{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:13:43Z","timestamp":1779927223943,"version":"3.53.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.cmi.2019.07.009","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T11:28:20Z","timestamp":1563276500000},"page":"358-365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Outcomes of the PIRASOA programme, an antimicrobial stewardship programme implemented in hospitals of the Public Health System of Andalusia, Spain: an ecologic study of time-trend analysis"],"prefix":"10.1016","volume":"26","author":[{"given":"J.","family":"Rodr\u00edguez-Ba\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"P\u00e9rez-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pe\u00f1alva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garnacho-Montero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Salcedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Fern\u00e1ndez-Urrusuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Neth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.V.","family":"Gil-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"P\u00e9rez-Milena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Estella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lupi\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Irastorza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1.","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Rojo-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"P\u00e9rez-Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Valencia-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Cisneros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2019.07.009_bib1","series-title":"Antibiotic resistance: key facts","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.cmi.2019.07.009_bib2","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/cid\/cix411","article-title":"Impact on morbidity, mortality and length of stay of hospital acquired infections by resistant microorganisms","volume":"65","author":"Barrasa-Villar","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2019.07.009_bib3","series-title":"Antibiotic\/antimicrobial resistance (AR\/AMR)","author":"Centers for Disease Control and Prevention (CDC)","year":"2018"},{"key":"10.1016\/j.cmi.2019.07.009_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2334-14-13","article-title":"A\u00a0systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance","volume":"14","author":"Bell","year":"2014","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.cmi.2019.07.009_bib5","series-title":"Antimicrobial resistance surveillance in Europe, 2013: annual report of the European antimicrobial resistance surveillance Network (EARS-Net)","year":"2014"},{"key":"10.1016\/j.cmi.2019.07.009_bib6","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1086\/678057","article-title":"Antimicrobial stewardship programs in inpatient hospital settings: a systematic review","volume":"35","author":"Wagner","year":"2014","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.cmi.2019.07.009_bib7","doi-asserted-by":"crossref","first-page":"22.e1","DOI":"10.1016\/j.eimc.2011.09.018","article-title":"Programs for optimizing the use of antibiotics (PROA) in Spanish hospitals: GEIH-SEIMC, SEFH and SEMPSPH consensus document. Consensus Development Conference; Practice Guideline","volume":"30","author":"Rodr\u00edguez-Ba\u00f1o","year":"2012","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.cmi.2019.07.009_bib8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcma.2016.09.012","article-title":"Implementation and outcomes of an antimicrobial stewardship program: effectiveness of education","volume":"80","author":"Chang","year":"2017","journal-title":"J\u00a0Chin Med Assoc"},{"key":"10.1016\/j.cmi.2019.07.009_bib9","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/S1473-3099(17)30325-0","article-title":"Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis","volume":"17","author":"Baur","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2019.07.009_bib10","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1093\/cid\/cix692","article-title":"Long-term impact of an educational antimicrobial stewardship program on hospital-acquired candidemia and multidrug-resistant bloodstream infections: a quasi-experimental study of interrupted time-series analysis","volume":"65","author":"Molina","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2019.07.009_bib11","author":"European Commission; European Centre for Disease Prevention and Control (EDEC)"},{"key":"10.1016\/j.cmi.2019.07.009_bib12","series-title":"Antimicrobial stewardship: quality standard","year":"2016"},{"key":"10.1016\/j.cmi.2019.07.009_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10096-014-2225-5","article-title":"The impact of an antimicrobial stewardship programme on the use of antimicrobials and the evolution of drug resistance","volume":"34","author":"Del Arco","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2019.07.009_bib14","series-title":"Point prevalence survey of healthcare associated infections and antimicrobial use in European acute care hospitals, 2011\u20132012. ECDC surveillance report","year":"2013"},{"key":"10.1016\/j.cmi.2019.07.009_bib15","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1126\/science.aaf9286","article-title":"Achieving global targets for antimicrobial resistance","volume":"353","author":"Laxminarayan","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.cmi.2019.07.009_bib16","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.23.46.1800393","article-title":"Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017","volume":"23","author":"Plachouras","year":"2018","journal-title":"Euro Surveill"},{"key":"10.1016\/j.cmi.2019.07.009_bib17","author":"Rojo-Mart\u00edn","year":"2018"},{"key":"10.1016\/j.cmi.2019.07.009_bib18","series-title":"Definition and general considerations: defined daily dose (DDD)","author":"World Health Organization Collaborating Center for Drug Statistics Methodology","year":"2018"},{"key":"10.1016\/j.cmi.2019.07.009_bib19","first-page":"39","article-title":"Preventing the spread of multidrug-resistant Gram-negative pathogens: recommendations of an expert panel of the German Society for Hygiene and Microbiology","volume":"109","author":"Mattner","year":"2012","journal-title":"Dtsch Arzteblatt Int"},{"key":"10.1016\/j.cmi.2019.07.009_bib20","series-title":"EUCAST guideline for the detection of resistance mechanisms and specific resistances of clinical and\/or epidemiological importance. Version 1.0","author":"European Committee on Antimicrobial Susceptibility Testing","year":"2013"},{"key":"10.1016\/j.cmi.2019.07.009_bib21","series-title":"Joinpoint regression program, version 4.5.0.1","year":"2017"},{"key":"10.1016\/j.cmi.2019.07.009_bib22","article-title":"The evolution of academic performance in nine subspecialties of internal medicine: an analysis of journal citation reports from 1998 to 2010","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cmi.2019.07.009_bib23","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/jcpt.12579","article-title":"A\u00a0network meta-analysis of primary prophylaxis for invasive fungal infection in haematological patients","volume":"42","author":"Leonart","year":"2017","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.cmi.2019.07.009_bib24","first-page":"CD003543","article-title":"Interventions to improve antibiotic prescribing practices for hospital inpatients","author":"Davey","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.cmi.2019.07.009_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2019.07.009_bib26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/cid\/ciw323","article-title":"Antibiotic stewardship programs in US acute care hospitals: findings from the 2014 National Healthcare Safety Network annual hospital survey","volume":"63","author":"Pollack","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2019.07.009_bib27","series-title":"Initial assessments of the national action plan for combating antibiotic-resistant bacteria","year":"2016"},{"key":"10.1016\/j.cmi.2019.07.009_bib28","first-page":"953","article-title":"Improving feedback of surveillance data on antimicrobial consumption, resistance and stewardship in England: putting the data at your fingertips","volume":"72","author":"Johnson","year":"2017","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2019.07.009_bib29","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1017\/ice.2018.65","article-title":"Novel indicators for enhancing the clinical outcome metrics of antimicrobial stewardship programs","volume":"39","author":"Molina","year":"2018","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.cmi.2019.07.009_bib30","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1093\/jac\/dkz185","article-title":"Antibiotic footprint as a communication tool to aid reduction of antibiotic","volume":"74","author":"Limmathurotsakul","year":"2019","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2019.07.009_bib31","series-title":"Care activity in hospital care: comparative analysis in Andalusia, 2012\u20132016","author":"Andalusian Health Service","year":"2017"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X19303982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X19303982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:24:34Z","timestamp":1761117874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X19303982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1198743X19303982"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2019.07.009","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Outcomes of the PIRASOA programme, an antimicrobial stewardship programme implemented in hospitals of the Public Health System of Andalusia, Spain: an ecologic study of time-trend analysis","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2019.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}