{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:46:34Z","timestamp":1790934394422,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100031288","name":"F2G","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.cmi.2025.12.016","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T23:49:13Z","timestamp":1767052153000},"page":"490-495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Paradoxical worsening on olorofim in patients undergoing treatment for invasive fungal diseases"],"prefix":"10.1016","volume":"32","author":[{"suffix":"III","given":"George R.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke H.W.","family":"Bruns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik","family":"Helweg-Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Jenks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bennett","family":"Penn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hoenigl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Maertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Spec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Bresnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Rex","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2025.12.016_bib1","doi-asserted-by":"crossref","first-page":"12809","DOI":"10.1073\/pnas.1608304113","article-title":"F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase","volume":"113","author":"Oliver","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.cmi.2025.12.016_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00231-18","article-title":"Effect of the novel antifungal drug F901318 (Olorofim) on growth and viability of Aspergillus fumigatus","volume":"62","author":"du Pr\u00e9","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2025.12.016_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00434-21","article-title":"In vivo efficacy of olorofim against systemic scedosporiosis and lomentosporiosis","volume":"65","author":"Seyedmousavi","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2025.12.016_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00129-19","article-title":"Efficacy of olorofim (F901318) against Aspergillus fumigatus, A. nidulans, and A. tanneri in murine models of profound neutropenia and chronic granulomatous disease","volume":"63","author":"Seyedmousavi","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2025.12.016_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00999-18","article-title":"The orotomide olorofim is efficacious in an experimental model of central nervous system coccidioidomycosis","volume":"62","author":"Wiederhold","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2025.12.016_bib6","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S1473-3099(25)00224-5","article-title":"Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study","volume":"25","author":"Maertens","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.cmi.2025.12.016_bib7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/01.md.0000189090.52626.7a","article-title":"Peripheral tuberculous lymphadenitis: Epidemiology, diagnosis, treatment, and outcome","volume":"84","author":"Polesky","year":"2005","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cmi.2025.12.016_bib8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1128\/CMR.19.2.338-381.2006","article-title":"The continuing challenges of leprosy","volume":"19","author":"Scollard","year":"2006","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.cmi.2025.12.016_bib9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/thx.2003.019224","article-title":"Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection","volume":"59","author":"Breen","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.cmi.2025.12.016_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0041-3879(77)90041-1","article-title":"Lymph node tuberculosis: a comparison of various methods of treatment","volume":"58","author":"Campbell","year":"1977","journal-title":"Tubercle"},{"key":"10.1016\/j.cmi.2025.12.016_bib11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10096-002-0821-2","article-title":"Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients","volume":"21","author":"Cheng","year":"2002","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2025.12.016_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.smim.2018.06.003","article-title":"Correlates of immune exacerbations in leprosy","volume":"39","author":"Geluk","year":"2018","journal-title":"Semin Immunol"},{"key":"10.1016\/j.cmi.2025.12.016_bib13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4269\/ajtmh.16-0434","article-title":"The Jarisch-Herxheimer reaction after antibiotic treatment of spirochetal infections: a review of recent cases and our understanding of pathogenesis","volume":"96","author":"Butler","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.cmi.2025.12.016_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2165\/00128071-200607050-00007","article-title":"Oral antifungal-exacerbated inflammatory flare-up reactions of dermatomycosis: case reports and review of the literature","volume":"7","author":"Nikkels","year":"2006","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.cmi.2025.12.016_bib21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1001\/jamadermatol.2015.4293","article-title":"Paradoxical reaction during a course of terbinafine treatment of trichophyton interdigitale infection in a child","volume":"152","author":"Hryncewicz-Gw\u00f3zdz","year":"2016","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.cmi.2025.12.016_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/dth.15632","article-title":"Paradoxical inflammatory reaction to terbinafine in the setting of Majocchi\u2019s granuloma due to Trichophyton interdigitale","volume":"35","author":"Paolino","year":"2022","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.cmi.2025.12.016_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.18700\/jnc.170018","article-title":"Paradoxical response after a voriconazole treatment in an immunocompetent host with a skull base osteomyelitis due to invasive Aspergillosis","volume":"10","author":"Kim","year":"2017","journal-title":"J Neurocrit Care"},{"key":"10.1016\/j.cmi.2025.12.016_bib24","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1086\/652290","article-title":"Paradoxical reaction to treatment in 2 patients with severe acute paracoccidioidomycosis: a previously unreported complication and its management with corticosteroids","volume":"50","author":"Gryschek","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2025.12.016_bib25","doi-asserted-by":"crossref","first-page":"e2789","DOI":"10.1093\/cid\/ciaa1901","article-title":"Outcomes in previously healthy cryptococcal meningoencephalitis patients treated with pulse taper corticosteroids for post-infectious inflammatory syndrome","volume":"73","author":"Anjum","year":"2021","journal-title":"Clin Infect Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X25006275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X25006275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:22:02Z","timestamp":1785363722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X25006275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1198743X25006275"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2025.12.016","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paradoxical worsening on olorofim in patients undergoing treatment for invasive fungal diseases","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2025.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.","name":"copyright","label":"Copyright"}]}}