{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:08:46Z","timestamp":1791083326925,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"am","delay-in-days":315,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JPMXP1020210316"],"award-info":[{"award-number":["JPMXP1020210316"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JP 20356547"],"award-info":[{"award-number":["JP 20356547"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJFR225R"],"award-info":[{"award-number":["JPMJFR225R"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202006250022"],"award-info":[{"award-number":["202006250022"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 20KK0099"],"award-info":[{"award-number":["JP 20KK0099"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 21K14306"],"award-info":[{"award-number":["JP 21K14306"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 21KD2002"],"award-info":[{"award-number":["JP 21KD2002"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 22H00237"],"award-info":[{"award-number":["JP 22H00237"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 22K14371"],"award-info":[{"award-number":["JP 22K14371"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 22K18300"],"award-info":[{"award-number":["JP 22K18300"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computer Methods and Programs in Biomedicine"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.cmpb.2024.108073","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T17:30:31Z","timestamp":1707413431000},"page":"108073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["In silico identification of viral loads in cough-generated droplets \u2013 Seamless integrated analysis of CFPD-HCD-EWF"],"prefix":"10.1016","volume":"246","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8384-0010","authenticated-orcid":false,"given":"Hanyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6123-8213","authenticated-orcid":false,"given":"Nguyen Dang","family":"Khoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6553-6936","authenticated-orcid":false,"given":"Kazuki","family":"Kuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7715-7896","authenticated-orcid":false,"given":"Kazuhide","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cmpb.2024.108073_bib0001","first-page":"195","article-title":"The effects of the COVID-19 pandemic on community respiratory virus activity","volume":"21","author":"Chow","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12199-020-00904-2","article-title":"Environmental factors involved in SARS-CoV-2 transmission: effect and role of indoor environmental quality in the strategy for COVID-19 infection control","volume":"25","author":"Azuma","year":"2020","journal-title":"Environ. Health Prev. Med."},{"issue":"8","key":"10.1016\/j.cmpb.2024.108073_bib0003","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41579-021-00535-6","article-title":"Transmissibility and transmission of respiratory viruses","volume":"19","author":"Leung","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"issue":"9","key":"10.1016\/j.cmpb.2024.108073_bib0004","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/j.ajic.2016.06.003","article-title":"Airborne spread of infectious agents in the indoor environment","volume":"44","author":"Wei","year":"2016","journal-title":"Am. J. Infect. Control"},{"issue":"5","key":"10.1016\/j.cmpb.2024.108073_bib0005","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/joim.13326","article-title":"Breathing, speaking, coughing or sneezing: what drives transmission of SARS-CoV-2?","volume":"290","author":"Stadnytskyi","year":"2021","journal-title":"J. Intern. Med."},{"issue":"5","key":"10.1016\/j.cmpb.2024.108073_bib0006","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1177\/1420326X211048539","article-title":"Multiple airflow patterns in human microenvironment and the influence on short-distance airborne cross-infection \u2013 a review","volume":"31","author":"Nielsen","year":"2022","journal-title":"Indoor Built. Environ."},{"issue":"6558","key":"10.1016\/j.cmpb.2024.108073_bib0007","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd9149","article-title":"Airborne transmission of respiratory viruses","volume":"373","author":"Wang","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.cmpb.2024.108073_bib0008","doi-asserted-by":"crossref","unstructured":"H.F. Boncristiani, \u201cRespiratory Viruses,\u201d no. January, pp. 500\u2013518, 2009.","DOI":"10.1016\/B978-012373944-5.00314-X"},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0009","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1128\/CMR.00014-10","article-title":"The airway epithelium: soldier in the fight against respiratory viruses","volume":"24","author":"Vareille","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"issue":"7","key":"10.1016\/j.cmpb.2024.108073_bib0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41579-021-00542-7","article-title":"Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract","volume":"19","author":"Flerlage","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.cmpb.2024.108073_bib0011","unstructured":"A. Losier, G. Gupta, and M. Caldararo, \u201cThe Impact o f Coronavirus Disease 2019 on Viral, Bacterial, and Fungal Respiratory Infections,\u201d no. January 2020."},{"issue":"January","key":"10.1016\/j.cmpb.2024.108073_bib0012","first-page":"19","article-title":"Respiratory virus infections: understanding COVID-19","author":"Kanta","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.cmpb.2024.108073_bib0013","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMc2004973","article-title":"Aerosol and Surface Stability of SARS-CoV-2 as compared with SARS-CoV-1","volume":"382","author":"Doremalen","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.cmpb.2024.108073_bib0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.20200678","article-title":"The many faces of the anti-COVID immune response","volume":"217","author":"Vardhana","year":"2020","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.cmpb.2024.108073_bib0015","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S1473-3099(20)30195-X","article-title":"Real estimates of mortality following COVID-19 infection","volume":"20","author":"Baud","year":"2020","journal-title":"Lancet Infect. Dis."},{"issue":"7","key":"10.1016\/j.cmpb.2024.108073_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/su14073896","article-title":"SARS-CoV-2 dynamics in the mucus layer of the human upper respiratory tract based on host\u2013cell dynamics","volume":"14","author":"Li","year":"2022","journal-title":"Sustainability"},{"key":"10.1016\/j.cmpb.2024.108073_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2023.107622","article-title":"Visual prediction and parameter optimization of viral dynamics in the mucus milieu of the upper airway based on CFPD-HCD analysis","author":"Li","year":"2023","journal-title":"Comput. Methods Programs Biomed."},{"issue":"2","key":"10.1016\/j.cmpb.2024.108073_bib0018","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/his.14134","article-title":"Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction","volume":"77","author":"Menter","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.cmpb.2024.108073_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ebiom.2020.102903","article-title":"SARS-CoV-2 detection in different respiratory sites: a systematic review and meta-analysis","volume":"59","author":"Mohammadi","year":"2020","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.cmpb.2024.108073_bib0020","first-page":"147","article-title":"SARS-CoV-2 viral load and shedding kinetics","volume":"21","author":"Puhach","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"issue":"15","key":"10.1016\/j.cmpb.2024.108073_bib0021","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/cid\/ciaa345","article-title":"Quantitative detection and viral load analysis of SARS-CoV-2 in infected patients","volume":"71","author":"Yu","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cmpb.2024.108073_bib0022","doi-asserted-by":"crossref","unstructured":"M.R.J. Faruque, F.J. Bikker, and M.L. Laine, \u201cComparing SARS-CoV-2 viral load in human saliva to oropharyngeal swabs, nasopharyngeal swabs, and sputum : a systematic review and meta-analysis,\u201d vol. 2023, no. 5807370, 2023.","DOI":"10.1155\/2023\/5807370"},{"issue":"11","key":"10.1016\/j.cmpb.2024.108073_bib0023","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1177\/0022034520946251","article-title":"Viral load dynamics in sputum and nasopharyngeal swab in patients with COVID-19","volume":"99","author":"Liu","year":"2020","journal-title":"J. Dent. Res."},{"issue":"3","key":"10.1016\/j.cmpb.2024.108073_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/diagnostics11030427","article-title":"Spatial and temporal virus load dynamics of sars-cov-2: a single-center cohort study","volume":"11","author":"Alidjinou","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.cmpb.2024.108073_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102916","article-title":"Spatial and temporal dynamics of SARS-CoV-2 in COVID-19 patients: a systematic review and meta-analysis","volume":"58","author":"Weiss","year":"2020","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-020-02893-8","article-title":"SARS-CoV-2 viral load in sputum correlates with risk of COVID-19 progression","volume":"24","author":"Yu","year":"2020","journal-title":"Crit. Care"},{"issue":"April","key":"10.1016\/j.cmpb.2024.108073_bib0027","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.2147\/IDR.S353688","article-title":"Delayed clearance of viral RNA in sputum for severity COVID-19 patients with initial high viral load","volume":"15","author":"Zhao","year":"2022","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.cmpb.2024.108073_bib0028","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ijid.2020.10.099","article-title":"Viral kinetics of SARS-CoV-2 over the preclinical, clinical, and postclinical period","volume":"102","author":"Jang","year":"2021","journal-title":"Int. J. Infect. Dis."},{"issue":"20","key":"10.1016\/j.cmpb.2024.108073_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3346\/jkms.2020.35.e195","article-title":"Clinical significance of a high SARS-CoV-2 viral load in the Saliva","volume":"35","author":"Yoon","year":"2020","journal-title":"J. Korean Med. Sci."},{"issue":"8","key":"10.1016\/j.cmpb.2024.108073_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ofid\/ofab153","article-title":"Viral load kinetics of severe acute respiratory syndrome coronavirus 2 in hospitalized individuals with coronavirus disease 2019","volume":"8","author":"Regan","year":"2021","journal-title":"Open Forum Infect. Dis."},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0031","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19057-5","article-title":"SARS-CoV-2 viral load is associated with increased disease severity and mortality","volume":"11","author":"Fajnzylber","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.cmpb.2024.108073_bib0032","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/cpt.2160","article-title":"Mechanistic modeling of SARS-CoV-2 and other infectious diseases and the effects of therapeutics","volume":"109","author":"Perelson","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"issue":"7809","key":"10.1016\/j.cmpb.2024.108073_bib0033","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-020-2196-x","article-title":"Virological assessment of hospitalized patients with COVID-2019","volume":"581","author":"W\u00f6lfel","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmpb.2024.108073_bib0034","article-title":"Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study","volume":"369","author":"Zheng","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.cmpb.2024.108073_bib0035","unstructured":"R. Ke, C. Zitzmann, R.M. Ribeiro, and A.S. Perelson, \u201cKinetics of SARS-CoV-2 infection in the human upper and lower respiratory tracts and their relationship with infectiousness,\u201d medRxiv, p. 2020.09.25.20201772, 2020, [Online]. Available: https:\/\/www.medrxiv.org\/content\/10.1101\/2020.09.25.20201772v1%0Ahttps:\/\/www.medrxiv.org\/content\/10.1101\/2020.09.25.20201772v1.abstract."},{"issue":"7","key":"10.1016\/j.cmpb.2024.108073_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3346\/jkms.2020.35.e86","article-title":"Viral load kinetics of SARS-CoV-2 infection in first two patients in Korea","volume":"35","author":"Kim","year":"2020","journal-title":"J. Korean Med. Sci."},{"issue":"4","key":"10.1016\/j.cmpb.2024.108073_bib0037","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(20)30113-4","article-title":"Viral load of SARS-CoV-2 in clinical samples","volume":"20","author":"Pan","year":"2020","journal-title":"Lancet Infect. Dis."},{"issue":"7824","key":"10.1016\/j.cmpb.2024.108073_bib0038","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-020-2324-7","article-title":"Respiratory disease in rhesus macaques inoculated with SARS-CoV-2","volume":"585","author":"Munster","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cmpb.2024.108073_bib0039","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jbiomech.2019.01.015","article-title":"Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity","volume":"85","author":"Shang","year":"2019","journal-title":"J. Biomech."},{"issue":"1 January","key":"10.1016\/j.cmpb.2024.108073_bib0040","first-page":"1","article-title":"Prediction of nasal spray drug absorption influenced by mucociliary clearance","volume":"16","author":"Shang","year":"2021","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.cmpb.2024.108073_bib0041","first-page":"2057","article-title":"Respiratory virus RNA is detectable in airborne and droplet particles","volume":"85","author":"Bartholomeusz","year":"2013","journal-title":"Antivir. Ther."},{"issue":"3","key":"10.1016\/j.cmpb.2024.108073_bib0042","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaerosci.2008.11.002","article-title":"Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities","volume":"40","author":"Morawska","year":"2009","journal-title":"J. Aerosol Sci."},{"issue":"17","key":"10.1016\/j.cmpb.2024.108073_bib0043","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2018995118","article-title":"A guideline to limit indoor airborne transmission of COVID-19","volume":"118","author":"Bazant","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cmpb.2024.108073_bib0044","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1017\/jfm.2014.88","article-title":"Violent expiratory events: on coughing and sneezing","volume":"745","author":"Bourouiba","year":"2014","journal-title":"J. Fluid Mech."},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-38808-z","article-title":"Aerosol emission and superemission during human speech increase with voice loudness","volume":"9","author":"Asadi","year":"2019","journal-title":"Sci. Rep."},{"issue":"March","key":"10.1016\/j.cmpb.2024.108073_bib0046","article-title":"Short-range airborne route dominates exposure of respiratory infection during close contact","volume":"176","author":"Chen","year":"2020","journal-title":"Build. Environ."},{"key":"10.1016\/j.cmpb.2024.108073_bib0047","series-title":"Inhalation Aerosols: Physical and Biological Basis For Therapy","author":"Hickey","year":"2019"},{"issue":"11","key":"10.1016\/j.cmpb.2024.108073_bib0048","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.chemosphere.2012.01.032","article-title":"Study on the initial velocity distribution of exhaled air from coughing and speaking","volume":"87","author":"Kwon","year":"2012","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0049","doi-asserted-by":"crossref","first-page":"127","DOI":"10.18186\/thermal.1243491","article-title":"CFD modeling of influenza virus diffusion during coughing and breathing in a ventilated room","volume":"9","author":"Aljabair","year":"2023","journal-title":"J. Therm. Eng."},{"issue":"12","key":"10.1016\/j.cmpb.2024.108073_bib0050","doi-asserted-by":"crossref","DOI":"10.1063\/5.0072148","article-title":"Large eddy simulation of cough jet dynamics, droplet transport, and inhalability over a ten minute exposure","volume":"33","author":"Calmet","year":"2021","journal-title":"Phys. Fluids"},{"issue":"4","key":"10.1016\/j.cmpb.2024.108073_bib0051","article-title":"Numerical investigation of the impacts of environmental conditions and breathing rate on droplet transmission during dental service","volume":"35","author":"Li","year":"2023","journal-title":"Phys. Fluids"},{"issue":"26","key":"10.1016\/j.cmpb.2024.108073_bib0052","doi-asserted-by":"crossref","first-page":"16876","DOI":"10.1021\/acsomega.1c01489","article-title":"CFD simulation of the airborne transmission of COVID-19 vectors emitted during respiratory mechanisms: revisiting the concept of safe distance","volume":"6","author":"Mariam","year":"2021","journal-title":"ACS Omega"},{"issue":"June","key":"10.1016\/j.cmpb.2024.108073_bib0053","article-title":"Seamless numerical analysis of transient infectious droplet dispersion and inhalation exposure - In silico study","volume":"244","author":"Nishihara","year":"2023","journal-title":"Build. Environ."},{"issue":"November 2020","key":"10.1016\/j.cmpb.2024.108073_bib0054","article-title":"Deposition features of inhaled viral droplets may lead to rapid secondary transmission of COVID-19","volume":"154","author":"Shang","year":"2021","journal-title":"J. Aerosol Sci."},{"key":"10.1016\/j.cmpb.2024.108073_bib0055","series-title":"Proceedings of the E3S Web of Conferences","article-title":"Various pathogen-laden aerosol deposition in the realistic human airway during inhalation","volume":"356","author":"Luo","year":"2022"},{"issue":"3","key":"10.1016\/j.cmpb.2024.108073_bib0056","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010972","article-title":"Large eddy simulation of droplet transport and deposition in the human respiratory tract to evaluate inhalation risk","volume":"19","author":"Murga","year":"2023","journal-title":"PLoS Comput. Biol."},{"issue":"April","key":"10.1016\/j.cmpb.2024.108073_bib0057","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaerosci.2019.04.009","article-title":"Lung aerosol dynamics of airborne influenza A virus-laden droplets and the resultant immune system responses: an in silico study","volume":"134","author":"Haghnegahdar","year":"2019","journal-title":"J. Aerosol Sci."},{"issue":"9","key":"10.1016\/j.cmpb.2024.108073_bib0058","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/jmv.25866","article-title":"Mathematical modeling of interaction between innate and adaptive immune responses in COVID-19 and implications for viral pathogenesis","volume":"92","author":"Du","year":"2020","journal-title":"J. Med. Virol."},{"issue":"9","key":"10.1016\/j.cmpb.2024.108073_bib0059","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/psp4.12543","article-title":"Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load","volume":"9","author":"Gon\u00e7alves","year":"2020","journal-title":"CPT Pharmacomet. Syst. Pharmacol."},{"issue":"September","key":"10.1016\/j.cmpb.2024.108073_bib0060","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.arcontrol.2020.09.006","article-title":"In-host mathematical modelling of COVID-19 in humans","volume":"50","author":"Hernandez-Vargas","year":"2020","journal-title":"Annu. Rev. Control"},{"issue":"49","key":"10.1016\/j.cmpb.2024.108073_bib0061","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2111477118","article-title":"In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness","volume":"118","author":"Ke","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cmpb.2024.108073_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbs.2020.108438","article-title":"Modeling the viral dynamics of SARS-CoV-2 infection","volume":"328","author":"Wang","year":"2020","journal-title":"Math. Biosci."},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0063","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-18788-3","article-title":"Coupled discrete phase model and Eulerian wall film model for numerical simulation of respiratory droplet generation during coughing","volume":"12","author":"Anzai","year":"2022","journal-title":"Sci. Rep."},{"issue":"112103","key":"10.1016\/j.cmpb.2024.108073_bib0064","article-title":"Coupled Eulerian wall film\u2013discrete phase model for predicting respiratory droplet generation during a coughing event","volume":"35","author":"Khoa","year":"2023","journal-title":"Phys. Fluids"},{"key":"10.1016\/j.cmpb.2024.108073_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2023.107589","article-title":"Computational fluid-particle dynamics modeling of ultrafine to coarse particles deposition in the human respiratory system, down to the terminal bronchiole","volume":"237","author":"Khoa","year":"2023","journal-title":"Comput. Methods Programs Biomed."},{"issue":"March","key":"10.1016\/j.cmpb.2024.108073_bib0066","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.scs.2018.04.023","article-title":"Assessment of transient inhalation exposure using in silico human model integrated with PBPK-CFD hybrid analysis","volume":"40","author":"Yoo","year":"2018","journal-title":"Sustain. Cities Soc."},{"issue":"5","key":"10.1016\/j.cmpb.2024.108073_bib0067","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/ina.12666","article-title":"A numerical investigation of the potential effects of e-cigarette smoking on local tissue dosimetry and the deterioration of indoor air quality","volume":"30","author":"Kuga","year":"2020","journal-title":"Indoor Air"},{"issue":"4","key":"10.1016\/j.cmpb.2024.108073_bib0068","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/2475-8876.12301","article-title":"Validation, verification, and quality control of computational fluid dynamics analysis for indoor environments using a computer-simulated person with respiratory tract","volume":"5","author":"Yoo","year":"2022","journal-title":"Jpn. Archit. Rev."},{"key":"10.1016\/j.cmpb.2024.108073_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2023.107501","article-title":"Effect of transient breathing cycle on the deposition\u00c2 of micro and nanoparticles on respiratory walls","volume":"236","author":"Kuga","year":"2023","journal-title":"Comput. Methods Programs Biomed."},{"issue":"3\u20134","key":"10.1016\/j.cmpb.2024.108073_bib0070","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0025-5564(73)90073-4","article-title":"Mucus flows","volume":"17","author":"Blake","year":"1973","journal-title":"Math. Biosci."},{"issue":"3","key":"10.1016\/j.cmpb.2024.108073_bib0071","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1016\/j.jinf.2020.06.059","article-title":"Viral dynamics of SARS-CoV-2 in saliva from infected patients","volume":"81","author":"Zhu","year":"2020","journal-title":"J. Infect."},{"issue":"23","key":"10.1016\/j.cmpb.2024.108073_bib0072","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMra0910061","article-title":"Airway mucus function and dysfunction","volume":"363","author":"Fahy","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0073","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1600-0668.2009.00623.x","article-title":"Characterizing exhaled airflow from breathing and talking","volume":"20","author":"Gupta","year":"2010","journal-title":"Indoor Air"},{"key":"10.1016\/j.cmpb.2024.108073_bib0074","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-022-01780-9","article-title":"Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults","author":"Killingley","year":"2022","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.cmpb.2024.108073_bib0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.cmpb.2024.108073_bib0076","doi-asserted-by":"crossref","unstructured":"Y.M. Bar-on, A.V.I. Flamholz, R.O.B. Phillips, and R.O.N. Milo, \u201cSARS-CoV-2 (COVID-19) by the numbers,\u201d vol. 2, pp. 1\u201315, 2020.","DOI":"10.7554\/eLife.57309.sa2"},{"key":"10.1016\/j.cmpb.2024.108073_bib0077","unstructured":"T. Berkemeier et al., \u201cRespiratory aerosols and droplets in the transmission of infectious diseases,\u201d 2021."},{"key":"10.1016\/j.cmpb.2024.108073_bib0078","unstructured":"N.D. Khoa, K. Kuga, K. Inthavong, and K. Ito, \u201cCoupled Eulerian Wall Film \u2013 discrete phase model,\u201d 2023, 10.1063\/5.0174014."},{"key":"10.1016\/j.cmpb.2024.108073_bib0079","unstructured":"A. Manual, \u201cAnsys Inc,\u201d Canonsburg, PA, vol. 15317, no. November, pp. 724\u2013746, 2000, [Online]. Available: http:\/\/scholar.google.co.uk\/scholar?hl=en&q=ansys&btnG=&as_sdt=1%2C5&as_sdtp=#7."},{"issue":"4","key":"10.1016\/j.cmpb.2024.108073_bib0080","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1089\/jam.2007.0610","article-title":"The size and concentration of droplets generated by coughing in human subjects","volume":"20","author":"Yang","year":"2007","journal-title":"J. Aerosol Med. Depos. Clear. Eff. Lung"},{"issue":"2","key":"10.1016\/j.cmpb.2024.108073_bib0081","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.addr.2008.09.012","article-title":"Micro- and macrorheology of mucus","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0083","doi-asserted-by":"crossref","first-page":"E241","DOI":"10.1093\/cid\/ciab797","article-title":"Infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in exhaled aerosols and efficacy of masks during early mild infection","volume":"75","author":"Adenaiye","year":"2022","journal-title":"Clin. Infect. Dis."},{"issue":"5","key":"10.1016\/j.cmpb.2024.108073_bib0084","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/cid\/ciac846","article-title":"Exhaled breath aerosol shedding of highly transmissible versus prior severe acute respiratory syndrome coronavirus 2 variants","volume":"76","author":"Lai","year":"2023","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.cmpb.2024.108073_bib0085","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0668.2009.00621.x","article-title":"Review and comparison between the Wells\u2013Riley and dose-response approaches to risk assessment of infectious respiratory diseases","volume":"20","author":"Sze To","year":"2010","journal-title":"Indoor Air"},{"issue":"10","key":"10.1016\/j.cmpb.2024.108073_bib0086","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241539","article-title":"Modeling the load of SARS-CoV-2 virus in human expelled particles during coughing and speaking","volume":"15","author":"Wang","year":"2020","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.cmpb.2024.108073_bib0087","doi-asserted-by":"crossref","DOI":"10.1115\/1.3005339","article-title":"An adjustable triple-bifurcation unit model for air-particle flow simulations in human tracheobronchial airways","volume":"131","author":"Kleinstreuer","year":"2009","journal-title":"J. Biomech. Eng."},{"issue":"March","key":"10.1016\/j.cmpb.2024.108073_bib0088","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaerosci.2017.03.004","article-title":"Pulmonary aerosol transport and deposition analysis in upper 17 generations of the human respiratory tract","volume":"108","author":"Islam","year":"2017","journal-title":"J. Aerosol Sci."},{"issue":"12","key":"10.1016\/j.cmpb.2024.108073_bib0089","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.4209\/aaqr.2020.02.0067","article-title":"Particle deposition in human lung airways: effects of airflow, particle size, and mechanisms","volume":"20","author":"Ou","year":"2020","journal-title":"Aerosol Air Qual. Res."},{"issue":"11","key":"10.1016\/j.cmpb.2024.108073_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/atmos12111402","article-title":"Aerosol particle transport and deposition in upper and lower airways of infant, child and adult human lungs","volume":"12","author":"Rahman","year":"2021","journal-title":"Atmosphere"},{"issue":"2","key":"10.1016\/j.cmpb.2024.108073_bib0091","doi-asserted-by":"crossref","first-page":"161","DOI":"10.24272\/j.issn.2095-8137.2020.329","article-title":"Lower respiratory tract samples are reliable for severe acute respiratory syndrome coronavirus 2 nucleic acid diagnosis and animal model study","volume":"42","author":"Tian","year":"2021","journal-title":"Zool. Res."}],"container-title":["Computer Methods and Programs in Biomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260724000695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169260724000695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T01:30:40Z","timestamp":1741656640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169260724000695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":90,"alternative-id":["S0169260724000695"],"URL":"https:\/\/doi.org\/10.1016\/j.cmpb.2024.108073","relation":{},"ISSN":["0169-2607"],"issn-type":[{"value":"0169-2607","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico identification of viral loads in cough-generated droplets \u2013 Seamless integrated analysis of CFPD-HCD-EWF","name":"articletitle","label":"Article Title"},{"value":"Computer Methods and Programs in Biomedicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cmpb.2024.108073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108073"}}