{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:13:54Z","timestamp":1761174834509,"version":"build-2065373602"},"reference-count":14,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.cmi.2023.05.027","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T12:41:40Z","timestamp":1685018500000},"page":"1468-1470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Which trial do we need? Doxycycline vs. doxycycline-hydroxychloroquine and treatment duration protocol for Q fever endovascular infections"],"prefix":"10.1016","volume":"29","author":[{"given":"Mical","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2023.05.027_bib1","first-page":"1","article-title":"Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q fever working group","volume":"62","author":"Anderson","year":"2013","journal-title":"MMWR Recomm Rep"},{"author":"Raoult","key":"10.1016\/j.cmi.2023.05.027_bib2"},{"key":"10.1016\/j.cmi.2023.05.027_bib3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/infdis\/166.5.1097","article-title":"Phagolysosomal alkalinization and the bactericidal effect of antibiotics: the Coxiella burnetii paradigm","volume":"166","author":"Maurin","year":"1992","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.cmi.2023.05.027_bib4","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1073\/pnas.78.5.3240","article-title":"Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetii","volume":"78","author":"Hackstadt","year":"1981","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.cmi.2023.05.027_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/archinte.159.2.167","article-title":"Treatment of Q fever endocarditis: comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine","volume":"159","author":"Raoult","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cmi.2023.05.027_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1473-3099(10)70135-3","article-title":"Long-term outcome of Q fever endocarditis: a 26-year personal survey","volume":"10","author":"Million","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2023.05.027_bib7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.cmi.2022.02.008","article-title":"Treatment of Coxiella burnetii endocarditis with hydroxychloroquine. Is it evidence-based?","volume":"28","author":"Stahl","year":"2022","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2023.05.027_bib8","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.cmi.2021.08.024","article-title":"Repurposed drugs for COVID-19: threshold and proof requirements for trials","volume":"27","author":"Paul","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2023.05.027_bib9","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/cid\/cix886","article-title":"Treatment of chronic Q fever: clinical efficacy and toxicity of antibiotic regimens","volume":"66","author":"van Roeden","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2023.05.027_bib10","first-page":"247","article-title":"Chronic Q fever: review of the literature and a proposal of new diagnostic criteria","volume":"64","author":"Wegdam-Blans","year":"2012","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.cmi.2023.05.027_bib11","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cmi.2021.06.017","article-title":"The prognostic value of serological titres in chronic Q fever: treat the patient, not the laboratory data","volume":"27","author":"Ghanem-Zoubi","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2023.05.027_bib12","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.cmi.2021.03.016","article-title":"The prognostic value of serological titres for clinical\u00a0outcomes during treatment and follow-up of patients with chronic Q\u00a0fever","volume":"27","author":"Buijs","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2023.05.027_bib13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jclinepi.2016.08.003","article-title":"Registry-based randomized controlled trials- what are the advantages, challenges, and areas for future research?","volume":"80","author":"Li","year":"2016","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.cmi.2023.05.027_bib14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/zph.12896","article-title":"Acute and chronic Q fever national surveillance - United States, 2008\u20132017","volume":"69","author":"Cherry","year":"2022","journal-title":"Zoonoses Public Health"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X23002513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X23002513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:35:27Z","timestamp":1761118527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X23002513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1198743X23002513"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2023.05.027","relation":{},"ISSN":["1198-743X"],"issn-type":[{"type":"print","value":"1198-743X"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Which trial do we need? Doxycycline vs. doxycycline-hydroxychloroquine and treatment duration protocol for Q fever endovascular infections","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2023.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}