{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:26:10Z","timestamp":1791545170194,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Fondo de Investigaciones Sanitarias","award":["CD11\/00110"],"award-info":[{"award-number":["CD11\/00110"]}]},{"name":"Spanish Ministry for Economics and Competitivity","award":["SAF2014-54336-R"],"award-info":[{"award-number":["SAF2014-54336-R"]}]},{"DOI":"10.13039\/100005564","name":"Gilead","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MSD"},{"name":"Astellas"},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundacion SEIMC-GESIDA"},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Development Regional Fund"},{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"name":"bioMerieux"},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp & Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007110","name":"Schering-Plough","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007110","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Soria Melguizo SA"},{"name":"Ferrer International"},{"name":"the Europea Union"},{"name":"the ALBAN program"},{"name":"the Spanish Agency for International Cooperation"},{"name":"the Spanish Ministry of Culture and Education"},{"name":"the Spanish Health Research Fund"},{"DOI":"10.13039\/501100004587","name":"the Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Ram\u00f3n Areces Foundation"},{"DOI":"10.13039\/100008061","name":"Mutua Madrile\u00f1a Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.cmi.2016.09.016","type":"journal-article","created":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T04:08:22Z","timestamp":1474776502000},"page":"49.e1-49.e8","source":"Crossref","is-referenced-by-count":52,"title":["Evaluation of the possible influence of trailing and paradoxical effects on the clinical outcome of patients with candidemia"],"prefix":"10.1016","volume":"23","author":[{"given":"C.","family":"Rueda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Puig-Asensio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Guinea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Almirante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cuenca-Estrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Zaragoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Guinea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Pa\u00f1o Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garc\u00eda-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garc\u00eda Cerrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fort\u00fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Campelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"de los Santos Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Buend\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.P.","family":"Gorricho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.S.","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Aguado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gonz\u00e1lez Romo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gorgolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Gadea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Losa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Delgado-Iribarren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"S\u00e1nchez Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Zaragoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cuenca-Estrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rodriguez-Ba\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Isabel Suarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Loza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.I.","family":"Aller Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mart\u00edn-Mazuelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"P\u00e9rez de Pipa\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garnacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.L.","family":"Maroto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Salavert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pem\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Blanquer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Camarena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Zaragoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Abril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gimeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hern\u00e1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ezpeleta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bereciartua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Hern\u00e1ndez Almaraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Montejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ayarza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Planes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"Camps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Almirante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mensa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Almela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gurgui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"S\u00e1nchez-Reus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Martinez-Montauti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Horcajada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sorli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gen\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Urrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Valerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"D\u00edaz-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Puchades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mularoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2016.09.016_bib1","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1097\/CCM.0b013e31819efac0","article-title":"Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005\u20132006)","volume":"37","author":"Leroy","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.cmi.2016.09.016_bib2","doi-asserted-by":"crossref","first-page":"O245","DOI":"10.1111\/1469-0691.12380","article-title":"Epidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain","volume":"20","author":"Puig-Asensio","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2016.09.016_bib3","doi-asserted-by":"crossref","first-page":"O50","DOI":"10.1111\/1469-0691.12312","article-title":"A\u00a0prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies","volume":"20","author":"Gamaletsou","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2016.09.016_bib4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/1471-2334-13-337","article-title":"Surveillance study of species distribution, antifungal susceptibility and mortality of nosocomial candidemia in a tertiary care hospital in China","volume":"13","author":"Ma","year":"2013","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.cmi.2016.09.016_bib5","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1086\/655698","article-title":"Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for prevention","volume":"51","author":"Zaoutis","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2016.09.016_bib6","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1128\/JCM.43.4.1829-1835.2005","article-title":"Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, Barcelona, Spain, from 2002 to 2003","volume":"43","author":"Almirante","year":"2005","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.cmi.2016.09.016_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1469-0691.2002.00446.x","article-title":"Candidemia in French hospitals: incidence rates and characteristics","volume":"8","author":"Richet","year":"2002","journal-title":"Clin Microbiol Infect"},{"issue":"Suppl.\u00a04","key":"10.1016\/j.cmi.2016.09.016_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1185\/03007995.2012.761134","article-title":"Fungal diagnosis: how do we do it and can we do better?","volume":"29","author":"Perfect","year":"2013","journal-title":"Curr Med Res Opin"},{"issue":"Suppl.\u00a02","key":"10.1016\/j.cmi.2016.09.016_bib9","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/S0924-8579(08)70006-2","article-title":"Epidemiology of candidemia in intensive care units","volume":"32","author":"Bouza","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.cmi.2016.09.016_bib10","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2146\/ajhp100456","article-title":"Echinocandins: addressing outstanding questions surrounding treatment of invasive fungal infections","volume":"68","author":"Holt","year":"2011","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.cmi.2016.09.016_bib11","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3109\/1040841X.2014.974500","article-title":"Novel strategies to fight Candida species infection","volume":"42","author":"Rodrigues","year":"2016","journal-title":"Crit Rev Microbiol"},{"key":"10.1016\/j.cmi.2016.09.016_bib12","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/QCO.0000000000000111","article-title":"Echinocandin resistance: an emerging clinical problem?","volume":"27","author":"Arendrup","year":"2014","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.cmi.2016.09.016_bib13","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1439-0507.2009.01739.x","article-title":"Influence of different susceptibility testing methods and media on determination of the relevant fluconazole minimum inhibitory concentrations for heavy trailing Candida isolates with low-high phenotype","volume":"53","author":"Alp","year":"2010","journal-title":"Mycoses"},{"key":"10.1016\/j.cmi.2016.09.016_bib14","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/mmy\/myw033","article-title":"Scope and frequency of fluconazole trailing assessed using EUCAST in invasive Candida spp. isolates","volume":"54","author":"Marcos-Zambrano","year":"2016","journal-title":"Med Mycol"},{"key":"10.1016\/j.cmi.2016.09.016_bib15","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1128\/AAC.47.10.3149-3154.2003","article-title":"Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States","volume":"47","author":"Ostrosky-Zeichner","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1590\/S0074-02762012000100005","article-title":"Cellular characterisation of Candida tropicalis presenting fluconazole-related trailing growth","volume":"107","author":"Dornelas-Ribeiro","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.cmi.2016.09.016_bib17","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1128\/AAC.43.6.1383","article-title":"The trailing end point phenotype in antifungal susceptibility testing is pH dependent","volume":"43","author":"Marr","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jac\/dkh040","article-title":"Drug resistance genes and trailing growth in Candida albicans isolates","volume":"53","author":"Lee","year":"2004","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib19","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.bmcl.2006.12.028","article-title":"Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans","volume":"17","author":"Mai","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.cmi.2016.09.016_bib20","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1128\/AAC.46.8.2477-2481.2002","volume":"46","author":"Arthington-Skaggs","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib21","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1128\/AAC.44.8.2081-2085.2000","article-title":"Quantitation of Candida albicans ergosterol content improves the correlation between in\u00a0vitro antifungal susceptibility test results and in\u00a0vivo outcome after fluconazole treatment in a murine model of invasive candidiasis","volume":"44","author":"Arthington-Skaggs","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1439-0507.2006.01329.x","article-title":"Susceptibility and trailing growth of Candida albicans to fluconazole: results of a Korean multicentre study","volume":"50","author":"Lee","year":"2007","journal-title":"Mycoses"},{"key":"10.1016\/j.cmi.2016.09.016_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1128\/AAC.42.1.129","article-title":"Optimizing the correlation between results of testing in\u00a0vitro and therapeutic outcome in\u00a0vivo for fluconazole by testing critical isolates in a murine model of invasive candidiasis","volume":"42","author":"Rex","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1439-0507.2009.01733.x","article-title":"Lack of correlation of 24- vs. 48-h itraconazole minimum inhibitory concentrations with microbiological and survival outcomes in a guinea pig model of disseminated candidiasis","volume":"53","author":"Odabasi","year":"2010","journal-title":"Mycoses"},{"key":"10.1016\/j.cmi.2016.09.016_bib25","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1128\/AAC.00095-07","article-title":"Paradoxical effect of echinocandins across Candida species in\u00a0vitro: evidence for echinocandin-specific and candida species-related differences","volume":"51","author":"Chamilos","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib26","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1128\/AAC.00946-13","article-title":"Paradoxical growth of Candida albicans in the presence of caspofungin is associated with multiple cell wall rearrangements and decreased virulence","volume":"58","author":"Rueda","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib27","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/AAC.48.9.3407-3411.2004","article-title":"Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations","volume":"48","author":"Stevens","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib28","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/AAC.00633-10","article-title":"Changes in cell wall synthesis and ultrastructure during paradoxical growth effect of caspofungin on four different Candida species","volume":"55","author":"Bizerra","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib29","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1128\/AAC.00563-06","article-title":"Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin;evidence for beta-1,6-glucan synthesis inhibition by caspofungin","volume":"50","author":"Stevens","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib30","doi-asserted-by":"crossref","first-page":"e1000040","DOI":"10.1371\/journal.ppat.1000040","article-title":"Stimulation of chitin synthesis rescues Candida albicans from echinocandins","volume":"4","author":"Walker","year":"2008","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.cmi.2016.09.016_bib31","first-page":"18","article-title":"Effect of nikkomycin Z and 50% human serum on the killing activity of high-concentration caspofungin against Candida species using time-kill methodology","volume":"24","author":"Szilagyi","year":"2012","journal-title":"J\u00a0Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib32","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1128\/AAC.00999-10","article-title":"Paradoxical effect of caspofungin against Candida bloodstream isolates is mediated by multiple pathways but eliminated in human serum","volume":"55","author":"Shields","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib33","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1128\/AAC.00095-11","article-title":"Five-minute exposure to caspofungin results in prolonged postantifungal effects and eliminates the paradoxical growth of Candida albicans","volume":"55","author":"Shields","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib34","first-page":"170","article-title":"In\u00a0vivo studies with a Candida tropicalis isolate exhibiting paradoxical growth in\u00a0vitro in the presence of high concentration of caspofungin","volume":"48","author":"Bayegan","year":"2010","journal-title":"J\u00a0Microbiol"},{"key":"10.1016\/j.cmi.2016.09.016_bib35","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1128\/AAC.50.4.1293-1297.2006","article-title":"Assessment of the paradoxical effect of caspofungin in therapy of candidiasis","volume":"50","author":"Clemons","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib36","series-title":"PCR protocols: a guide to methods and applications","first-page":"315","article-title":"Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics","author":"White","year":"1990"},{"key":"10.1016\/j.cmi.2016.09.016_bib37","doi-asserted-by":"crossref","first-page":"E246","DOI":"10.1111\/j.1469-0691.2012.03880.x","article-title":"EUCAST technical note on the EUCAST definitive document EDef 7.2: method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts EDef 7.2 (EUCAST-AFST)","volume":"18","author":"Arendrup","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2016.09.016_bib38","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1469-0691.2007.01935.x","volume":"14","author":"Rodriguez-Tudela","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2016.09.016_bib39","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1128\/AAC.02155-13","article-title":"Molecular identification and antifungal susceptibility of yeast isolates causing fungemia collected in a population-based study in Spain in 2010 and 2011","volume":"58","author":"Guinea","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/599376","article-title":"Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America","volume":"49","author":"Mermel","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2016.09.016_bib41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1086\/420816","article-title":"Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases","volume":"39","author":"Paterson","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2016.09.016_bib42","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.cmi.2016.09.016_bib43","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1128\/AAC.50.3.917-921.2006","article-title":"Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi","volume":"50","author":"Cuenca-Estrella","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib44","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1128\/AAC.00683-11","article-title":"Elevated cell wall chitin in Candida albicans confers echinocandin resistance in\u00a0vivo","volume":"56","author":"Lee","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2016.09.016_bib45","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1086\/598933","article-title":"A\u00a0Multicenter, double-blind trial of a high-dose caspofungin treatment regimen versus a standard caspofungin treatment regimen for adult patients with invasive candidiasis","volume":"48","author":"Betts","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2016.09.016_bib46","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1128\/AAC.01519-13","article-title":"Interlaboratory variability of caspofungin MICs for Candida spp. Using CLSI and EUCAST methods: should the clinical laboratory be testing this agent?","volume":"57","author":"Espinel-Ingroff","year":"2013","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X16304220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X16304220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T07:26:03Z","timestamp":1601105163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X16304220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S1198743X16304220"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2016.09.016","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}