{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:28:25Z","timestamp":1793320105375,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Governmental Funding of Research within the Clinical Health Sciences"},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cmi.2025.05.027","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:14:38Z","timestamp":1748430878000},"page":"1532-1538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of time to positivity with disease severity in bloodstream infections\u2014a population-based cohort study"],"prefix":"10.1016","volume":"31","author":[{"given":"Oskar","family":"Ljungquist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Tverring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Oldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torgny","family":"Sunnerhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustav","family":"Torisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2025.05.027_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/1469-0691.12195","article-title":"Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe","volume":"19","author":"Goto","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2025.05.027_bib2","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2023.28.10.2200519","article-title":"Incidence, aetiology and temporal trend of bloodstream infections in southern Sweden from 2006 to 2019: a population-based study","volume":"28","author":"Ljungquist","year":"2023","journal-title":"Euro Surveill"},{"key":"10.1016\/j.cmi.2025.05.027_bib3","article-title":"Hospitalisations with infectious disease diagnoses in somatic healthcare between 1998 and 2019: a nationwide, register-based study in Swedish adults","volume":"16","author":"Torisson","year":"2022","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.cmi.2025.05.027_bib4","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.3201\/eid2710.204826","article-title":"Population-based study of bloodstream infection incidence and mortality rates, Finland, 2004\u20132018","volume":"27","author":"Kontula","year":"2021","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.cmi.2025.05.027_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cll.2020.07.001","article-title":"Modern blood culture: management decisions and method options","volume":"40","author":"Gonzalez","year":"2020","journal-title":"Clin Lab Med"},{"key":"10.1016\/j.cmi.2025.05.027_bib6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cmi.2018.12.001","article-title":"Blood culture time-to-positivity: making use of the hidden information","volume":"25","author":"Lamy","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2025.05.027_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofac163","article-title":"Time to blood culture positivity: an independent predictor of mortality in Streptococcus pyogenes bacteremia","volume":"9","author":"Bl\u00e4ckberg","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.cmi.2025.05.027_bib8","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s10096-021-04210-9","article-title":"Short time to blood culture positivity in Enterococcus faecalis infective endocarditis","volume":"40","author":"Oldberg","year":"2021","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2025.05.027_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/23744235.2023.2182910","article-title":"Time to positivity of blood cultures in bloodstream infections with Streptococcus dysgalactiae and association with outcome","volume":"55","author":"Bl\u00e4ckberg","year":"2023","journal-title":"Infect Dis (Lond)"},{"key":"10.1016\/j.cmi.2025.05.027_bib10","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.cmi.2024.03.032","article-title":"Time to positivity is a risk factor for death among patients with bloodstream infections: a population-based cohort","volume":"40","author":"Laupland","year":"2024","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2025.05.027_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.anaerobe.2021.102474","article-title":"Short blood culture time-to-positivity in Fusobacterium necrophorum bacteremia is associated with Lemierre\u2019s syndrome","volume":"73","author":"Nygren","year":"2022","journal-title":"Anaerobe"},{"key":"10.1016\/j.cmi.2025.05.027_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182436","article-title":"Time to blood culture positivity as a predictor of clinical outcomes and severity in adults with bacteremic pneumococcal pneumonia","volume":"12","author":"Cill\u00f3niz","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.cmi.2025.05.027_bib13","article-title":"Relationship between blood culture time to positivity, mortality rate, and severity of bacteremia","volume":"54","author":"Deguchi","year":"2024","journal-title":"Infect Dis Now"},{"key":"10.1016\/j.cmi.2025.05.027_bib14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12879-022-07098-8","article-title":"Short time to positivity of blood culture predicts mortality and septic shock in bacteremic patients: a systematic review and meta-analysis","volume":"22","author":"Hsieh","year":"2022","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.cmi.2025.05.027_bib15","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1086\/432472","article-title":"Time to positivity in Staphylococcus aureus bacteremia: possible correlation with the source and outcome of infection","volume":"41","author":"Khatib","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2025.05.027_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2021.05.043","article-title":"Time to positivity in bloodstream infection is not a prognostic marker for mortality: analysis of a prospective multicentre randomized control trial","volume":"28","author":"Hamilton","year":"2022","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2025.05.027_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/599376","article-title":"Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America","volume":"49","author":"Mermel","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2025.05.027_bib18","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1002\/cpz1.20","article-title":"Growth and maintenance of Escherichia coli laboratory strains","volume":"1","author":"Tuttle","year":"2021","journal-title":"Curr Protoc"},{"key":"10.1016\/j.cmi.2025.05.027_bib19","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1128\/JCM.01198-14","article-title":"Time to positivity and detection of growth in anaerobic blood culture vials predict the presence of Candida glabrata in candidemia: a two-center European cohort study","volume":"52","author":"Cobos-Trigueros","year":"2014","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.cmi.2025.05.027_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2020.11.007","article-title":"Time to blood culture positivity in Staphylococcus aureus bacteraemia to determine risk of infective endocarditis","volume":"27","author":"Kahn","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2025.05.027_bib21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10096-021-04339-7","article-title":"Blood culture time to positivity in non-\u03b2-hemolytic streptococcal bacteremia as a predictor of infective endocarditis\u2013A retrospective cohort study","volume":"41","author":"Krus","year":"2022","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2025.05.027_bib22","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/j.1469-0691.2009.02720.x","article-title":"Correlation between time to positivity of blood cultures with clinical presentation and outcomes in patients with Klebsiella pneumoniae bacteraemia: prospective cohort study","volume":"15","author":"Liao","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.cmi.2025.05.027_bib23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2147\/CLEP.S282475","article-title":"Adaptation of the Charlson comorbidity index for register-based research in Sweden","volume":"13","author":"Ludvigsson","year":"2021","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.cmi.2025.05.027_bib24","series-title":"National early warning Score (NEWS) 2: standardising the assessment of acute-illness severity in the NHS","year":"2017"},{"key":"10.1016\/j.cmi.2025.05.027_bib25","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.eimc.2016.10.003","article-title":"Time to positivity of blood cultures in patients with bloodstream infections: a useful prognostic tool","volume":"35","author":"Mart\u00edn-Guti\u00e9rrez","year":"2017","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.cmi.2025.05.027_bib26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.diagmicrobio.2013.03.031","article-title":"Transport time for blood culture bottles: underlying factors and its consequences","volume":"76","author":"R\u00f6nnberg","year":"2013","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X25002587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X25002587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T21:50:42Z","timestamp":1758664242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X25002587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1198743X25002587"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2025.05.027","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of time to positivity with disease severity in bloodstream infections\u2014a population-based cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2025.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.","name":"copyright","label":"Copyright"}]}}