{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:13:09Z","timestamp":1761293589579,"version":"3.37.3"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/03834-7"],"award-info":[{"award-number":["2012\/03834-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.cmi.2017.06.013","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T13:00:18Z","timestamp":1498222818000},"page":"146-151","source":"Crossref","is-referenced-by-count":11,"title":["Ceftriaxone versus ceftriaxone plus a macrolide for community-acquired pneumonia in hospitalized patients with HIV\/AIDS: a randomized controlled trial"],"prefix":"10.1016","volume":"24","author":[{"given":"C.","family":"Figueiredo-Mello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Naucler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Negra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2017.06.013_bib1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0140-6736(15)60733-4","article-title":"Community-acquired pneumonia","volume":"386","author":"Prina","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.cmi.2017.06.013_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2796.2012.02554.x","article-title":"Treatment with anti-inflammatory drugs in community-acquired pneumonia","volume":"272","author":"Meijvis","year":"2012","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib3","doi-asserted-by":"crossref","first-page":"34S","DOI":"10.1016\/S0002-9343(99)00098-4","article-title":"Bacteremic pneumococcal pneumonia in one American city: a 20-year longitudinal study, 1978\u20131997","volume":"107","author":"Mufson","year":"1999","journal-title":"Am J Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1086\/367541","article-title":"Addition of a macrolide to a \u03b2-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia","volume":"36","author":"Mart\u00ednez","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2017.06.013_bib5","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1155\/2004\/461392","article-title":"Clinical characteristics at initial presentation and impact of dual therapy on the outcome of bacteremic Streptococcus pneumoniae pneumonia in adults","volume":"11","author":"Weiss","year":"2004","journal-title":"Can Respir J"},{"key":"10.1016\/j.cmi.2017.06.013_bib6","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1378\/chest.06-1426","article-title":"Antibiotics for bacteremic pneumonia: IMPROVED outcomes with macrolides but not fluoroquinolones","volume":"131","author":"Metersky","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.cmi.2017.06.013_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1183\/09031936.00054108","article-title":"Impact of macrolide therapy on mortality for patients with severe sepsis due to pneumonia","volume":"33","author":"Restrepo","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.cmi.2017.06.013_bib8","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00134-009-1730-y","article-title":"Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia","volume":"36","author":"Martin-Loeches","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib9","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/jac\/dku033","article-title":"\u03b2-Lactam\/macrolide dual therapy versus \u03b2-lactam monotherapy for the treatment of community-acquired pneumonia in adults: a systematic review and meta-analysis","volume":"69","author":"Nie","year":"2014","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2017.06.013_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/cid\/cis414","article-title":"Macrolide-based regimens and mortality in hospitalized patients with community-acquired pneumonia: a systematic review and meta-analysis","volume":"55","author":"Asadi","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2017.06.013_bib11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/resp.12835","article-title":"\u03b2-Lactam plus macrolides or \u03b2-lactam alone for community-acquired pneumonia: a systematic review and meta-analysis","volume":"21","author":"Horita","year":"2016","journal-title":"Respirology"},{"key":"10.1016\/j.cmi.2017.06.013_bib12","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1056\/NEJMoa1406330","article-title":"Antibiotic treatment strategies for community-acquired pneumonia in adults","volume":"372","author":"Postma","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib13","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1001\/jamainternmed.2014.4887","article-title":"\u03b2-Lactam monotherapy vs \u03b2-lactam-macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial","volume":"174","author":"Garin","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib14","first-page":"201","article-title":"Bacterial community-acquired pneumonia in HIV-infected patients","volume":"16","author":"Madeddu","year":"2010","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib15","first-page":"262","article-title":"Impact of macrolide therapy on mortality of HIV-infected patients with community-acquired pneumonia in a tertiary teaching hospital","volume":"15","author":"Mello","year":"2011","journal-title":"Braz J Infect Dis"},{"key":"10.1016\/j.cmi.2017.06.013_bib16","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults","volume":"44","author":"Mandell","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2017.06.013_bib17","first-page":"574","article-title":"Diretrizes brasileiras para pneumonia adquirida na comunidade em adultos imunocompetentes","volume":"35","author":"Corr\u00eaa","year":"2009","journal-title":"J\u00a0Bras Pneumol"},{"key":"10.1016\/j.cmi.2017.06.013_bib18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200405-644ST","article-title":"Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia","volume":"171","author":"American Thoracic Society; Infectious Diseases Society of America","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib19","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1001\/jama.279.18.1452","article-title":"Time to clinical stability in patients hospitalized with community-acquired pneumonia: implications for practice guidelines","volume":"279","author":"Halm","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.cmi.2017.06.013_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/thorax.58.5.377","article-title":"Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study","volume":"58","author":"Lim","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.cmi.2017.06.013_bib21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1056\/NEJM199701233360402","article-title":"A\u00a0prediction rule to identify low-risk patients with community-acquired pneumonia","volume":"336","author":"Fine","year":"1997","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib22","doi-asserted-by":"crossref","first-page":"e5778","DOI":"10.1097\/MD.0000000000005778","article-title":"Prospective etiological investigation of community-acquired pulmonar infections in hospitalized people living with HIV","volume":"96","author":"Figueiredo-Mello","year":"2017","journal-title":"Medicine"},{"key":"10.1016\/j.cmi.2017.06.013_bib23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/bmj.319.7203.185","article-title":"Understanding controlled trials: baseline imbalance in randomised controlled trials","volume":"319","author":"Roberts","year":"1999","journal-title":"BMJ"},{"key":"10.1016\/j.cmi.2017.06.013_bib24","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00228-011-1161-x","article-title":"Macrolides: from in\u00a0vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases","volume":"68","author":"Zarogoulidis","year":"2012","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.cmi.2017.06.013_bib25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1128\/CMR.00078-09","article-title":"Mechanisms of action and clinical application of macrolides as immunomodulatory medications","volume":"23","author":"Kanoh","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.cmi.2017.06.013_bib26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2334-12-134","article-title":"Etiology of community-acquired pneumonia in a population-based study: link between etiology and patients characteristics, process-of-care, clinical evolution and outcomes","volume":"12","author":"Capelastegui","year":"2012","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.cmi.2017.06.013_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1469-0691.2006.01629.x","article-title":"Clinical characterisation of pneumonia caused by atypical pathogens combining classic and novel predictors","volume":"13","author":"Masi\u00e1","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2017.06.013_bib28","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1164\/rccm.200603-350OC","article-title":"A\u00a0worldwide perspective of atypical pathogens in community-acquired pneumonia","volume":"175","author":"Arnold","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.cmi.2017.06.013_bib29","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1183\/09031936.00155813","article-title":"Community-acquired lung respiratory infections in HIV-infected patients: microbial aetiology and outcome","volume":"43","author":"Cilloniz","year":"2014","journal-title":"Eur Respir J"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X17303324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X17303324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T06:04:48Z","timestamp":1657433088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X17303324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S1198743X17303324"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2017.06.013","relation":{},"ISSN":["1198-743X"],"issn-type":[{"type":"print","value":"1198-743X"}],"subject":[],"published":{"date-parts":[[2018,2]]}}}