{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:15:35Z","timestamp":1761174935006,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sharp and Dohme"},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sharp and Dohme"},{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015756","name":"Janssen Cilag","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015756","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp & Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish AIDS Research Network (RIS) project"},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences, Inc.","doi-asserted-by":"publisher","award":["GLD18\/00087"],"award-info":[{"award-number":["GLD18\/00087"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Health Ministry","award":["RD06\/0006\/0035","RD12\/0017\/0037","RD16\/0025\/0019"],"award-info":[{"award-number":["RD06\/0006\/0035","RD12\/0017\/0037","RD16\/0025\/0019"]}]},{"DOI":"10.13039\/501100007671","name":"Fundaci\u00f3n para la Investigaci\u00f3n y Prevenci\u00f3n del SIDA en Espa\u00f1a","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007671","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en SIDA","award":["RIS C03\/173","RD12\/0017\/0018","RD16\/0002\/0006"],"award-info":[{"award-number":["RIS C03\/173","RD12\/0017\/0018","RD16\/0002\/0006"]}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo de Desarrollo Regional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences, Inc.","doi-asserted-by":"publisher","award":["GLD18\/00087"],"award-info":[{"award-number":["GLD18\/00087"]}],"id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.cmi.2020.09.053","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T04:16:23Z","timestamp":1602821783000},"page":"1171.e1-1171.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cryptococcal infection in HIV-infected patients with CD4+ T-cell counts under 100\/\u03bcL diagnosed in a high-income country: a multicentre cohort study"],"prefix":"10.1016","volume":"27","author":[{"given":"Mar\u00eda Asunci\u00f3n","family":"P\u00e9rez-Jacoiste As\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otilia","family":"Bisbal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Iribarren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"P\u00e9rez-Rivilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Mican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Dronda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Mar\u00eda","family":"Gonz\u00e1lez-Domenech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Vinuesa-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Mac\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Lumbreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2020.09.053_bib1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrmicro.2015.6","article-title":"Cryptococcus: from environmental saprophyte to global pathogen","volume":"14","author":"May","year":"2016","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.cmi.2020.09.053_bib2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1258\/ijsa.2010.010182","article-title":"An update on Cryptococcus among HIV-infected patients","volume":"21","author":"Warkentien","year":"2010","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.cmi.2020.09.053_bib3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1097\/QAD.0b013e328352d1d8","article-title":"Decreasing incidence of cryptococcal meningitis in West Africa in the era of highly active antiretroviral therapy","volume":"26","author":"Bamba","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.cmi.2020.09.053_bib4","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1086\/368091","article-title":"The changing epidemiology of cryptococcosis: an update from population-based active surveillance in 2 large metropolitan areas, 1992-2000","volume":"36","author":"Mirza","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis","volume":"17","author":"Rajasingham","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib6","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1365-3156.2007.01874.x","article-title":"Asymptomatic serum cryptococcal antigenemia and early mortality during antiretroviral therapy in rural Uganda","volume":"12","author":"Liechty","year":"2007","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.cmi.2020.09.053_bib7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/cid\/cix872","article-title":"High cryptococcal antigen titers in blood are predictive of subclinical cryptococcal meningitis among human immunodeficiency virus-infected patients","volume":"66","author":"Wake","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib8","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1086\/597262","article-title":"Screening for cryptococcal antigenemia in patients accessing an antiretroviral treatment program in South Africa","volume":"48","author":"Jarvis","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049541","article-title":"Clinical utility of the cryptococcal antigen lateral flow assay in a diagnostic mycology laboratory","volume":"7","author":"McMullan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cmi.2020.09.053_bib10","first-page":"1122","article-title":"Impact of routine cryptococcal antigen screening and targeted pre-emptive fluconazole therapy in antiretroviral naive HIV-infected adults with less than 100 CD4 cells\/\u03bcL: a systematic review and meta-analysis","volume":"66","author":"Temfack","year":"2018","journal-title":"Clin Infect Dis"},{"year":"2011","series-title":"Rapid advice: diagnosis, prevention and management of cryptococcal disease in HIV infected adults, adolescents and children","author":"World Health Organization","key":"10.1016\/j.cmi.2020.09.053_bib11"},{"key":"10.1016\/j.cmi.2020.09.053_bib12","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1093\/cid\/cix1143","article-title":"CD4 Cell count threshold for cryptococcal antigen screening of HIV-infected individuals: a systematic review and meta-analysis","volume":"66","author":"Ford","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib13","first-page":"110","article-title":"Cryptococcosis in HIV-infected hospitalized patients in Germany: evidence for routine antigen testing","volume":"71","author":"Katchanov","year":"2015","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2020.09.053_bib14","first-page":"75","article-title":"The prevalence of cryptococcal antigenemia in newly diagnosed HIV patients in a Southwest London cohort","volume":"66","author":"Patel","year":"2013","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2020.09.053_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fmicb.2018.00409","article-title":"Cryptococcal antigen screening in asymptomatic HIV-infected antiretroviral na\u00efve patients in Cameroon and evaluation of the new semi-quantitative Biosynex CryptoPS Test","volume":"9","author":"Temfack","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.cmi.2020.09.053_bib19","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1128\/jcm.30.10.2544-2550.1992","article-title":"Evaluation of a monoclonal antibody-based latex agglutination test for diagnosis of cryptococcosis: comparison with two tests using polyclonal antibodies","volume":"30","author":"Temstet","year":"1992","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.cmi.2020.09.053_bib20","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1086\/655143","article-title":"Cost-effectiveness of serum cryptococcal antigen screening to prevent deaths among HIV-infected persons with a CD4+ cell count < or\u00a0= 100 cells\/microL who start HIV therapy in resource-limited settings","volume":"51","author":"Meya","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib21","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s10096-013-1915-8","article-title":"Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment","volume":"32","author":"Gullo","year":"2013","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib22","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.1542\/peds.107.5.e66","article-title":"Serologic evidence for Cryptococcus neoformans infection in early childhood","volume":"107","author":"Goldman","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.cmi.2020.09.053_bib23","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1378\/chest.115.3.734","article-title":"Pulmonary cryptococcosis in patients without HIV infection","volume":"115","author":"Aberg","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.cmi.2020.09.053_bib24","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/cid\/ciu937","article-title":"Prevalence, correlates, and outcomes of cryptococcal antigen positivity among patients with AIDS, United States, 1986\u20132012","volume":"60","author":"McKenney","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib25","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/S0140-6736(08)61311-2","article-title":"Global epidemiology of injecting drug use and HIV among people who inject drugs: a systematic review","volume":"372","author":"Mathers","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.cmi.2020.09.053_bib26","doi-asserted-by":"crossref","first-page":"18821","DOI":"10.7448\/IAS.17.1.18821","article-title":"Asymptomatic cryptococcal antigenemia is associated with mortality among HIV-positive patients in Indonesia","volume":"17","author":"Ganiem","year":"2014","journal-title":"J\u00a0Int AIDS Soc"},{"key":"10.1016\/j.cmi.2020.09.053_bib27","first-page":"200","article-title":"Seroprevalence of viral hepatitis and infectious complications among human immunodeficiency virus-infected injection drug users at a referral hospital","volume":"41","author":"Liang","year":"2008","journal-title":"J\u00a0Microbiol Immunol Infect"},{"key":"10.1016\/j.cmi.2020.09.053_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.11604\/pamj.2018.29.18.14099","article-title":"Increased mortality among HIV infected patients with cryptococcal antigenemia in Guinea-Bissau","volume":"29","author":"Thomsen","year":"2018","journal-title":"Pan Afr Med J"},{"key":"10.1016\/j.cmi.2020.09.053_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofv046","article-title":"Cryptococcal antigenemia in immunocompromised human immunodeficiency virus patients in rural Tanzania: a preventable cause of early mortality","volume":"2","author":"Letang","year":"2015","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1086\/381261","article-title":"Discontinuation of maintenance therapy for cryptococcal meningitis in patients with AIDS treated with highly active antiretroviral therapy: an international observational study","volume":"38","author":"Mussini","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib31","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1099\/jmm.0.000830","article-title":"Correlation between serum cryptococcal antigen titre and meningitis in immunocompetent patients","volume":"67","author":"Gassiep","year":"2018","journal-title":"J\u00a0Med Microbiol"},{"key":"10.1016\/j.cmi.2020.09.053_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3201\/eid2001.130906","article-title":"Multisite validation of cryptococcal antigen lateral flow assay and quantification by laser thermal contrast","volume":"20","author":"Boulware","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.cmi.2020.09.053_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069288","article-title":"Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa","volume":"8","author":"Jarvis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cmi.2020.09.053_bib34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/1545109712459077","article-title":"Cryptococcal antigen screening and preemptive therapy in patients initiating antiretroviral therapy in resource-limited settings: a proposed algorithm for clinical implementation","volume":"11","author":"Jarvis","year":"2012","journal-title":"J\u00a0Int Assoc Physicians AIDS Care (Chic)"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X20306078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X20306078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:28:39Z","timestamp":1761118119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X20306078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1198743X20306078"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2020.09.053","relation":{},"ISSN":["1198-743X"],"issn-type":[{"type":"print","value":"1198-743X"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryptococcal infection in HIV-infected patients with CD4+ T-cell counts under 100\/\u03bcL diagnosed in a high-income country: a multicentre cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2020.09.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}