{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:40:31Z","timestamp":1785444031617,"version":"3.56.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1078930"],"award-info":[{"award-number":["1078930"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CG21APR1011"],"award-info":[{"award-number":["CG21APR1011"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CG21APR2005"],"award-info":[{"award-number":["CG21APR2005"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CTGIIL\/003\/2015"],"award-info":[{"award-number":["NMRC\/CTGIIL\/003\/2015"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-000018-00"],"award-info":[{"award-number":["MOH-000018-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalmicrobiologyandinfection.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Microbiology and Infection"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.cmi.2026.01.032","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T07:58:10Z","timestamp":1770710290000},"page":"829-837","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of in vitro synergy and additivity of vancomycin or daptomycin plus an antistaphylococcal \u03b2-lactam for methicillin-resistant Staphylococcus aureus bacteraemia on mortality: preplanned analysis from CAMERA2"],"prefix":"10.1016","volume":"32","author":[{"given":"Joel Z.Y.","family":"Soo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze-Peng","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayden J.Y.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Y.C.","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.H.","family":"Kwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna","family":"Yahav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Sud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Owen Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Archuleta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Cass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Foo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mical","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian R.","family":"Tramontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve B.","family":"Walls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"McBride","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narin","family":"Bak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niladri","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna P.","family":"Ralph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Dotel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve L.","family":"McKew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha E.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgyn S.","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Kalimuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barnaby E.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Runnegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Andresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A.","family":"Anagnostou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Chatfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Vance G.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin P.","family":"Howden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Meagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan J.","family":"van Hal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew V.N.O.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmi.2026.01.032_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1055\/s-0034-1396906","article-title":"Combination antibiotic treatment of serious methicillin-resistant Staphylococcus aureus infections","volume":"36","author":"Davis","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.cmi.2026.01.032_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00109-013-1100-7","article-title":"Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus","volume":"92","author":"Sakoulas","year":"2014","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.cmi.2026.01.032_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/ciz746","article-title":"Daptomycin plus \u03b2-lactam combination therapy for methicillin-resistant Staphylococcus aureus bloodstream infections: A retrospective, comparative cohort study","volume":"71","author":"Jorgensen","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2026.01.032_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.drup.2013.10.002","article-title":"Reduced glycopeptide and lipopeptide susceptibility in Staphylococcus aureus and the \u201cseesaw effect\u201d: Taking advantage of the back door left open?","volume":"16","author":"Ortwine","year":"2013","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.cmi.2026.01.032_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/jama.2020.0103","article-title":"Effect of vancomycin or daptomycin with vs without an antistaphylococcal \u03b2-lactam on mortality, bacteremia, relapse, or treatment failure in patients with MRSA bacteremia: A randomized clinical trial","volume":"323","author":"Tong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.cmi.2026.01.032_bib6","unstructured":"EUCAST. Clinical breakpoints and dosing of antibiotics. https:\/\/www.eucast.org\/clinical_breakpoints. Accessed 20 September 2023."},{"key":"10.1016\/j.cmi.2026.01.032_bib7","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1128\/AAC.42.4.744","article-title":"Use of pharmacodynamic parameters to predict efficacy of combination therapy by using fractional inhibitory concentration kinetics","volume":"42","author":"den Hollander","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2026.01.032_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0732-8893(00)00163-2","article-title":"Evaluation of antibiotic synergy against Acinetobacter baumannii: A comparison with Etest, time-kill, and checkerboard methods","volume":"38","author":"Bonapace","year":"2000","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2026.01.032_bib9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.cmi.2026.01.032_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0924-8579(98)00060-0","article-title":"Combination antibiotic therapy versus monotherapy for gram-negative bacteraemia: A commentary","volume":"11","author":"Chow","year":"1999","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.cmi.2026.01.032_bib11","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","article-title":"Serial evaluation of the SOFA score to predict outcome in critically Ill patients","volume":"286","author":"Ferreira","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.cmi.2026.01.032_bib12","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.16984","article-title":"Microbial susceptibility and plasmid profiles of methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus","volume":"7","author":"Shahkarami","year":"2014","journal-title":"Jundishapur J Microbiol"},{"key":"10.1016\/j.cmi.2026.01.032_bib13","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1093\/cid\/ciq146","article-title":"Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children","volume":"52","author":"Liu","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.cmi.2026.01.032_bib14","doi-asserted-by":"crossref","first-page":"ofaa538","DOI":"10.1093\/ofid\/ofaa538","article-title":"Vancomycin exposure and acute kidney injury outcome: A snapshot from the CAMERA2 study","volume":"7","author":"Liu","year":"2020","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.cmi.2026.01.032_bib15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jgar.2019.01.004","article-title":"Clinical relevance of in vitro synergistic activity of antibiotics for multidrug-resistant Gram-negative infections: A systematic review","volume":"17","author":"Vardakas","year":"2019","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.cmi.2026.01.032_bib16","doi-asserted-by":"crossref","first-page":"ofac096","DOI":"10.1093\/ofid\/ofac096","article-title":"What is the optimal follow-up length for mortality in Staphylococcus aureus bacteremia? Observations from a systematic review of attributable mortality","volume":"9","author":"Bai","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.cmi.2026.01.032_bib17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/AAC.00700-07","article-title":"Outcome of vancomycin treatment in patients with methicillin-susceptible Staphylococcus aureus bacteremia","volume":"52","author":"Kim","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cmi.2026.01.032_bib18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/23744235.2018.1470666","article-title":"Predictors of one-year all-cause mortality and infection-related mortality in patients with Staphylococcus aureus bacteraemia","volume":"50","author":"Eskesen","year":"2018","journal-title":"Infect Dis (Lond)"},{"key":"10.1016\/j.cmi.2026.01.032_bib19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jinf.2016.07.005","article-title":"Long-term mortality and causes of death associated with Staphylococcus aureus bacteremia. A matched cohort study","volume":"73","author":"Gotland","year":"2016","journal-title":"J Infect"},{"key":"10.1016\/j.cmi.2026.01.032_bib20","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s10096-016-2598-8","article-title":"Risk factors for long-term mortality of Staphylococcus aureus bacteremia","volume":"35","author":"Yahav","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.cmi.2026.01.032_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0732-8893(02)00473-X","article-title":"Comparison of methods of interpretation of checkerboard synergy testing","volume":"44","author":"Bonapace","year":"2002","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["Clinical Microbiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X26000583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1198743X26000583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:18:19Z","timestamp":1777609099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1198743X26000583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S1198743X26000583"],"URL":"https:\/\/doi.org\/10.1016\/j.cmi.2026.01.032","relation":{},"ISSN":["1198-743X"],"issn-type":[{"value":"1198-743X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of in vitro synergy and additivity of vancomycin or daptomycin plus an antistaphylococcal \u03b2-lactam for methicillin-resistant Staphylococcus aureus bacteraemia on mortality: preplanned analysis from CAMERA2","name":"articletitle","label":"Article Title"},{"value":"Clinical Microbiology and Infection","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmi.2026.01.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}