{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:41:31Z","timestamp":1793446891508,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.cmi.2019.09.007","type":"journal-article","created":{"date-parts":[[2019,9,17]],"date-time":"2019-09-17T19:34:06Z","timestamp":1568748846000},"page":"499-505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Suppressive antibiotic therapy in prosthetic joint infections: a multicentre cohort study"],"prefix":"10.1016","volume":"26","author":[{"given":"R.","family":"Escudero-Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Senneville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Digumber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"del Toro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bahamonde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"del Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Guio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Murillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Garc\u00eda-Pa\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Rodr\u00edguez-Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Iribarren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fresco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Muriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ariza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2019.09.007_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s15010-002-3079-9","article-title":"Management of infection associated with prosthetic joints","volume":"31","author":"Zimmerli","year":"2003","journal-title":"Infection"},{"key":"10.1016\/j.cmi.2019.09.007_bib2","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.suc.2014.08.009","article-title":"Periprosthetic joint infection","volume":"94","author":"Chen","year":"2014","journal-title":"Surg Clin N Am"},{"key":"10.1016\/j.cmi.2019.09.007_bib3","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1111\/j.1469-0691.2010.03333.x","article-title":"Early prosthetic joint infection: outcomes with debridement and implant retention followed by antibiotic therapy","volume":"17","author":"Cobo","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2019.09.007_bib4","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1302\/0301-620X.99B11.BJJ-2017-0088.R1","article-title":"Outcomes following debridement, antibiotics and implant retention in the management of periprosthetic infections of the hip. A review of cohort studies","volume":"99\u2013B","author":"Tsang","year":"2017","journal-title":"Bone Jt J"},{"key":"10.1016\/j.cmi.2019.09.007_bib5","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3928\/0147-7447-19910801-07","article-title":"Suppressive antibiotic therapy in chronic prosthetic joint infections","volume":"14","author":"Tsukayama","year":"1991","journal-title":"Orthopedics"},{"key":"10.1016\/j.cmi.2019.09.007_bib6","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1086\/514951","article-title":"Prolonged suppressive antibiotic therapy for infected orthopedic prostheses","volume":"27","author":"Segreti","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2019.09.007_bib7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijid.2014.09.012","article-title":"Outcome of patients over 80 years of age on prolonged suppressive antibiotic therapy for at least 6 months for prosthetic joint infection","volume":"29","author":"Prendki","year":"2014","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.cmi.2019.09.007_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/01.blo.0000087321.60612.cf","article-title":"Long-term suppression of infection in total joint arthroplasty","volume":"414","author":"Rao","year":"2003","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.cmi.2019.09.007_bib9","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2106\/JBJS.16.00123","article-title":"Synovial fluid cell count for diagnosis of chronic periprosthetic hip infection","volume":"99","author":"Higuera","year":"2017","journal-title":"J\u00a0Bone Jt Surg Am Vol"},{"key":"10.1016\/j.cmi.2019.09.007_bib10","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.2106\/JBJS.G.00470","article-title":"Cell count and differential of aspirated fluid in the diagnosis of infection at the site of total knee arthroplasty","volume":"90","author":"Ghanem","year":"2008","journal-title":"J\u00a0Bone Jt Surg Ser A"},{"key":"10.1016\/j.cmi.2019.09.007_bib11","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2106\/00004623-199604000-00005","article-title":"Infection after Total Hip Arthroplasty. A study of the treatment of one hundred and six infections","volume":"78","author":"Tsukayama","year":"1996","journal-title":"J\u00a0Bone Jt Surg"},{"key":"10.1016\/j.cmi.2019.09.007_bib12","series-title":"Analysing survival data from clinical trials and observational studie","first-page":"432","author":"Marubini","year":"1995"},{"key":"10.1016\/j.cmi.2019.09.007_bib13","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A\u00a0proportional hazards model for the subdistribution of a competing risk author","volume":"94","author":"Fine","year":"1999","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.cmi.2019.09.007_bib14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/jech.2004.029454","article-title":"A\u00a0brief conceptual tutorial of multilevel analysis in social epidemiology: using measures of clustering in multilevel logistic regression to investigate contextual phenomena","volume":"60","author":"Merlo","year":"2006","journal-title":"J\u00a0Epidemiol Community Health"},{"key":"10.1016\/j.cmi.2019.09.007_bib15","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/jac\/dkp107","article-title":"One hundred and twelve infected arthroplasties treated with \u201cDAIR\u201d (debridement, antibiotics and implant retention): antibiotic duration and outcome","volume":"63","author":"Byren","year":"2009","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2019.09.007_bib16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ijantimicag.2017.04.019","article-title":"Suppressive antibiotic therapy with oral doxycycline for Staphylococcus aureus prosthetic joint infection: a retrospective study of 39 patients","volume":"50","author":"Pradier","year":"2017","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.cmi.2019.09.007_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s15010-017-1077-1","article-title":"Suppressive antibiotic therapy with oral tetracyclines for prosthetic joint infections: a retrospective study of 78 patients","volume":"46","author":"Pradier","year":"2018","journal-title":"Infection"},{"key":"10.1016\/j.cmi.2019.09.007_bib18","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2106\/JBJS.N.00999","article-title":"Chronic suppression of periprosthetic joint infections with oral antibiotics increases infection-free survivorship","volume":"97","author":"Siqueira","year":"2015","journal-title":"J\u00a0Bone Jt Surg Am"},{"key":"10.1016\/j.cmi.2019.09.007_bib19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1157\/13123843","article-title":"Infecciones relacionadas con las pr\u00f3tesis articulares","volume":"26","author":"Ariza","year":"2008","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.cmi.2019.09.007_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.7150\/jbji.17353","article-title":"Efficacy of antibiotic suppressive therapy in patients with a prosthetic joint infection","volume":"2","author":"Wouthuyzen-Bakker","year":"2017","journal-title":"J\u00a0Bone Jt Infect"},{"key":"10.1016\/j.cmi.2019.09.007_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2288-12-28","article-title":"Hospital-level associations with 30-day patient mortality after cardiac surgery: a tutorial on the application and interpretation of marginal and multilevel logistic regression","volume":"12","author":"Sanagou","year":"2012","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.cmi.2019.09.007_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/aje\/kwi017","article-title":"Appropriate assessment of neighborhood effects on individual health: integrating random and fixed effects in multilevel logistic regression","volume":"161","author":"Larsen","year":"2005","journal-title":"Am J Epidemiol"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X19304926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X19304926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:23:59Z","timestamp":1761117839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X19304926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1198743X19304926"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2019.09.007","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppressive antibiotic therapy in prosthetic joint infections: a multicentre cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2019.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}