{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:46:55Z","timestamp":1790567215605,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.cmi.2019.10.032","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T02:49:26Z","timestamp":1573094966000},"page":"783.e1-783.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Longitudinal profiling of plasma cytokines in melioidosis and their association with mortality: a prospective cohort study"],"prefix":"10.1016","volume":"26","author":[{"given":"T.","family":"Kaewarpai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ekchariyawat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Phunpang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.W.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dulsuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Moonmueangsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Morakot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Thiansukhon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.P.J.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lertmemongkolchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.E.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Chantratita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2019.10.032_bib1","doi-asserted-by":"crossref","first-page":"17107","DOI":"10.1038\/nrdp.2017.107","article-title":"Melioidosis","volume":"4","author":"Wiersinga","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.cmi.2019.10.032_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1055\/s-0034-1398389","article-title":"Melioidosis: evolving concepts in epidemiology, pathogenesis, and treatment","volume":"36","author":"Currie","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.cmi.2019.10.032_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004152","article-title":"T-cell responses are associated with survival in acute melioidosis patients","volume":"9","author":"Jenjaroen","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.cmi.2019.10.032_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1086\/498983","article-title":"Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection","volume":"193","author":"Haque","year":"2006","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2019.10.032_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081617","article-title":"Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide","volume":"8","author":"Chantratita","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cmi.2019.10.032_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/gene.2013.60","article-title":"Screen of whole blood responses to flagellin identifies TLR5 variation associated with outcome in melioidosis","volume":"15","author":"Chantratita","year":"2014","journal-title":"Genes Immun"},{"key":"10.1016\/j.cmi.2019.10.032_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198906","article-title":"Immune response to recombinant Burkholderia pseudomallei FliC","volume":"13","author":"Koosakulnirand","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.cmi.2019.10.032_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005587","article-title":"A\u00a0nonsense mutation in TLR5 is associated with survival and reduced IL-10 and TNF-\u03b1 levels in human melioidosis","volume":"11","author":"Chaichana","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.cmi.2019.10.032_bib9","doi-asserted-by":"crossref","first-page":"47e1","DOI":"10.1016\/j.cmi.2016.08.028","article-title":"TLR4 genetic variation is associated with inflammatory responses in Gram-positive sepsis","volume":"23","author":"Chantratita","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2019.10.032_bib10","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4049\/jimmunol.1301436","article-title":"The role of NOD2 in murine and human melioidosis","volume":"192","author":"Myers","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.cmi.2019.10.032_bib11","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.4049\/jimmunol.1202974","article-title":"Impaired TLR5 functionality is associated with survival in melioidosis","volume":"190","author":"West","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.cmi.2019.10.032_bib12","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1086\/315155","article-title":"Elevated plasma concentrations of interferon (IFN)-\u03b3 and the IFN-\u03b3-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis","volume":"180","author":"Lauw","year":"1999","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2019.10.032_bib13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1086\/315271","article-title":"Prognostic value of cytokine concentrations (tumor necrosis factor-\u03b1, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis","volume":"181","author":"Simpson","year":"2000","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2019.10.032_bib14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00134-012-2752-4","article-title":"Inflammatory cytokine measurement quickly discriminates Gram-negative from Gram-positive bacteraemia in pediatric hematology\/oncology patients with septic shock","volume":"39","author":"Xu","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cmi.2019.10.032_bib15","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/cc8872","article-title":"Sepsis biomarkers: a review","volume":"14","author":"Pierrakos","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.cmi.2019.10.032_bib16","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1462-5822.2006.00716.x","article-title":"Interferon signalling network in innate defence","volume":"8","author":"Takaoka","year":"2006","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.cmi.2019.10.032_bib17","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1128\/IAI.67.7.3593-3600.1999","article-title":"Obligatory role of gamma interferon for host survival in a murine model of infection with Burkholderia pseudomallei","volume":"67","author":"Santanirand","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.cmi.2019.10.032_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00121-17","article-title":"Gene expression profile of human cytokines in response to Burkholderia pseudomallei infection","volume":"2","author":"Krishnananthasivam","year":"2017","journal-title":"mSphere"},{"key":"10.1016\/j.cmi.2019.10.032_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00430-015-0440-z","article-title":"Burkholderia pseudomallei induces IL-23 production in primary human monocytes","volume":"205","author":"Kulsantiwong","year":"2016","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.cmi.2019.10.032_bib20","doi-asserted-by":"crossref","first-page":"42791","DOI":"10.1038\/srep42791","article-title":"Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei","volume":"7","author":"Kessler","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.cmi.2019.10.032_bib21","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.cmi.2019.10.032_bib22","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1001\/archinte.167.15.1655","article-title":"Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the genetic and inflammatory markers of sepsis (GenIMS) study","volume":"167","author":"Kellum","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cmi.2019.10.032_bib23","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1086\/520223","article-title":"Risk factors for melioidosis and bacteraemic melioidosis","volume":"29","author":"Suputtamongkol","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2019.10.032_bib24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/IAI.00503-08","article-title":"Human polymorphonuclear neutrophil responses to Burkholderia pseudomallei in healthy and diabetic subjects","volume":"77","author":"Chanchamroen","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.cmi.2019.10.032_bib25","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/cid\/ciq192","article-title":"Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis","volume":"52","author":"Koh","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2019.10.032_bib26","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1160\/TH11-07-0504","article-title":"Diabetes does not influence activation of coagulation, fibrinolysis or anticoagulant pathways in Gram-negative sepsis (melioidosis)","volume":"106","author":"Koh","year":"2011","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.cmi.2019.10.032_bib27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4269\/ajtmh.2010.10-0038","article-title":"Increasing incidence of human melioidosis in Northeast Thailand","volume":"82","author":"Limmathurotsakul","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cmi.2019.10.032_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000900","article-title":"The epidemiology and clinical spectrum of melioidosis: 540 cases from the 20 year Darwin prospective study","volume":"4","author":"Currie","year":"2010","journal-title":"PLoS Negl Trop Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X19305877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X19305877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:25:37Z","timestamp":1761117937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X19305877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S1198743X19305877"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2019.10.032","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal profiling of plasma cytokines in melioidosis and their association with mortality: a prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2019.10.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.","name":"copyright","label":"Copyright"}]}}