{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:32:00Z","timestamp":1790285520783,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014533","name":"Center for Communicable Disease Dynamics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473031"],"award-info":[{"award-number":["81473031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX1020100 1"],"award-info":[{"award-number":["2018ZX1020100 1"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["ID 16\/137\/109"],"award-info":[{"award-number":["ID 16\/137\/109"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014095","name":"Oregon Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["81525023"],"award-info":[{"award-number":["81525023"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014588","name":"Sanofi Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014588","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.cmi.2019.06.029","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T11:32:02Z","timestamp":1562239922000},"page":"373-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cost-effectiveness of bivalent versus monovalent vaccines against hand, foot and mouth disease"],"prefix":"10.1016","volume":"26","author":[{"given":"D.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.T.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2019.06.029_bib1","series-title":"A\u00a0guide to clinical management and public health response for hand, foot and mouth disease (HFMD)","year":"2011"},{"key":"10.1016\/j.cmi.2019.06.029_bib2","series-title":"Notice of integrating hand, foot and mouth disease into the management of the notifiable diseases [in Chinese]","year":"2008"},{"key":"10.1016\/j.cmi.2019.06.029_bib3","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2017.22.50.16-00824","article-title":"Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine","volume":"22","author":"Yang","year":"2017","journal-title":"Euro Surveill"},{"key":"10.1016\/j.cmi.2019.06.029_bib4","series-title":"Fact sheets - hand, foot and mouth disease","author":"World Health Organization","year":"2012"},{"key":"10.1016\/j.cmi.2019.06.029_bib5","series-title":"List of licensed drugs approved by China food and drug administration in december 2015 [in Chinese]","author":"China Food and Drug Administration","year":"2016"},{"key":"10.1016\/j.cmi.2019.06.029_bib6","series-title":"The monovalent EV71 vaccine developed by National Vaccine & Serum Institute has been licensed [in Chinese]","author":"Vaccine","year":"2016"},{"key":"10.1016\/j.cmi.2019.06.029_bib7","article-title":"Routine pediatric enterovirus 71 vaccination in China: a cost-effectiveness analysis","volume":"13","author":"Wu","year":"2016","journal-title":"PLoS Med"},{"key":"10.1016\/j.cmi.2019.06.029_bib8","series-title":"Zhiyan consulting. China's new vaccine market in-depth survey and market demand forecast report for 2018-2024 [in Chinese]","year":"2018"},{"key":"10.1016\/j.cmi.2019.06.029_bib9","series-title":"Text record of press conference by National Health Commission of China on Apr 9, 2018 [in Chinese] [press release]","year":"2018"},{"key":"10.1016\/j.cmi.2019.06.029_bib10","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.vaccine.2014.03.012","article-title":"A\u00a0combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses","volume":"32","author":"Cai","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.cmi.2019.06.029_bib11","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.4161\/hv.29823","article-title":"Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice","volume":"10","author":"Sun","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.cmi.2019.06.029_bib12","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1016\/j.vaccine.2014.06.025","article-title":"A\u00a0virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice","volume":"32","author":"Ku","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.cmi.2019.06.029_bib13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(13)70342-6","article-title":"Hand, foot, and mouth disease in China, 2008\u201312: an epidemiological study","volume":"14","author":"Xing","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2019.06.029_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184266","article-title":"Economic costs and health-related quality of life for hand, foot and mouth disease (HFMD) patients in China","volume":"12","author":"Zheng","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cmi.2019.06.029_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001958","article-title":"Hand, foot, and mouth disease in China: modeling epidemic dynamics of enterovirus serotypes and implications for vaccination","volume":"13","author":"Takahashi","year":"2016","journal-title":"PLoS Med"},{"key":"10.1016\/j.cmi.2019.06.029_bib16","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1126\/science.aat6777","article-title":"Serotype-specific immunity explains the incidence of diseases caused by human enteroviruses","volume":"361","author":"Pons-Salort","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.cmi.2019.06.029_bib17","series-title":"The core information of prevention and control of hand, foot and mouth disease [in Chinese]","year":"2018"},{"key":"10.1016\/j.cmi.2019.06.029_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005899","article-title":"Cost-effectiveness of a national enterovirus 71 vaccination program in China","volume":"11","author":"Wang","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.cmi.2019.06.029_bib19","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1303224","article-title":"An inactivated enterovirus 71 vaccine in healthy children","volume":"370","author":"Li","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cmi.2019.06.029_bib20","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa1304923","article-title":"Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China","volume":"370","author":"Zhu","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cmi.2019.06.029_bib21","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/S0140-6736(13)61049-1","article-title":"Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","volume":"381","author":"Zhu","year":"2013","journal-title":"The Lancet"},{"key":"10.1016\/j.cmi.2019.06.029_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(15)00601-7","article-title":"Cost-effectiveness of partial reimbursement for hepatitis B anti-viral drugs in Beijing, China: an analysis based on a retrospective cohort study","volume":"386","author":"Qiu","year":"2015","journal-title":"The Lancet"},{"key":"10.1016\/j.cmi.2019.06.029_bib23","doi-asserted-by":"crossref","first-page":"e816","DOI":"10.1016\/S2214-109X(16)30265-0","article-title":"Cost-effectiveness and resource implications of aggressive action on tuberculosis in China, India, and South Africa: a combined analysis of nine models","volume":"4","author":"Menzies","year":"2016","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.cmi.2019.06.029_bib24","series-title":"Consumer Price Indices by category (The same month last year\u00a0= 100) [in Chinese]","year":"2018"},{"key":"10.1016\/j.cmi.2019.06.029_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/rmv.1827","article-title":"Comparative epidemiology and virology of fatal and nonfatal cases of hand, foot and mouth disease in mainland China from 2008 to 2014","volume":"25","author":"Liu","year":"2015","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.cmi.2019.06.029_bib26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.virol.2018.03.012","article-title":"An emerging and expanding clade accounts for the persistent outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in China since 2013","volume":"518","author":"He","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.cmi.2019.06.029_bib27","doi-asserted-by":"crossref","DOI":"10.3201\/eid2403.171303","article-title":"Epidemiology of recurrent hand, foot and mouth disease, China, 2008-2015","volume":"24","author":"Huang","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.cmi.2019.06.029_bib28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/infdis\/jiw502","article-title":"2-Year efficacy, immunogenicity, and safety of Vigoo enterovirus 71 vaccine in healthy Chinese children: a randomized open-label study","volume":"215","author":"Wei","year":"2017","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2019.06.029_bib29","series-title":"Routine paediatric vaccination in different periods in China [in Chinese]","year":"2016"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X19303805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X19303805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:23:15Z","timestamp":1778592195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X19303805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1198743X19303805"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2019.06.029","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cost-effectiveness of bivalent versus monovalent vaccines against hand, foot and mouth disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2019.06.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.","name":"copyright","label":"Copyright"}]}}