{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:12:06Z","timestamp":1773850326632,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":418,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.cmi.2022.10.001","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T02:07:02Z","timestamp":1665194822000},"page":"360-365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["A risk score for identifying patients at a low risk of bacterial meningitis amongst adults with cerebrospinal fluid leucocytosis and a negative gram stain result: a derivation and validation study"],"prefix":"10.1016","volume":"29","author":[{"given":"Thijs M.","family":"van Soest","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liora ter","family":"Horst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Chekrouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merijn W.","family":"Bijlsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs C.","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Urueta","family":"Portillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diederik","family":"van de Beek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Hasbun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2022.10.001_bib1","first-page":"1","article-title":"Adults with suspected central nervous system infection: a prospective study of diagnostic accuracy","volume":"74","author":"Khatib","year":"2017","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2022.10.001_bib2","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/CMR.00070-09","article-title":"Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis","volume":"23","author":"Brouwer","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.cmi.2022.10.001_bib3","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0140-6736(21)00883-7","article-title":"Community-acquired bacterial meningitis","volume":"398","author":"van de Beek","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cmi.2022.10.001_bib4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/03007995.2021.1876007","article-title":"Hospital incidence, in-hospital mortality and medical costs of pneumococcal disease in Spain (2008-2017): a retrospective multicentre study","volume":"37","author":"Darba","year":"2021","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.cmi.2022.10.001_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1524-4733.2006.00113.x","article-title":"Managing meningococcal disease in the United States: hospital case characteristics and costs by age","volume":"9","author":"O'Brien","year":"2006","journal-title":"Value Health"},{"key":"10.1016\/j.cmi.2022.10.001_bib6","first-page":"143","article-title":"Systematic review and validation of diagnostic prediction models in patients suspected of meningitis","volume":"80","author":"van Zeggeren","year":"2020","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2022.10.001_bib7","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1093\/cid\/ciw861","article-title":"2017 Infectious Diseases Society of America\u2019s clinical practice guidelines for healthcare-associated ventriculitis and meningitis","volume":"64","author":"Tunkel","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2022.10.001_bib8","doi-asserted-by":"crossref","first-page":"862","DOI":"10.7326\/0003-4819-129-11_Part_1-199812010-00004","article-title":"Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing","volume":"129","author":"Aronin","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cmi.2022.10.001_bib9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jcv.2017.07.016","article-title":"Aseptic meningitis in adults and children: diagnostic and management challenges","volume":"94","author":"Shukla","year":"2017","journal-title":"J\u00a0Clin Virol"},{"key":"10.1016\/j.cmi.2022.10.001_bib10","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/cid\/cit458","article-title":"Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium","volume":"57","author":"Venkatesan","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2022.10.001_bib11","first-page":"259","article-title":"The incidence of bacterial meningitis in The Netherlands\u2014a comparison of three registration systems, 1977-1982","volume":"11","author":"Spanjaard","year":"1985","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2022.10.001_bib12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1473-3099(15)00430-2","article-title":"Community-acquired bacterial meningitis in adults in The Netherlands, 2006-14: a prospective cohort study","volume":"16","author":"Bijlsma","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2022.10.001_bib13","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1001\/jama.1989.03430190084036","article-title":"Differential diagnosis of acute meningitis: an analysis of the predictive value of initial observations","volume":"262","author":"Spanos","year":"1989","journal-title":"JAMA"},{"key":"10.1016\/j.cmi.2022.10.001_bib14","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1177\/0962280215592907","article-title":"Estimating negative likelihood ratio confidence when test sensitivity is 100%: a bootstrapping approach","volume":"26","author":"Marill","year":"2017","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.cmi.2022.10.001_bib15","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1007\/s00134-005-2811-1","article-title":"Accuracy of clinical presentation for differentiating bacterial from viral meningitis in adults: a multivariate approach","volume":"31","author":"Brivet","year":"2005","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.cmi.2022.10.001_bib16","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2169\/internalmedicine.48.1832","article-title":"Identifying low-risk patients for bacterial meningitis in adult patients with acute meningitis","volume":"48","author":"Tokuda","year":"2009","journal-title":"Intern Med"},{"key":"10.1016\/j.cmi.2022.10.001_bib17","doi-asserted-by":"crossref","first-page":"1102.e1","DOI":"10.1016\/j.cmi.2018.01.016","article-title":"Infectious meningitis and encephalitis in adults in Denmark: a prospective nationwide observational cohort study (DASGIB)","volume":"24","author":"Bodilsen","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2022.10.001_bib18","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S1473-3099(18)30245-7","article-title":"Incidence, etiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study","volume":"18","author":"McGill","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2022.10.001_bib19","doi-asserted-by":"crossref","first-page":"631.e7","DOI":"10.1016\/j.cmi.2020.06.012","article-title":"Diagnostic accuracy of VIDISCA-NGS in patients with suspected central nervous system infections","volume":"27","author":"van Zeggeren","year":"2021","journal-title":"Clin Microbiol Infect"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X22005146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X22005146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:34:47Z","timestamp":1761118487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X22005146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S1198743X22005146"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2022.10.001","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A risk score for identifying patients at a low risk of bacterial meningitis amongst adults with cerebrospinal fluid leucocytosis and a negative gram stain result: a derivation and validation study","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2022.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}