{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:49:08Z","timestamp":1792518548678,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.cmi.2025.08.009","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T20:59:29Z","timestamp":1755809969000},"page":"2056-2062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Key predictors of mortality in Crimean-Congo haemorrhagic fever: a retrospective multicentre cohort study"],"prefix":"10.1016","volume":"31","author":[{"given":"Deniz","family":"G\u00fcll\u00fc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defne","family":"Yigci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurcan","family":"Baykam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysel Kocag\u00fcl","family":"\u00c7elikba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Yapar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Akdo\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemalettin","family":"\u00d6zden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukiye \u0130nan","family":"Sar\u0131kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130mran","family":"Hasano\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmet","family":"G\u00fcner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Karake\u00e7ili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handan","family":"Alay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep T\u00fcre","family":"Y\u00fcce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esma Ery\u0131lmaz","family":"Eren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Erbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eebnem Eren","family":"G\u00f6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem","family":"Kader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze \u00dcn\u00fcvar","family":"Kal\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azize","family":"Yeti\u015fgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fcge","family":"\u00d6zg\u00fcler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu","family":"\u015eenol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6m\u00fcr","family":"G\u00fcnda\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve \u00c7a\u011flar","family":"\u00d6zer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firuze","family":"Soyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fc\u015fra","family":"Tan\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u015f\u0131l Deniz","family":"Al\u0131ravc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcle","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bar\u00e7\u0131n","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahad\u0131r Orkun","family":"\u00d6zbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatihan","family":"P\u0131narl\u0131k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mert","family":"Ku\u015fkucu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6nder","family":"Erg\u00f6n\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2025.08.009_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijid.2023.12.004","article-title":"Climate change and the rising incidence of vector-borne diseases globally","volume":"139","author":"George","year":"2024","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.meegid.2017.04.017","article-title":"Crimean-Congo hemorrhagic fever virus in ticks in Turkey: A broad range tick surveillance study","volume":"52","author":"Orkun","year":"2017","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.cmi.2025.08.009_bib3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41590-020-0648-y","article-title":"Climate change: An enduring challenge for vector-borne disease prevention and control","volume":"21","author":"Rockl\u00f6v","year":"2020","journal-title":"Nat Immunol"},{"key":"10.1016\/j.cmi.2025.08.009_bib4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1473-3099(06)70435-2","article-title":"Crimean-Congo haemorrhagic fever","volume":"6","author":"Erg\u00f6n\u00fcl","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/trstmh\/trv050","article-title":"The global distribution of Crimean-Congo hemorrhagic fever","volume":"109","author":"Messina","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.cmi.2025.08.009_bib6","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3390\/pathogens13090770","article-title":"Crimean-Congo hemorrhagic fever virus: An emerging threat in Europe with a focus on epidemiology in Spain","volume":"13","author":"Eslava","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.cmi.2025.08.009_bib7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3201\/eid3101.241264","article-title":"Fatal case of Crimean-Congo hemorrhagic fever, Portugal, 2024","volume":"31","author":"Z\u00e9-Z\u00e9","year":"2025","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib8","doi-asserted-by":"crossref","first-page":"2400023","DOI":"10.2807\/1560-7917.ES.2024.29.6.2400023","article-title":"Detection of Crimean-Congo haemorrhagic fever virus in Hyalomma marginatum ticks, southern France, May 2022 and April 2023","volume":"29","author":"Bernard","year":"2024","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.cmi.2025.08.009_bib9","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3390\/microorganisms10081551","article-title":"The scenario of ticks and tick-borne pathogens of sheep on a mediterranean Island","volume":"10","author":"Saratsis","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.cmi.2025.08.009_bib10","doi-asserted-by":"crossref","unstructured":"Grandi G., Chitimia-Dobler L., Choklikitumnuey P., Strube C., Springer A., Albihn A., et al. First records of adult Hyalomma marginatum and H. rufipes ticks (Acari: Ixodidae) in Sweden. Ticks and tick-borne diseases, vol. 11; 2020. 101403. https:\/\/doi.org\/10.1016\/j.ttbdis.2020.101403.","DOI":"10.1016\/j.ttbdis.2020.101403"},{"key":"10.1016\/j.cmi.2025.08.009_bib11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.coviro.2012.03.001","article-title":"Crimean-Congo hemorrhagic fever virus: New outbreaks, new discoveries","volume":"2","author":"Ergonul","year":"2012","journal-title":"Curr Opin Virol"},{"key":"10.1016\/j.cmi.2025.08.009_bib12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.antiviral.2013.07.006","article-title":"Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity","volume":"100","author":"Bente","year":"2013","journal-title":"Antivir Res"},{"key":"10.1016\/j.cmi.2025.08.009_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.antiviral.2007.11.002","article-title":"Treatment of Crimean-Congo hemorrhagic fever","volume":"78","author":"Ergonul","year":"2008","journal-title":"Antivir Res"},{"key":"10.1016\/j.cmi.2025.08.009_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.antiviral.2016.06.011","article-title":"Prognostic factors, pathophysiology and novel biomarkers in Crimean-Congo hemorrhagic fever","volume":"132","author":"Akinci","year":"2016","journal-title":"Antivir Res"},{"key":"10.1016\/j.cmi.2025.08.009_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10096-014-2238-0","article-title":"Validation of a severity grading score (SGS) system for predicting the course of disease and mortality in patients with Crimean-Congo hemorrhagic fever (CCHF)","volume":"34","author":"Bak\u0131r","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib16","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/cid\/cit527","article-title":"Severity scoring index for Crimean-Congo hemorrhagic fever and the impact of ribavirin and corticosteroids on fatality","volume":"57","author":"Dokuzoguz","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib17","series-title":"Guideline for management of Crimean-Congo hemorrhagic fever patients","year":"2025"},{"key":"10.1016\/j.cmi.2025.08.009_bib18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.26719\/2024.30.8.570","article-title":"Crimean-Congo haemorrhagic fever in Iraq","volume":"30","author":"Baghdadi","year":"2024","journal-title":"East Mediterr Health J"},{"key":"10.1016\/j.cmi.2025.08.009_bib19","series-title":"Crimean-Congo haemorrhagic fever WHO website","year":"2025"},{"key":"10.1016\/j.cmi.2025.08.009_bib20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4269\/ajtmh.23-0630","article-title":"Predictors of mortality in Crimean-Congo hemorrhagic fever patients admitted at a tertiary care hospital in Pakistan over the last 10 years: a case-control study","volume":"111","author":"Sethi","year":"2024","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cmi.2025.08.009_bib21","doi-asserted-by":"crossref","first-page":"e616","DOI":"10.1016\/j.ijid.2012.04.009","article-title":"C-type natriuretic peptide is associated with the severity of Crimean-Congo hemorrhagic fever","volume":"16","author":"Turkdogan","year":"2012","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib22","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/sj.bjp.0703393","article-title":"Endothelial dysfunction in diabetes","volume":"130","author":"De Vriese","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.cmi.2025.08.009_bib23","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00705-017-3653-1","article-title":"Evaluation of the associations between endothelial dysfunction, inflammation and coagulation in Crimean-Congo hemorrhagic fever patients","volume":"163","author":"Do\u011fan","year":"2018","journal-title":"Arch Virol"},{"key":"10.1016\/j.cmi.2025.08.009_bib24","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s10096-009-0728-2","article-title":"The role of ribavirin in the therapy of Crimean-Congo hemorrhagic fever: Early use is promising","volume":"28","author":"Tasdelen Fisgin","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib25","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijid.2014.08.016","article-title":"Evidence supports ribavirin use in Crimean-Congo hemorrhagic fever","volume":"29","author":"Ergonul","year":"2014","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1471-2334-10-207","article-title":"Ribavirin for Crimean-Congo hemorrhagic fever: Systematic review and meta-analysis","volume":"10","author":"Soares-Weiser","year":"2010","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.cmi.2025.08.009_bib27","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/jac\/dkr136","article-title":"Ribavirin for patients with Crimean-Congo haemorrhagic fever: A systematic review and meta-analysis","volume":"66","author":"Ascioglu","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.cmi.2025.08.009_bib28","doi-asserted-by":"crossref","first-page":"e799","DOI":"10.1016\/j.ijid.2013.02.030","article-title":"Ribavirin is not effective against Crimean-Congo hemorrhagic fever: Observations from the Turkish experience","volume":"17","author":"Ceylan","year":"2013","journal-title":"Int J Infect Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X25004033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X25004033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T08:04:08Z","timestamp":1764230648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X25004033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1198743X25004033"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2025.08.009","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Key predictors of mortality in Crimean-Congo haemorrhagic fever: a retrospective multicentre cohort study","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2025.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}