{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:11:27Z","timestamp":1784657487468,"version":"3.55.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,15]],"date-time":"2017-04-15T00:00:00Z","timestamp":1492214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council, Australia","doi-asserted-by":"publisher","award":["GNT1008973"],"award-info":[{"award-number":["GNT1008973"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BPH","award":["GNT1105905"],"award-info":[{"award-number":["GNT1105905"]}]},{"name":"TPS","award":["GNT1008549"],"award-info":[{"award-number":["GNT1008549"]}]},{"name":"AYP","award":["GNT1047916"],"award-info":[{"award-number":["GNT1047916"]}]},{"name":"Australian Postgraduate Award"},{"name":"Monash University Postgraduate Publication Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.cmi.2017.03.027","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T22:19:05Z","timestamp":1491603545000},"page":"767-773","source":"Crossref","is-referenced-by-count":25,"title":["Vancomycin-intermediate Staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors"],"prefix":"10.1016","volume":"23","author":[{"given":"D.R.","family":"Cameron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-H.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Trouillet-Assant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Tafani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Kostoulias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Mouhtouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Visvanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Baines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Howden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"Monk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.P.","family":"Stinear","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.P.","family":"Howden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.Y.","family":"Peleg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2017.03.027_bib1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1086\/381093","article-title":"Clinical features associated with bacteremia due to heterogeneous vancomycin-intermediate Staphylococcus aureus","volume":"38","author":"Charles","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2017.03.027_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1086\/524667","article-title":"Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia","volume":"46","author":"Soriano","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2017.03.027_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1128\/AAC.00534-07","article-title":"Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance","volume":"52","author":"Neoh","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2017.03.027_bib4","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1128\/AAC.01613-07","article-title":"Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus aureus","volume":"52","author":"Howden","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2017.03.027_bib5","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1128\/AAC.00422-06","article-title":"Isolates with low-level vancomycin resistance associated with persistent methicillin-resistant Staphylococcus aureus bacteremia","volume":"50","author":"Howden","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2017.03.027_bib6","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1002\/j.1460-2075.1993.tb06074.x","article-title":"Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule","volume":"12","author":"Novick","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/j.cmi.2017.03.027_bib7","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1128\/AAC.46.5.1492-1502.2002","article-title":"Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin","volume":"46","author":"Sakoulas","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2017.03.027_bib8","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1086\/596511","article-title":"Reduced susceptibility to vancomycin influences pathogenicity in Staphylococcus aureus infection","volume":"199","author":"Peleg","year":"2009","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2017.03.027_bib9","doi-asserted-by":"crossref","first-page":"e1002359","DOI":"10.1371\/journal.ppat.1002359","article-title":"Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR","volume":"7","author":"Howden","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.cmi.2017.03.027_bib10","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.micpath.2008.09.003","article-title":"Development of glycopeptide-intermediate resistance by Staphylococcus aureus leads to attenuated infectivity in a rat model of endocarditis","volume":"45","author":"Majcherczyk","year":"2008","journal-title":"Microb Pathog"},{"key":"10.1016\/j.cmi.2017.03.027_bib11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1128\/AAC.01133-10","article-title":"Systematic review and meta-analysis of the significance of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates","volume":"55","author":"van Hal","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2017.03.027_bib12","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/cid\/cir473","article-title":"The interface between antibiotic resistance and virulence in Staphylococcus aureus and its impact upon clinical outcomes","volume":"53","author":"Cameron","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2017.03.027_bib13","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1128\/JCM.41.4.1687-1693.2003","article-title":"Evolution of a vancomycin-intermediate Staphylococcus aureus strain in\u00a0vivo: multiple changes in the antibiotic resistance phenotypes of a single lineage of methicillin-resistant S.\u00a0aureus under the impact of antibiotics administered for chemotherapy","volume":"41","author":"Sieradzki","year":"2003","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.cmi.2017.03.027_bib14","doi-asserted-by":"crossref","first-page":"9451","DOI":"10.1073\/pnas.0609839104","article-title":"Tracking the in\u00a0vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing","volume":"104","author":"Mwangi","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cmi.2017.03.027_bib15","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/infdis\/jis252","article-title":"Serine\/threonine phosphatase stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus","volume":"205","author":"Cameron","year":"2012","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2017.03.027_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2180-14-31","article-title":"Hyperexpression of \u03b1-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus","volume":"14","author":"Chua","year":"2014","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.cmi.2017.03.027_bib17","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1128\/IAI.69.11.7074-7082.2001","article-title":"agr expression precedes escape of internalized Staphylococcus aureus from the host endosome","volume":"69","author":"Qazi","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.cmi.2017.03.027_bib18","doi-asserted-by":"crossref","first-page":"12055","DOI":"10.1073\/pnas.92.26.12055","article-title":"Cell density control of staphylococcal virulence mediated by an octapeptide pheromone","volume":"92","author":"Ji","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cmi.2017.03.027_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.mimet.2011.04.012","article-title":"A\u00a0novel flow cytometry-based assay for the quantification of Staphylococcus aureus adhesion to and invasion of eukaryotic cells","volume":"86","author":"Trouillet","year":"2011","journal-title":"J\u00a0Microbiol Methods"},{"key":"10.1016\/j.cmi.2017.03.027_bib20","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/infdis\/jis772","article-title":"The RpoB H481Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus","volume":"207","author":"Gao","year":"2013","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2017.03.027_bib21","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1038\/nm1207-1405","article-title":"Poring over pores: \u03b1-hemolysin and Panton\u2013Valentine leukocidin in Staphylococcus aureus pneumonia","volume":"13","author":"Bubeck Wardenburg","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.cmi.2017.03.027_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1099\/jmm.0.035204-0","article-title":"Downregulation of RNAIII in vancomycin-intermediate Staphylococcus aureus strains regardless of the presence of agr mutation","volume":"61","author":"Park","year":"2012","journal-title":"J\u00a0Med Microbiol"},{"key":"10.1016\/j.cmi.2017.03.027_bib23","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/j.1365-2958.2006.04986.x","article-title":"A\u00a0slipped-mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate delta- and \u03b1-haemolysins","volume":"59","author":"Traber","year":"2006","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.cmi.2017.03.027_bib24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1099\/mic.0.063016-0","article-title":"Staphylococcus aureus protein A binding to osteoblast tumour necrosis factor receptor 1 results in activation of nuclear factor \u03baB and release of interleukin-6 in bone infection","volume":"159","author":"Claro","year":"2013","journal-title":"Microbiology"},{"key":"10.1016\/j.cmi.2017.03.027_bib25","doi-asserted-by":"crossref","first-page":"e92355","DOI":"10.1371\/journal.pone.0092355","article-title":"The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract","volume":"9","author":"Kung","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.cmi.2017.03.027_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2180-8-39","article-title":"Different bacterial gene expression patterns and attenuated host immune responses are associated with the evolution of low-level vancomycin resistance during persistent methicillin-resistant Staphylococcus aureus bacteraemia","volume":"8","author":"Howden","year":"2008","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.cmi.2017.03.027_bib27","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1128\/IAI.70.7.3389-3395.2002","article-title":"Overproduction of type 8 capsular polysaccharide augments Staphylococcus aureus virulence","volume":"70","author":"Luong","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.cmi.2017.03.027_bib28","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.ajpath.2012.07.005","article-title":"A\u00a0novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection: an integrated view of disease pathogenesis","volume":"181","author":"Horst","year":"2012","journal-title":"Am J Pathol"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X17301994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X17301994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T20:08:13Z","timestamp":1569010093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X17301994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S1198743X17301994"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2017.03.027","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}