{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:15:21Z","timestamp":1791213321470,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.cmi.2015.09.028","type":"journal-article","created":{"date-parts":[[2015,10,17]],"date-time":"2015-10-17T02:40:13Z","timestamp":1445049613000},"page":"98.e7-98.e10","source":"Crossref","is-referenced-by-count":9,"title":["Protease inhibitor monotherapy is effective in controlling human immunodeficiency virus 1 shedding in the male genital tract"],"prefix":"10.1016","volume":"22","author":[{"given":"A.","family":"Torres-Cornejo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.J.","family":"BenMarzouk-Hidalgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Viciana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"L\u00f3pez-Ruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.F.","family":"L\u00f3pez-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Guti\u00e9rrez-Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2015.09.028_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa1105243","article-title":"Prevention of HIV-1 infection with early antiretroviral therapy","volume":"365","author":"Cohen","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cmi.2015.09.028_bib2","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1056\/NEJM200003303421303","article-title":"Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai project study group","volume":"342","author":"Quinn","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cmi.2015.09.028_bib3","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1128\/JVI.71.8.6271-6275.1997","article-title":"High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors","volume":"71","author":"Gupta","year":"1997","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.cmi.2015.09.028_bib4","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1097\/00002030-199708000-00006","article-title":"Quantification of HIV in semen: correlation with antiviral treatment and immune status","volume":"11","author":"Vernazza","year":"1997","journal-title":"AIDS"},{"key":"10.1016\/j.cmi.2015.09.028_bib5","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJM199812173392502","article-title":"Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy","volume":"339","author":"Zhang","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cmi.2015.09.028_bib6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1086\/514213","article-title":"Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood","volume":"177","author":"Coombs","year":"1998","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2015.09.028_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/OLQ.0b013e318141fe9b","article-title":"Human immunodeficiency virus viral load in blood plasma and semen: review and implications of empirical findings","volume":"35","author":"Kalichman","year":"2008","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.cmi.2015.09.028_bib8","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/QAD.0b013e328352ae09","article-title":"Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma on a 2002\u20132011 survey","volume":"26","author":"Lambert-Niclot","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.cmi.2015.09.028_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1742-6405-10-3","article-title":"Boosted protease inhibitor monotherapy in HIV-infected adults: outputs from a pan-European expert panel meeting","volume":"10","author":"Arribas","year":"2013","journal-title":"AIDS Res Ther"},{"key":"10.1016\/j.cmi.2015.09.028_bib10","series-title":"Efficacy of PI monotherapy versus triple therapy for 2202 patients in 12 randomised trials. 12th International Congress on Drug Therapy in HIV Infection","author":"Arribas","year":"2014"},{"key":"10.1016\/j.cmi.2015.09.028_bib11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3851\/IMP2737","article-title":"HIV-1 genital shedding in HIV-infected patients randomized to second-line lopinavir\/ritonavir monotherapy versus tenofovir\/lamivudine\/lopinavir\/ritonavir","volume":"19","author":"Bunupuradah","year":"2014","journal-title":"Antivir Ther"},{"key":"10.1016\/j.cmi.2015.09.028_bib12","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/jac\/dkn098","article-title":"Absence of HIV-1 shedding in male genital tract after 1 year of first-line lopinavir\/ritonavir alone or in combination with zidovudine\/lamivudine","volume":"61","author":"Ghosn","year":"2008","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2015.09.028_bib13","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1310\/hct1006-368","article-title":"Monotherapy with lopinavir\/ritonavir as maintenance after HIV-1 viral suppression: results of a 96-week randomized, controlled, open-label, pilot trial (Kalmo study)","volume":"10","author":"Nunes","year":"2009","journal-title":"HIV Clin Trials"},{"key":"10.1016\/j.cmi.2015.09.028_bib14","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1128\/AAC.00725-10","article-title":"Low frequency of intermittent HIV-1 semen excretion in patients treated with darunavir-ritonavir at 600\/100 milligrams twice a day plus two nucleoside reverse transcriptase inhibitors or monotherapy","volume":"54","author":"Lambert-Niclot","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2015.09.028_bib15","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3851\/IMP1919","article-title":"Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract","volume":"16","author":"Else","year":"2011","journal-title":"Antivir Ther"},{"issue":"14","key":"10.1016\/j.cmi.2015.09.028_bib16","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1097\/00002030-200409240-00014","article-title":"Penetration of enfuvirtide, tenofovir, efavirenz, and protease inhibitors in the genital tract of HIV-1-infected men","volume":"18","author":"Ghosn","year":"2004","journal-title":"AIDS"},{"issue":"16","key":"10.1016\/j.cmi.2015.09.028_bib17","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1097\/QAD.0b013e32833ead18","article-title":"Darunavir concentrations exceed the protein-corrected EC50 for wild-type HIV in the semen of HIV-1-infected men","volume":"24","author":"Taylor","year":"2010","journal-title":"AIDS"},{"issue":"2","key":"10.1016\/j.cmi.2015.09.028_bib18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2217\/14622416.10.2.311","article-title":"ABCB1 polymorphisms and the concentrations of lopinavir and ritonavir in blood, semen and saliva of HIV-infected men under antiretroviral therapy","volume":"10","author":"Estrela Rde","year":"2009","journal-title":"Pharmacogenomics"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15008988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15008988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T22:12:35Z","timestamp":1599689555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X15008988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1198743X15008988"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2015.09.028","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}