{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:18:11Z","timestamp":1789251491990,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":630,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.cmi.2022.03.018","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T21:29:07Z","timestamp":1648070947000},"page":"1149.e1-1149.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of neutropenia on clinical manifestations and outcome of Staphylococcus aureus bloodstream infection: a propensity score-based overlap weight analysis in two large, prospectively evaluated cohorts"],"prefix":"10.1016","volume":"28","author":[{"given":"Johannes","family":"Camp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Filla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Glaubitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim J.","family":"Kaasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frieder","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Scarborough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Bin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Tilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Edgeworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Nsutebu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Eduardo","family":"L\u00f3pez-Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Morata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Llewelyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Vance G.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Thwaites","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried V.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegbert","family":"Rieg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2022.03.018_bib1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.cmi.2022.03.018_bib3","first-page":"242","article-title":"Staphylococcus aureus bloodstream infection: a pooled analysis of five prospective, observational studies","volume":"68","author":"Kaasch","year":"2014","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2022.03.018_bib4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/QCO.0b013e32833bcc8a","article-title":"Management of Staphylococcus aureus bacteremia and endocarditis: progresses and challenges","volume":"23","author":"Kern","year":"2010","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib5","first-page":"575","article-title":"Staphylococcus aureus bacteremia in patients with rheumatoid arthritis\u2013Data from the prospective INSTINCT cohort","volume":"74","author":"Joost","year":"2017","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2022.03.018_bib6","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/CMR.05022-11","article-title":"Predictors of mortality in Staphylococcus aureus bacteremia","volume":"25","author":"van Hal","year":"2012","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.cmi.2022.03.018_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmi.2016.06.002","article-title":"Gender differences in the outcome of community-acquired Staphylococcus aureus bacteraemia: a historical population-based cohort study","volume":"23","author":"Smit","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2022.03.018_bib11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3109\/00365549509047068","article-title":"Staphylococcus aureus bacteremia: a 14-year nationwide study in hematological patients with malignant disease or agranulocytosis","volume":"27","author":"Skov","year":"1995","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib12","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/00007611-200207000-00029","article-title":"Staphylococcus aureus bacteremia in patients with neutropenia","volume":"95","author":"Shah","year":"2002","journal-title":"South Med J"},{"key":"10.1016\/j.cmi.2022.03.018_bib13","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.0954-6820.1987.tb10966.x","article-title":"Staphylococcus aureus bacteremia in patients with hematological malignancies and\/or agranulocytosis","volume":"222","author":"Espersen","year":"1987","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.cmi.2022.03.018_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10096-005-0077-8","article-title":"Comparative study of clinical characteristics of neutropenic and non-neutropenic adult cancer patients with bloodstream infections","volume":"25","author":"Velasco","year":"2006","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib15","first-page":"923","article-title":"Staphylococcus aureus bacteremia in patients with hematologic malignancies: a retrospective case-control study","volume":"88","author":"Venditti","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.cmi.2022.03.018_bib16","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S1473-3099(20)30447-3","article-title":"Defining persistent Staphylococcus aureus bacteraemia: secondary analysis of a prospective cohort study","volume":"20","author":"Kuehl","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib17","first-page":"516","article-title":"Survival following Staphylococcus aureus bloodstream infection: a prospective multinational cohort study assessing the impact of place of care","volume":"77","author":"Nambiar","year":"2018","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2022.03.018_bib18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cmi.2016.08.026","article-title":"Combination antimicrobial therapy in patients with Staphylococcus aureus bacteraemia\u2013A post hoc analysis in 964 prospectively evaluated patients","volume":"23","author":"Rieg","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2022.03.018_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/cid\/ciy908","article-title":"Investigating the impact of early valve surgery on survival in Staphylococcus aureus infective endocarditis using a marginal structural model approach: results of a large, prospectively evaluated cohort","volume":"69","author":"Rieg","year":"2019","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib20","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/cid\/ciab385","article-title":"Impact of immunosuppressive agents on clinical manifestations and outcome of Staphylococcus aureus bloodstream infection: a propensity score-matched analysis in 2 large, prospectively evaluated cohorts","volume":"73","author":"Camp","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib21","first-page":"232","article-title":"Mortality of S.\u00a0aureus bacteremia and infectious diseases specialist consultation\u2013A study of 521 patients in Germany","volume":"59","author":"Rieg","year":"2009","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2022.03.018_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A\u00a0new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J\u00a0Chronic Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s15010-018-1165-x","article-title":"Onset of symptoms, diagnostic confirmation, and occurrence of multiple infective foci in patients with Staphylococcus aureus bloodstream infection: a look into the order of events and potential clinical implications","volume":"46","author":"Smit","year":"2018","journal-title":"Infection"},{"key":"10.1016\/j.cmi.2022.03.018_bib24","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/01621459.2016.1260466","article-title":"Balancing covariates via propensity score weighting","volume":"113","author":"Li","year":"2018","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.cmi.2022.03.018_bib25","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/sim.5984","article-title":"The use of propensity score methods with survival or time-to-event outcomes: reporting measures of effect similar to those used in randomized experiments","volume":"33","author":"Austin","year":"2014","journal-title":"Stat Med"},{"key":"10.1016\/j.cmi.2022.03.018_bib26","doi-asserted-by":"crossref","first-page":"djw154","DOI":"10.1093\/jnci\/djw154","article-title":"Beyond composite endpoints analysis: semicompeting risks as an underutilized framework for cancer research","volume":"108","author":"Jazi\u0107","year":"2016","journal-title":"J\u00a0Natl Cancer Inst"},{"key":"10.1016\/j.cmi.2022.03.018_bib27","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/biomet\/88.4.907","article-title":"On semi-competing risks data","volume":"88","author":"Fine","year":"2001","journal-title":"Biometrika"},{"key":"10.1016\/j.cmi.2022.03.018_bib28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1161\/CIRCULATIONAHA.115.017719","article-title":"Introduction to the analysis of survival data in the presence of competing risks","volume":"133","author":"Austin","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.cmi.2022.03.018_bib29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/biom.13332","article-title":"Variance estimation in inverse probability weighted Cox models","volume":"77","author":"Shu","year":"2021","journal-title":"Biometrics"},{"key":"10.1016\/j.cmi.2022.03.018_bib30","doi-asserted-by":"crossref","first-page":"5642","DOI":"10.1002\/sim.7084","article-title":"Variance estimation when using inverse probability of treatment weighting (IPTW) with survival analysis","volume":"35","author":"Austin","year":"2016","journal-title":"Stat Med"},{"key":"10.1016\/j.cmi.2022.03.018_bib35","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1469-0691.2005.01359.x","article-title":"Course and outcome of Staphylococcus aureus bacteraemia: a retrospective analysis of 308 episodes in a Swiss tertiary-care centre","volume":"12","author":"Kaech","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2022.03.018_bib36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1444-0903.2001.00029.x","article-title":"Prospective study of 424 cases of Staphylococcus aureus bacteraemia: determination of factors affecting incidence and mortality","volume":"31","author":"Hill","year":"2001","journal-title":"Intern Med J"},{"key":"10.1016\/j.cmi.2022.03.018_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/PL00011241","article-title":"Predisposing factors and outcome of Staphylococcus aureus bacteremia in neutropenic patients with cancer","volume":"20","author":"Gonz\u00e1lez-Barca","year":"2001","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib38","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s10096-019-03802-w","article-title":"Impact of neutropenia on the clinical outcomes of Staphylococcus aureus bacteremia in patients with hematologic malignancies: a 10-year experience in a tertiary care hospital","volume":"39","author":"Ryu","year":"2020","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib39","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1056\/NEJM199808203390806","article-title":"Staphylococcus aureus infections","volume":"339","author":"Lowy","year":"1998","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cmi.2022.03.018_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/00365540500372846","article-title":"Persistence in Staphylococcus aureus bacteremia: incidence, characteristics of patients and outcome","volume":"38","author":"Khatib","year":"2006","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.cmi.2022.03.018_bib41","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.4049\/jimmunol.164.7.3713","article-title":"Survival of Staphylococcus aureus inside neutrophils contributes to infection","volume":"164","author":"Gresham","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.cmi.2022.03.018_bib42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrmicro2508","article-title":"Are bloodstream leukocytes Trojan horses for the metastasis of Staphylococcus aureus?","volume":"9","author":"Thwaites","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.cmi.2022.03.018_bib43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature16057","article-title":"Novel antibody-antibiotic conjugate eliminates intracellular S.\u00a0aureus","volume":"527","author":"Lehar","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cmi.2022.03.018_bib44","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1302\/2046-3758.94.BJR-2019-0205.R1","article-title":"Intestinal methicillin-resistant Staphylococcus aureus causes prosthetic infection via 'Trojan horse' mechanism: evidence from a rat model","volume":"9","author":"Zhu","year":"2020","journal-title":"Bone Jt Res"},{"key":"10.1016\/j.cmi.2022.03.018_bib45","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/SLA.0000000000002173","article-title":"Can methicillin-resistant Staphylococcus aureus silently travel from the gut to the wound and cause postoperative infection? Modeling the \"Trojan horse hypothesis","volume":"267","author":"Krezalek","year":"2018","journal-title":"Ann Surg"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X22001574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X22001574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:30:56Z","timestamp":1761118256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X22001574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S1198743X22001574"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2022.03.018","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of neutropenia on clinical manifestations and outcome of Staphylococcus aureus bloodstream infection: a propensity score-based overlap weight analysis in two large, prospectively evaluated cohorts","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2022.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}