{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:58:48Z","timestamp":1790823528645,"version":"4.1.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.cmi.2025.04.023","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T14:46:15Z","timestamp":1745678775000},"page":"1618-1622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model"],"prefix":"10.1016","volume":"31","author":[{"given":"Jenny L.","family":"Schnyder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna K.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel B.","family":"Bache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier M.","family":"van Hest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"B\u00e9lard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hanscheid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Kremsner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Grobusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2025.04.023_bib1","series-title":"Chapter 7. Malaria. International Travel and Health","year":"2020"},{"key":"10.1016\/j.cmi.2025.04.023_bib2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/jac\/dkm337","article-title":"A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria","volume":"60","author":"Nakato","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2025.04.023_bib3","doi-asserted-by":"crossref","first-page":"102520","DOI":"10.1016\/j.tmaid.2022.102520","article-title":"On the potential for discontinuing atovaquone-proguanil (AP) ad-hoc post-exposure and other abbreviated AP-regimens: Pharmacology, pharmacokinetics and perspectives","volume":"52","author":"Schnyder","year":"2022","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.cmi.2025.04.023_bib5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1086\/514710","article-title":"Efficacy and safety of atovaquone\/proguanil as suppressive prophylaxis for Plasmodium falciparum malaria","volume":"27","author":"Shanks","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2025.04.023_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4269\/ajtmh.1999.60.521","article-title":"A randomized, double-blind, placebo-controlled field trial to determine the efficacy and safety of Malarone (atovaquone\/proguanil) for the prophylaxis of malaria in Zambia","volume":"60","author":"Sukwa","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cmi.2025.04.023_bib7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(97)09222-2","article-title":"Randomised placebo-controlled study of atovaquone plus proguanil for malaria prophylaxis in children","volume":"351","author":"Lell","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.cmi.2025.04.023_bib8","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1086\/322694","article-title":"Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: Results from a randomized, double-blind study","volume":"33","author":"Overbosch","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2025.04.023_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1708-8305.2007.00116.x","article-title":"Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: Results from a randomized, double-blind study","volume":"14","author":"Van Genderen","year":"2007","journal-title":"J Travel Med"},{"key":"10.1016\/j.cmi.2025.04.023_bib10","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1086\/421086","article-title":"Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: Results of an international, randomized, open-label study","volume":"38","author":"Camus","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2025.04.023_bib11","doi-asserted-by":"crossref","first-page":"102812","DOI":"10.1016\/j.tmaid.2025.102812","article-title":"Travellers\u2019 adherence to atovaquone\/proguanil malaria chemoprophylaxis after return from endemic areas","volume":"64","author":"Schnyder","year":"2025","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.cmi.2025.04.023_bib12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1093\/cid\/cir770","article-title":"Prolonged protection provided by a single dose of atovaquone-proguanil for the chemoprophylaxis of Plasmodium falciparum malaria in a human challenge model","volume":"54","author":"Deye","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2025.04.023_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12936-015-0628-0","article-title":"Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: A dose-finding trial in two centres","volume":"14","author":"Mordm\u00fcller","year":"2015","journal-title":"Malar J"},{"key":"10.1016\/j.cmi.2025.04.023_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038434","article-title":"Comparison of clinical and parasitological data from controlled human malaria infection trials","volume":"7","author":"Roestenberg","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.cmi.2025.04.023_bib15","series-title":"Investigational Brochure PfSPZ Challenge (NF54)","year":"2022"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X25001867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X25001867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:22:07Z","timestamp":1790821327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X25001867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1198743X25001867"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2025.04.023","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Which trial do we need? A randomised controlled study to compare the protective efficacy of early post-exposure discontinuation versus standard atovaquone-proguanil malaria prophylaxis in a human Plasmodium falciparum challenge model","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2025.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}