{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:05:35Z","timestamp":1783573535728,"version":"3.55.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.cmpb.2023.107774","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:23:03Z","timestamp":1692757383000},"page":"107774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Effect of uncertain clinical conditions on the early healing and stability of distal radius fractures"],"prefix":"10.1016","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-8735","authenticated-orcid":false,"given":"Xuanchi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinJing","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8562-495X","authenticated-orcid":false,"given":"Minoo","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6943-7444","authenticated-orcid":false,"given":"Saeed","family":"Miramini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cmpb.2023.107774_bib0001","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.hcl.2012.02.001","article-title":"The epidemiology of distal radius fractures","volume":"28","author":"Nellans","year":"2012","journal-title":"Hand Clin."},{"key":"10.1016\/j.cmpb.2023.107774_bib0002","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.2106\/JBJS.J.01597","article-title":"A prospective randomized trial comparing nonoperative treatment with volar locking plate fixation for displaced and unstable distal radial fractures in patients sixty-five years of age and older","volume":"93A","author":"Arora","year":"2011","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0003","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1471-2474-9-129","article-title":"The prevalence of pain and disability one year post fracture of the distal radius in a UK population: a cross sectional survey","volume":"9","author":"Moore","year":"2008","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.cmpb.2023.107774_bib0004","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3109\/17453670903171875","article-title":"Open reduction and internal fixation compared to closed reduction and external fixation in distal radial fractures A randomized study of 50 patients","volume":"80","author":"Abramo","year":"2009","journal-title":"Acta Orthop."},{"key":"10.1016\/j.cmpb.2023.107774_bib0005","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jht.2016.03.003","article-title":"Epidemiology of distal radius fractures and factors predicting risk and prognosis","volume":"29","author":"Macintyre","year":"2016","journal-title":"J. Hand Ther."},{"key":"10.1016\/j.cmpb.2023.107774_bib0006","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.jhsa.2012.06.001","article-title":"Distal Radius Fractures: current Concepts","volume":"37A","author":"Schneppendahl","year":"2012","journal-title":"J. Hand Surg. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0007","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s00402-011-1346-x","article-title":"Internal fixation of dorsally comminuted fractures of the distal part of the radius: a biomechanical analysis of volar plate and intramedullary nail fracture stability","volume":"131","author":"Konstantinidis","year":"2011","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"10.1016\/j.cmpb.2023.107774_bib0008","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1053\/jhsu.2002.32081","article-title":"Volar fixation for dorsally displaced fractures of the distal radius: a preliminary report","volume":"27A","author":"Orbay","year":"2002","journal-title":"J. Hand Surg. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0009","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1302\/0301-620X.84B8.0841093","article-title":"Evolution of the internal fixation of long bone fractures - The scientific basis of biological internal fixation: choosing a new balance between stability and biology","volume":"84B","author":"Perren","year":"2002","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.cmpb.2023.107774_bib0010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0021-9290(96)00140-6","article-title":"Biophysical stimuli on cells during tissue differentiation at implant interfaces","volume":"30","author":"Prendergast","year":"1997","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmpb.2023.107774_bib0011","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13246-015-0407-9","article-title":"The relationship between interfragmentary movement and cell differentiation in early fracture healing under locking plate fixation","volume":"39","author":"Miramini","year":"2016","journal-title":"Australas. Phys. Eng. Sci. Med."},{"key":"10.1016\/j.cmpb.2023.107774_bib0012","doi-asserted-by":"crossref","DOI":"10.1007\/s10439-021-02815-x","article-title":"Balance between mechanical stability and mechano-biology of fracture healing under volar locking plate","author":"Liu","year":"2021","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2023.107774_bib0013","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jor.1100150414","article-title":"Influence of size and stability of the osteotomy gap on the success of fracture healing","volume":"15","author":"Claes","year":"1997","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.cmpb.2023.107774_bib0014","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0268-0033(95)99799-8","article-title":"Effect of dynamization on gap healing of diaphyseal fractures under external fixation","volume":"10","author":"Claes","year":"1995","journal-title":"Clin. Biomech."},{"key":"10.1016\/j.cmpb.2023.107774_bib0015","first-page":"11","article-title":"Biomechanical testing of the LCP - how can stability in locked internal fixators be controlled?","volume":"34","author":"Stoffel","year":"2003","journal-title":"Inj. Int. J. Care. Inj."},{"key":"10.1016\/j.cmpb.2023.107774_bib0016","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1007\/s10439-018-2083-x","article-title":"Role of dynamic loading on early stage of bone fracture healing","volume":"46","author":"Ghimire","year":"2018","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2023.107774_bib0017","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0021-9290(02)00086-6","article-title":"A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading","volume":"35","author":"Lacroix","year":"2002","journal-title":"J. Biomech."},{"key":"10.1016\/j.cmpb.2023.107774_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207044","article-title":"Open reduction and internal fixation of displaced proximal humeral fractures. Does the surgeon\u2018s experience have an impact on outcomes?","volume":"13","author":"Helfen","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmpb.2023.107774_bib0019","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.apmr.2008.09.575","article-title":"Physiotherapy after volar plating of wrist fractures is effective using a home exercise program","volume":"90","author":"Krischak","year":"2009","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.cmpb.2023.107774_bib0020","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2106\/JBJS.J.01452","article-title":"A prospective randomized controlled trial comparing occupational therapy with independent exercises after volar plate fixation of a fracture of the distal part of the radius","volume":"93A","author":"Souer","year":"2011","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0021","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jht.2013.12.010","article-title":"Therapist supervised clinic-based therapy versus instruction in a home program following distal radius fracture: a systematic review","volume":"27","author":"Valdes","year":"2014","journal-title":"J. Hand Ther."},{"key":"10.1016\/j.cmpb.2023.107774_bib0022","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1243\/09544119JEIM739","article-title":"A review of probabilistic analysis in orthopaedic biomechanics","volume":"224","author":"Laz","year":"2010","journal-title":"Proc. Inst. Mechan. Eng. Part H J. Eng. Med."},{"key":"10.1016\/j.cmpb.2023.107774_bib0023","article-title":"A probabilistic approach for modelling bone fracture healing under Ilizarov circular fixator","volume":"37","author":"Ganadhiepan","year":"2021","journal-title":"Int. J. Num. Method Biomed. Eng."},{"key":"10.1016\/j.cmpb.2023.107774_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2019.105011","article-title":"A probabilistic-based approach for computational simulation of bone fracture healing","volume":"180","author":"Miramini","year":"2019","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cmpb.2023.107774_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2022.106626","article-title":"Influence of therapeutic grip exercises induced loading rates in distal radius fracture healing with volar locking plate fixation","volume":"215","author":"Liu","year":"2022","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cmpb.2023.107774_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2023.107464","article-title":"Development of numerical model-based machine learning algorithms for different healing stages of distal radius fracture healing","volume":"233","author":"Liu","year":"2023","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.cmpb.2023.107774_bib0027","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.medengphy.2016.07.007","article-title":"Influence of fracture geometry on bone healing under locking plate fixations: a comparison between oblique and transverse tibial fractures","volume":"38","author":"Miramini","year":"2016","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.cmpb.2023.107774_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2020.103915","article-title":"Computational study on synovial fluid flow behaviour in cartilage contact gap under osteoarthritic condition","volume":"123","author":"Liao","year":"2020","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cmpb.2023.107774_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105904","article-title":"Influences of variability and uncertainty in vertical and horizontal surface roughness on articular cartilage lubrication","volume":"148","author":"Liao","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cmpb.2023.107774_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.107292","article-title":"Depth camera-based model for studying the effects of muscle loading on distal radius fracture healing","volume":"164","author":"Li","year":"2023","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.cmpb.2023.107774_bib0031","series-title":"Computational Models of Tissue Differentiation","author":"Prendergast","year":"2010"},{"key":"10.1016\/j.cmpb.2023.107774_bib0032","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1080\/10255842.2013.855729","article-title":"Computational simulation of the early stage of bone healing under different configurations of locking compression plates","volume":"18","author":"Miramini","year":"2015","journal-title":"Comput. Methods Biomech. Biomed. Eng."},{"key":"10.1016\/j.cmpb.2023.107774_bib0033","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1115\/1.4043037","article-title":"The effects of dynamic loading on bone fracture healing under ilizarov circular fixators","volume":"141","author":"Ganadhiepan","year":"2019","journal-title":"J. Biomech. Eng. Trans. ASME"},{"key":"10.1016\/j.cmpb.2023.107774_bib0034","first-page":"18","article-title":"Bone fracture healing under Ilizarov fixator: influence of fixator configuration, fracture geometry, and loading","volume":"35","author":"Ganadhiepan","year":"2019","journal-title":"Int. J. Num. Method Biomed. Eng."},{"key":"10.1016\/j.cmpb.2023.107774_bib0035","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s11517-018-1945-6","article-title":"Biomechanical considerations in the design of patient-specific fixation plates for the distal radius","volume":"57","author":"Caiti","year":"2019","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.cmpb.2023.107774_bib0036","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jmatprotec.2005.04.104","article-title":"Comparative performance of a flexible fixation implant to a rigid implant in static and repetitive incremental loading","volume":"169","author":"McCartney","year":"2005","journal-title":"J. Mater. Process. Technol."},{"key":"10.1016\/j.cmpb.2023.107774_bib0037","unstructured":"A. International, ASTM F67-13-standard specification for unalloyed titanium, for surgical implant applications (UNS R50250, UNS R50400, UNS R50550, UNS R50700), ASTM International West Conshohocken, 2017."},{"key":"10.1016\/j.cmpb.2023.107774_bib0038","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1121\/1.1755239","article-title":"Ultrasonic wave propagation in human cancellous bone: application of Biot theory","volume":"116","author":"Fellah","year":"2004","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0039","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.medengphy.2014.11.001","article-title":"Permeability study of cancellous bone and its idealised structures","volume":"37","author":"Syahrom","year":"2015","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.cmpb.2023.107774_bib0040","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jhsa.2007.07.005","article-title":"A comparative study of clinical and radiological outcomes of dorsally angulated, unstable distal radius fractures in elderly patients: intrafocal pinning versus volar locking plating","volume":"32A","author":"Oshige","year":"2007","journal-title":"J. Hand Surg. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0041","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0736-0266(02)00259-0","article-title":"The initial phase of fracture healing is specifically sensitive to mechanical conditions","volume":"21","author":"Klein","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.cmpb.2023.107774_bib0042","first-page":"551","article-title":"The biology of fracture healing","volume":"42","author":"Marsell","year":"2011","journal-title":"Inj. Int. J. Care Inj."},{"key":"10.1016\/j.cmpb.2023.107774_bib0043","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1302\/0301-620X.60B2.350882","article-title":"The biology of fracture healing in long bones","volume":"60","author":"McKibbin","year":"1978","journal-title":"J. Bone Joint Surg. Br."},{"key":"10.1016\/j.cmpb.2023.107774_bib0044","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.actbio.2008.02.030","article-title":"Measurement of fracture callus material properties via nanoindentation","volume":"4","author":"Leong","year":"2008","journal-title":"Acta Biomater."},{"key":"10.1016\/j.cmpb.2023.107774_bib0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5435\/00124635-200701000-00004","article-title":"Malunion of the distal radius","volume":"15","author":"Bushnell","year":"2007","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.cmpb.2023.107774_bib0046","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s10409-020-00926-7","article-title":"Large deformation plasticity","volume":"36","author":"Bruhns","year":"2020","journal-title":"Acta Mechan. Sin."},{"key":"10.1016\/j.cmpb.2023.107774_bib0047","series-title":"Tailor Welded Blanks for Advanced Manufacturing","first-page":"68","article-title":"4 - numerical simulation modeling of tailor welded blank forming","author":"Zadpoor","year":"2011"},{"key":"10.1016\/j.cmpb.2023.107774_bib0048","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s12540-013-4014-6","article-title":"Strain hardening model of pure titanium considering effects of deformation twinning","volume":"19","author":"Ahn","year":"2013","journal-title":"Metals Mater. Int."},{"key":"10.1016\/j.cmpb.2023.107774_bib0049","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1061\/(ASCE)0733-9445(1996)122:12(1459)","article-title":"Method for probabilistic evaluation of seismic structural damage","volume":"122","author":"Singhal","year":"1996","journal-title":"J. Struct. Eng."},{"key":"10.1016\/j.cmpb.2023.107774_bib0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/jhsu.2003.50016","article-title":"Comparison of different distal radius dorsal and volar fracture fixation plates: a biomechanical study","volume":"28A","author":"Osada","year":"2003","journal-title":"J. Hand Surg. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0051","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.engfracmech.2003.08.003","article-title":"Modelling bone tissue fracture and healing: a review","volume":"71","author":"Doblar\u00e9","year":"2004","journal-title":"Eng. Fract. Mech."},{"key":"10.1016\/j.cmpb.2023.107774_bib0052","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.clinbiomech.2007.08.004","article-title":"A review of locking compression plate biomechanics and their advantages as internal fixators in fracture healing","volume":"22","author":"Miller","year":"2007","journal-title":"Clin. Biomech."},{"key":"10.1016\/j.cmpb.2023.107774_bib0053","first-page":"785","article-title":"Breakage of a volar locking plate after delayed union of a distal radius fracture","volume":"73","author":"De Baere","year":"2007","journal-title":"Acta Orthop. Belg."},{"issue":"Suppl 4","key":"10.1016\/j.cmpb.2023.107774_bib0054","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0020-1383(00)80016-9","article-title":"Unalloyed titanium for implants in bone surgery","volume":"31","author":"Pohler","year":"2000","journal-title":"Injury"},{"key":"10.1016\/j.cmpb.2023.107774_bib0055","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1586\/erd.10.53","article-title":"The use of titanium and stainless steel in fracture fixation","volume":"7","author":"Hayes","year":"2010","journal-title":"Expert Rev. Med. Devices"},{"key":"10.1016\/j.cmpb.2023.107774_bib0056","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jhsa.2009.01.004","article-title":"Early breakage of a titanium volar locking plate for fixation of a distal radius fracture: case report","volume":"34A","author":"Yukata","year":"2009","journal-title":"J. Hand Surg. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0057","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.jhsa.2012.03.021","article-title":"Biomechanical properties of fixed-angle volar distal radius plates under dynamic loading","volume":"37A","author":"Dahl","year":"2012","journal-title":"J. Hand Surg. Am."},{"key":"10.1016\/j.cmpb.2023.107774_bib0058","first-page":"6","article-title":"Biomechanical properties of 3-dimensional printed volar locking distal radius plate: comparison with conventional volar locking plate","volume":"42","author":"Kim","year":"2017","journal-title":"J. Hand Surg. Am. Vol.,"},{"key":"10.1016\/j.cmpb.2023.107774_bib0059","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s11517-006-0082-9","article-title":"Buttressing angle of the double-plating fixation of a distal radius fracture: a finite element study","volume":"44","author":"Lin","year":"2006","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.cmpb.2023.107774_bib0060","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1023\/A:1018520914512","article-title":"A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation","volume":"8","author":"Huiskes","year":"1997","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.cmpb.2023.107774_bib0061","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jtbi.2009.11.023","article-title":"On the role of diffusible binding partners in modulating the transport and concentration of proteins in tissues","volume":"263","author":"Zhang","year":"2010","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.cmpb.2023.107774_bib0062","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1440-1681.2011.05652.x","article-title":"Role of chemical and mechanical stimuli in mediating bone fracture healing","volume":"39","author":"Zhang","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.cmpb.2023.107774_bib0063","doi-asserted-by":"crossref","first-page":"e66870","DOI":"10.1371\/journal.pone.0066870","article-title":"Modeling the insulin-like growth factor system in articular cartilage","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.cmpb.2023.107774_bib0064","first-page":"175","article-title":"Physical and biological aspects of fracture-healing with special reference to internal-fixation","author":"Perren","year":"1979","journal-title":"Clin. Orthop. Rel. Res."},{"key":"10.1016\/j.cmpb.2023.107774_bib0065","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/jor.20118","article-title":"Corroboration of mechanoregulatory algorithms for tissue differentiation during fracture healing: comparison with in vivo results","volume":"24","author":"Isaksson","year":"2006","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.cmpb.2023.107774_bib0066","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1055\/s-0035-1558831","article-title":"Is bone grafting necessary in the treatment of malunited distal radius fractures?","volume":"04","author":"Poeze","year":"2015","journal-title":"J. Wrist Surg."},{"key":"10.1016\/j.cmpb.2023.107774_bib0067","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.injury.2006.08.058","article-title":"Biomechanical testing of the locking compression plate: when does the distance between bone and implant significantly reduce construct stability?","volume":"38","author":"Ahmad","year":"2007","journal-title":"Injury"},{"key":"10.1016\/j.cmpb.2023.107774_bib0068","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/S0020-1383(18)30296-1","article-title":"Pre-operative planning for fracture fixation using locking plates: device configuration and other considerations","volume":"49","author":"MacLeod","year":"2018","journal-title":"Injury"},{"key":"10.1016\/j.cmpb.2023.107774_bib0069","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","article-title":"Fracture healing under healthy and inflammatory conditions","volume":"8","author":"Claes","year":"2012","journal-title":"Nat. Rev. Rheumatol."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260723004406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260723004406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:21:57Z","timestamp":1759206117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260723004406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":69,"alternative-id":["S0169260723004406"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2023.107774","relation":{},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of uncertain clinical conditions on the early healing and stability of distal radius fractures","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2023.107774","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107774"}}