{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:34:13Z","timestamp":1789529653203,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["1613 FISR2019_03221"],"award-info":[{"award-number":["1613 FISR2019_03221"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.cmpb.2022.106912","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:49:46Z","timestamp":1653522586000},"page":"106912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Patient-specific multi-scale design optimization of transcatheter aortic valve stents"],"prefix":"10.1016","volume":"221","author":[{"given":"Sara","family":"Barati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-027X","authenticated-orcid":false,"given":"Nasser","family":"Fatouraee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malikeh","family":"Nabaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Petrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4644-630X","authenticated-orcid":false,"given":"Francesco","family":"Migliavacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Luraghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e8 Felix Rodriguez","family":"Matas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmpb.2022.106912_bib0001","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1001\/jamainternmed.2016.8104","article-title":"Transcatheter aortic valve replacement in younger individuals","volume":"177","author":"Sedrakyan","year":"2017","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.cmpb.2022.106912_bib0002","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cmpb.2022.106912_bib0003","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s10439-016-1759-3","article-title":"On the mechanics of transcatheter aortic valve replacement","volume":"45","author":"Dasi","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2022.106912_bib0004","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/17434440.2018.1536427","article-title":"Principles of TAVR valve design, modelling, and testing","volume":"15","author":"Rotman","year":"2018","journal-title":"Expert Rev. Med. Devices."},{"key":"10.1016\/j.cmpb.2022.106912_bib0005","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"Surgical or transcatheter aortic-valve replacement in intermediate-risk patients","volume":"376","author":"Reardon","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cmpb.2022.106912_bib0006","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jacc.2013.01.047","article-title":"Incidence, predictors, and outcomes of aortic regurgitation after transcatheter aortic valve replacement: meta-analysis and systematic review of literature","volume":"61","author":"Athappan","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cmpb.2022.106912_bib0007","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.recesp.2017.03.032","article-title":"Timing of onset and outcome of new conduction abnormalities following transcatheter aortic valve implantation: role of balloon aortic valvuloplasty","volume":"71","author":"Campelo-Parada","year":"2018","journal-title":"Rev. Espa\u00f1ola Cardiol. Engl. Ed."},{"key":"10.1016\/j.cmpb.2022.106912_bib0008","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jcin.2016.01.002","article-title":"Bicuspid aortic valve stenosis: favorable early outcomes with a next-generation transcatheter heart valve in a multicenter study","volume":"9","author":"Perlman","year":"2016","journal-title":"JACC Cardiovasc. Interv."},{"key":"10.1016\/j.cmpb.2022.106912_bib0009","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1016\/j.jbiomech.2015.10.048","article-title":"Prediction of patient-specific post-operative outcomes of TAVI procedure: the impact of the positioning strategy on valve performance","volume":"49","author":"Morganti","year":"2016","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmpb.2022.106912_bib0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10237-018-1094-8","article-title":"Patient-specific simulation of transcatheter aortic valve replacement: impact of deployment options on paravalvular leakage","volume":"18","author":"Bianchi","year":"2019","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.cmpb.2022.106912_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIRCINTERVENTIONS.117.005344","article-title":"Patient-specific computer simulation to elucidate the role of contact pressure in the development of new conduction abnormalities after catheter-based implantation of a self-expanding aortic valve","volume":"11","author":"Rocatello","year":"2018","journal-title":"Circ. Cardiovasc. Interv."},{"key":"10.1016\/j.cmpb.2022.106912_bib0012","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.medengphy.2021.02.004","article-title":"Performance of high conformability vs. high radial force devices in the virtual treatment of TAVI patients with bicuspid aortic valve","volume":"89","author":"Finotello","year":"2021","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.cmpb.2022.106912_bib0013","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1016\/j.jbiomech.2016.06.024","article-title":"A validated methodology for patient specific computational modeling of self-expandable transcatheter aortic valve implantation","volume":"49","author":"Bosmans","year":"2016","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmpb.2022.106912_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1115\/1.4040457","article-title":"Numerical parametric study of paravalvular leak following a transcatheter aortic valve deployment into a patient-specific aortic root","volume":"140","author":"Mao","year":"2018","journal-title":"J. Biomech. Eng."},{"key":"10.1016\/j.cmpb.2022.106912_bib0015","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s13239-019-00427-0","article-title":"On the modeling of patient-specific transcatheter aortic valve replacement: a fluid\u2013structure interaction approach","volume":"10","author":"Luraghi","year":"2019","journal-title":"Cardiovasc. Eng. Technol."},{"key":"10.1016\/j.cmpb.2022.106912_bib0016","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1007\/s10237-020-01304-9","article-title":"Numerical evaluation of transcatheter aortic valve performance during heart beating and its post-deployment fluid\u2013structure interaction analysis","volume":"19","author":"Ghosh","year":"2020","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.cmpb.2022.106912_bib0017","first-page":"1","article-title":"The impact of calcification patterns in transcatheter aortic valve performance: a fluid-structure interaction analysis","volume":"0","author":"Luraghi","year":"2020","journal-title":"Comput. Methods Biomech. Biomed. Engin."},{"key":"10.1016\/j.cmpb.2022.106912_bib0018","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jbiomech.2018.02.017","article-title":"Population-specific material properties of the implantation site for transcatheter aortic valve replacement finite element simulations","volume":"71","author":"Bosi","year":"2018","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmpb.2022.106912_bib0019","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s13239-019-00420-7","article-title":"Optimization of a transcatheter heart valve frame using patient-specific computer simulation","volume":"10","author":"Rocatello","year":"2019","journal-title":"Cardiovasc. Eng. Technol."},{"key":"10.1016\/j.cmpb.2022.106912_bib0020","first-page":"0","article-title":"In silico biomechanical design of the metal frame of transcatheter aortic valves: multi-objective shape and cross-sectional size optimization","author":"Carbonaro","year":"2021","journal-title":"Struct. Multidiscip. Optim."},{"key":"10.1016\/j.cmpb.2022.106912_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104942","article-title":"A computational optimization study of a self-expandable transcatheter aortic valve","volume":"139","author":"Barati","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cmpb.2022.106912_bib0022","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1016\/j.jbiomech.2016.03.036","article-title":"Impact of different aortic valve calcification patterns on the outcome of transcatheter aortic valve implantation: a finite element study","volume":"49","author":"Sturla","year":"2016","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmpb.2022.106912_bib0023","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jbiomech.2018.10.010","article-title":"An in vitro model quantifying the effect of calcification on the tissue\u2013stent interaction in a stenosed aortic root","volume":"82","author":"McGee","year":"2019","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmpb.2022.106912_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.medengphy.2017.06.045","article-title":"Finite element analysis of TAVI: impact of native aortic root computational modeling strategies on simulation outcomes","volume":"47","author":"Finotello","year":"2017","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.cmpb.2022.106912_bib0025","first-page":"53","article-title":"Technical characteristics and evidence to date for FDA-and CE Mark-approved valves","volume":"11","author":"Todaro","year":"2017","journal-title":"Interv. Today."},{"key":"10.1016\/j.cmpb.2022.106912_bib0026","first-page":"1","article-title":"Understanding TAVR device expansion as it relates to morphology of the bicuspid aortic valve: a simulation study","volume":"16","author":"Kusneri","year":"2021","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmpb.2022.106912_bib0027","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s11517-020-02138-4","article-title":"Simulation study of transcatheter heart valve implantation in patients with stenotic bicuspid aortic valve","volume":"58","author":"Pasta","year":"2020","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.cmpb.2022.106912_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cnm.2798","article-title":"Computational comparison of regional stress and deformation characteristics in tricuspid and bicuspid aortic valve leaflets","volume":"33","author":"Cao","year":"2017","journal-title":"Int. J. Numer. Method Biomed. Eng."},{"key":"10.1016\/j.cmpb.2022.106912_bib0029","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1515\/cdbme-2018-0046","article-title":"Numerical simulation of a transcatheter aortic heart valve under application-related loading","volume":"4","author":"Pfensig","year":"2018","journal-title":"Curr. Dir. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2022.106912_bib0030","series-title":"Fatigue Analysis of Nitinol Cardiovascular Devices","author":"Dordoni","year":"2014"},{"key":"10.1016\/j.cmpb.2022.106912_bib0031","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/10255842.2015.1058928","article-title":"Assessing the impact of including leaflets in the simulation of TAVI deployment into a patient-specific aortic root","volume":"19","author":"Bailey","year":"2016","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2022.106912_bib0032","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jcin.2015.02.005","article-title":"Optimal implantation depth and adherence to guidelines on permanent pacing to improve the results of transcatheter aortic valve replacement with the medtronic corevalve system: the CoreValve prospective, international, post-market ADVANCE-II study","volume":"8","author":"Petronio","year":"2015","journal-title":"JACC Cardiovasc. Interv."},{"key":"10.1016\/j.cmpb.2022.106912_bib0033","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10439-012-0694-1","article-title":"Quantification of biomechanical interaction of transcatheter aortic valve stent deployed in porcine and ovine hearts","volume":"41","author":"Mummert","year":"2013","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2022.106912_bib0034","first-page":"911","article-title":"Geometry and degree of apposition of the CoreValve ReValving system with multislice computed tomography after implantation in patients with aortic stenosis","volume":"54","author":"Schultz","year":"2009","journal-title":"JAC"},{"key":"10.1016\/j.cmpb.2022.106912_bib0035","doi-asserted-by":"crossref","DOI":"10.1142\/S1793604712500129","article-title":"Fatigue behavior characterization of nitinol for peripheral stents","volume":"5","author":"Petrini","year":"2012","journal-title":"Funct. Mater. Lett."},{"key":"10.1016\/j.cmpb.2022.106912_bib0036","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/0954411917696336","article-title":"The role of inelastic deformations in the mechanical response of endovascular shape memory alloy devices","volume":"231","author":"Petrini","year":"2017","journal-title":"Proc. Inst. Mech. Eng. Part H J. Eng. Med."},{"key":"10.1016\/j.cmpb.2022.106912_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cnm.3125","article-title":"Surrogate-based visualization and sensitivity analysis of coronary stent performance: a study on the influence of geometric design","volume":"34","author":"Ribeiro","year":"2018","journal-title":"Int. J. Numer. Method Biomed. Eng."},{"key":"10.1016\/j.cmpb.2022.106912_bib0038","unstructured":"ASTM F3067-14, Guide for radial loading of balloon expandable and self expanding, (2014). 10.1520\/F3067."},{"key":"10.1016\/j.cmpb.2022.106912_bib0039","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/icvts\/ivaa231","article-title":"Outcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices","volume":"32","author":"Gorla","year":"2021","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"10.1016\/j.cmpb.2022.106912_bib0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ijcard.2017.11.106","article-title":"Quantitative assessment of paravalvular leakage after transcatheter aortic valve replacement using a patient-specific pulsatile flow model","volume":"258","author":"Tanaka","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.cmpb.2022.106912_bib0041","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10237-014-0583-7","article-title":"Simulations of transcatheter aortic valve implantation: implications for aortic root rupture","volume":"14","author":"Wang","year":"2014","journal-title":"Biomech. Model. Mechanobiol."},{"key":"10.1016\/j.cmpb.2022.106912_bib0042","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jmbbm.2017.02.006","article-title":"Understanding the requirements of self-expandable stents for heart valve replacement: radial force, hoop force and equilibrium","volume":"68","author":"Cabrera","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.cmpb.2022.106912_bib0043","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.ejrad.2015.04.003","article-title":"Aortic annulus eccentricity before and after transcatheter aortic valve implantation: comparison of balloon-expandable and self-expanding prostheses","volume":"84","author":"Schuhbaeck","year":"2015","journal-title":"Eur. J. Radiol."},{"key":"10.1016\/j.cmpb.2022.106912_bib0044","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s12265-019-09877-2","article-title":"The impact of size and position of a mechanical expandable transcatheter aortic valve: novel insights through computational modelling and simulation","volume":"12","author":"Rocatello","year":"2019","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.cmpb.2022.106912_bib0045","first-page":"144","article-title":"Trends in the occurrence of new conduction abnormalities after transcatheter aortic valve implantation","volume":"85","author":"Van Der Boon","year":"2015","journal-title":"Catheter. Cardiovasc. Interv."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260722002942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260722002942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:17:37Z","timestamp":1759205857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260722002942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":45,"alternative-id":["S0169260722002942"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2022.106912","relation":{},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patient-specific multi-scale design optimization of transcatheter aortic valve stents","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2022.106912","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106912"}}