{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:11:37Z","timestamp":1791756697503,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"vor","delay-in-days":366,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.cmi.2015.10.017","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T23:45:25Z","timestamp":1445643925000},"page":"179.e1-179.e10","source":"Crossref","is-referenced-by-count":78,"title":["Increased risk of infections and infection-related mortality in children undergoing haematopoietic stem cell transplantation compared to conventional anticancer therapy: a multicentre nationwide study"],"prefix":"10.1016","volume":"22","author":[{"given":"J.","family":"Styczynski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Czyzewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wysocki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Gryniewicz-Kwiatkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kolodziejczyk-Gietka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Salamonowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Hutnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Zajac-Spychala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zaucha-Prazmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chelmecka-Wiktorczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Siewiera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fraczkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Malas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tomaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Irga-Jaworska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Plonowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ociepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pierlejewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Gamrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Urbanek-Dadela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gozdzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Stolpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dembowska-Baginska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Perek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Matysiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wachowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kowalczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Balwierz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kalwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chybicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Badowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Szczepanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Drozynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Krawczuk-Rybak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Urasinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Mlynarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Woszczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Karolczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sobol-Milejska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2015.10.017_bib1","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa1004383","article-title":"Reduced mortality after allogeneic hematopoietic-cell transplantation","volume":"363","author":"Gooley","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cmi.2015.10.017_bib2","unstructured":"Pasquini MC, Zhu X. Current use and outcome of hematopoietic stem cell transplantation: 2014 CIBMTR summary slides. Available at: http:\/\/www.cibmtr.org."},{"key":"10.1016\/j.cmi.2015.10.017_bib3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbmt.2012.08.012","article-title":"Timeline, epidemiology, and risk factors for bacterial, fungal, and viral infections in children and adolescents after allogeneic hematopoietic stem cell transplantation","volume":"19","author":"Srinivasan","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/tid.12165","article-title":"Early infections after autologous hematopoietic stem cell transplantation in children and adolescents: the St. Jude experience","volume":"16","author":"Srinivasan","year":"2014","journal-title":"Transpl Infect Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.cmi.2015.10.017_bib5","article-title":"Infection-related deaths in the haematopoietic stem cell transplant setting","volume":"47","author":"Sinko","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib6","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/sj.bmt.1705856","article-title":"Risk factors for fatal infectious complications developing late after allogeneic stem cell transplantation","volume":"40","author":"Bjorklund","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib7","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/bmt.2010.177","article-title":"Reduction of infection-related mortality after allogeneic PBSCT from HLA-identical siblings: longitudinal analysis from 1994 to 2008 at a single institution","volume":"46","author":"Martino","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib8","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1182\/asheducation-2013.1.428","article-title":"Multidrug-resistant bacteria: what is the threat?","volume":"2013","author":"Bassetti","year":"2013","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.cmi.2015.10.017_bib9","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.3324\/haematol.2013.091330","article-title":"Targeted therapy against multi-resistant bacteria in leukemic and hematopoietic stem cell transplant recipients: guidelines of the 4th European Conference on Infections in Leukemia (ECIL-4, 2011)","volume":"98","author":"Averbuch","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.cmi.2015.10.017_bib10","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3324\/haematol.2013.091025","article-title":"European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia","volume":"98","author":"Averbuch","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.cmi.2015.10.017_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1086\/323335","article-title":"Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus","volume":"34","author":"Ascioglu","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.10.017_bib12","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.10.017_bib13","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1016\/S1470-2045(14)70017-8","article-title":"Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation","volume":"15","author":"Groll","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.cmi.2015.10.017_bib14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1182\/asheducation.V2012.1.265.3800160","article-title":"Delayed opportunistic infections in hematopoietic stem cell transplantation patients: a surmountable challenge","volume":"2012","author":"Marr","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.cmi.2015.10.017_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/bmt.2008.162","article-title":"Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT","volume":"42","author":"Ljungman","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib16","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/bmt.2008.386","article-title":"Management of HSV, VZV and EBV infections in patients with hematological malignancies and after SCT: guidelines from the Second European Conference on Infections in Leukemia","volume":"43","author":"Styczynski","year":"2009","journal-title":"Bone Marrow Transplant"},{"issue":"Suppl. 2","key":"10.1016\/j.cmi.2015.10.017_bib17","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1038\/bmt.2008.289","article-title":"Prevention of infectious complications in pediatric HSCT","volume":"42","author":"Styczynski","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib18","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/bmt.2010.175","article-title":"European guidelines for antifungal management in leukemia and hematopoietic stem cell transplant recipients: summary of the ECIL 3\u20132009 update","volume":"46","author":"Maertens","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O","article-title":"Estimation of failure probabilities in the presence of competing risks: new representations of old estimators","volume":"18","author":"Gooley","year":"1999","journal-title":"Stat Med"},{"key":"10.1016\/j.cmi.2015.10.017_bib20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.cmi.2015.10.017_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/01.mph.0000155861.38641.ca","article-title":"Invasive fungal infections in pediatric oncology patients: 11-year experience at a single institution","volume":"27","author":"Rosen","year":"2005","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.cmi.2015.10.017_bib22","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/01.inf.0000220256.69385.2e","article-title":"Fungal infections in children with cancer: a prospective, multicenter surveillance study","volume":"25","author":"Castagnola","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.cmi.2015.10.017_bib23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2141.2009.08072.x","article-title":"Epidemiology of paediatric invasive fungal infections and a case-control study of risk factors in acute leukaemia or post stem cell transplant","volume":"149","author":"Hale","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cmi.2015.10.017_bib24","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1086\/339202","article-title":"Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients","volume":"34","author":"Marr","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.10.017_bib25","first-page":"986","article-title":"Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989\u20132003)","volume":"91","author":"Chamilos","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.cmi.2015.10.017_bib26","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1200\/JCO.2013.48.6522","article-title":"Intensive chemotherapy for childhood acute lymphoblastic leukemia: results of the randomized intercontinental trial ALL IC-BFM 2002","volume":"32","author":"Stary","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.cmi.2015.10.017_bib27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/bmt.2009.258","article-title":"Viral disease prevention after hematopoietic cell transplantation","volume":"44","author":"Zaia","year":"2009","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib28","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/cid\/cit391","volume":"57","author":"Styczynski","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2015.10.017_bib29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3109\/10428194.2012.718342","article-title":"Intrathecal therapy with rituximab in central nervous system involvement of post-transplant lymphoproliferative disorder","volume":"54","author":"Czyzewski","year":"2013","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.cmi.2015.10.017_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbmt.2008.10.024","article-title":"Blood stream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of Gram-negative rods and increasing antibiotic resistance","volume":"15","author":"Mikulska","year":"2009","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.cmi.2015.10.017_bib31","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3324\/haematol.2009.020867","article-title":"Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation","volume":"95","author":"Caselli","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.cmi.2015.10.017_bib32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s15010-007-6350-2","article-title":"Infectious complication in 314 patients after high-dose therapy and autologous hematopoietic stem cell transplantation: risk factors analysis and outcome","volume":"35","author":"Gil","year":"2007","journal-title":"Infection"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15009179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X15009179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T04:57:41Z","timestamp":1599713861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X15009179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1198743X15009179"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2015.10.017","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}