with debridement and retention of components","volume":"42","author":"Marculescu","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.04.012_bib3","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/clinids\/24.5.914","article-title":"Staphylococcus aureus prosthetic joint infection treated with debridement and prosthesis retention","volume":"24","author":"Brandt","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.04.012_bib4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.arth.2009.04.028","article-title":"The fate of acute methicillin-resistant Staphylococcus aureus periprosthetic knee infections treated by open debridement and retention of components","volume":"24","author":"Bradbury","year":"2009","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.cmi.2015.04.012_bib5","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1007\/s11999-011-1910-2","article-title":"Infection control rate of irrigation and debridement for periprosthetic joint infection","volume":"469","author":"Koyonos","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.cmi.2015.04.012_bib6","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.arth.2010.01.104","article-title":"Irrigation\u00a0and debridement in the management of prosthetic joint infection: traditional indications revisited","volume":"25","author":"Azzam","year":"2010","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.cmi.2015.04.012_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s11999-012-2373-9","article-title":"Failure of irrigation and debridement for early postoperative periprosthetic infection","volume":"471","author":"Fehring","year":"2012","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.cmi.2015.04.012_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjmed.2006.03.036","article-title":"Conservative treatment of staphylococcal prosthetic joint infections in elderly patients","volume":"119","author":"Barber\u00e1n","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.cmi.2015.04.012_bib9","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1111\/j.1469-0691.2010.03333.x","article-title":"Early prosthetic joint infection: outcomes with debridement and implant retention followed by antibiotic therapy","volume":"17","author":"Cobo","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2015.04.012_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1469-0691.2010.03244.x","article-title":"Outcome and predictors of treatment failure in early post-surgical prosthetic joint infections due to Staphylococcus aureus treated with debridement","volume":"17","author":"Vilchez","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2015.04.012_bib11","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/jac\/dkp107","article-title":"One hundred and twelve infected arthroplasties treated with \u201cDAIR\u201d (debridement, antibiotics and implant retention): antibiotic duration and outcome","volume":"63","author":"Byren","year":"2009","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2015.04.012_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/cid\/cir402","article-title":"Outcome and predictors of treatment failure in total hip\/knee prosthetic joint infections due to Staphylococcus aureus","volume":"53","author":"Senneville","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.04.012_bib13","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s10096-010-0952-9","article-title":"Efficacy and safety of rifampin containing regimen for staphylococcal prosthetic joint infections treated with debridement and retention","volume":"29","author":"Helou El","year":"2010","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2015.04.012_bib14","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1001\/jama.279.19.1537","article-title":"Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial","volume":"279","author":"Zimmerli","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.cmi.2015.04.012_bib15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/cid\/cis746","article-title":"A\u00a0large multicenter study of methicillin-susceptible and methicillin-resistant Staphylococcus aureus prosthetic joint infections managed with implant retention","volume":"56","author":"Lora-Tamayo","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.04.012_bib16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/17453674.2013.859422","article-title":"2-stage revision recommended for treatment of fungal hip and knee prosthetic joint infections","volume":"84","author":"Kuiper","year":"2013","journal-title":"Acta Orthop"},{"key":"10.1016\/j.cmi.2015.04.012_bib17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11999-010-1434-1","article-title":"The Chitranjan Ranawat Award: fate of two-stage reimplantation after failed irrigation and debridement for periprosthetic knee infection","volume":"469","author":"Sherrell","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.cmi.2015.04.012_bib18","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s11999-010-1417-2","article-title":"Can this prosthesis be saved?: implant salvage attempts in infected primary TKA","volume":"469","author":"Gardner","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.cmi.2015.04.012_bib19","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/j.1469-0691.2006.01463.x","article-title":"Treatment of acute post-surgical infection of joint arthroplasty","volume":"12","author":"Soriano","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2015.04.012_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jhin.2010.03.012","article-title":"Risk factors for treatment failure in patients with prosthetic joint infections","volume":"75","author":"Lee","year":"2010","journal-title":"J\u00a0Hosp Infect"},{"key":"10.1016\/j.cmi.2015.04.012_bib21","first-page":"582","article-title":"Microbiological markers suggesting high inoculum size at time of surgery are risk factors for relapse in patients with Staphylococcus aureus prosthetic joint infection","volume":"65","author":"Bouaziz","year":"2012","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2015.04.012_bib22","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.arth.2012.01.003","article-title":"The preoperative prediction of success following irrigation and debridement with polyethylene exchange for hip and knee prosthetic joint infections","volume":"27","author":"Buller","year":"2012","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.cmi.2015.04.012_bib23","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1007\/s11999-011-2102-9","article-title":"New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society","volume":"469","author":"Parvizi","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.cmi.2015.04.012_bib24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/17453674.2014.927729","article-title":"Similar success rates for single and multiple debridement surgery for acute hip arthroplasty infection","volume":"85","author":"Moojen","year":"2014","journal-title":"Acta Orthop"},{"key":"10.1016\/j.cmi.2015.04.012_bib25","doi-asserted-by":"crossref","first-page":"S656","DOI":"10.1097\/CCM.0b013e3181f2453a","article-title":"We should be measuring genomic bacterial load and virulence factors","volume":"38","author":"Lisboa","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.cmi.2015.04.012_bib26","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1128\/AAC.40.12.2686","article-title":"Correlation of pharmacodynamic parameters of five beta-lactam antibiotics with therapeutic efficacies in an animal model","volume":"40","author":"Soriano","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2015.04.012_bib27","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1128\/AAC.48.12.4665-4672.2004","article-title":"Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in\u00a0vitro pharmacodynamic model","volume":"48","author":"LaPlante","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2015.04.012_bib28","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s10096-005-0011-0","article-title":"Rapid decrease of free vancomycin in dense staphylococcal cultures","volume":"24","author":"Ekdahl","year":"2005","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2015.04.012_bib29","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/infdis\/jiu514","article-title":"Effect of biofilms on recalcitrance of staphylococcal joint infection to antibiotic treatment","volume":"211","author":"Dastgheyb","year":"2015","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2015.04.012_bib30","first-page":"1","article-title":"Guiding empirical antibiotic therapy in orthopaedics: the microbiology of prosthetic joint infection managed by debridement, irrigation and prosthesis retention","volume":"55","author":"Moran","year":"2007","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2015.04.012_bib31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jhin.2012.09.005","article-title":"Early onset prosthetic hip and knee joint infection: treatment and outcomes in Victoria, Australia","volume":"82","author":"Peel","year":"2012","journal-title":"J\u00a0Hosp Infect"},{"key":"10.1016\/j.cmi.2015.04.012_bib32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s15010-014-0584-6","article-title":"Characteristics and treatment outcomes of 69 cases with early prosthetic joint infections of the hip and knee","volume":"42","author":"Achermann","year":"2014","journal-title":"Infection"},{"key":"10.1016\/j.cmi.2015.04.012_bib33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.diagmicrobio.2014.05.022","article-title":"High doses of daptomycin (10 mg\/kg\/d) plus rifampin for the treatment of staphylococcal prosthetic joint infection managed with implant retention: a comparative study","volume":"80","author":"Lora-Tamayo","year":"2014","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15004231?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15004231?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T15:14:58Z","timestamp":1566659698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X15004231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S1198743X15004231"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2015.04.012","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}